Reviewed,
UniProtKB/Swiss-Prot Q15126 (PMVK_HUMAN)
Last modified
July 7, 2009.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phosphomevalonate kinase Short name=PMKase EC=2.7.4.2 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 192 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate. |
| Pathway | |
| Subunit structure | Monomer By similarity. |
| Subcellular location | |
| Tissue specificity | Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta, and lung. |
| Induction | By sterol. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cholesterol biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Cellular component | Peroxisome |
| Coding sequence diversity | Polymorphism |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Ref.4Traceable author statement. Source: ProtInc |
| Cellular component | peroxisome Ref.4 Traceable author statement. Source: ProtInc |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphomevalonate kinase activity Ref.4Traceable author statement. Source: ProtInc protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CENPH | Q9H3R5 | 1 | EBI-1055562,EBI-1003700 | |
| MLF2 | Q15773 | 1 | EBI-1055562,EBI-1051875 | |
| MPDU1 | O75352 | 1 | EBI-1055562,EBI-1046501 | |
| PITPNA | Q00169 | 1 | EBI-1055562,EBI-1042490 | |
| RGS20 | O76081 | 1 | EBI-1055562,EBI-1052678 | |
| SSB | P05455 | 1 | EBI-1055562,EBI-358037 | |
| TBPL1 | P62380 | 1 | EBI-1055562,EBI-716225 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 192 | 191 | Phosphomevalonate kinase | PRO_0000058472 | |||||
Regions | |||||||||
| Motif | 190 – 192 | 3 | Microbody targeting signal Potential | ||||||
Natural variations | |||||||||
| Natural variant | 125 | 1 | V → M: dbSNP rs16836525. Ref.2 | VAR_051283 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence." Chambliss K.L., Slaughter C.A., Schreiner R., Hoffmann G.F., Gibson K.M. J. Biol. Chem. 271:17330-17334(1996) [PubMed: 8663599] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| [2] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-125. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin and Uterus. |
| [4] | "Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting." Olivier L.M., Chambliss K.L., Gibson K.M., Krisans S.K. J. Lipid Res. 40:672-679(1999) [PubMed: 10191291] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-192. |
| [5] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| L77213 mRNA. Translation: AAC37593.1. BT019976 mRNA. Translation: AAV38779.1. BC006089 mRNA. Translation: AAH06089.1. BC007694 mRNA. Translation: AAH07694.1. AF026069 Genomic DNA. Translation: AAC60791.1. | |||||||||||||
| IPI | IPI00220648. | ||||||||||||
| RefSeq | NP_006547.1. | ||||||||||||
| UniGene | Hs.30954 | ||||||||||||
3D structure databases | |||||||||||||
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q15126. 9 interactions. | ||||||||||||
2-D gel databases | |||||||||||||
| REPRODUCTION-2DPAGE | IPI00220648. | ||||||||||||
Proteomic databases | |||||||||||||
| PeptideAtlas | Q15126. | ||||||||||||
| PRIDE | Q15126. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000163344. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 10654. | ||||||||||||
| KEGG | hsa:10654. | ||||||||||||
| UCSC | uc001ffq.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC01M153163. | ||||||||||||
| H-InvDB | HIX0001026. HIX0076097. | ||||||||||||
| HGNC | HGNC:9141. PMVK. | ||||||||||||
| MIM | 607622. gene. | ||||||||||||
| PharmGKB | PA33465. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | Q15126. | ||||||||||||
| HOVERGEN | Q15126. | ||||||||||||
| OMA | Q15126. QYAQEHG. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BRENDA | 2.7.4.2. 247. | ||||||||||||
| Reactome | REACT_602. Metabolism of lipids and lipoproteins. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q15126. | ||||||||||||
| Bgee | Q15126. | ||||||||||||
| CleanEx | HS_PMVK. | ||||||||||||
| GermOnline | ENSG00000163344. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR005919. Pmev_kin_anim. [Graphical view] | ||||||||||||
| PANTHER | PTHR13101. Pmev_kin_anim. 1 hit. | ||||||||||||
| Pfam | PF04275. P-mevalo_kinase. 1 hit. [Graphical view] | ||||||||||||
| PIRSF | PIRSF036639. PMK_anim. 1 hit. | ||||||||||||
| TIGRFAMs | TIGR01223. Pmev_kin_anim. 1 hit. | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 40503. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | PMVK_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q15126 Secondary accession number(s): Q5TZW9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |

Clusters with


