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Reviewed, UniProtKB/Swiss-Prot Q15120 (PDK3_HUMAN)

Last modified November 25, 2008. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial
    EC=2.7.11.2
Alternative name(s):
    Pyruvate dehydrogenase kinase isoform 3
Gene names
Name: PDK3
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

Catalytic activity

ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.

Subcellular location

Mitochondrion matrix.

Tissue specificity

Found almost exclusively in heart and skeletal muscle.

Sequence similarities

Belongs to the PDK/BCKDK protein kinase family.

Contains 1 histidine kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 406[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrialPRO_0000023443

Regions

Domain131 – 362232Histidine kinase

Natural variations

Natural variant2191E → A in a head & Neck squamous cell carcinoma sample; somatic mutation.
VAR_042297

Secondary structure

1 .............................................. 406
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q15120-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: EF2415D3F9D8D61E

FASTA40646,939
        10         20         30         40         50         60 
MRLFRWLLKQ PVPKQIERYS RFSPSPLSIK QFLDFGRDNA CEKTSYMFLR KELPVRLANT 

        70         80         90        100        110        120 
MREVNLLPDN LLNRPSVGLV QSWYMQSFLE LLEYENKSPE DPQVLDNFLQ VLIKVRNRHN 

       130        140        150        160        170        180 
DVVPTMAQGV IEYKEKFGFD PFISTNIQYF LDRFYTNRIS FRMLINQHTL LFGGDTNPVH 

       190        200        210        220        230        240 
PKHIGSIDPT CNVADVVKDA YETAKMLCEQ YYLVAPELEV EEFNAKAPDK PIQVVYVPSH 

       250        260        270        280        290        300 
LFHMLFELFK NSMRATVELY EDRKEGYPAV KTLVTLGKED LSIKISDLGG GVPLRKIDRL 

       310        320        330        340        350        360 
FNYMYSTAPR PSLEPTRAAP LAGFGYGLPI SRLYARYFQG DLKLYSMEGV GTDAVIYLKA 

       370        380        390        400 
LSSESFERLP VFNKSAWRHY KTTPEADDWS NPSSEPRDAS KYKAKQ

« Hide

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References

« Hide 'large scale' references
[1]"Diversity of the pyruvate dehydrogenase kinase gene family in humans."
Gudi R., Bowker-Kinley M.M., Kedishvili N.Y., Zhao Y., Popov K.M.
J. Biol. Chem. 270:28989-28994(1995) [PubMed: 7499431] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[3]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed: 17344846] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-219.
+Additional computationally mapped references.

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Cross-references

Sequence databases

L42452 mRNA. Translation: AAC42011.1.
BC015948 mRNA. Translation: AAH15948.1.
PIRI70160.
RefSeqNP_005382.1.
UniGeneHs.658190

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1Y8NX-ray2.60A9-406[»]
1Y8OX-ray2.48A9-406[»]
1Y8PX-ray2.63A9-406[»]
2PNRX-ray2.50A/B/E/F9-406[»]
2Q8IX-ray2.60A9-406[»]
ModBaseSearch...

PTM databases

PhosphoSiteQ15120.

Genome annotation databases

EnsemblENSG00000067992. Homo sapiens. [Contig view]
GeneID5165.
KEGGhsa:5165.

Organism-specific databases

H-InvDBHIX0016707.
HGNCHGNC:8811. PDK3.
MIM602526. gene.
PharmGKBPA33156.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ15120.
HOVERGENQ15120.

Gene expression databases

ArrayExpressQ15120.
CleanExHS_PDK3.
GermOnlineENSG00000067992. Homo sapiens.

Family and domain databases

InterProIPR003594. ATP_bd_ATPase.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
[Graphical view]
Gene3DG3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
PfamPF02518. HATPase_c. 1 hit.
[Graphical view]
PRINTSPR00344. BCTRLSENSOR.
SMARTSM00387. HATPase_c. 1 hit.
[Graphical view]
PROSITEPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubQ15120.
NextBio19982.
SOURCESearch...

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Entry information

Entry namePDK3_HUMAN
AccessionPrimary (citable) accession number: Q15120
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 25, 2008
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

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Human chromosome X: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

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Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

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SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents