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Protein

Platelet-activating factor acetylhydrolase IB subunit gamma

Gene

PAFAH1B3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei47By similarity1
Active sitei192By similarity1
Active sitei195By similarity1

GO - Molecular functioni

GO - Biological processi

  • brain development Source: GO_Central
  • lipid catabolic process Source: UniProtKB-KW
  • lipid metabolic process Source: ProtInc
  • nervous system development Source: ProtInc
  • spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciZFISH:ENSG00000079462-MONOMER.
ReactomeiR-HSA-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase IB subunit gamma (EC:3.1.1.47)
Alternative name(s):
PAF acetylhydrolase 29 kDa subunit
Short name:
PAF-AH 29 kDa subunit
PAF-AH subunit gamma
Short name:
PAFAH subunit gamma
Gene namesi
Name:PAFAH1B3
Synonyms:PAFAHG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8576. PAFAH1B3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000079462.
PharmGKBiPA32907.

Chemistry databases

ChEMBLiCHEMBL5108.

Polymorphism and mutation databases

BioMutaiPAFAH1B3.
DMDMi3024344.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000581552 – 231Platelet-activating factor acetylhydrolase IB subunit gammaAdd BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ15102.
MaxQBiQ15102.
PaxDbiQ15102.
PeptideAtlasiQ15102.
PRIDEiQ15102.

2D gel databases

REPRODUCTION-2DPAGEIPI00014808.

PTM databases

iPTMnetiQ15102.
PhosphoSitePlusiQ15102.
SwissPalmiQ15102.

Expressioni

Tissue specificityi

In the adult, expressed in brain, skeletal muscle, kidney, thymus, spleen, colon, testis, ovary and peripheral blood leukocytes. In the fetus, highest expression occurs in brain.

Gene expression databases

BgeeiENSG00000079462.
CleanExiHS_PAFAH1B3.
ExpressionAtlasiQ15102. baseline and differential.
GenevisibleiQ15102. HS.

Organism-specific databases

HPAiHPA035639.

Interactioni

Subunit structurei

Cytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-711522,EBI-711522
LNX1Q8TBB16EBI-711522,EBI-739832
PAFAH1B2P684023EBI-711522,EBI-713724
SDCBP2Q9H1903EBI-711522,EBI-742426

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi111087. 44 interactors.
IntActiQ15102. 37 interactors.
MINTiMINT-1368260.
STRINGi9606.ENSP00000262890.

Structurei

3D structure databases

ProteinModelPortaliQ15102.
SMRiQ15102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IMK6. Eukaryota.
ENOG410XPWQ. LUCA.
GeneTreeiENSGT00390000016520.
HOGENOMiHOG000232143.
HOVERGENiHBG053477.
InParanoidiQ15102.
KOiK16795.
OMAiATQHVLW.
OrthoDBiEOG091G0OII.
PhylomeDBiQ15102.
TreeFamiTF323955.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13472. Lipase_GDSL_2. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEENPASK PTPVQDVQGD GRWMSLHHRF VADSKDKEPE VVFIGDSLVQ
60 70 80 90 100
LMHQCEIWRE LFSPLHALNF GIGGDGTQHV LWRLENGELE HIRPKIVVVW
110 120 130 140 150
VGTNNHGHTA EQVTGGIKAI VQLVNERQPQ ARVVVLGLLP RGQHPNPLRE
160 170 180 190 200
KNRQVNELVR AALAGHPRAH FLDADPGFVH SDGTISHHDM YDYLHLSRLG
210 220 230
YTPVCRALHS LLLRLLAQDQ GQGAPLLEPA P
Length:231
Mass (Da):25,734
Last modified:November 1, 1996 - v1
Checksum:i58A4CB8E7076AE23
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051261214R → G.Corresponds to variant rs1043818dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63391 mRNA. Translation: BAA09706.1.
CR407626 mRNA. Translation: CAG28554.1.
AC006486 Genomic DNA. Translation: AAD11989.1.
CH471126 Genomic DNA. Translation: EAW57122.1.
BC003016 mRNA. Translation: AAH03016.1.
BC007863 mRNA. Translation: AAH07863.1.
CCDSiCCDS12602.1.
PIRiJC4246.
RefSeqiNP_001139411.1. NM_001145939.1.
NP_001139412.1. NM_001145940.1.
NP_002564.1. NM_002573.3.
UniGeneiHs.466831.

Genome annotation databases

EnsembliENST00000262890; ENSP00000262890; ENSG00000079462.
ENST00000538771; ENSP00000444935; ENSG00000079462.
GeneIDi5050.
KEGGihsa:5050.
UCSCiuc002otg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63391 mRNA. Translation: BAA09706.1.
CR407626 mRNA. Translation: CAG28554.1.
AC006486 Genomic DNA. Translation: AAD11989.1.
CH471126 Genomic DNA. Translation: EAW57122.1.
BC003016 mRNA. Translation: AAH03016.1.
BC007863 mRNA. Translation: AAH07863.1.
CCDSiCCDS12602.1.
PIRiJC4246.
RefSeqiNP_001139411.1. NM_001145939.1.
NP_001139412.1. NM_001145940.1.
NP_002564.1. NM_002573.3.
UniGeneiHs.466831.

3D structure databases

ProteinModelPortaliQ15102.
SMRiQ15102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111087. 44 interactors.
IntActiQ15102. 37 interactors.
MINTiMINT-1368260.
STRINGi9606.ENSP00000262890.

Chemistry databases

ChEMBLiCHEMBL5108.

PTM databases

iPTMnetiQ15102.
PhosphoSitePlusiQ15102.
SwissPalmiQ15102.

Polymorphism and mutation databases

BioMutaiPAFAH1B3.
DMDMi3024344.

2D gel databases

REPRODUCTION-2DPAGEIPI00014808.

Proteomic databases

EPDiQ15102.
MaxQBiQ15102.
PaxDbiQ15102.
PeptideAtlasiQ15102.
PRIDEiQ15102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262890; ENSP00000262890; ENSG00000079462.
ENST00000538771; ENSP00000444935; ENSG00000079462.
GeneIDi5050.
KEGGihsa:5050.
UCSCiuc002otg.3. human.

Organism-specific databases

CTDi5050.
GeneCardsiPAFAH1B3.
HGNCiHGNC:8576. PAFAH1B3.
HPAiHPA035639.
MIMi603074. gene.
neXtProtiNX_Q15102.
OpenTargetsiENSG00000079462.
PharmGKBiPA32907.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMK6. Eukaryota.
ENOG410XPWQ. LUCA.
GeneTreeiENSGT00390000016520.
HOGENOMiHOG000232143.
HOVERGENiHBG053477.
InParanoidiQ15102.
KOiK16795.
OMAiATQHVLW.
OrthoDBiEOG091G0OII.
PhylomeDBiQ15102.
TreeFamiTF323955.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000079462-MONOMER.
ReactomeiR-HSA-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Miscellaneous databases

ChiTaRSiPAFAH1B3. human.
GeneWikiiPAFAH1B3.
GenomeRNAii5050.
PROiQ15102.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079462.
CleanExiHS_PAFAH1B3.
ExpressionAtlasiQ15102. baseline and differential.
GenevisibleiQ15102. HS.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13472. Lipase_GDSL_2. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPA1B3_HUMAN
AccessioniPrimary (citable) accession number: Q15102
Secondary accession number(s): Q53X88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.