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Protein

Astrocytic phosphoprotein PEA-15

Gene

PEA15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.By similarity2 Publications

GO - Biological processi

Keywordsi

Biological processApoptosis, Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-5673001 RAF/MAP kinase cascade
SignaLinkiQ15121
SIGNORiQ15121

Names & Taxonomyi

Protein namesi
Recommended name:
Astrocytic phosphoprotein PEA-15
Alternative name(s):
15 kDa phosphoprotein enriched in astrocytes
Phosphoprotein enriched in diabetes
Short name:
PED
Gene namesi
Name:PEA15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162734.12
HGNCiHGNC:8822 PEA15
MIMi603434 gene
neXtProtiNX_Q15121

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi8682
OpenTargetsiENSG00000162734
PharmGKBiPA33166

Polymorphism and mutation databases

BioMutaiPEA15
DMDMi32470612

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912821 – 130Astrocytic phosphoprotein PEA-15Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineCombined sources1
Modified residuei90PhosphoserineBy similarity1
Modified residuei104PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15121
MaxQBiQ15121
PaxDbiQ15121
PeptideAtlasiQ15121
PRIDEiQ15121
ProteomicsDBi60449
TopDownProteomicsiQ15121-1 [Q15121-1]

PTM databases

iPTMnetiQ15121
PhosphoSitePlusiQ15121

Miscellaneous databases

PMAP-CutDBiQ15121

Expressioni

Tissue specificityi

Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.1 Publication

Gene expression databases

BgeeiENSG00000162734
CleanExiHS_PEA15
ExpressionAtlasiQ15121 baseline and differential
GenevisibleiQ15121 HS

Organism-specific databases

HPAiHPA028356
HPA070820

Interactioni

Subunit structurei

Binds RPS6KA3, MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD.By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114230, 17 interactors
IntActiQ15121, 13 interactors
MINTiQ15121
STRINGi9606.ENSP00000353660

Structurei

Secondary structure

1130
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 13Combined sources13
Helixi17 – 27Combined sources11
Turni28 – 30Combined sources3
Helixi32 – 34Combined sources3
Helixi42 – 51Combined sources10
Helixi61 – 69Combined sources9
Helixi73 – 90Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IZ5X-ray3.19E/F/G/H1-130[»]
4IZAX-ray1.93B1-96[»]
ProteinModelPortaliQ15121
SMRiQ15121
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81DEDPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 107Microtubule-bindingSequence analysis10
Regioni122 – 129Microtubule-bindingSequence analysis8

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00390000000230
HOGENOMiHOG000049048
HOVERGENiHBG053557
InParanoidiQ15121
OMAiSPVMAEY
OrthoDBiEOG091G0TNX
PhylomeDBiQ15121
TreeFamiTF332405

Family and domain databases

CDDicd08338 DED_PEA15, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR001875 DED_dom
IPR029546 PEA15
PANTHERiPTHR15094 PTHR15094, 1 hit
PfamiView protein in Pfam
PF01335 DED, 1 hit
SMARTiView protein in SMART
SM00031 DED, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50168 DED, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15121-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE
60 70 80 90 100
SHNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT
110 120 130
RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA
Length:130
Mass (Da):15,040
Last modified:July 3, 2003 - v2
Checksum:i8D0F93A40B299FB2
GO
Isoform 2 (identifier: Q15121-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEDEGNKLCQAPPWPGQTSPVM

Note: No experimental confirmation available.
Show »
Length:151
Mass (Da):17,307
Checksum:i4BA064CDB2A9AA53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → V in CAA60499 (PubMed:8662970).Curated1
Sequence conflicti8L → F in CAA60499 (PubMed:8662970).Curated1
Sequence conflicti62Y → I in CAA60499 (PubMed:8662970).Curated1
Sequence conflicti124A → G in CAA60499 (PubMed:8662970).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561741M → MEDEGNKLCQAPPWPGQTSP VM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86809 mRNA Translation: CAA60499.1
Y13736 mRNA Translation: CAA74076.1
AF153274, AF153273 Genomic DNA Translation: AAD56775.1
AK095879 mRNA Translation: BAG53155.1
AL121987 Genomic DNA No translation available.
AL139011 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52735.1
BC002426 mRNA Translation: AAH02426.1
BC022554 mRNA Translation: AAH22554.1
BT007252 mRNA Translation: AAP35916.1
CCDSiCCDS1199.1 [Q15121-1]
CCDS72954.1 [Q15121-2]
PIRiS55384
RefSeqiNP_001284505.1, NM_001297576.1 [Q15121-2]
NP_001284506.1, NM_001297577.1 [Q15121-1]
NP_001284507.1, NM_001297578.1
NP_003759.1, NM_003768.4 [Q15121-1]
XP_006711662.1, XM_006711599.2 [Q15121-1]
UniGeneiHs.517216

Genome annotation databases

EnsembliENST00000360472; ENSP00000353660; ENSG00000162734 [Q15121-1]
ENST00000368076; ENSP00000357055; ENSG00000162734 [Q15121-2]
GeneIDi8682
KEGGihsa:8682
UCSCiuc001fvk.4 human [Q15121-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPEA15_HUMAN
AccessioniPrimary (citable) accession number: Q15121
Secondary accession number(s): B1AKZ3, O00511
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 3, 2003
Last modified: June 20, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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