Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q15077

- P2RY6_HUMAN

UniProt

Q15077 - P2RY6_HUMAN

Protein

P2Y purinoceptor 6

Gene

P2RY6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
    2. G-protein coupled receptor activity Source: ProtInc
    3. UDP-activated nucleotide receptor activity Source: Ensembl

    GO - Biological processi

    1. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
    2. positive regulation of smooth muscle cell migration Source: Ensembl
    3. transepithelial chloride transport Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18289. P2Y receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2Y purinoceptor 6
    Short name:
    P2Y6
    Gene namesi
    Name:P2RY6
    ORF Names:PP2891
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8543. P2RY6.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32872.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328P2Y purinoceptor 6PRO_0000070028Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 177PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ15077.
    PaxDbiQ15077.
    PRIDEiQ15077.

    Expressioni

    Gene expression databases

    ArrayExpressiQ15077.
    BgeeiQ15077.
    CleanExiHS_P2RY6.
    GenevestigatoriQ15077.

    Organism-specific databases

    HPAiCAB022740.

    Interactioni

    Protein-protein interaction databases

    BioGridi111070. 1 interaction.
    STRINGi9606.ENSP00000309771.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2B6Rmodel-A1-318[»]
    ProteinModelPortaliQ15077.
    SMRiQ15077. Positions 27-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 6214CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini84 – 10118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 14422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 19429ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 23621CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 28023ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini304 – 32825CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30323Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149481.
    HOGENOMiHOG000231307.
    HOVERGENiHBG101120.
    InParanoidiQ15077.
    KOiK04272.
    OMAiFQRYLGI.
    OrthoDBiEOG7P2XSD.
    PhylomeDBiQ15077.
    TreeFamiTF330775.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001973. P2Y6_rcpt.
    [Graphical view]
    PANTHERiPTHR24231:SF16. PTHR24231:SF16. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01068. P2Y6PRNOCPTR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15077-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEWDNGTGQA LGLPPTTCVY RENFKQLLLP PVYSAVLAAG LPLNICVITQ    50
    ICTSRRALTR TAVYTLNLAL ADLLYACSLP LLIYNYAQGD HWPFGDFACR 100
    LVRFLFYANL HGSILFLTCI SFQRYLGICH PLAPWHKRGG RRAAWLVCVA 150
    VWLAVTTQCL PTAIFAATGI QRNRTVCYDL SPPALATHYM PYGMALTVIG 200
    FLLPFAALLA CYCLLACRLC RQDGPAEPVA QERRGKAARM AVVVAAAFAI 250
    SFLPFHITKT AYLAVRSTPG VPCTVLEAFA AAYKGTRPFA SANSVLDPIL 300
    FYFTQKKFRR RPHELLQKLT AKWQRQGR 328
    Length:328
    Mass (Da):36,429
    Last modified:November 1, 1996 - v1
    Checksum:iAAD6C55A43818107
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 32Missing(PubMed:9286708)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97058 mRNA. Translation: CAA65770.1.
    U52464 mRNA. Translation: AAB03572.1.
    AF007892 mRNA. Translation: AAB80713.1.
    AF007891 mRNA. Translation: AAB80712.1.
    AF218005 mRNA. Translation: AAG17247.1.
    AF498920 mRNA. Translation: AAM18129.1.
    BT006771 mRNA. Translation: AAP35417.1.
    BC000571 mRNA. Translation: AAH00571.1.
    BC009391 mRNA. Translation: AAH09391.1.
    CCDSiCCDS8220.1.
    PIRiJC4800.
    RefSeqiNP_001264133.1. NM_001277204.1.
    NP_001264134.1. NM_001277205.1.
    NP_001264135.1. NM_001277206.1.
    NP_001264136.1. NM_001277207.1.
    NP_001264137.1. NM_001277208.1.
    NP_789766.1. NM_176796.2.
    NP_789767.1. NM_176797.2.
    NP_789768.1. NM_176798.2.
    XP_005274079.1. XM_005274022.1.
    XP_005274080.1. XM_005274023.2.
    XP_006718634.1. XM_006718571.1.
    UniGeneiHs.16362.

    Genome annotation databases

    EnsembliENST00000349767; ENSP00000309771; ENSG00000171631.
    ENST00000393590; ENSP00000377215; ENSG00000171631.
    ENST00000393591; ENSP00000377216; ENSG00000171631.
    ENST00000393592; ENSP00000377217; ENSG00000171631.
    ENST00000538328; ENSP00000442990; ENSG00000171631.
    ENST00000540124; ENSP00000442551; ENSG00000171631.
    ENST00000540342; ENSP00000443427; ENSG00000171631.
    ENST00000542092; ENSP00000445652; ENSG00000171631.
    GeneIDi5031.
    KEGGihsa:5031.
    UCSCiuc001otm.4. human.

    Polymorphism databases

    DMDMi2495018.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97058 mRNA. Translation: CAA65770.1 .
    U52464 mRNA. Translation: AAB03572.1 .
    AF007892 mRNA. Translation: AAB80713.1 .
    AF007891 mRNA. Translation: AAB80712.1 .
    AF218005 mRNA. Translation: AAG17247.1 .
    AF498920 mRNA. Translation: AAM18129.1 .
    BT006771 mRNA. Translation: AAP35417.1 .
    BC000571 mRNA. Translation: AAH00571.1 .
    BC009391 mRNA. Translation: AAH09391.1 .
    CCDSi CCDS8220.1.
    PIRi JC4800.
    RefSeqi NP_001264133.1. NM_001277204.1.
    NP_001264134.1. NM_001277205.1.
    NP_001264135.1. NM_001277206.1.
    NP_001264136.1. NM_001277207.1.
    NP_001264137.1. NM_001277208.1.
    NP_789766.1. NM_176796.2.
    NP_789767.1. NM_176797.2.
    NP_789768.1. NM_176798.2.
    XP_005274079.1. XM_005274022.1.
    XP_005274080.1. XM_005274023.2.
    XP_006718634.1. XM_006718571.1.
    UniGenei Hs.16362.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2B6R model - A 1-318 [» ]
    ProteinModelPortali Q15077.
    SMRi Q15077. Positions 27-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111070. 1 interaction.
    STRINGi 9606.ENSP00000309771.

    Chemistry

    BindingDBi Q15077.
    ChEMBLi CHEMBL4714.
    GuidetoPHARMACOLOGYi 326.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 2495018.

    Proteomic databases

    MaxQBi Q15077.
    PaxDbi Q15077.
    PRIDEi Q15077.

    Protocols and materials databases

    DNASUi 5031.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000349767 ; ENSP00000309771 ; ENSG00000171631 .
    ENST00000393590 ; ENSP00000377215 ; ENSG00000171631 .
    ENST00000393591 ; ENSP00000377216 ; ENSG00000171631 .
    ENST00000393592 ; ENSP00000377217 ; ENSG00000171631 .
    ENST00000538328 ; ENSP00000442990 ; ENSG00000171631 .
    ENST00000540124 ; ENSP00000442551 ; ENSG00000171631 .
    ENST00000540342 ; ENSP00000443427 ; ENSG00000171631 .
    ENST00000542092 ; ENSP00000445652 ; ENSG00000171631 .
    GeneIDi 5031.
    KEGGi hsa:5031.
    UCSCi uc001otm.4. human.

    Organism-specific databases

    CTDi 5031.
    GeneCardsi GC11P072975.
    HGNCi HGNC:8543. P2RY6.
    HPAi CAB022740.
    MIMi 602451. gene.
    neXtProti NX_Q15077.
    PharmGKBi PA32872.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149481.
    HOGENOMi HOG000231307.
    HOVERGENi HBG101120.
    InParanoidi Q15077.
    KOi K04272.
    OMAi FQRYLGI.
    OrthoDBi EOG7P2XSD.
    PhylomeDBi Q15077.
    TreeFami TF330775.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18289. P2Y receptors.

    Miscellaneous databases

    GeneWikii P2RY6.
    GenomeRNAii 5031.
    NextBioi 19378.
    PROi Q15077.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15077.
    Bgeei Q15077.
    CleanExi HS_P2RY6.
    Genevestigatori Q15077.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001973. P2Y6_rcpt.
    [Graphical view ]
    PANTHERi PTHR24231:SF16. PTHR24231:SF16. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01068. P2Y6PRNOCPTR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, functional expression and tissue distribution of the human P2Y6 receptor."
      Communi D., Parmentier M., Boeynaems J.-M.
      Biochem. Biophys. Res. Commun. 222:303-308(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family."
      Somers G.R., Hammet F., Woollatt E., Richards R.I., Southey M.C., Venter D.J.
      Genomics 44:127-130(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues."
      Maier R., Glatz A., Mosbacher J., Bilbe G.
      Biochem. Biophys. Res. Commun. 237:297-302(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    4. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiP2RY6_HUMAN
    AccessioniPrimary (citable) accession number: Q15077
    Secondary accession number(s): Q15754
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3