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Protein

Advanced glycosylation end product-specific receptor

Gene

AGER

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.By similarity4 Publications

GO - Molecular functioni

  • advanced glycation end-product binding Source: Ensembl
  • advanced glycation end-product receptor activity Source: ARUK-UCL
  • amyloid-beta binding Source: ARUK-UCL
  • heparin binding Source: Ensembl
  • identical protein binding Source: IntAct
  • S100 protein binding Source: UniProtKB
  • scavenger receptor activity Source: ARUK-UCL
  • signaling receptor activity Source: ARUK-UCL
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • astrocyte development Source: Ensembl
  • cell surface receptor signaling pathway Source: ProtInc
  • cellular response to amyloid-beta Source: ARUK-UCL
  • glucose mediated signaling pathway Source: CAFA
  • induction of positive chemotaxis Source: Ensembl
  • inflammatory response Source: ProtInc
  • innate immune response Source: Reactome
  • learning or memory Source: ARUK-UCL
  • modulation of age-related behavioral decline Source: ARUK-UCL
  • negative regulation of advanced glycation end-product receptor activity Source: Ensembl
  • negative regulation of connective tissue replacement involved in inflammatory response wound healing Source: Ensembl
  • negative regulation of interleukin-10 production Source: UniProtKB
  • negative regulation of long term synaptic depression Source: ARUK-UCL
  • negative regulation of long-term synaptic potentiation Source: ARUK-UCL
  • neuron projection development Source: UniProtKB
  • positive regulation of activated T cell proliferation Source: UniProtKB
  • positive regulation of astrocyte activation Source: ARUK-UCL
  • positive regulation of dendritic cell differentiation Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
  • positive regulation of interleukin-12 production Source: UniProtKB
  • positive regulation of JNK cascade Source: ARUK-UCL
  • positive regulation of JUN kinase activity Source: Ensembl
  • positive regulation of microglial cell activation Source: ARUK-UCL
  • positive regulation of monocyte chemotactic protein-1 production Source: Ensembl
  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • positive regulation of NIK/NF-kappaB signaling Source: ARUK-UCL
  • positive regulation of p38MAPK cascade Source: ARUK-UCL
  • positive regulation of protein phosphorylation Source: ARUK-UCL
  • protein localization to membrane Source: Ensembl
  • regulation of CD4-positive, alpha-beta T cell activation Source: UniProtKB
  • regulation of DNA binding Source: Ensembl
  • regulation of long-term synaptic potentiation Source: ARUK-UCL
  • regulation of NIK/NF-kappaB signaling Source: ARUK-UCL
  • regulation of p38MAPK cascade Source: ARUK-UCL
  • regulation of spontaneous synaptic transmission Source: ARUK-UCL
  • regulation of synaptic plasticity Source: ARUK-UCL
  • regulation of T cell mediated cytotoxicity Source: UniProtKB
  • response to amyloid-beta Source: ARUK-UCL
  • response to hypoxia Source: Ensembl
  • response to wounding Source: ProtInc

Keywordsi

Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-933542 TRAF6 mediated NF-kB activation
SIGNORiQ15109

Names & Taxonomyi

Protein namesi
Recommended name:
Advanced glycosylation end product-specific receptor
Alternative name(s):
Receptor for advanced glycosylation end products
Gene namesi
Name:AGER
Synonyms:RAGE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204305.13
HGNCiHGNC:320 AGER
MIMi600214 gene
neXtProtiNX_Q15109

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 342ExtracellularSequence analysisAdd BLAST320
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 404CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi177
OpenTargetsiENSG00000204305
PharmGKBiPA24617

Chemistry databases

ChEMBLiCHEMBL2176846
GuidetoPHARMACOLOGYi2843

Polymorphism and mutation databases

BioMutaiAGER
DMDMi2497317

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001492323 – 404Advanced glycosylation end product-specific receptorAdd BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi38 ↔ 994 Publications
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 2084 Publications
Disulfide bondi259Interchain1 Publication
Disulfide bondi301Interchain1 Publication
Modified residuei391PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ15109
PeptideAtlasiQ15109
PRIDEiQ15109

PTM databases

iPTMnetiQ15109
PhosphoSitePlusiQ15109

Expressioni

Tissue specificityi

Endothelial cells.

Gene expression databases

BgeeiENSG00000204305
CleanExiHS_AGER
HS_RAGE
ExpressionAtlasiQ15109 baseline and differential
GenevisibleiQ15109 HS

Organism-specific databases

HPAiCAB011682
HPA064436

Interactioni

Subunit structurei

Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.By similarity6 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • S100 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi106685, 6 interactors
DIPiDIP-40658N
IntActiQ15109, 13 interactors
MINTiQ15109
STRINGi9606.ENSP00000364217

Chemistry databases

BindingDBiQ15109

Structurei

Secondary structure

1404
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 29Combined sources6
Beta strandi34 – 36Combined sources3
Beta strandi43 – 46Combined sources4
Beta strandi48 – 55Combined sources8
Beta strandi58 – 60Combined sources3
Beta strandi62 – 64Combined sources3
Helixi71 – 74Combined sources4
Beta strandi76 – 78Combined sources3
Turni80 – 82Combined sources3
Beta strandi84 – 88Combined sources5
Helixi91 – 93Combined sources3
Beta strandi95 – 102Combined sources8
Turni104 – 106Combined sources3
Beta strandi108 – 119Combined sources12
Beta strandi125 – 128Combined sources4
Beta strandi131 – 133Combined sources3
Beta strandi139 – 151Combined sources13
Beta strandi154 – 159Combined sources6
Beta strandi162 – 164Combined sources3
Beta strandi171 – 179Combined sources9
Turni181 – 183Combined sources3
Beta strandi186 – 194Combined sources9
Beta strandi206 – 211Combined sources6
Beta strandi213 – 216Combined sources4
Beta strandi228 – 230Combined sources3
Beta strandi237 – 244Combined sources8
Beta strandi247 – 249Combined sources3
Beta strandi251 – 253Combined sources3
Beta strandi255 – 260Combined sources6
Beta strandi262 – 264Combined sources3
Beta strandi268 – 273Combined sources6
Beta strandi284 – 288Combined sources5
Helixi293 – 295Combined sources3
Beta strandi297 – 305Combined sources9
Beta strandi308 – 312Combined sources5
Beta strandi316 – 320Combined sources5
Beta strandi322 – 324Combined sources3
Beta strandi364 – 366Combined sources3
Turni367 – 369Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PWImodel-A1-404[»]
2BJPmodel-A1-404[»]
2E5ENMR-A23-121[»]
2ENSNMR-A235-323[»]
2L7UNMR-A23-125[»]
2LE9NMR-A/D235-327[»]
2LMBNMR-A363-404[»]
2M1KNMR-A/C23-121[»]
2MJWNMR-A/C23-121[»]
2MOVNMR-A23-125[»]
3CJJX-ray1.85A23-240[»]
3O3UX-ray1.50N23-231[»]
4LP4X-ray2.40A/B23-231[»]
4LP5X-ray3.80A/B23-323[»]
4OF5X-ray2.80A/B23-237[»]
4OFVX-ray3.10A/B23-235[»]
4OI7X-ray3.10A/B23-237[»]
4OI8X-ray3.10A/B23-237[»]
4P2YX-ray2.30A23-323[»]
4XYNX-ray2.55P54-68[»]
4YBHX-ray2.40A23-323[»]
5D7FX-ray1.30P65-79[»]
ProteinModelPortaliQ15109
SMRiQ15109
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15109

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 116Ig-like V-typeAdd BLAST94
Domaini124 – 221Ig-like C2-type 1Add BLAST98
Domaini227 – 317Ig-like C2-type 2Add BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi380 – 384Poly-Glu5

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVT2 Eukaryota
ENOG4111C4I LUCA
GeneTreeiENSGT00890000139566
HOGENOMiHOG000232122
HOVERGENiHBG004350
InParanoidiQ15109
KOiK19722
OMAiPNKVGTC
OrthoDBiEOG091G0BCY
PhylomeDBiQ15109
TreeFamiTF337155

