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Q15102

- PA1B3_HUMAN

UniProt

Q15102 - PA1B3_HUMAN

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Protein
Platelet-activating factor acetylhydrolase IB subunit gamma
Gene
PAFAH1B3, PAFAHG
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei47 – 471 By similarity
Active sitei192 – 1921 By similarity
Active sitei195 – 1951 By similarity

GO - Molecular functioni

  1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: UniProtKB-EC
  2. protein binding Source: IntAct

GO - Biological processi

  1. brain development Source: Ensembl
  2. lipid catabolic process Source: UniProtKB-KW
  3. lipid metabolic process Source: ProtInc
  4. nervous system development Source: ProtInc
  5. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase IB subunit gamma (EC:3.1.1.47)
Alternative name(s):
PAF acetylhydrolase 29 kDa subunit
Short name:
PAF-AH 29 kDa subunit
PAF-AH subunit gamma
Short name:
PAFAH subunit gamma
Gene namesi
Synonyms:PAFAHG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:8576. PAFAH1B3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 231230Platelet-activating factor acetylhydrolase IB subunit gamma
PRO_0000058155Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine3 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ15102.
PaxDbiQ15102.
PeptideAtlasiQ15102.
PRIDEiQ15102.

2D gel databases

REPRODUCTION-2DPAGEIPI00014808.

PTM databases

PhosphoSiteiQ15102.

Expressioni

Tissue specificityi

In the adult, expressed in brain, skeletal muscle, kidney, thymus, spleen, colon, testis, ovary and peripheral blood leukocytes. In the fetus, highest expression occurs in brain.

Gene expression databases

ArrayExpressiQ15102.
BgeeiQ15102.
CleanExiHS_PAFAH1B3.
GenevestigatoriQ15102.

Organism-specific databases

HPAiHPA035639.

Interactioni

Subunit structurei

Cytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.

Binary interactionsi

WithEntry#Exp.IntActNotes
LNX1Q8TBB12EBI-711522,EBI-739832

Protein-protein interaction databases

BioGridi111087. 41 interactions.
IntActiQ15102. 32 interactions.
MINTiMINT-1368260.
STRINGi9606.ENSP00000262890.

Structurei

3D structure databases

ProteinModelPortaliQ15102.
SMRiQ15102. Positions 5-207.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG69837.
HOGENOMiHOG000232143.
HOVERGENiHBG053477.
InParanoidiQ15102.
KOiK16795.
OMAiFAPLHCL.
OrthoDBiEOG7HB5BS.
PhylomeDBiQ15102.
TreeFamiTF323955.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15102-1 [UniParc]FASTAAdd to Basket

« Hide

MSGEENPASK PTPVQDVQGD GRWMSLHHRF VADSKDKEPE VVFIGDSLVQ    50
LMHQCEIWRE LFSPLHALNF GIGGDGTQHV LWRLENGELE HIRPKIVVVW 100
VGTNNHGHTA EQVTGGIKAI VQLVNERQPQ ARVVVLGLLP RGQHPNPLRE 150
KNRQVNELVR AALAGHPRAH FLDADPGFVH SDGTISHHDM YDYLHLSRLG 200
YTPVCRALHS LLLRLLAQDQ GQGAPLLEPA P 231
Length:231
Mass (Da):25,734
Last modified:November 1, 1996 - v1
Checksum:i58A4CB8E7076AE23
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti214 – 2141R → G.
Corresponds to variant rs1043818 [ dbSNP | Ensembl ].
VAR_051261

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63391 mRNA. Translation: BAA09706.1.
CR407626 mRNA. Translation: CAG28554.1.
AC006486 Genomic DNA. Translation: AAD11989.1.
CH471126 Genomic DNA. Translation: EAW57122.1.
BC003016 mRNA. Translation: AAH03016.1.
BC007863 mRNA. Translation: AAH07863.1.
CCDSiCCDS12602.1.
PIRiJC4246.
RefSeqiNP_001139411.1. NM_001145939.1.
NP_001139412.1. NM_001145940.1.
NP_002564.1. NM_002573.3.
UniGeneiHs.466831.

Genome annotation databases

EnsembliENST00000262890; ENSP00000262890; ENSG00000079462.
ENST00000538771; ENSP00000444935; ENSG00000079462.
GeneIDi5050.
KEGGihsa:5050.
UCSCiuc002otg.2. human.

Polymorphism databases

DMDMi3024344.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63391 mRNA. Translation: BAA09706.1 .
CR407626 mRNA. Translation: CAG28554.1 .
AC006486 Genomic DNA. Translation: AAD11989.1 .
CH471126 Genomic DNA. Translation: EAW57122.1 .
BC003016 mRNA. Translation: AAH03016.1 .
BC007863 mRNA. Translation: AAH07863.1 .
CCDSi CCDS12602.1.
PIRi JC4246.
RefSeqi NP_001139411.1. NM_001145939.1.
NP_001139412.1. NM_001145940.1.
NP_002564.1. NM_002573.3.
UniGenei Hs.466831.

3D structure databases

ProteinModelPortali Q15102.
SMRi Q15102. Positions 5-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111087. 41 interactions.
IntActi Q15102. 32 interactions.
MINTi MINT-1368260.
STRINGi 9606.ENSP00000262890.

Chemistry

ChEMBLi CHEMBL5108.

PTM databases

PhosphoSitei Q15102.

Polymorphism databases

DMDMi 3024344.

2D gel databases

REPRODUCTION-2DPAGE IPI00014808.

Proteomic databases

MaxQBi Q15102.
PaxDbi Q15102.
PeptideAtlasi Q15102.
PRIDEi Q15102.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262890 ; ENSP00000262890 ; ENSG00000079462 .
ENST00000538771 ; ENSP00000444935 ; ENSG00000079462 .
GeneIDi 5050.
KEGGi hsa:5050.
UCSCi uc002otg.2. human.

Organism-specific databases

CTDi 5050.
GeneCardsi GC19M042801.
HGNCi HGNC:8576. PAFAH1B3.
HPAi HPA035639.
MIMi 603074. gene.
neXtProti NX_Q15102.
PharmGKBi PA32907.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG69837.
HOGENOMi HOG000232143.
HOVERGENi HBG053477.
InParanoidi Q15102.
KOi K16795.
OMAi FAPLHCL.
OrthoDBi EOG7HB5BS.
PhylomeDBi Q15102.
TreeFami TF323955.

Miscellaneous databases

GeneWikii PAFAH1B3.
GenomeRNAii 5050.
NextBioi 19460.
PROi Q15102.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15102.
Bgeei Q15102.
CleanExi HS_PAFAH1B3.
Genevestigatori Q15102.

Family and domain databases

Gene3Di 3.40.50.1110. 1 hit.
InterProi IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues."
    Adachi H., Tsujimoto M., Hattori M., Arai H., Inoue K.
    Biochem. Biophys. Res. Commun. 214:180-187(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal liver.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Uterus.
  6. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 84-127; 133-141 AND 199-231, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPA1B3_HUMAN
AccessioniPrimary (citable) accession number: Q15102
Secondary accession number(s): Q53X88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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