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Protein

P2Y purinoceptor 6

Gene

P2RY6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 6
Short name:
P2Y6
Gene namesi
Name:P2RY6
ORF Names:PP2891
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8543. P2RY6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 6214CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei63 – 8321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini84 – 10118ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini123 – 14422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini166 – 19429ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini216 – 23621CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 28023ExtracellularSequence AnalysisAdd
BLAST
Transmembranei281 – 30323Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini304 – 32825CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32872.

Polymorphism and mutation databases

DMDMi2495018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328P2Y purinoceptor 6PRO_0000070028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ15077.
PaxDbiQ15077.
PRIDEiQ15077.

Expressioni

Gene expression databases

BgeeiQ15077.
CleanExiHS_P2RY6.
ExpressionAtlasiQ15077. baseline and differential.
GenevestigatoriQ15077.

Organism-specific databases

HPAiCAB022740.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10235794,EBI-10172290
PLSCR1O151623EBI-10235794,EBI-740019

Protein-protein interaction databases

BioGridi111070. 4 interactions.
IntActiQ15077. 2 interactions.
STRINGi9606.ENSP00000309771.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B6Rmodel-A1-318[»]
ProteinModelPortaliQ15077.
SMRiQ15077. Positions 27-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149481.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiQ15077.
KOiK04272.
OMAiFQRYLGI.
OrthoDBiEOG7P2XSD.
PhylomeDBiQ15077.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001973. P2Y6_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF16. PTHR24231:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWDNGTGQA LGLPPTTCVY RENFKQLLLP PVYSAVLAAG LPLNICVITQ
60 70 80 90 100
ICTSRRALTR TAVYTLNLAL ADLLYACSLP LLIYNYAQGD HWPFGDFACR
110 120 130 140 150
LVRFLFYANL HGSILFLTCI SFQRYLGICH PLAPWHKRGG RRAAWLVCVA
160 170 180 190 200
VWLAVTTQCL PTAIFAATGI QRNRTVCYDL SPPALATHYM PYGMALTVIG
210 220 230 240 250
FLLPFAALLA CYCLLACRLC RQDGPAEPVA QERRGKAARM AVVVAAAFAI
260 270 280 290 300
SFLPFHITKT AYLAVRSTPG VPCTVLEAFA AAYKGTRPFA SANSVLDPIL
310 320
FYFTQKKFRR RPHELLQKLT AKWQRQGR
Length:328
Mass (Da):36,429
Last modified:November 1, 1996 - v1
Checksum:iAAD6C55A43818107
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 32Missing (PubMed:9286708).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97058 mRNA. Translation: CAA65770.1.
U52464 mRNA. Translation: AAB03572.1.
AF007892 mRNA. Translation: AAB80713.1.
AF007891 mRNA. Translation: AAB80712.1.
AF218005 mRNA. Translation: AAG17247.1.
AF498920 mRNA. Translation: AAM18129.1.
BT006771 mRNA. Translation: AAP35417.1.
BC000571 mRNA. Translation: AAH00571.1.
BC009391 mRNA. Translation: AAH09391.1.
CCDSiCCDS8220.1.
PIRiJC4800.
RefSeqiNP_001264133.1. NM_001277204.1.
NP_001264134.1. NM_001277205.1.
NP_001264135.1. NM_001277206.1.
NP_001264136.1. NM_001277207.1.
NP_001264137.1. NM_001277208.1.
NP_789766.1. NM_176796.2.
NP_789767.1. NM_176797.2.
NP_789768.1. NM_176798.2.
XP_005274079.1. XM_005274022.2.
XP_006718634.1. XM_006718571.2.
UniGeneiHs.16362.

