Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Procollagen C-endopeptidase enhancer 1

Gene

PCOLCE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.
C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.

GO - Molecular functioni

  • collagen binding Source: MGI
  • heparin binding Source: MGI
  • peptidase activator activity Source: MGI

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: Ensembl
  • multicellular organism development Source: ProtInc
  • proteolysis Source: Ensembl

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-2243919 Crosslinking of collagen fibrils

Names & Taxonomyi

Protein namesi
Recommended name:
Procollagen C-endopeptidase enhancer 1
Alternative name(s):
Procollagen COOH-terminal proteinase enhancer 1
Short name:
PCPE-1
Short name:
Procollagen C-proteinase enhancer 1
Type 1 procollagen C-proteinase enhancer protein
Type I procollagen COOH-terminal proteinase enhancer
Gene namesi
Name:PCOLCE
Synonyms:PCPE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106333.12
HGNCiHGNC:8738 PCOLCE
MIMi600270 gene
neXtProtiNX_Q15113

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5118
OpenTargetsiENSG00000106333
PharmGKBiPA33083

Polymorphism and mutation databases

BioMutaiPCOLCE
DMDMi6919941

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002202326 – 449Procollagen C-endopeptidase enhancer 1Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi37 ↔ 63PROSITE-ProRule annotation
Modified residuei50PhosphoserineBy similarity1
Disulfide bondi90 ↔ 112PROSITE-ProRule annotation
Disulfide bondi159 ↔ 186PROSITE-ProRule annotation
Disulfide bondi213 ↔ 236PROSITE-ProRule annotation
Disulfide bondi318 ↔ 3861 Publication
Disulfide bondi322 ↔ 3891 Publication
Disulfide bondi333 ↔ 4371 Publication
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

C-terminally processed at multiple positions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei287 – 288Cleavage1 Publication2
Sitei288 – 289Cleavage1 Publication2
Sitei293 – 294Cleavage1 Publication2
Sitei299 – 300Cleavage1 Publication2
Sitei303 – 304Cleavage1 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ15113
MaxQBiQ15113
PaxDbiQ15113
PeptideAtlasiQ15113
PRIDEiQ15113
ProteomicsDBi60442

PTM databases

iPTMnetiQ15113
PhosphoSitePlusiQ15113

Expressioni

Gene expression databases

BgeeiENSG00000106333
CleanExiHS_PCOLCE
GenevisibleiQ15113 HS

Organism-specific databases

HPAiCAB017623
HPA042927

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111147, 1 interactor
IntActiQ15113, 21 interactors
MINTiQ15113
STRINGi9606.ENSP00000223061

Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi328 – 334Combined sources7
Beta strandi336 – 348Combined sources13
Beta strandi354 – 358Combined sources5
Beta strandi362 – 366Combined sources5
Beta strandi380 – 385Combined sources6
Beta strandi387 – 390Combined sources4
Beta strandi397 – 405Combined sources9
Turni406 – 408Combined sources3
Beta strandi409 – 411Combined sources3
Beta strandi417 – 420Combined sources4
Helixi423 – 434Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UAPNMR-A313-442[»]
ProteinModelPortaliQ15113
SMRiQ15113
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15113

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 149CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini159 – 273CUB 2PROSITE-ProRule annotationAdd BLAST115
Domaini318 – 437NTRPROSITE-ProRule annotationAdd BLAST120

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IPS8 Eukaryota
ENOG410Y9AW LUCA
GeneTreeiENSGT00760000119018
HOGENOMiHOG000059592
HOVERGENiHBG053528
InParanoidiQ15113
OMAiRGFLLWY
OrthoDBiEOG091G05Y2
PhylomeDBiQ15113
TreeFamiTF316506

Family and domain databases

CDDicd00041 CUB, 2 hits
cd03576 NTR_PCOLCE, 1 hit
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR035814 NTR_PCOLCE
IPR028870 PCOLCE
IPR035914 Sperma_CUB_dom_sf
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR44264:SF2 PTHR44264:SF2, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00042 CUB, 2 hits
SUPFAMiSSF49854 SSF49854, 2 hits
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS50189 NTR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPAATASLL GPLLTACALL PFAQGQTPNY TRPVFLCGGD VKGESGYVAS
60 70 80 90 100
EGFPNLYPPN KECIWTITVP EGQTVSLSFR VFDLELHPAC RYDALEVFAG
110 120 130 140 150
SGTSGQRLGR FCGTFRPAPL VAPGNQVTLR MTTDEGTGGR GFLLWYSGRA
160 170 180 190 200
TSGTEHQFCG GRLEKAQGTL TTPNWPESDY PPGISCSWHI IAPPDQVIAL
210 220 230 240 250
TFEKFDLEPD TYCRYDSVSV FNGAVSDDSR RLGKFCGDAV PGSISSEGNE
260 270 280 290 300
LLVQFVSDLS VTADGFSASY KTLPRGTAKE GQGPGPKRGT EPKVKLPPKS
310 320 330 340 350
QPPEKTEESP SAPDAPTCPK QCRRTGTLQS NFCASSLVVT ATVKSMVREP
360 370 380 390 400
GEGLAVTVSL IGAYKTGGLD LPSPPTGASL KFYVPCKQCP PMKKGVSYLL
410 420 430 440
MGQVEENRGP VLPPESFVVL HRPNQDQILT NLSKRKCPSQ PVRAAASQD
Length:449
Mass (Da):47,972
Last modified:May 30, 2000 - v2
Checksum:i3D88430158648796
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33799 mRNA Translation: AAA61949.1 Sequence problems.
AB008549 mRNA Translation: BAA23281.1
AF053356 Genomic DNA Translation: AAC78800.1
AF083655 Genomic DNA Translation: AAD16041.1
AK313748 mRNA Translation: BAG36488.1
CH471091 Genomic DNA Translation: EAW76515.1
BC000574 mRNA Translation: AAH00574.1
BC033205 mRNA Translation: AAH33205.1
CCDSiCCDS5700.1
PIRiA55362
RefSeqiNP_002584.2, NM_002593.3
UniGeneiHs.202097

Genome annotation databases

EnsembliENST00000223061; ENSP00000223061; ENSG00000106333
GeneIDi5118
KEGGihsa:5118
UCSCiuc003uvo.5 human

Similar proteinsi

Entry informationi

Entry nameiPCOC1_HUMAN
AccessioniPrimary (citable) accession number: Q15113
Secondary accession number(s): B2R9E1, O14550
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: June 20, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health