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit

Sequences (10)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15109-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGTAVGAW VLVLSLWGAV VGAQNITARI GEPLVLKCKG APKKPPQRLE
60 70 80 90 100
WKLNTGRTEA WKVLSPQGGG PWDSVARVLP NGSLFLPAVG IQDEGIFRCQ
110 120 130 140 150
AMNRNGKETK SNYRVRVYQI PGKPEIVDSA SELTAGVPNK VGTCVSEGSY
160 170 180 190 200
PAGTLSWHLD GKPLVPNEKG VSVKEQTRRH PETGLFTLQS ELMVTPARGG
210 220 230 240 250
DPRPTFSCSF SPGLPRHRAL RTAPIQPRVW EPVPLEEVQL VVEPEGGAVA
260 270 280 290 300
PGGTVTLTCE VPAQPSPQIH WMKDGVPLPL PPSPVLILPE IGPQDQGTYS
310 320 330 340 350
CVATHSSHGP QESRAVSISI IEPGEEGPTA GSVGGSGLGT LALALGILGG
360 370 380 390 400
LGTAALLIGV ILWQRRQRRG EERKAPENQE EEEERAELNQ SEEPEAGESS

TGGP
Length:404
Mass (Da):42,803
Last modified:November 1, 1997 - v1
Checksum:i0D584C436C30CCE7
GO
Isoform 2 (identifier: Q15109-2) [UniParc]FASTAAdd to basket
Also known as: RAGESEC

The sequence of this isoform differs from the canonical sequence as follows:
     54-67: Missing.
     275-404: GVPLPLPPSP...EAGESSTGGP → VSDLERGAGR...ACRTESVGGT

Show »
Length:342
Mass (Da):36,193
Checksum:i35DDF66A13E39B38
GO
Isoform 3 (identifier: Q15109-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-404: SVGGSGLGTL...EAGESSTGGP → EGFDKVREAEDSPQHM

Show »
Length:347
Mass (Da):37,050
Checksum:i519E377C4D6AC62C
GO
Isoform 4 (identifier: Q15109-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: K → KVVEESRRSRKRPCEQE
     332-404: SVGGSGLGTL...EAGESSTGGP → EGFDKVREAEDSPQHM

Show »
Length:363
Mass (Da):39,020
Checksum:i82CC2FB0B9F209EA
GO
Isoform 5 (identifier: Q15109-5) [UniParc]FASTAAdd to basket
Also known as: del exon3-7

The sequence of this isoform differs from the canonical sequence as follows:
     113-121: YRVRVYQIP → WWWSQKVEQ
     122-404: Missing.

Show »
Length:121
Mass (Da):13,192
Checksum:iE97FC3AF05656A12
GO
Isoform 6 (identifier: Q15109-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: K → KVVEESRRSRKRPCEQE

Show »
Length:420
Mass (Da):44,773
Checksum:i5C7E88B8E689D4E5
GO
Isoform 7 (identifier: Q15109-7) [UniParc]FASTAAdd to basket
Also known as: del exon3

The sequence of this isoform differs from the canonical sequence as follows:
     54-67: Missing.

Show »
Length:390
Mass (Da):41,234
Checksum:i45A848CAF877F023
GO
Isoform 8 (identifier: Q15109-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-325: GVPLPLPPSP...VSISIIEPGE → NQARRGQLQV...TRRKRRSVQN
     326-404: Missing.

Show »
Length:325
Mass (Da):35,322
Checksum:iF69D13970D2A81B6
GO
Isoform 9 (identifier: Q15109-9) [UniParc]FASTAAdd to basket
Also known as: del exon8-9

The sequence of this isoform differs from the canonical sequence as follows:
     276-355: VPLPLPPSPV...GILGGLGTAA → LRTREPTAVW...TRRKRRSVQN
     356-404: Missing.

Show »
Length:355
Mass (Da):38,379
Checksum:i728DA303F36B4175
GO
Isoform 10 (identifier: Q15109-10) [UniParc]FASTAAdd to basket
Also known as: delta-ICD, variant 20

The sequence of this isoform differs from the canonical sequence as follows:
     374-404: KAPENQEEEEERAELNQSEEPEAGESSTGGP → PQKTRRKRRSVQN

Note: Detected in lung, brain, heart and kidney.
Show »
Length:386
Mass (Da):41,098
Checksum:i4D3BCF036D55A052
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → G in AAA03574 (PubMed:1378843).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02450082G → S1 PublicationCorresponds to variant dbSNP:rs2070600Ensembl.1
Natural variantiVAR_011338100Q → R1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00255154 – 67Missing in isoform 2 and isoform 7. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_047884113 – 121YRVRVYQIP → WWWSQKVEQ in isoform 5. 1 Publication9
Alternative sequenceiVSP_047885122 – 404Missing in isoform 5. 1 PublicationAdd BLAST283
Alternative sequenceiVSP_043528140K → KVVEESRRSRKRPCEQE in isoform 4 and isoform 6. 1 Publication1
Alternative sequenceiVSP_002552275 – 404GVPLP…STGGP → VSDLERGAGRTRRGGANCRL CGRIRAGNSSPGPGDPGRPG DSRPAHWGHLVAKAATPRRG EEGPRKPGGRGGACRTESVG GT in isoform 2. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_047886275 – 325GVPLP…IEPGE → NQARRGQLQVRGLIKSGKQK IAPNTCDWGDGQQERNGRPQ KTRRKRRSVQN in isoform 8. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_047887276 – 355VPLPL…LGTAA → LRTREPTAVWPPIPATGPRK AVLSASASSNQARRGQLQVR GLIKSGKQKIAPNTCDWGDG QQERNGRPQKTRRKRRSVQN in isoform 9. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_047888326 – 404Missing in isoform 8. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_042011332 – 404SVGGS…STGGP → EGFDKVREAEDSPQHM in isoform 3 and isoform 4. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_047889356 – 404Missing in isoform 9. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_055321374 – 404KAPEN…STGGP → PQKTRRKRRSVQN in isoform 10. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91211 mRNA Translation: AAA03574.1
D28769 Genomic DNA Translation: BAA05958.1
AB036432 mRNA Translation: BAA89369.1
AJ133822 mRNA Translation: CAB43108.1
AB061668 mRNA Translation: BAC65465.1
U89336 Genomic DNA Translation: AAB47491.1
AY755619 mRNA Translation: AAX07272.1
AY755620 mRNA Translation: AAX07273.1
AY755621 mRNA Translation: AAX07274.1
AY755622 mRNA Translation: AAX07275.1
AY755623 mRNA Translation: AAX07276.1
AY755624 mRNA Translation: AAX07277.1
AY755625 mRNA Translation: AAX07278.1
AY755628 mRNA Translation: AAX07281.1
DQ104252 mRNA Translation: AAZ32413.1
EU117141 mRNA Translation: ABV03807.1
KC692917 mRNA Translation: AHB30241.1
AK313178 mRNA Translation: BAG35995.1
AL662830 Genomic DNA Translation: CAI17535.1
AL662830 Genomic DNA Translation: CAI17536.1
AL662830 Genomic DNA Translation: CAM24893.1
AL662884 Genomic DNA Translation: CAI18354.1
AL662884 Genomic DNA Translation: CAI18355.1
AL662884 Genomic DNA Translation: CAM25647.1
AL845464 Genomic DNA Translation: CAI41809.1
AL845464 Genomic DNA Translation: CAI41810.1
AL845464 Genomic DNA Translation: CAM25716.1
BX284686 Genomic DNA Translation: CAM26223.1
BX284686 Genomic DNA Translation: CAM26225.1
BX927239 Genomic DNA Translation: CAQ06596.1
BX927239 Genomic DNA Translation: CAQ06597.1
CR933878 Genomic DNA Translation: CAQ09624.1
CR812478 Genomic DNA Translation: CAQ10699.1
CH471081 Genomic DNA Translation: EAX03610.1
CH471081 Genomic DNA Translation: EAX03611.1
BC020669 mRNA Translation: AAH20669.1
AF208289 Genomic DNA Translation: AAG35728.1
CCDSiCCDS4746.1 [Q15109-1]
CCDS4747.1 [Q15109-2]
CCDS56417.1 [Q15109-4]
CCDS56418.1 [Q15109-3]
CCDS75429.1 [Q15109-6]
PIRiI61596
RefSeqiNP_001127.1, NM_001136.4 [Q15109-1]
NP_001193858.1, NM_001206929.1 [Q15109-6]
NP_001193861.1, NM_001206932.1 [Q15109-7]
NP_001193863.1, NM_001206934.1 [Q15109-4]
NP_001193865.1, NM_001206936.1 [Q15109-9]
NP_001193869.1, NM_001206940.1 [Q15109-3]
NP_001193883.1, NM_001206954.1 [Q15109-8]
NP_001193895.1, NM_001206966.1 [Q15109-3]
NP_751947.1, NM_172197.2 [Q15109-2]
UniGeneiHs.534342

