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Protein

Advanced glycosylation end product-specific receptor

Gene

AGER

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.By similarity4 Publications

GO - Molecular functioni

  • advanced glycation end-product binding Source: Ensembl
  • heparin binding Source: Ensembl
  • receptor activity Source: ProtInc
  • S100 protein binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • astrocyte development Source: Ensembl
  • cell surface receptor signaling pathway Source: ProtInc
  • induction of positive chemotaxis Source: Ensembl
  • inflammatory response Source: ProtInc
  • innate immune response Source: Reactome
  • negative regulation of advanced glycation end-product receptor activity Source: Ensembl
  • negative regulation of connective tissue replacement involved in inflammatory response wound healing Source: Ensembl
  • negative regulation of interleukin-10 production Source: UniProtKB
  • neuron projection development Source: UniProtKB
  • positive regulation of activated T cell proliferation Source: UniProtKB
  • positive regulation of dendritic cell differentiation Source: UniProtKB
  • positive regulation of interleukin-12 production Source: UniProtKB
  • positive regulation of JUN kinase activity Source: Ensembl
  • positive regulation of monocyte chemotactic protein-1 production Source: Ensembl
  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • protein localization to membrane Source: Ensembl
  • regulation of CD4-positive, alpha-beta T cell activation Source: UniProtKB
  • regulation of DNA binding Source: Ensembl
  • regulation of T cell mediated cytotoxicity Source: UniProtKB
  • response to hypoxia Source: Ensembl
  • response to wounding Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-1810476. RIP-mediated NFkB activation via ZBP1.
R-HSA-3134963. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
R-HSA-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-HSA-879415. Advanced glycosylation endproduct receptor signaling.
R-HSA-933542. TRAF6 mediated NF-kB activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Advanced glycosylation end product-specific receptor
Alternative name(s):
Receptor for advanced glycosylation end products
Gene namesi
Name:AGER
Synonyms:RAGE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:320. AGER.

Subcellular locationi

Isoform 10 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 342ExtracellularSequence analysisAdd BLAST320
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 404CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi177.
OpenTargetsiENSG00000204305.
ENSG00000206320.
ENSG00000229058.
ENSG00000234729.
ENSG00000237405.
PharmGKBiPA24617.

Chemistry databases

ChEMBLiCHEMBL2176846.
GuidetoPHARMACOLOGYi2843.

Polymorphism and mutation databases

BioMutaiAGER.
DMDMi2497317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001492323 – 404Advanced glycosylation end product-specific receptorAdd BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi38 ↔ 994 Publications
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi144 ↔ 2084 Publications
Disulfide bondi259Interchain1 Publication
Disulfide bondi301Interchain1 Publication
Modified residuei391PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ15109.
PeptideAtlasiQ15109.
PRIDEiQ15109.

PTM databases

iPTMnetiQ15109.
PhosphoSitePlusiQ15109.

Expressioni

Tissue specificityi

Endothelial cells.

Gene expression databases

BgeeiENSG00000204305.
CleanExiHS_AGER.
HS_RAGE.
ExpressionAtlasiQ15109. baseline and differential.
GenevisibleiQ15109. HS.

Organism-specific databases

HPAiCAB011682.
HPA064436.

Interactioni

Subunit structurei

Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1646426,EBI-1646426
DIAPH1O606103EBI-1646426,EBI-3959709
GRB2P629932EBI-1646426,EBI-401755
HMGB1P094293EBI-1646426,EBI-389432
NCK1P163332EBI-1646426,EBI-389883
RHOAP615862EBI-1646426,EBI-446668
S100BP042715EBI-1646426,EBI-458391
S100PP258152EBI-1646426,EBI-743700
TTRP027662EBI-1646426,EBI-711909

GO - Molecular functioni

  • S100 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi106685. 6 interactors.
DIPiDIP-40658N.
IntActiQ15109. 10 interactors.
MINTiMINT-2635420.
STRINGi9606.ENSP00000364217.

Chemistry databases

BindingDBiQ15109.

Structurei

Secondary structure

1404
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 29Combined sources6
Beta strandi34 – 36Combined sources3
Beta strandi43 – 46Combined sources4
Beta strandi48 – 55Combined sources8
Beta strandi58 – 60Combined sources3
Beta strandi62 – 64Combined sources3
Helixi71 – 74Combined sources4
Beta strandi76 – 78Combined sources3
Turni80 – 82Combined sources3
Beta strandi84 – 88Combined sources5
Helixi91 – 93Combined sources3
Beta strandi95 – 102Combined sources8
Turni104 – 106Combined sources3
Beta strandi108 – 119Combined sources12
Beta strandi125 – 128Combined sources4
Beta strandi131 – 133Combined sources3
Beta strandi139 – 151Combined sources13
Beta strandi154 – 159Combined sources6
Beta strandi162 – 164Combined sources3
Beta strandi171 – 179Combined sources9
Turni181 – 183Combined sources3
Beta strandi186 – 194Combined sources9
Beta strandi206 – 211Combined sources6
Beta strandi213 – 216Combined sources4
Beta strandi228 – 230Combined sources3
Beta strandi237 – 244Combined sources8
Beta strandi247 – 249Combined sources3
Beta strandi251 – 253Combined sources3
Beta strandi255 – 260Combined sources6
Beta strandi262 – 264Combined sources3
Beta strandi268 – 273Combined sources6
Beta strandi284 – 288Combined sources5
Helixi293 – 295Combined sources3
Beta strandi297 – 305Combined sources9
Beta strandi308 – 312Combined sources5
Beta strandi316 – 320Combined sources5
Beta strandi322 – 324Combined sources3
Beta strandi364 – 366Combined sources3
Turni367 – 369Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PWImodel-A1-404[»]
2BJPmodel-A1-404[»]
2E5ENMR-A23-121[»]
2ENSNMR-A235-323[»]
2L7UNMR-A23-125[»]
2LE9NMR-A/D235-327[»]
2LMBNMR-A363-404[»]
2M1KNMR-A/C23-121[»]
2MJWNMR-A/C23-121[»]
2MOVNMR-A23-125[»]
3CJJX-ray1.85A23-240[»]
3O3UX-ray1.50N23-231[»]
4LP4X-ray2.40A/B23-231[»]
4LP5X-ray3.80A/B23-323[»]
4OF5X-ray2.80A/B23-237[»]
4OFVX-ray3.10A/B23-235[»]
4OI7X-ray3.10A/B23-237[»]
4OI8X-ray3.10A/B23-237[»]
4P2YX-ray2.30A23-323[»]
4XYNX-ray2.55P54-68[»]
4YBHX-ray2.40A23-323[»]
5D7FX-ray1.30P65-79[»]
ProteinModelPortaliQ15109.
SMRiQ15109.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15109.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 116Ig-like V-typeAdd BLAST94
Domaini124 – 221Ig-like C2-type 1Add BLAST98
Domaini227 – 317Ig-like C2-type 2Add BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi380 – 384Poly-Glu5

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVT2. Eukaryota.
ENOG4111C4I. LUCA.
GeneTreeiENSGT00530000063457.
HOGENOMiHOG000232122.
HOVERGENiHBG004350.
InParanoidiQ15109.
KOiK19722.
OMAiPNKVGTC.
OrthoDBiEOG091G0BCY.
PhylomeDBiQ15109.
TreeFamiTF337155.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (10)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15109-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGTAVGAW VLVLSLWGAV VGAQNITARI GEPLVLKCKG APKKPPQRLE
60 70 80 90 100
WKLNTGRTEA WKVLSPQGGG PWDSVARVLP NGSLFLPAVG IQDEGIFRCQ
110 120 130 140 150
AMNRNGKETK SNYRVRVYQI PGKPEIVDSA SELTAGVPNK VGTCVSEGSY
160 170 180 190 200
PAGTLSWHLD GKPLVPNEKG VSVKEQTRRH PETGLFTLQS ELMVTPARGG
210 220 230 240 250
DPRPTFSCSF SPGLPRHRAL RTAPIQPRVW EPVPLEEVQL VVEPEGGAVA
260 270 280 290 300
PGGTVTLTCE VPAQPSPQIH WMKDGVPLPL PPSPVLILPE IGPQDQGTYS
310 320 330 340 350
CVATHSSHGP QESRAVSISI IEPGEEGPTA GSVGGSGLGT LALALGILGG
360 370 380 390 400
LGTAALLIGV ILWQRRQRRG EERKAPENQE EEEERAELNQ SEEPEAGESS

TGGP
Length:404
Mass (Da):42,803
Last modified:November 1, 1997 - v1
Checksum:i0D584C436C30CCE7
GO
Isoform 2 (identifier: Q15109-2) [UniParc]FASTAAdd to basket
Also known as: RAGESEC

The sequence of this isoform differs from the canonical sequence as follows:
     54-67: Missing.
     275-404: GVPLPLPPSP...EAGESSTGGP → VSDLERGAGR...ACRTESVGGT

Show »
Length:342
Mass (Da):36,193
Checksum:i35DDF66A13E39B38
GO
Isoform 3 (identifier: Q15109-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-404: SVGGSGLGTL...EAGESSTGGP → EGFDKVREAEDSPQHM

Show »
Length:347
Mass (Da):37,050
Checksum:i519E377C4D6AC62C
GO
Isoform 4 (identifier: Q15109-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: K → KVVEESRRSRKRPCEQE
     332-404: SVGGSGLGTL...EAGESSTGGP → EGFDKVREAEDSPQHM

Show »
Length:363
Mass (Da):39,020
Checksum:i82CC2FB0B9F209EA
GO
Isoform 5 (identifier: Q15109-5) [UniParc]FASTAAdd to basket
Also known as: del exon3-7

The sequence of this isoform differs from the canonical sequence as follows:
     113-121: YRVRVYQIP → WWWSQKVEQ
     122-404: Missing.

Show »
Length:121
Mass (Da):13,192
Checksum:iE97FC3AF05656A12
GO
Isoform 6 (identifier: Q15109-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: K → KVVEESRRSRKRPCEQE

Show »
Length:420
Mass (Da):44,773
Checksum:i5C7E88B8E689D4E5
GO
Isoform 7 (identifier: Q15109-7) [UniParc]FASTAAdd to basket
Also known as: del exon3

The sequence of this isoform differs from the canonical sequence as follows:
     54-67: Missing.

Show »
Length:390
Mass (Da):41,234
Checksum:i45A848CAF877F023
GO
Isoform 8 (identifier: Q15109-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-325: GVPLPLPPSP...VSISIIEPGE → NQARRGQLQV...TRRKRRSVQN
     326-404: Missing.

Show »
Length:325
Mass (Da):35,322
Checksum:iF69D13970D2A81B6
GO
Isoform 9 (identifier: Q15109-9) [UniParc]FASTAAdd to basket
Also known as: del exon8-9

The sequence of this isoform differs from the canonical sequence as follows:
     276-355: VPLPLPPSPV...GILGGLGTAA → LRTREPTAVW...TRRKRRSVQN
     356-404: Missing.

Show »
Length:355
Mass (Da):38,379
Checksum:i728DA303F36B4175
GO
Isoform 10 (identifier: Q15109-10) [UniParc]FASTAAdd to basket
Also known as: delta-ICD, variant 20

The sequence of this isoform differs from the canonical sequence as follows:
     374-404: KAPENQEEEEERAELNQSEEPEAGESSTGGP → PQKTRRKRRSVQN

Note: Detected in lung, brain, heart and kidney.
Show »
Length:386
Mass (Da):41,098
Checksum:i4D3BCF036D55A052
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → G in AAA03574 (PubMed:1378843).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02450082G → S.1 PublicationCorresponds to variant rs2070600dbSNPEnsembl.1
Natural variantiVAR_011338100Q → R.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00255154 – 67Missing in isoform 2 and isoform 7. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_047884113 – 121YRVRVYQIP → WWWSQKVEQ in isoform 5. 1 Publication9
Alternative sequenceiVSP_047885122 – 404Missing in isoform 5. 1 PublicationAdd BLAST283
Alternative sequenceiVSP_043528140K → KVVEESRRSRKRPCEQE in isoform 4 and isoform 6. 1 Publication1
Alternative sequenceiVSP_002552275 – 404GVPLP…STGGP → VSDLERGAGRTRRGGANCRL CGRIRAGNSSPGPGDPGRPG DSRPAHWGHLVAKAATPRRG EEGPRKPGGRGGACRTESVG GT in isoform 2. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_047886275 – 325GVPLP…IEPGE → NQARRGQLQVRGLIKSGKQK IAPNTCDWGDGQQERNGRPQ KTRRKRRSVQN in isoform 8. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_047887276 – 355VPLPL…LGTAA → LRTREPTAVWPPIPATGPRK AVLSASASSNQARRGQLQVR GLIKSGKQKIAPNTCDWGDG QQERNGRPQKTRRKRRSVQN in isoform 9. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_047888326 – 404Missing in isoform 8. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_042011332 – 404SVGGS…STGGP → EGFDKVREAEDSPQHM in isoform 3 and isoform 4. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_047889356 – 404Missing in isoform 9. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_055321374 – 404KAPEN…STGGP → PQKTRRKRRSVQN in isoform 10. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91211 mRNA. Translation: AAA03574.1.
D28769 Genomic DNA. Translation: BAA05958.1.
AB036432 mRNA. Translation: BAA89369.1.
AJ133822 mRNA. Translation: CAB43108.1.
AB061668 mRNA. Translation: BAC65465.1.
U89336 Genomic DNA. Translation: AAB47491.1.
AY755619 mRNA. Translation: AAX07272.1.
AY755620 mRNA. Translation: AAX07273.1.
AY755621 mRNA. Translation: AAX07274.1.
AY755622 mRNA. Translation: AAX07275.1.
AY755623 mRNA. Translation: AAX07276.1.
AY755624 mRNA. Translation: AAX07277.1.
AY755625 mRNA. Translation: AAX07278.1.
AY755628 mRNA. Translation: AAX07281.1.
DQ104252 mRNA. Translation: AAZ32413.1.
EU117141 mRNA. Translation: ABV03807.1.
KC692917 mRNA. Translation: AHB30241.1.
AK313178 mRNA. Translation: BAG35995.1.
AL662830 Genomic DNA. Translation: CAI17535.1.
AL662830 Genomic DNA. Translation: CAI17536.1.
AL662830 Genomic DNA. Translation: CAM24893.1.
AL662884 Genomic DNA. Translation: CAI18354.1.
AL662884 Genomic DNA. Translation: CAI18355.1.
AL662884 Genomic DNA. Translation: CAM25647.1.
AL845464 Genomic DNA. Translation: CAI41809.1.
AL845464 Genomic DNA. Translation: CAI41810.1.
AL845464 Genomic DNA. Translation: CAM25716.1.
BX284686 Genomic DNA. Translation: CAM26223.1.
BX284686 Genomic DNA. Translation: CAM26225.1.
BX927239 Genomic DNA. Translation: CAQ06596.1.
BX927239 Genomic DNA. Translation: CAQ06597.1.
CR933878 Genomic DNA. Translation: CAQ09624.1.
CR812478 Genomic DNA. Translation: CAQ10699.1.
CH471081 Genomic DNA. Translation: EAX03610.1.
CH471081 Genomic DNA. Translation: EAX03611.1.
BC020669 mRNA. Translation: AAH20669.1.
AF208289 Genomic DNA. Translation: AAG35728.1.
CCDSiCCDS4746.1. [Q15109-1]
CCDS4747.1. [Q15109-2]
CCDS56417.1. [Q15109-4]
CCDS56418.1. [Q15109-3]
CCDS75429.1. [Q15109-6]
PIRiI61596.
RefSeqiNP_001127.1. NM_001136.4. [Q15109-1]
NP_001193858.1. NM_001206929.1. [Q15109-6]
NP_001193861.1. NM_001206932.1. [Q15109-7]
NP_001193863.1. NM_001206934.1. [Q15109-4]
NP_001193865.1. NM_001206936.1. [Q15109-9]
NP_001193869.1. NM_001206940.1. [Q15109-3]
NP_001193883.1. NM_001206954.1. [Q15109-8]
NP_001193895.1. NM_001206966.1. [Q15109-3]
NP_751947.1. NM_172197.2. [Q15109-2]
UniGeneiHs.534342.

Genome annotation databases

EnsembliENST00000375055; ENSP00000364195; ENSG00000204305. [Q15109-3]
ENST00000375067; ENSP00000364208; ENSG00000204305. [Q15109-2]
ENST00000375069; ENSP00000364210; ENSG00000204305. [Q15109-6]
ENST00000375076; ENSP00000364217; ENSG00000204305. [Q15109-1]
ENST00000383275; ENSP00000372762; ENSG00000206320. [Q15109-3]
ENST00000383279; ENSP00000372766; ENSG00000206320. [Q15109-2]
ENST00000412470; ENSP00000387853; ENSG00000229058. [Q15109-2]
ENST00000426138; ENSP00000415144; ENSG00000230514.
ENST00000427822; ENSP00000416042; ENSG00000231268.
ENST00000432831; ENSP00000413391; ENSG00000237405. [Q15109-3]
ENST00000436456; ENSP00000397227; ENSG00000234729. [Q15109-1]
ENST00000438221; ENSP00000387887; ENSG00000204305. [Q15109-4]
ENST00000441180; ENSP00000388462; ENSG00000234729. [Q15109-2]
ENST00000441804; ENSP00000391743; ENSG00000237405. [Q15109-2]
ENST00000447921; ENSP00000395812; ENSG00000237405. [Q15109-1]
ENST00000449037; ENSP00000400667; ENSG00000229058. [Q15109-3]
ENST00000451115; ENSP00000401068; ENSG00000206320. [Q15109-1]
ENST00000453588; ENSP00000399686; ENSG00000234729. [Q15109-3]
ENST00000456918; ENSP00000409457; ENSG00000229058. [Q15109-1]
ENST00000547328; ENSP00000448579; ENSG00000206320. [Q15109-6]
ENST00000547651; ENSP00000449708; ENSG00000229058. [Q15109-4]
ENST00000548464; ENSP00000450134; ENSG00000234729. [Q15109-6]
ENST00000549758; ENSP00000447301; ENSG00000229058. [Q15109-6]
ENST00000550562; ENSP00000446835; ENSG00000234729. [Q15109-4]
ENST00000551254; ENSP00000449226; ENSG00000206320. [Q15109-4]
ENST00000551381; ENSP00000448979; ENSG00000237405. [Q15109-6]
ENST00000551827; ENSP00000449042; ENSG00000237405. [Q15109-4]
GeneIDi177.
KEGGihsa:177.
UCSCiuc003oal.3. human. [Q15109-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91211 mRNA. Translation: AAA03574.1.
D28769 Genomic DNA. Translation: BAA05958.1.
AB036432 mRNA. Translation: BAA89369.1.
AJ133822 mRNA. Translation: CAB43108.1.
AB061668 mRNA. Translation: BAC65465.1.
U89336 Genomic DNA. Translation: AAB47491.1.
AY755619 mRNA. Translation: AAX07272.1.
AY755620 mRNA. Translation: AAX07273.1.
AY755621 mRNA. Translation: AAX07274.1.
AY755622 mRNA. Translation: AAX07275.1.
AY755623 mRNA. Translation: AAX07276.1.
AY755624 mRNA. Translation: AAX07277.1.
AY755625 mRNA. Translation: AAX07278.1.
AY755628 mRNA. Translation: AAX07281.1.
