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Protein

P2Y purinoceptor 6

Gene

P2RY6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171631-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 6
Short name:
P2Y6
Gene namesi
Name:P2RY6
ORF Names:PP2891
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8543. P2RY6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 62CytoplasmicSequence analysisAdd BLAST14
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini84 – 101ExtracellularSequence analysisAdd BLAST18
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 144CytoplasmicSequence analysisAdd BLAST22
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 194ExtracellularSequence analysisAdd BLAST29
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 236CytoplasmicSequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 280ExtracellularSequence analysisAdd BLAST23
Transmembranei281 – 303Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini304 – 328CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5031.
OpenTargetsiENSG00000171631.
PharmGKBiPA32872.

Chemistry databases

ChEMBLiCHEMBL4714.
GuidetoPHARMACOLOGYi326.

Polymorphism and mutation databases

DMDMi2495018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700281 – 328P2Y purinoceptor 6Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ15077.
PaxDbiQ15077.
PRIDEiQ15077.

PTM databases

iPTMnetiQ15077.
PhosphoSitePlusiQ15077.

Expressioni

Gene expression databases

BgeeiENSG00000171631.
CleanExiHS_P2RY6.
ExpressionAtlasiQ15077. baseline and differential.
GenevisibleiQ15077. HS.

Organism-specific databases

HPAiCAB022740.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10235794,EBI-10172290
PLSCR1O151623EBI-10235794,EBI-740019

Protein-protein interaction databases

BioGridi111070. 3 interactors.
IntActiQ15077. 9 interactors.
STRINGi9606.ENSP00000309771.

Chemistry databases

BindingDBiQ15077.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B6Rmodel-A1-318[»]
ProteinModelPortaliQ15077.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJR4. Eukaryota.
ENOG410YAZW. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiQ15077.
KOiK04272.
OMAiRPFASAN.
OrthoDBiEOG091G0DD3.
PhylomeDBiQ15077.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001973. P2Y6_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF16. PTHR24231:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWDNGTGQA LGLPPTTCVY RENFKQLLLP PVYSAVLAAG LPLNICVITQ
60 70 80 90 100
ICTSRRALTR TAVYTLNLAL ADLLYACSLP LLIYNYAQGD HWPFGDFACR
110 120 130 140 150
LVRFLFYANL HGSILFLTCI SFQRYLGICH PLAPWHKRGG RRAAWLVCVA
160 170 180 190 200
VWLAVTTQCL PTAIFAATGI QRNRTVCYDL SPPALATHYM PYGMALTVIG
210 220 230 240 250
FLLPFAALLA CYCLLACRLC RQDGPAEPVA QERRGKAARM AVVVAAAFAI
260 270 280 290 300
SFLPFHITKT AYLAVRSTPG VPCTVLEAFA AAYKGTRPFA SANSVLDPIL
310 320
FYFTQKKFRR RPHELLQKLT AKWQRQGR
Length:328
Mass (Da):36,429
Last modified:November 1, 1996 - v1
Checksum:iAAD6C55A43818107
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3Missing (PubMed:9286708).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97058 mRNA. Translation: CAA65770.1.
U52464 mRNA. Translation: AAB03572.1.
AF007892 mRNA. Translation: AAB80713.1.
AF007891 mRNA. Translation: AAB80712.1.
AF218005 mRNA. Translation: AAG17247.1.
AF498920 mRNA. Translation: AAM18129.1.
BT006771 mRNA. Translation: AAP35417.1.
BC000571 mRNA. Translation: AAH00571.1.
BC009391 mRNA. Translation: AAH09391.1.
CCDSiCCDS8220.1.
PIRiJC4800.
RefSeqiNP_001264133.1. NM_001277204.1.
NP_001264134.1. NM_001277205.1.
NP_001264135.1. NM_001277206.1.
NP_001264136.1. NM_001277207.1.
NP_001264137.1. NM_001277208.1.
NP_789766.1. NM_176796.2.
NP_789767.1. NM_176797.2.
NP_789768.1. NM_176798.2.
XP_005274079.1. XM_005274022.3.
XP_006718634.1. XM_006718571.3.
XP_011543379.1. XM_011545077.2.
XP_011543381.1. XM_011545079.2.
UniGeneiHs.16362.