Genome annotation databases

EnsembliENST00000375055; ENSP00000364195; ENSG00000204305 [Q15109-3]
ENST00000375067; ENSP00000364208; ENSG00000204305 [Q15109-2]
ENST00000375069; ENSP00000364210; ENSG00000204305 [Q15109-6]
ENST00000375076; ENSP00000364217; ENSG00000204305 [Q15109-1]
ENST00000383275; ENSP00000372762; ENSG00000206320 [Q15109-3]
ENST00000383279; ENSP00000372766; ENSG00000206320 [Q15109-2]
ENST00000412470; ENSP00000387853; ENSG00000229058 [Q15109-2]
ENST00000426138; ENSP00000415144; ENSG00000230514
ENST00000427822; ENSP00000416042; ENSG00000231268
ENST00000432831; ENSP00000413391; ENSG00000237405 [Q15109-3]
ENST00000436456; ENSP00000397227; ENSG00000234729 [Q15109-1]
ENST00000438221; ENSP00000387887; ENSG00000204305 [Q15109-4]
ENST00000441180; ENSP00000388462; ENSG00000234729 [Q15109-2]
ENST00000441804; ENSP00000391743; ENSG00000237405 [Q15109-2]
ENST00000447921; ENSP00000395812; ENSG00000237405 [Q15109-1]
ENST00000449037; ENSP00000400667; ENSG00000229058 [Q15109-3]
ENST00000451115; ENSP00000401068; ENSG00000206320 [Q15109-1]
ENST00000453588; ENSP00000399686; ENSG00000234729 [Q15109-3]
ENST00000456918; ENSP00000409457; ENSG00000229058 [Q15109-1]
ENST00000547328; ENSP00000448579; ENSG00000206320 [Q15109-6]
ENST00000547651; ENSP00000449708; ENSG00000229058 [Q15109-4]
ENST00000548464; ENSP00000450134; ENSG00000234729 [Q15109-6]
ENST00000549758; ENSP00000447301; ENSG00000229058 [Q15109-6]
ENST00000550562; ENSP00000446835; ENSG00000234729 [Q15109-4]
ENST00000551254; ENSP00000449226; ENSG00000206320 [Q15109-4]
ENST00000551381; ENSP00000448979; ENSG00000237405 [Q15109-6]
ENST00000551827; ENSP00000449042; ENSG00000237405 [Q15109-4]
GeneIDi177
KEGGihsa:177
UCSCiuc003oal.3 human [Q15109-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRAGE_HUMAN
AccessioniPrimary (citable) accession number: Q15109
Secondary accession number(s): A2BFI7
, A6NKF0, A7Y2U9, B0V176, Q15279, Q3L1R4, Q3L1R5, Q3L1R6, Q3L1R7, Q3L1R8, Q3L1S0, Q86SN1, Q9H2X7, Q9Y3R3, V5R6A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 190 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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