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Q15077 (P2RY6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P2Y purinoceptor 6

Short name=P2Y6
Gene names
Name:P2RY6
ORF Names:PP2891
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328P2Y purinoceptor 6
PRO_0000070028

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 4821Helical; Name=1; Potential
Topological domain49 – 6214Cytoplasmic Potential
Transmembrane63 – 8321Helical; Name=2; Potential
Topological domain84 – 10118Extracellular Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 14422Cytoplasmic Potential
Transmembrane145 – 16521Helical; Name=4; Potential
Topological domain166 – 19429Extracellular Potential
Transmembrane195 – 21521Helical; Name=5; Potential
Topological domain216 – 23621Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 28023Extracellular Potential
Transmembrane281 – 30323Helical; Name=7; Potential
Topological domain304 – 32825Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 177 By similarity

Experimental info

Sequence conflict2 – 32Missing Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q15077 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: AAD6C55A43818107

FASTA32836,429
        10         20         30         40         50         60 
MEWDNGTGQA LGLPPTTCVY RENFKQLLLP PVYSAVLAAG LPLNICVITQ ICTSRRALTR 

        70         80         90        100        110        120 
TAVYTLNLAL ADLLYACSLP LLIYNYAQGD HWPFGDFACR LVRFLFYANL HGSILFLTCI 

       130        140        150        160        170        180 
SFQRYLGICH PLAPWHKRGG RRAAWLVCVA VWLAVTTQCL PTAIFAATGI QRNRTVCYDL 

       190        200        210        220        230        240 
SPPALATHYM PYGMALTVIG FLLPFAALLA CYCLLACRLC RQDGPAEPVA QERRGKAARM 

       250        260        270        280        290        300 
AVVVAAAFAI SFLPFHITKT AYLAVRSTPG VPCTVLEAFA AAYKGTRPFA SANSVLDPIL 

       310        320 
FYFTQKKFRR RPHELLQKLT AKWQRQGR 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, functional expression and tissue distribution of the human P2Y6 receptor."
Communi D., Parmentier M., Boeynaems J.-M.
Biochem. Biophys. Res. Commun. 222:303-308(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family."
Somers G.R., Hammet F., Woollatt E., Richards R.I., Southey M.C., Venter D.J.
Genomics 44:127-130(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues."
Maier R., Glatz A., Mosbacher J., Bilbe G.
Biochem. Biophys. Res. Commun. 237:297-302(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[4]Erratum
Maier R., Glatz A., Mosbacher J., Bilbe G.
Biochem. Biophys. Res. Commun. 240:298-302(1997) [PubMed] [Europe PMC] [Abstract]
[5]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X97058 mRNA. Translation: CAA65770.1.
U52464 mRNA. Translation: AAB03572.1.
AF007892 mRNA. Translation: AAB80713.1.
AF007891 mRNA. Translation: AAB80712.1.
AF218005 mRNA. Translation: AAG17247.1.
AF498920 mRNA. Translation: AAM18129.1.
BT006771 mRNA. Translation: AAP35417.1.
BC000571 mRNA. Translation: AAH00571.1.
BC009391 mRNA. Translation: AAH09391.1.
PIRJC4800.
RefSeqNP_001264133.1. NM_001277204.1.
NP_001264134.1. NM_001277205.1.
NP_001264135.1. NM_001277206.1.
NP_001264136.1. NM_001277207.1.
NP_001264137.1. NM_001277208.1.
NP_789766.1. NM_176796.2.
NP_789767.1. NM_176797.2.
NP_789768.1. NM_176798.2.
XP_005274079.1. XM_005274022.1.
XP_005274080.1. XM_005274023.2.
UniGeneHs.16362.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2B6Rmodel-A1-318[»]
ProteinModelPortalQ15077.
SMRQ15077. Positions 27-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111070. 1 interaction.
STRING9606.ENSP00000309771.

Chemistry

BindingDBQ15077.
ChEMBLCHEMBL4714.
GuidetoPHARMACOLOGY326.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM2495018.

Proteomic databases

PaxDbQ15077.
PRIDEQ15077.

Protocols and materials databases

DNASU5031.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000349767; ENSP00000309771; ENSG00000171631.
ENST00000393590; ENSP00000377215; ENSG00000171631.
ENST00000393591; ENSP00000377216; ENSG00000171631.
ENST00000393592; ENSP00000377217; ENSG00000171631.
ENST00000538328; ENSP00000442990; ENSG00000171631.
ENST00000540124; ENSP00000442551; ENSG00000171631.
ENST00000540342; ENSP00000443427; ENSG00000171631.
ENST00000542092; ENSP00000445652; ENSG00000171631.
GeneID5031.
KEGGhsa:5031.
UCSCuc001otm.4. human.

Organism-specific databases

CTD5031.
GeneCardsGC11P072975.
HGNCHGNC:8543. P2RY6.
HPACAB022740.
MIM602451. gene.
neXtProtNX_Q15077.
PharmGKBPA32872.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149481.
HOGENOMHOG000231307.
HOVERGENHBG101120.
InParanoidQ15077.
KOK04272.
OMAFQRYLGI.
OrthoDBEOG7P2XSD.
PhylomeDBQ15077.
TreeFamTF330775.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ15077.
BgeeQ15077.
CleanExHS_P2RY6.
GenevestigatorQ15077.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001973. P2Y6_rcpt.
[Graphical view]
PANTHERPTHR24231:SF16. PTHR24231:SF16. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiP2RY6.
GenomeRNAi5031.
NextBio19378.
PROQ15077.
SOURCESearch...

Entry information

Entry nameP2RY6_HUMAN
AccessionPrimary (citable) accession number: Q15077
Secondary accession number(s): Q15754
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries