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Protein

Phosphoglucomutase-like protein 5

Gene

PGM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity.

Cofactori

Mg2+CuratedNote: Binds 1 Mg2+ ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei28SubstrateBy similarity1
Active sitei122Phosphoserine intermediateBy similarity1
Metal bindingi122Magnesium; via phosphate groupBy similarity1
Binding sitei135SubstrateBy similarity1
Metal bindingi293MagnesiumBy similarity1
Metal bindingi295MagnesiumBy similarity1
Metal bindingi297MagnesiumBy similarity1
Binding sitei394SubstrateBy similarity1
Binding sitei520SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCarbohydrate metabolism, Cell adhesion, Glucose metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglucomutase-like protein 5
Alternative name(s):
Aciculin
Phosphoglucomutase-related protein
Short name:
PGM-RP
Gene namesi
Name:PGM5
Synonyms:PGMRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000154330.12
HGNCiHGNC:8908 PGM5
MIMi600981 gene
neXtProtiNX_Q15124

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi5239
OpenTargetsiENSG00000154330
PharmGKBiPA33245

Polymorphism and mutation databases

BioMutaiPGM5
DMDMi152031655

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477871 – 567Phosphoglucomutase-like protein 5Add BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphothreonineBy similarity1
Modified residuei122PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15124
MaxQBiQ15124
PaxDbiQ15124
PeptideAtlasiQ15124
PRIDEiQ15124
ProteomicsDBi60450
60451 [Q15124-2]
TopDownProteomicsiQ15124-2 [Q15124-2]

PTM databases

iPTMnetiQ15124
PhosphoSitePlusiQ15124

Expressioni

Tissue specificityi

Detected in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component. Low levels are present in liver, kidney, skin and brain (at protein level).2 Publications

Developmental stagei

In the developing aorta, expressed at low levels in 10-12 week old fetuses. Levels increase progressively in 24 week fetus, 6 month old child and 1.5 year old child aortic smooth muscle, reaching a maximum at maturity.1 Publication

Gene expression databases

BgeeiENSG00000154330
CleanExiHS_PGM5
ExpressionAtlasiQ15124 baseline and differential
GenevisibleiQ15124 HS

Organism-specific databases

HPAiCAB034397
HPA046329
HPA067102

Interactioni

Subunit structurei

Interacts with cytoskeletal proteins dystrophin and utrophin.

Protein-protein interaction databases

BioGridi111258, 9 interactors
STRINGi9606.ENSP00000379678

Structurei

3D structure databases

ProteinModelPortaliQ15124
SMRiQ15124
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 123Substrate bindingBy similarity2
Regioni297 – 298Substrate bindingBy similarity2
Regioni381 – 383Substrate bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi510 – 513Poly-Ser4

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiKOG0625 Eukaryota
COG0033 LUCA
GeneTreeiENSGT00390000011831
HOGENOMiHOG000009550
HOVERGENiHBG001599
InParanoidiQ15124
KOiK15636
OMAiPTAPYED
OrthoDBiEOG091G0HZ0
PhylomeDBiQ15124
TreeFamiTF300350

Family and domain databases

InterProiView protein in InterPro
IPR005844 A-D-PHexomutase_a/b/a-I
IPR016055 A-D-PHexomutase_a/b/a-I/II/III
IPR005845 A-D-PHexomutase_a/b/a-II
IPR005846 A-D-PHexomutase_a/b/a-III
IPR036900 A-D-PHexomutase_C_sf
IPR016066 A-D-PHexomutase_CS
IPR005841 Alpha-D-phosphohexomutase_SF
PfamiView protein in Pfam
PF02878 PGM_PMM_I, 1 hit
PF02879 PGM_PMM_II, 1 hit
PF02880 PGM_PMM_III, 1 hit
PRINTSiPR00509 PGMPMM
SUPFAMiSSF53738 SSF53738, 3 hits
SSF55957 SSF55957, 1 hit
PROSITEiView protein in PROSITE
PS00710 PGM_PMM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15124-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGSPIPVLT VPTAPYEDQR PAGGGGLRRP TGLFEGQRNY LPNFIQSVLS
60 70 80 90 100
SIDLRDRQGC TMVVGSDGRY FSRTAIEIVV QMAAANGIGR LIIGQNGILS
110 120 130 140 150
TPAVSCIIRK IKAAGGIILT ASHCPGGPGG EFGVKFNVAN GGPAPDVVSD
160 170 180 190 200
KIYQISKTIE EYAICPDLRI DLSRLGRQEF DLENKFKPFR VEIVDPVDIY
210 220 230 240 250
LNLLRTIFDF HAIKGLLTGP SQLKIRIDAM HGVMGPYVRK VLCDELGAPA
260 270 280 290 300
NSAINCVPLE DFGGQHPDPN LTYATTLLEA MKGGEYGFGA AFDADGDRYM
310 320 330 340 350
ILGQNGFFVS PSDSLAIIAA NLSCIPYFRQ MGVRGFGRSM PTSMALDRVA
360 370 380 390 400
KSMKVPVYET PAGWRFFSNL MDSGRCNLCG EESFGTGSDH LREKDGLWAV
410 420 430 440 450
LVWLSIIAAR KQSVEEIVRD HWAKFGRHYY CRFDYEGLDP KTTYYIMRDL
460 470 480 490 500
EALVTDKSFI GQQFAVGSHV YSVAKTDSFE YVDPVDGTVT KKQGLRIIFS
510 520 530 540 550
DASRLIFRLS SSSGVRATLR LYAESYERDP SGHDQEPQAV LSPLIAIALK
560
ISQIHERTGR RGPTVIT
Length:567
Mass (Da):62,225
Last modified:July 10, 2007 - v2
Checksum:i00583A442977A025
GO
Isoform 2 (identifier: Q15124-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-387: G → V
     388-567: Missing.

Note: No experimental confirmation available.
Show »
Length:387
Mass (Da):41,790
Checksum:i31FF5EACAFB47DC4
GO

Sequence cautioni

The sequence AAC41948 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH33073 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA73882 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22A → S in CAA73882 (PubMed:9342213).Curated1
Sequence conflicti244D → E AA sequence (PubMed:8175905).Curated1
Sequence conflicti260 – 261ED → DE AA sequence (PubMed:8175905).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030014387G → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_030015388 – 567Missing in isoform 2. 1 PublicationAdd BLAST180

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297108 mRNA Translation: BAG59618.1
AL161457 Genomic DNA No translation available.
AL353608 Genomic DNA No translation available.
AL353616 Genomic DNA No translation available.
BC033073 mRNA Translation: AAH33073.1 Different initiation.
Y13478 Genomic DNA Translation: CAA73882.1 Different initiation.
L40933 Genomic DNA Translation: AAC41948.1 Different initiation.
CCDSiCCDS6622.2 [Q15124-1]
PIRiS62629
RefSeqiNP_068800.2, NM_021965.3 [Q15124-1]
UniGeneiHs.307835

Genome annotation databases

EnsembliENST00000396392; ENSP00000379674; ENSG00000154330 [Q15124-2]
ENST00000396396; ENSP00000379678; ENSG00000154330 [Q15124-1]
GeneIDi5239
KEGGihsa:5239
UCSCiuc004agr.3 human [Q15124-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPGM5_HUMAN
AccessioniPrimary (citable) accession number: Q15124
Secondary accession number(s): B1AM46
, B4DLQ6, Q5VYV3, Q8N527, Q9UDH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 10, 2007
Last modified: June 20, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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