P2Y purinoceptor 6 - Homo sapiens (Human)

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Q15077 (P2RY6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 114. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
P2Y purinoceptor 6
Short name=P2Y6

Gene names

Name:	P2RY6
ORF Names:	PP2891

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phospholipase C-activating G-protein coupled receptor signaling pathway Traceable author statement Ref.1. Source: ProtInc positive regulation of smooth muscle cell migration Inferred from electronic annotation. Source: Compara transepithelial chloride transport Inferred from electronic annotation. Source: Compara
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara basolateral plasma membrane Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled purinergic nucleotide receptor activity Inferred from electronic annotation. Source: InterPro G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc UDP-activated nucleotide receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 328

328

P2Y purinoceptor 6

PRO_0000070028

Regions

Topological domain

1 – 27

Extracellular Potential

Transmembrane

28 – 48

Helical; Name=1; Potential

Topological domain

49 – 62

Cytoplasmic Potential

Transmembrane

63 – 83

Helical; Name=2; Potential

Topological domain

84 – 101

Extracellular Potential

Transmembrane

102 – 122

Helical; Name=3; Potential

Topological domain

123 – 144

Cytoplasmic Potential

Transmembrane

145 – 165

Helical; Name=4; Potential

Topological domain

166 – 194

Extracellular Potential

Transmembrane

195 – 215

Helical; Name=5; Potential

Topological domain

216 – 236

Cytoplasmic Potential

Transmembrane

237 – 257

Helical; Name=6; Potential

Topological domain

258 – 280

Extracellular Potential

Transmembrane

281 – 303

Helical; Name=7; Potential

Topological domain

304 – 328

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

99 ↔ 177

By similarity

Experimental info

Sequence conflict

2 – 3

Missing Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q15077 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: AAD6C55A43818107
Show »

FASTA

328

36,429

        10         20         30         40         50         60 
MEWDNGTGQA LGLPPTTCVY RENFKQLLLP PVYSAVLAAG LPLNICVITQ ICTSRRALTR 

        70         80         90        100        110        120 
TAVYTLNLAL ADLLYACSLP LLIYNYAQGD HWPFGDFACR LVRFLFYANL HGSILFLTCI 

       130        140        150        160        170        180 
SFQRYLGICH PLAPWHKRGG RRAAWLVCVA VWLAVTTQCL PTAIFAATGI QRNRTVCYDL 

       190        200        210        220        230        240 
SPPALATHYM PYGMALTVIG FLLPFAALLA CYCLLACRLC RQDGPAEPVA QERRGKAARM 

       250        260        270        280        290        300 
AVVVAAAFAI SFLPFHITKT AYLAVRSTPG VPCTVLEAFA AAYKGTRPFA SANSVLDPIL 

       310        320 
FYFTQKKFRR RPHELLQKLT AKWQRQGR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, functional expression and tissue distribution of the human P2Y6 receptor." Communi D., Parmentier M., Boeynaems J.-M. Biochem. Biophys. Res. Commun. 222:303-308(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family." Somers G.R., Hammet F., Woollatt E., Richards R.I., Southey M.C., Venter D.J. Genomics 44:127-130(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues." Maier R., Glatz A., Mosbacher J., Bilbe G. Biochem. Biophys. Res. Commun. 237:297-302(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[4]	Erratum Maier R., Glatz A., Mosbacher J., Bilbe G. Biochem. Biophys. Res. Commun. 240:298-302(1997) [PubMed] [Europe PMC] [Abstract]
[5]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X97058 mRNA. Translation: CAA65770.1.
U52464 mRNA. Translation: AAB03572.1.
AF007892 mRNA. Translation: AAB80713.1.
AF007891 mRNA. Translation: AAB80712.1.
AF218005 mRNA. Translation: AAG17247.1.
AF498920 mRNA. Translation: AAM18129.1.
BT006771 mRNA. Translation: AAP35417.1.
BC000571 mRNA. Translation: AAH00571.1.
BC009391 mRNA. Translation: AAH09391.1.

IPI

IPI00014315.

PIR

JC4800.

RefSeq

NP_004145.1. NM_004154.3.
NP_789766.1. NM_176796.1.
NP_789767.1. NM_176797.1.
NP_789768.1. NM_176798.1.

UniGene

Hs.16362.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2B6R	model	-	A	1-318	[»]

ProteinModelPortal

Q15077.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000309771.

Protein family/group databases

GPCRDB

Search...

Polymorphism databases

DMDM

2495018.

Proteomic databases

PaxDb

Q15077.

PRIDE

Q15077.

Protocols and materials databases

DNASU

5031.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000349767; ENSP00000309771; ENSG00000171631.
ENST00000393590; ENSP00000377215; ENSG00000171631.
ENST00000393591; ENSP00000377216; ENSG00000171631.
ENST00000393592; ENSP00000377217; ENSG00000171631.
ENST00000538328; ENSP00000442990; ENSG00000171631.
ENST00000540124; ENSP00000442551; ENSG00000171631.
ENST00000540342; ENSP00000443427; ENSG00000171631.
ENST00000542092; ENSP00000445652; ENSG00000171631.

GeneID

5031.

KEGG

hsa:5031.

UCSC

uc001otm.3. human.

Organism-specific databases

CTD

5031.

GeneCards

GC11P072975.

HGNC

HGNC:8543. P2RY6.

HPA

CAB022740.

MIM

602451. gene.

neXtProt

NX_Q15077.

PharmGKB

PA32872.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG149481.

HOGENOM

HOG000231307.

HOVERGEN

HBG101120.

InParanoid

Q15077.

K04272.

OMA

PYGMALT.

OrthoDB

EOG4QVCCG.

PhylomeDB

Q15077.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

Q15077.

Bgee

Q15077.

CleanEx

HS_P2RY6.

Genevestigator

Q15077.

GermOnline

ENSG00000171631. Homo sapiens.

Family and domain databases

InterPro

IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002286. P2_purnocptor.
IPR001973. P2Y6_purnocptor.
[Graphical view]

Pfam

PF00001. 7tm_1. 1 hit.
[Graphical view]

PRINTS

PR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PR01157. P2YPURNOCPTR.

PROSITE

PS00237. G_PROTEIN_RECEP_F1_1. False negative.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q15077.

ChEMBL

CHEMBL4714.

GenomeRNAi

5031.

NextBio

19378.

SOURCE

Search...

Entry information

Entry name

P2RY6_HUMAN

Accession

Primary (citable) accession number: Q15077
Secondary accession number(s): Q15754

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents