Reviewed,
UniProtKB/Swiss-Prot Q15102 (PA1B3_HUMAN)
Last modified
December 15, 2009.
Version 87.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Platelet-activating factor acetylhydrolase IB subunit gamma EC=3.1.1.47 Alternative name(s): PAF acetylhydrolase 29 kDa subunit Short name=PAF-AH 29 kDa subunit PAF-AH subunit gamma PAFAH subunit gamma | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 231 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain. |
| Catalytic activity | 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. |
| Subunit structure | Cytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity. |
| Subcellular location | |
| Tissue specificity | In the adult, expressed in brain, skeletal muscle, kidney, thymus, spleen, colon, testis, ovary and peripheral blood leukocytes. In the fetus, highest expression occurs in brain. |
| Sequence similarities | Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid degradation |
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Molecular function | Hydrolase |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 1-alkyl-2-acetylglycerophosphocholine esterase activity Inferred from electronic annotation. Source: EC protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 231 | 231 | Platelet-activating factor acetylhydrolase IB subunit gamma | PRO_0000058155 | |||||
Sites | |||||||||
| Active site | 47 | 1 | By similarity | ||||||
| Active site | 192 | 1 | By similarity | ||||||
| Active site | 195 | 1 | By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 214 | 1 | R → G: dbSNP rs1043818. | VAR_051261 | |||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues." Adachi H., Tsujimoto M., Hattori M., Arai H., Inoue K. Biochem. Biophys. Res. Commun. 214:180-187(1995) [PubMed: 7669037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal liver. |
| [2] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M.Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Uterus. |
| [6] | Lubec G., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 84-127; 133-141 AND 199-231, MASS SPECTROMETRY. Tissue: Fetal brain cortex. |
| [7] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D63391 mRNA. Translation: BAA09706.1. CR407626 mRNA. Translation: CAG28554.1. AC006486 Genomic DNA. Translation: AAD11989.1. CH471126 Genomic DNA. Translation: EAW57122.1. BC003016 mRNA. Translation: AAH03016.1. BC007863 mRNA. Translation: AAH07863.1. | |
| IPI | IPI00014808. |
| PIR | JC4246. |
| RefSeq | NP_001139411.1. NP_001139412.1. NP_002564.1. |
| UniGene | Hs.466831 |
3D structure databases | |
| SMR | Q15102. Positions 5-215. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q15102. 31 interactions. |
| STRING | Q15102. |
2-D gel databases | |
| REPRODUCTION-2DPAGE | IPI00014808. |
Proteomic databases | |
| PeptideAtlas | Q15102. |
| PRIDE | Q15102. |
Genome annotation databases | |
| Ensembl | ENST00000262890; ENSP00000262890; ENSG00000079462; Homo sapiens. [Genome view] |
| GeneID | 5050. |
| KEGG | hsa:5050. |
| UCSC | uc002otg.1. human. |
Organism-specific databases | |
| CTD | 5050. |
| GeneCards | GC19M047493. |
| H-InvDB | HIX0015176. HIX0027549. |
| HGNC | HGNC:8576. PAFAH1B3. |
| MIM | 603074. gene. |
| PharmGKB | PA32907. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG715888. |
| HOVERGEN | Q15102. |
| InParanoid | Q15102. |
| OMA | NQRQPQA. |
| OrthoDB | EOG900445. |
Enzyme and pathway databases | |
| BRENDA | 3.1.1.47. 247. |
| Pathway_Interaction_DB | lis1pathway. Lissencephaly gene (LIS1) in neuronal migration and development. |
Gene expression databases | |
| ArrayExpress | Q15102. |
| Bgee | Q15102. |
| CleanEx | HS_PAFAH1B3. |
| Genevestigator | Q15102. |
| GermOnline | ENSG00000079462. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR013830. Esterase_SGNH_hydro-type. IPR013831. Esterase_SGNH_hydro-type_subgr. IPR001087. Lipase_GDSL. [Graphical view] |
| Gene3D | G3DSA:3.40.50.1110. Esterase_SGNH_hydro-type_subgr. 1 hit. |
| Pfam | PF00657. Lipase_GDSL. 1 hit. [Graphical view] |
| PROSITE | PS01098. LIPASE_GDSL_SER. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 19460. |
| SOURCE | Search... |
Entry information
| Entry name | PA1B3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q15102 Secondary accession number(s): Q53X88 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