Genome annotation databases

EnsembliENST00000349767; ENSP00000309771; ENSG00000171631.
ENST00000393590; ENSP00000377215; ENSG00000171631.
ENST00000393591; ENSP00000377216; ENSG00000171631.
ENST00000393592; ENSP00000377217; ENSG00000171631.
ENST00000538328; ENSP00000442990; ENSG00000171631.
ENST00000540124; ENSP00000442551; ENSG00000171631.
ENST00000540342; ENSP00000443427; ENSG00000171631.
ENST00000542092; ENSP00000445652; ENSG00000171631.
ENST00000618468; ENSP00000480966; ENSG00000171631.
GeneIDi5031.
KEGGihsa:5031.
UCSCiuc001otm.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97058 mRNA. Translation: CAA65770.1.
U52464 mRNA. Translation: AAB03572.1.
AF007892 mRNA. Translation: AAB80713.1.
AF007891 mRNA. Translation: AAB80712.1.
AF218005 mRNA. Translation: AAG17247.1.
AF498920 mRNA. Translation: AAM18129.1.
BT006771 mRNA. Translation: AAP35417.1.
BC000571 mRNA. Translation: AAH00571.1.
BC009391 mRNA. Translation: AAH09391.1.
CCDSiCCDS8220.1.
PIRiJC4800.
RefSeqiNP_001264133.1. NM_001277204.1.
NP_001264134.1. NM_001277205.1.
NP_001264135.1. NM_001277206.1.
NP_001264136.1. NM_001277207.1.
NP_001264137.1. NM_001277208.1.
NP_789766.1. NM_176796.2.
NP_789767.1. NM_176797.2.
NP_789768.1. NM_176798.2.
XP_005274079.1. XM_005274022.2.
XP_006718634.1. XM_006718571.2.
UniGeneiHs.16362.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B6Rmodel-A1-318[»]
ProteinModelPortaliQ15077.
SMRiQ15077. Positions 27-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111070. 4 interactions.
IntActiQ15077. 2 interactions.
STRINGi9606.ENSP00000309771.

Chemistry

BindingDBiQ15077.
ChEMBLiCHEMBL4714.
GuidetoPHARMACOLOGYi326.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi2495018.

Proteomic databases

MaxQBiQ15077.
PaxDbiQ15077.
PRIDEiQ15077.

Protocols and materials databases

DNASUi5031.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349767; ENSP00000309771; ENSG00000171631.
ENST00000393590; ENSP00000377215; ENSG00000171631.
ENST00000393591; ENSP00000377216; ENSG00000171631.
ENST00000393592; ENSP00000377217; ENSG00000171631.
ENST00000538328; ENSP00000442990; ENSG00000171631.
ENST00000540124; ENSP00000442551; ENSG00000171631.
ENST00000540342; ENSP00000443427; ENSG00000171631.
ENST00000542092; ENSP00000445652; ENSG00000171631.
ENST00000618468; ENSP00000480966; ENSG00000171631.
GeneIDi5031.
KEGGihsa:5031.
UCSCiuc001otm.4. human.

Organism-specific databases

CTDi5031.
GeneCardsiGC11P072975.
HGNCiHGNC:8543. P2RY6.
HPAiCAB022740.
MIMi602451. gene.
neXtProtiNX_Q15077.
PharmGKBiPA32872.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG149481.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiQ15077.
KOiK04272.
OMAiFQRYLGI.
OrthoDBiEOG7P2XSD.
PhylomeDBiQ15077.
TreeFamiTF330775.

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.

Miscellaneous databases

GeneWikiiP2RY6.
GenomeRNAii5031.
NextBioi19378.
PROiQ15077.
SOURCEiSearch...

Gene expression databases

BgeeiQ15077.
CleanExiHS_P2RY6.
ExpressionAtlasiQ15077. baseline and differential.
GenevestigatoriQ15077.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001973. P2Y6_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF16. PTHR24231:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01068. P2Y6PRNOCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, functional expression and tissue distribution of the human P2Y6 receptor."
    Communi D., Parmentier M., Boeynaems J.-M.
    Biochem. Biophys. Res. Commun. 222:303-308(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family."
    Somers G.R., Hammet F., Woollatt E., Richards R.I., Southey M.C., Venter D.J.
    Genomics 44:127-130(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues."
    Maier R., Glatz A., Mosbacher J., Bilbe G.
    Biochem. Biophys. Res. Commun. 237:297-302(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  4. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiP2RY6_HUMAN
AccessioniPrimary (citable) accession number: Q15077
Secondary accession number(s): Q15754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 27, 2015
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.