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Protein

P2Y purinoceptor 6

Gene

P2RY6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 6
Short name:
P2Y6
Gene namesi
Name:P2RY6
ORF Names:PP2891
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000171631.14.
HGNCiHGNC:8543. P2RY6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 62CytoplasmicSequence analysisAdd BLAST14
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini84 – 101ExtracellularSequence analysisAdd BLAST18
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 144CytoplasmicSequence analysisAdd BLAST22
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 194ExtracellularSequence analysisAdd BLAST29
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 236CytoplasmicSequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 280ExtracellularSequence analysisAdd BLAST23
Transmembranei281 – 303Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini304 – 328CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5031.
OpenTargetsiENSG00000171631.
PharmGKBiPA32872.

Chemistry databases

ChEMBLiCHEMBL4714.
GuidetoPHARMACOLOGYi326.

Polymorphism and mutation databases

DMDMi2495018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700281 – 328P2Y purinoceptor 6Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ15077.
MaxQBiQ15077.
PaxDbiQ15077.
PeptideAtlasiQ15077.
PRIDEiQ15077.

PTM databases

iPTMnetiQ15077.
PhosphoSitePlusiQ15077.

Expressioni

Gene expression databases

BgeeiENSG00000171631.
CleanExiHS_P2RY6.
ExpressionAtlasiQ15077. baseline and differential.
GenevisibleiQ15077. HS.

Organism-specific databases

HPAiCAB022740.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111070. 3 interactors.
IntActiQ15077. 12 interactors.
STRINGi9606.ENSP00000309771.

Chemistry databases

BindingDBiQ15077.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B6Rmodel-A1-318[»]
ProteinModelPortaliQ15077.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJR4. Eukaryota.
ENOG410YAZW. LUCA.
GeneTreeiENSGT00900000140782.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiQ15077.
KOiK04272.
OMAiILFYFTQ.
OrthoDBiEOG091G0DD3.
PhylomeDBiQ15077.
TreeFamiTF330775.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001973. P2Y6_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWDNGTGQA LGLPPTTCVY RENFKQLLLP PVYSAVLAAG LPLNICVITQ
60 70 80 90 100
ICTSRRALTR TAVYTLNLAL ADLLYACSLP LLIYNYAQGD HWPFGDFACR
110 120 130 140 150
LVRFLFYANL HGSILFLTCI SFQRYLGICH PLAPWHKRGG RRAAWLVCVA
160 170 180 190 200
VWLAVTTQCL PTAIFAATGI QRNRTVCYDL SPPALATHYM PYGMALTVIG
210 220 230 240 250
FLLPFAALLA CYCLLACRLC RQDGPAEPVA QERRGKAARM AVVVAAAFAI
260 270 280 290 300
SFLPFHITKT AYLAVRSTPG VPCTVLEAFA AAYKGTRPFA SANSVLDPIL
310 320
FYFTQKKFRR RPHELLQKLT AKWQRQGR
Length:328
Mass (Da):36,429
Last modified:November 1, 1996 - v1
Checksum:iAAD6C55A43818107
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3Missing (PubMed:9286708).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97058 mRNA. Translation: CAA65770.1.
U52464 mRNA. Translation: AAB03572.1.
AF007892 mRNA. Translation: AAB80713.1.
AF007891 mRNA. Translation: AAB80712.1.
AF218005 mRNA. Translation: AAG17247.1.
AF498920 mRNA. Translation: AAM18129.1.
BT006771 mRNA. Translation: AAP35417.1.
BC000571 mRNA. Translation: AAH00571.1.
BC009391 mRNA. Translation: AAH09391.1.
CCDSiCCDS8220.1.
PIRiJC4800.
RefSeqiNP_001264133.1. NM_001277204.1.
NP_001264134.1. NM_001277205.1.
NP_001264135.1. NM_001277206.1.
NP_001264136.1. NM_001277207.1.
NP_001264137.1. NM_001277208.1.
NP_789766.1. NM_176796.2.
NP_789767.1. NM_176797.2.
NP_789768.1. NM_176798.2.
XP_005274079.1. XM_005274022.3.
XP_006718634.1. XM_006718571.3.
XP_011543379.1. XM_011545077.2.
XP_011543381.1. XM_011545079.2.
UniGeneiHs.16362.

Genome annotation databases

EnsembliENST00000349767; ENSP00000309771; ENSG00000171631.
ENST00000393590; ENSP00000377215; ENSG00000171631.
ENST00000393591; ENSP00000377216; ENSG00000171631.
ENST00000393592; ENSP00000377217; ENSG00000171631.
ENST00000538328; ENSP00000442990; ENSG00000171631.
ENST00000540124; ENSP00000442551; ENSG00000171631.
ENST00000540342; ENSP00000443427; ENSG00000171631.
ENST00000542092; ENSP00000445652; ENSG00000171631.
ENST00000618468; ENSP00000480966; ENSG00000171631.
GeneIDi5031.
KEGGihsa:5031.
UCSCiuc001otm.5. human.

Similar proteinsi

Entry informationi

Entry nameiP2RY6_HUMAN
AccessioniPrimary (citable) accession number: Q15077
Secondary accession number(s): Q15754
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families