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Q15078

- CD5R1_HUMAN

UniProt

Q15078 - CD5R1_HUMAN

Protein

Cyclin-dependent kinase 5 activator 1

Gene

CDK5R1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei98 – 992Cleavage; by calpainBy similarity

    GO - Molecular functioni

    1. cadherin binding Source: UniProtKB
    2. calcium ion binding Source: UniProtKB
    3. cyclin-dependent protein kinase 5 activator activity Source: Ensembl
    4. cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    5. kinase activity Source: UniProtKB
    6. protein binding Source: UniProtKB
    7. protein kinase activity Source: ProtInc
    8. protein kinase binding Source: UniProtKB
    9. protein serine/threonine kinase activator activity Source: UniProtKB

    GO - Biological processi

    1. axonal fasciculation Source: UniProtKB
    2. axon guidance Source: UniProtKB
    3. brain development Source: UniProtKB
    4. cell proliferation Source: ProtInc
    5. cerebellum development Source: Ensembl
    6. embryo development Source: UniProtKB
    7. ephrin receptor signaling pathway Source: UniProtKB
    8. G-protein coupled acetylcholine receptor signaling pathway Source: UniProtKB
    9. hippocampus development Source: Ensembl
    10. ionotropic glutamate receptor signaling pathway Source: UniProtKB
    11. layer formation in cerebral cortex Source: Ensembl
    12. negative regulation of axon extension Source: Ensembl
    13. negative regulation of transcription, DNA-templated Source: DFLAT
    14. neuron cell-cell adhesion Source: UniProtKB
    15. neuron differentiation Source: UniProtKB
    16. neuron migration Source: UniProtKB
    17. neuron projection development Source: UniProtKB
    18. peptidyl-serine phosphorylation Source: UniProtKB
    19. peptidyl-threonine phosphorylation Source: UniProtKB
    20. positive regulation of neuron apoptotic process Source: UniProtKB
    21. positive regulation of protein targeting to membrane Source: Ensembl
    22. regulation of actin cytoskeleton organization Source: Ensembl
    23. regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
    24. regulation of dendritic spine morphogenesis Source: UniProtKB
    25. regulation of microtubule cytoskeleton organization Source: Ensembl
    26. regulation of neuron differentiation Source: UniProtKB
    27. rhythmic process Source: UniProtKB-KW
    28. serine phosphorylation of STAT3 protein Source: Ensembl
    29. superior olivary nucleus maturation Source: Ensembl

    Keywords - Biological processi

    Biological rhythms

    Enzyme and pathway databases

    ReactomeiREACT_19199. CRMPs in Sema3A signaling.
    SignaLinkiQ15078.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 5 activator 1
    Short name:
    CDK5 activator 1
    Alternative name(s):
    Cyclin-dependent kinase 5 regulatory subunit 1
    TPKII regulatory subunit
    Cleaved into the following 2 chains:
    Alternative name(s):
    Tau protein kinase II 23 kDa subunit
    Short name:
    p23
    Gene namesi
    Name:CDK5R1
    Synonyms:CDK5R, NCK5A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:1775. CDK5R1.

    Subcellular locationi

    Chain Cyclin-dependent kinase 5 activator 1, p35 : Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
    Note: In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
    Chain Cyclin-dependent kinase 5 activator 1, p25 : Nucleus. Cytoplasmperinuclear region
    Note: The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites.

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. contractile fiber Source: UniProtKB
    3. cyclin-dependent protein kinase 5 holoenzyme complex Source: InterPro
    4. cytoplasm Source: UniProtKB
    5. cytosol Source: Reactome
    6. dendrite Source: UniProtKB
    7. dendritic spine Source: UniProtKB
    8. growth cone Source: UniProtKB
    9. membrane Source: UniProtKB
    10. neuromuscular junction Source: UniProtKB
    11. neuronal cell body Source: UniProtKB
    12. nucleus Source: UniProtKB
    13. perinuclear region of cytoplasm Source: UniProtKB
    14. plasma membrane Source: UniProtKB-SubCell
    15. postsynaptic density Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi2 – 21G → A: Absent from the cell periphery. 2 Publications
    Mutagenesisi8 – 81S → A: Increased susceptibility to calpain. 1 Publication
    Mutagenesisi8 – 81S → E: Reduced susceptibility to calpain. 1 Publication
    Mutagenesisi138 – 1381T → A: Increased susceptibility to calpain. 1 Publication
    Mutagenesisi138 – 1381T → E: Reduced susceptibility to calpain. 1 Publication

    Organism-specific databases

    PharmGKBiPA26311.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 307306Cyclin-dependent kinase 5 activator 1, p35PRO_0000004794Add
    BLAST
    Chaini99 – 307209Cyclin-dependent kinase 5 activator 1, p25PRO_0000004795Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycine2 Publications
    Modified residuei8 – 81Phosphoserine; by CDK51 Publication
    Modified residuei138 – 1381Phosphothreonine; by CDK51 Publication

    Post-translational modificationi

    The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo By similarity.By similarity
    Myristoylated. A proper myristoylation signal is essential for the proper distribution of p35.2 Publications
    Ubiquitinated. Degradation of p35 by proteasome results in down-regulation of CDK5 activity. During this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation.1 Publication
    Phosphorylation at Ser-8 and Thr-138 by CDK5 prevents calpain-mediated proteolysis.1 Publication

    Keywords - PTMi

    Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ15078.
    PRIDEiQ15078.

    PTM databases

    PhosphoSiteiQ15078.

    Miscellaneous databases

    PMAP-CutDBQ15078.

    Expressioni

    Tissue specificityi

    Brain and neuron specific.

    Gene expression databases

    BgeeiQ15078.
    CleanExiHS_CDK5R1.
    GenevestigatoriQ15078.

    Interactioni

    Subunit structurei

    Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4 By similarity. Interacts with RASGRF2. The complex p35/CDK5 interacts with CLOCK.By similarity5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AATKQ6ZMQ8-12EBI-746189,EBI-2008436
    AATKQ6ZMQ8-26EBI-746189,EBI-2008441
    CDK5Q005356EBI-746189,EBI-1041567

    Protein-protein interaction databases

    BioGridi114376. 24 interactions.
    DIPiDIP-24222N.
    IntActiQ15078. 8 interactions.
    MINTiMINT-128009.
    STRINGi9606.ENSP00000318486.

    Structurei

    Secondary structure

    1
    307
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi148 – 16215
    Helixi172 – 18716
    Helixi198 – 21114
    Helixi219 – 23719
    Beta strandi239 – 2413
    Helixi246 – 2483
    Helixi254 – 27724
    Helixi279 – 29012

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1H4LX-ray2.65D/E147-293[»]
    1UNGX-ray2.30D/E100-307[»]
    1UNHX-ray2.35D/E100-307[»]
    1UNLX-ray2.20D/E100-307[»]
    3O0GX-ray1.95D/E145-293[»]
    ProteinModelPortaliQ15078.
    SMRiQ15078. Positions 145-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ15078.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG283789.
    HOGENOMiHOG000063677.
    HOVERGENiHBG050853.
    InParanoidiQ15078.
    KOiK11716.
    OMAiCANLSSF.
    OrthoDBiEOG7GTT4Q.
    PhylomeDBiQ15078.
    TreeFamiTF101036.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR004944. CDK5_activator.
    IPR013763. Cyclin-like.
    [Graphical view]
    PANTHERiPTHR23401. PTHR23401. 1 hit.
    PfamiPF03261. CDK5_activator. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009324. Cdk5_activator. 1 hit.
    SUPFAMiSSF47954. SSF47954. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q15078-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTVLSLSPS YRKATLFEDG AATVGHYTAV QNSKNAKDKN LKRHSIISVL    50
    PWKRIVAVSA KKKNSKKVQP NSSYQNNITH LNNENLKKSL SCANLSTFAQ 100
    PPPAQPPAPP ASQLSGSQTG GSSSVKKAPH PAVTSAGTPK RVIVQASTSE 150
    LLRCLGEFLC RRCYRLKHLS PTDPVLWLRS VDRSLLLQGW QDQGFITPAN 200
    VVFLYMLCRD VISSEVGSDH ELQAVLLTCL YLSYSYMGNE ISYPLKPFLV 250
    ESCKEAFWDR CLSVINLMSS KMLQINADPH YFTQVFSDLK NESGQEDKKR 300
    LLLGLDR 307
    Length:307
    Mass (Da):34,060
    Last modified:November 1, 1997 - v1
    Checksum:iD1C29A07AFF1B644
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80343 mRNA. Translation: CAA56587.1.
    AY376350 Genomic DNA. Translation: AAQ74776.1.
    BT019573 mRNA. Translation: AAV38380.1.
    CH471147 Genomic DNA. Translation: EAW80227.1.
    CH471147 Genomic DNA. Translation: EAW80228.1.
    BC020580 mRNA. Translation: AAH20580.1.
    CCDSiCCDS11273.1.
    PIRiS50861.
    RefSeqiNP_003876.1. NM_003885.2.
    UniGeneiHs.500015.