Genome annotation databases

EnsembliENST00000349767; ENSP00000309771; ENSG00000171631.
ENST00000393590; ENSP00000377215; ENSG00000171631.
ENST00000393591; ENSP00000377216; ENSG00000171631.
ENST00000393592; ENSP00000377217; ENSG00000171631.
ENST00000538328; ENSP00000442990; ENSG00000171631.
ENST00000540124; ENSP00000442551; ENSG00000171631.
ENST00000540342; ENSP00000443427; ENSG00000171631.
ENST00000542092; ENSP00000445652; ENSG00000171631.
ENST00000618468; ENSP00000480966; ENSG00000171631.
GeneIDi5031.
KEGGihsa:5031.
UCSCiuc001otm.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97058 mRNA. Translation: CAA65770.1.
U52464 mRNA. Translation: AAB03572.1.
AF007892 mRNA. Translation: AAB80713.1.
AF007891 mRNA. Translation: AAB80712.1.
AF218005 mRNA. Translation: AAG17247.1.
AF498920 mRNA. Translation: AAM18129.1.
BT006771 mRNA. Translation: AAP35417.1.
BC000571 mRNA. Translation: AAH00571.1.
BC009391 mRNA. Translation: AAH09391.1.
CCDSiCCDS8220.1.
PIRiJC4800.
RefSeqiNP_001264133.1. NM_001277204.1.
NP_001264134.1. NM_001277205.1.
NP_001264135.1. NM_001277206.1.
NP_001264136.1. NM_001277207.1.
NP_001264137.1. NM_001277208.1.
NP_789766.1. NM_176796.2.
NP_789767.1. NM_176797.2.
NP_789768.1. NM_176798.2.
XP_005274079.1. XM_005274022.3.
XP_006718634.1. XM_006718571.3.
XP_011543379.1. XM_011545077.2.
XP_011543381.1. XM_011545079.2.
UniGeneiHs.16362.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B6Rmodel-A1-318[»]
ProteinModelPortaliQ15077.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111070. 3 interactors.
IntActiQ15077. 9 interactors.
STRINGi9606.ENSP00000309771.

Chemistry databases

BindingDBiQ15077.
ChEMBLiCHEMBL4714.
GuidetoPHARMACOLOGYi326.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ15077.
PhosphoSitePlusiQ15077.

Polymorphism and mutation databases

DMDMi2495018.

Proteomic databases

MaxQBiQ15077.
PaxDbiQ15077.
PRIDEiQ15077.

Protocols and materials databases

DNASUi5031.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349767; ENSP00000309771; ENSG00000171631.
ENST00000393590; ENSP00000377215; ENSG00000171631.
ENST00000393591; ENSP00000377216; ENSG00000171631.
ENST00000393592; ENSP00000377217; ENSG00000171631.
ENST00000538328; ENSP00000442990; ENSG00000171631.
ENST00000540124; ENSP00000442551; ENSG00000171631.
ENST00000540342; ENSP00000443427; ENSG00000171631.
ENST00000542092; ENSP00000445652; ENSG00000171631.
ENST00000618468; ENSP00000480966; ENSG00000171631.
GeneIDi5031.
KEGGihsa:5031.
UCSCiuc001otm.5. human.

Organism-specific databases

CTDi5031.
DisGeNETi5031.
GeneCardsiP2RY6.
HGNCiHGNC:8543. P2RY6.
HPAiCAB022740.
MIMi602451. gene.
neXtProtiNX_Q15077.
OpenTargetsiENSG00000171631.
PharmGKBiPA32872.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJR4. Eukaryota.
ENOG410YAZW. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiQ15077.
KOiK04272.
OMAiRPFASAN.
OrthoDBiEOG091G0DD3.
PhylomeDBiQ15077.
TreeFamiTF330775.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171631-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.

Miscellaneous databases

GeneWikiiP2RY6.
GenomeRNAii5031.
PROiQ15077.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171631.
CleanExiHS_P2RY6.
ExpressionAtlasiQ15077. baseline and differential.
GenevisibleiQ15077. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001973. P2Y6_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF16. PTHR24231:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2RY6_HUMAN
AccessioniPrimary (citable) accession number: Q15077
Secondary accession number(s): Q15754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.