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Protein

Procollagen C-endopeptidase enhancer 1

Gene

PCOLCE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.
C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.

GO - Molecular functioni

  • collagen binding Source: MGI
  • heparin binding Source: MGI
  • peptidase activator activity Source: MGI

GO - Biological processi

  • multicellular organism development Source: ProtInc
  • proteolysis Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106333-MONOMER.
ReactomeiR-HSA-1650814. Collagen biosynthesis and modifying enzymes.
R-HSA-2243919. Crosslinking of collagen fibrils.

Names & Taxonomyi

Protein namesi
Recommended name:
Procollagen C-endopeptidase enhancer 1
Alternative name(s):
Procollagen COOH-terminal proteinase enhancer 1
Short name:
PCPE-1
Short name:
Procollagen C-proteinase enhancer 1
Type 1 procollagen C-proteinase enhancer protein
Type I procollagen COOH-terminal proteinase enhancer
Gene namesi
Name:PCOLCE
Synonyms:PCPE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:8738. PCOLCE.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5118.
OpenTargetsiENSG00000106333.
PharmGKBiPA33083.

Polymorphism and mutation databases

BioMutaiPCOLCE.
DMDMi6919941.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002202326 – 449Procollagen C-endopeptidase enhancer 1Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi37 ↔ 63PROSITE-ProRule annotation
Modified residuei50PhosphoserineBy similarity1
Disulfide bondi90 ↔ 112PROSITE-ProRule annotation
Disulfide bondi159 ↔ 186PROSITE-ProRule annotation
Disulfide bondi213 ↔ 236PROSITE-ProRule annotation
Disulfide bondi318 ↔ 3861 Publication
Disulfide bondi322 ↔ 3891 Publication
Disulfide bondi333 ↔ 4371 Publication
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

C-terminally processed at multiple positions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei287 – 288Cleavage1 Publication2
Sitei288 – 289Cleavage1 Publication2
Sitei293 – 294Cleavage1 Publication2
Sitei299 – 300Cleavage1 Publication2
Sitei303 – 304Cleavage1 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ15113.
MaxQBiQ15113.
PaxDbiQ15113.
PeptideAtlasiQ15113.
PRIDEiQ15113.

PTM databases

iPTMnetiQ15113.
PhosphoSitePlusiQ15113.

Expressioni

Gene expression databases

BgeeiENSG00000106333.
CleanExiHS_PCOLCE.
GenevisibleiQ15113. HS.

Organism-specific databases

HPAiCAB017623.
HPA042927.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPP050673EBI-8869614,EBI-821758
COL18A1P390604EBI-8869614,EBI-2566375
FN1P075892EBI-8869614,EBI-11147184From a different organism.
Sdc1P188284EBI-8869614,EBI-9985816From a different organism.
Sdc2P434074EBI-8869614,EBI-11578890From a different organism.
Sdc4O359882EBI-8869614,EBI-9986850From a different organism.
THBS1P079963EBI-8869614,EBI-2530274

GO - Molecular functioni

  • collagen binding Source: MGI

Protein-protein interaction databases

BioGridi111147. 1 interactor.
IntActiQ15113. 19 interactors.
STRINGi9606.ENSP00000223061.

Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi328 – 334Combined sources7
Beta strandi336 – 348Combined sources13
Beta strandi354 – 358Combined sources5
Beta strandi362 – 366Combined sources5
Beta strandi380 – 385Combined sources6
Beta strandi387 – 390Combined sources4
Beta strandi397 – 405Combined sources9
Turni406 – 408Combined sources3
Beta strandi409 – 411Combined sources3
Beta strandi417 – 420Combined sources4
Helixi423 – 434Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UAPNMR-A313-442[»]
ProteinModelPortaliQ15113.
SMRiQ15113.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15113.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 149CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini159 – 273CUB 2PROSITE-ProRule annotationAdd BLAST115
Domaini318 – 437NTRPROSITE-ProRule annotationAdd BLAST120

Sequence similaritiesi

Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IPS8. Eukaryota.
ENOG410Y9AW. LUCA.
GeneTreeiENSGT00760000119018.
HOGENOMiHOG000059592.
HOVERGENiHBG053528.
InParanoidiQ15113.
OMAiTRPVFLC.
OrthoDBiEOG091G05Y2.
PhylomeDBiQ15113.
TreeFamiTF316506.

Family and domain databases

CDDicd00041. CUB. 2 hits.
Gene3Di2.60.120.290. 2 hits.
InterProiIPR000859. CUB_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR028870. PCOLCE.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR10127:SF628. PTHR10127:SF628. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00042. CUB. 2 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF50242. SSF50242. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPAATASLL GPLLTACALL PFAQGQTPNY TRPVFLCGGD VKGESGYVAS
60 70 80 90 100
EGFPNLYPPN KECIWTITVP EGQTVSLSFR VFDLELHPAC RYDALEVFAG
110 120 130 140 150
SGTSGQRLGR FCGTFRPAPL VAPGNQVTLR MTTDEGTGGR GFLLWYSGRA
160 170 180 190 200
TSGTEHQFCG GRLEKAQGTL TTPNWPESDY PPGISCSWHI IAPPDQVIAL
210 220 230 240 250
TFEKFDLEPD TYCRYDSVSV FNGAVSDDSR RLGKFCGDAV PGSISSEGNE
260 270 280 290 300
LLVQFVSDLS VTADGFSASY KTLPRGTAKE GQGPGPKRGT EPKVKLPPKS
310 320 330 340 350
QPPEKTEESP SAPDAPTCPK QCRRTGTLQS NFCASSLVVT ATVKSMVREP
360 370 380 390 400
GEGLAVTVSL IGAYKTGGLD LPSPPTGASL KFYVPCKQCP PMKKGVSYLL
410 420 430 440
MGQVEENRGP VLPPESFVVL HRPNQDQILT NLSKRKCPSQ PVRAAASQD
Length:449
Mass (Da):47,972
Last modified:May 30, 2000 - v2
Checksum:i3D88430158648796
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33799 mRNA. Translation: AAA61949.1. Sequence problems.
AB008549 mRNA. Translation: BAA23281.1.
AF053356 Genomic DNA. Translation: AAC78800.1.
AF083655 Genomic DNA. Translation: AAD16041.1.
AK313748 mRNA. Translation: BAG36488.1.
CH471091 Genomic DNA. Translation: EAW76515.1.
BC000574 mRNA. Translation: AAH00574.1.
BC033205 mRNA. Translation: AAH33205.1.
CCDSiCCDS5700.1.
PIRiA55362.
RefSeqiNP_002584.2. NM_002593.3.
UniGeneiHs.202097.

Genome annotation databases

EnsembliENST00000223061; ENSP00000223061; ENSG00000106333.
GeneIDi5118.
KEGGihsa:5118.
UCSCiuc003uvo.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33799 mRNA. Translation: AAA61949.1. Sequence problems.
AB008549 mRNA. Translation: BAA23281.1.
AF053356 Genomic DNA. Translation: AAC78800.1.
AF083655 Genomic DNA. Translation: AAD16041.1.
AK313748 mRNA. Translation: BAG36488.1.
CH471091 Genomic DNA. Translation: EAW76515.1.
BC000574 mRNA. Translation: AAH00574.1.
BC033205 mRNA. Translation: AAH33205.1.
CCDSiCCDS5700.1.
PIRiA55362.
RefSeqiNP_002584.2. NM_002593.3.
UniGeneiHs.202097.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UAPNMR-A313-442[»]
ProteinModelPortaliQ15113.
SMRiQ15113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111147. 1 interactor.
IntActiQ15113. 19 interactors.
STRINGi9606.ENSP00000223061.

PTM databases

iPTMnetiQ15113.
PhosphoSitePlusiQ15113.

Polymorphism and mutation databases

BioMutaiPCOLCE.
DMDMi6919941.

Proteomic databases

EPDiQ15113.
MaxQBiQ15113.
PaxDbiQ15113.
PeptideAtlasiQ15113.
PRIDEiQ15113.

Protocols and materials databases

DNASUi5118.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223061; ENSP00000223061; ENSG00000106333.
GeneIDi5118.
KEGGihsa:5118.
UCSCiuc003uvo.5. human.

Organism-specific databases

CTDi5118.
DisGeNETi5118.
GeneCardsiPCOLCE.
HGNCiHGNC:8738. PCOLCE.
HPAiCAB017623.
HPA042927.
MIMi600270. gene.
neXtProtiNX_Q15113.
OpenTargetsiENSG00000106333.
PharmGKBiPA33083.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPS8. Eukaryota.
ENOG410Y9AW. LUCA.
GeneTreeiENSGT00760000119018.
HOGENOMiHOG000059592.
HOVERGENiHBG053528.
InParanoidiQ15113.
OMAiTRPVFLC.
OrthoDBiEOG091G05Y2.
PhylomeDBiQ15113.
TreeFamiTF316506.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106333-MONOMER.
ReactomeiR-HSA-1650814. Collagen biosynthesis and modifying enzymes.
R-HSA-2243919. Crosslinking of collagen fibrils.

Miscellaneous databases

ChiTaRSiPCOLCE. human.
EvolutionaryTraceiQ15113.
GeneWikiiPCOLCE.
GenomeRNAii5118.
PROiQ15113.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106333.
CleanExiHS_PCOLCE.
GenevisibleiQ15113. HS.

Family and domain databases

CDDicd00041. CUB. 2 hits.
Gene3Di2.60.120.290. 2 hits.
InterProiIPR000859. CUB_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR028870. PCOLCE.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR10127:SF628. PTHR10127:SF628. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00042. CUB. 2 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF50242. SSF50242. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCOC1_HUMAN
AccessioniPrimary (citable) accession number: Q15113
Secondary accession number(s): B2R9E1, O14550
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.