    Genome annotation databases

    EnsembliENST00000313401; ENSP00000318486; ENSG00000176749.
    GeneIDi8851.
    KEGGihsa:8851.
    UCSCiuc002hhn.3. human.

    Polymorphism databases

    DMDMi2498217.

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80343 mRNA. Translation: CAA56587.1 .
    AY376350 Genomic DNA. Translation: AAQ74776.1 .
    BT019573 mRNA. Translation: AAV38380.1 .
    CH471147 Genomic DNA. Translation: EAW80227.1 .
    CH471147 Genomic DNA. Translation: EAW80228.1 .
    BC020580 mRNA. Translation: AAH20580.1 .
    CCDSi CCDS11273.1.
    PIRi S50861.
    RefSeqi NP_003876.1. NM_003885.2.
    UniGenei Hs.500015.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1H4L X-ray 2.65 D/E 147-293 [» ]
    1UNG X-ray 2.30 D/E 100-307 [» ]
    1UNH X-ray 2.35 D/E 100-307 [» ]
    1UNL X-ray 2.20 D/E 100-307 [» ]
    3O0G X-ray 1.95 D/E 145-293 [» ]
    ProteinModelPortali Q15078.
    SMRi Q15078. Positions 145-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114376. 24 interactions.
    DIPi DIP-24222N.
    IntActi Q15078. 8 interactions.
    MINTi MINT-128009.
    STRINGi 9606.ENSP00000318486.

    Chemistry

    BindingDBi Q15078.
    ChEMBLi CHEMBL1907600.

    PTM databases

    PhosphoSitei Q15078.

    Polymorphism databases

    DMDMi 2498217.

    Proteomic databases

    PaxDbi Q15078.
    PRIDEi Q15078.

    Protocols and materials databases

    DNASUi 8851.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313401 ; ENSP00000318486 ; ENSG00000176749 .
    GeneIDi 8851.
    KEGGi hsa:8851.
    UCSCi uc002hhn.3. human.

    Organism-specific databases

    CTDi 8851.
    GeneCardsi GC17P030813.
    HGNCi HGNC:1775. CDK5R1.
    MIMi 603460. gene.
    neXtProti NX_Q15078.
    PharmGKBi PA26311.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283789.
    HOGENOMi HOG000063677.
    HOVERGENi HBG050853.
    InParanoidi Q15078.
    KOi K11716.
    OMAi CANLSSF.
    OrthoDBi EOG7GTT4Q.
    PhylomeDBi Q15078.
    TreeFami TF101036.

    Enzyme and pathway databases

    Reactomei REACT_19199. CRMPs in Sema3A signaling.
    SignaLinki Q15078.