DQ104252 mRNA. Translation: AAZ32413.1.
EU117141 mRNA. Translation: ABV03807.1.
KC692917 mRNA. Translation: AHB30241.1.
AK313178 mRNA. Translation: BAG35995.1.
AL662830 Genomic DNA. Translation: CAI17535.1.
AL662830 Genomic DNA. Translation: CAI17536.1.
AL662830 Genomic DNA. Translation: CAM24893.1.
AL662884 Genomic DNA. Translation: CAI18354.1.
AL662884 Genomic DNA. Translation: CAI18355.1.
AL662884 Genomic DNA. Translation: CAM25647.1.
AL845464 Genomic DNA. Translation: CAI41809.1.
AL845464 Genomic DNA. Translation: CAI41810.1.
AL845464 Genomic DNA. Translation: CAM25716.1.
BX284686 Genomic DNA. Translation: CAM26223.1.
BX284686 Genomic DNA. Translation: CAM26225.1.
BX927239 Genomic DNA. Translation: CAQ06596.1.
BX927239 Genomic DNA. Translation: CAQ06597.1.
CR933878 Genomic DNA. Translation: CAQ09624.1.
CR812478 Genomic DNA. Translation: CAQ10699.1.
CH471081 Genomic DNA. Translation: EAX03610.1.
CH471081 Genomic DNA. Translation: EAX03611.1.
BC020669 mRNA. Translation: AAH20669.1.
AF208289 Genomic DNA. Translation: AAG35728.1.
CCDSiCCDS4746.1. [Q15109-1]
CCDS4747.1. [Q15109-2]
CCDS56417.1. [Q15109-4]
CCDS56418.1. [Q15109-3]
CCDS75429.1. [Q15109-6]
PIRiI61596.
RefSeqiNP_001127.1. NM_001136.4. [Q15109-1]
NP_001193858.1. NM_001206929.1. [Q15109-6]
NP_001193861.1. NM_001206932.1. [Q15109-7]
NP_001193863.1. NM_001206934.1. [Q15109-4]
NP_001193865.1. NM_001206936.1. [Q15109-9]
NP_001193869.1. NM_001206940.1. [Q15109-3]
NP_001193883.1. NM_001206954.1. [Q15109-8]
NP_001193895.1. NM_001206966.1. [Q15109-3]
NP_751947.1. NM_172197.2. [Q15109-2]
UniGeneiHs.534342.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PWImodel-A1-404[»]
2BJPmodel-A1-404[»]
2E5ENMR-A23-121[»]
2ENSNMR-A235-323[»]
2L7UNMR-A23-125[»]
2LE9NMR-A/D235-327[»]
2LMBNMR-A363-404[»]
2M1KNMR-A/C23-121[»]
2MJWNMR-A/C23-121[»]
2MOVNMR-A23-125[»]
3CJJX-ray1.85A23-240[»]
3O3UX-ray1.50N23-231[»]
4LP4X-ray2.40A/B23-231[»]
4LP5X-ray3.80A/B23-323[»]
4OF5X-ray2.80A/B23-237[»]
4OFVX-ray3.10A/B23-235[»]
4OI7X-ray3.10A/B23-237[»]
4OI8X-ray3.10A/B23-237[»]
4P2YX-ray2.30A23-323[»]
4XYNX-ray2.55P54-68[»]
4YBHX-ray2.40A23-323[»]
5D7FX-ray1.30P65-79[»]
ProteinModelPortaliQ15109.
SMRiQ15109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106685. 6 interactors.
DIPiDIP-40658N.
IntActiQ15109. 10 interactors.
MINTiMINT-2635420.
STRINGi9606.ENSP00000364217.