    Miscellaneous databases

    EvolutionaryTracei Q15078.
    GeneWikii CDK5R1.
    GenomeRNAii 8851.
    NextBioi 33227.
    PMAP-CutDB Q15078.
    PROi Q15078.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q15078.
    CleanExi HS_CDK5R1.
    Genevestigatori Q15078.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR004944. CDK5_activator.
    IPR013763. Cyclin-like.
    [Graphical view ]
    PANTHERi PTHR23401. PTHR23401. 1 hit.
    Pfami PF03261. CDK5_activator. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009324. Cdk5_activator. 1 hit.
    SUPFAMi SSF47954. SSF47954. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5."
      Tsai L.-H., Delalle I., Caviness V.S. Jr., Chae T., Harlow E.
      Nature 371:419-423(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. NIEHS SNPs program
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    6. "Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration."
      Patrick G.N., Zukerberg L., Nikolic M., de la Monte S., Dikkes P., Tsai L.H.
      Nature 402:615-622(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF GLY-2, SUBCELLULAR LOCATION, INVOLVEMENT IN NEURODEGENERATIVE DISEASES.
    7. "Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35."
      Kerokoski P., Suuronen T., Salminen A., Soininen H., Pirttilae T.
      Brain Res. Mol. Brain Res. 106:50-56(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY CDK5, UBIQUITINATION.
    8. "p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent extracellular signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons."
      Kesavapany S., Amin N., Zheng Y.-L., Nijhara R., Jaffe H., Sihag R., Gutkind J.S., Takahashi S., Kulkarni A., Grant P., Pant H.C.
      J. Neurosci. 24:4421-4431(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RASGRF2.
    9. "Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation."
      Kamei H., Saito T., Ozawa M., Fujita Y., Asada A., Bibb J.A., Saido T.C., Sorimachi H., Hisanaga S.
      J. Biol. Chem. 282:1687-1694(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-8 AND THR-138, MUTAGENESIS OF SER-8 AND THR-138.
    10. "Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35."
      Sato K., Zhu Y.-S., Saito T., Yotsumoto K., Asada A., Hasegawa M., Hisanaga S.
      J. Neurosci. Res. 85:3071-3078(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY CDK5, INTERACTION WITH CDK5, SUBCELLULAR LOCATION.
    11. "Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes."
      Asada A., Yamamoto N., Gohda M., Saito T., Hayashi N., Hisanaga S.
      J. Neurochem. 106:1325-1336(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MYRISTOYLATION, MUTAGENESIS OF GLY-2.
    12. "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."
      Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E., Tsunasawa S., Utsumi T.
      Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: MYRISTOYLATION AT GLY-2.
    13. "Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation."
      Kwak Y., Jeong J., Lee S., Park Y.U., Lee S.A., Han D.H., Kim J.H., Ohshima T., Mikoshiba K., Suh Y.H., Cho S., Park S.K.
      J. Biol. Chem. 288:36878-36889(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CLOCK.
    14. "Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation."
      Ahn J.S., Radhakrishnan M.L., Mapelli M., Choi S., Tidor B., Cuny G.D., Musacchio A., Yeh L.A., Kosik K.S.
      Chem. Biol. 12:811-823(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 145-293 IN COMPLEX WITH CDK5.
    15. Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 100-307 IN COMPLEX WITH CDK5 AND INHIBITORS.

    Entry informationi

    Entry nameiCD5R1_HUMAN
    AccessioniPrimary (citable) accession number: Q15078
    Secondary accession number(s): E1P664, Q5U0G3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 152 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Cleavage of p35 to p25 may be involved in the pathogenesis of cytoskeletal abnormalities and neuronal death in neurodegenerative diseases. The p25 form accumulates in neurons in the brain of patients with Alzheimer disease, but not in normal brain. This accumulation correlates with an increase in CDK5 kinase activity. Application of amyloid beta peptide A-beta(1-42) induced the conversion of p35 to p25 in primary cortical neurons. Expression of the p25/Cdk5 complex in cultured primary neurons induces cytoskeletal disruption, morphological degeneration and apoptosis.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3