Chemistry databases

BindingDBiQ15109.
ChEMBLiCHEMBL2176846.
GuidetoPHARMACOLOGYi2843.

PTM databases

iPTMnetiQ15109.
PhosphoSitePlusiQ15109.

Polymorphism and mutation databases

BioMutaiAGER.
DMDMi2497317.

Proteomic databases

PaxDbiQ15109.
PeptideAtlasiQ15109.
PRIDEiQ15109.

Protocols and materials databases

DNASUi177.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375055; ENSP00000364195; ENSG00000204305. [Q15109-3]
ENST00000375067; ENSP00000364208; ENSG00000204305. [Q15109-2]
ENST00000375069; ENSP00000364210; ENSG00000204305. [Q15109-6]
ENST00000375076; ENSP00000364217; ENSG00000204305. [Q15109-1]
ENST00000383275; ENSP00000372762; ENSG00000206320. [Q15109-3]
ENST00000383279; ENSP00000372766; ENSG00000206320. [Q15109-2]
ENST00000412470; ENSP00000387853; ENSG00000229058. [Q15109-2]
ENST00000426138; ENSP00000415144; ENSG00000230514.
ENST00000427822; ENSP00000416042; ENSG00000231268.
ENST00000432831; ENSP00000413391; ENSG00000237405. [Q15109-3]
ENST00000436456; ENSP00000397227; ENSG00000234729. [Q15109-1]
ENST00000438221; ENSP00000387887; ENSG00000204305. [Q15109-4]
ENST00000441180; ENSP00000388462; ENSG00000234729. [Q15109-2]
ENST00000441804; ENSP00000391743; ENSG00000237405. [Q15109-2]
ENST00000447921; ENSP00000395812; ENSG00000237405. [Q15109-1]
ENST00000449037; ENSP00000400667; ENSG00000229058. [Q15109-3]
ENST00000451115; ENSP00000401068; ENSG00000206320. [Q15109-1]
ENST00000453588; ENSP00000399686; ENSG00000234729. [Q15109-3]
ENST00000456918; ENSP00000409457; ENSG00000229058. [Q15109-1]
ENST00000547328; ENSP00000448579; ENSG00000206320. [Q15109-6]
ENST00000547651; ENSP00000449708; ENSG00000229058. [Q15109-4]
ENST00000548464; ENSP00000450134; ENSG00000234729. [Q15109-6]
ENST00000549758; ENSP00000447301; ENSG00000229058. [Q15109-6]
ENST00000550562; ENSP00000446835; ENSG00000234729. [Q15109-4]
ENST00000551254; ENSP00000449226; ENSG00000206320. [Q15109-4]
ENST00000551381; ENSP00000448979; ENSG00000237405. [Q15109-6]
ENST00000551827; ENSP00000449042; ENSG00000237405. [Q15109-4]
GeneIDi177.
KEGGihsa:177.
UCSCiuc003oal.3. human. [Q15109-1]

Organism-specific databases

CTDi177.
DisGeNETi177.
GeneCardsiAGER.
HGNCiHGNC:320. AGER.
HPAiCAB011682.
HPA064436.
MIMi600214. gene.
neXtProtiNX_Q15109.
OpenTargetsiENSG00000204305.
ENSG00000206320.
ENSG00000229058.
ENSG00000234729.
ENSG00000237405.
PharmGKBiPA24617.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVT2. Eukaryota.
ENOG4111C4I. LUCA.
GeneTreeiENSGT00530000063457.
HOGENOMiHOG000232122.
HOVERGENiHBG004350.
InParanoidiQ15109.
KOiK19722.
OMAiPNKVGTC.
OrthoDBiEOG091G0BCY.
PhylomeDBiQ15109.
TreeFamiTF337155.

Enzyme and pathway databases

ReactomeiR-HSA-1810476. RIP-mediated NFkB activation via ZBP1.
R-HSA-3134963. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
R-HSA-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-HSA-879415. Advanced glycosylation endproduct receptor signaling.
R-HSA-933542. TRAF6 mediated NF-kB activation.

Miscellaneous databases

ChiTaRSiAGER. human.
EvolutionaryTraceiQ15109.
GeneWikiiRAGE_(receptor).
GenomeRNAii177.
PROiQ15109.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204305.
CleanExiHS_AGER.
HS_RAGE.
ExpressionAtlasiQ15109. baseline and differential.
GenevisibleiQ15109. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAGE_HUMAN
AccessioniPrimary (citable) accession number: Q15109
Secondary accession number(s): A2BFI7
, A6NKF0, A7Y2U9, B0V176, Q15279, Q3L1R4, Q3L1R5, Q3L1R6, Q3L1R7, Q3L1R8, Q3L1S0, Q86SN1, Q9H2X7, Q9Y3R3, V5R6A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 177 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.