Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein OZF

Gene

ZNF146

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 3823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri44 – 6623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri72 – 9423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri100 – 12223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri128 – 15023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri156 – 17823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • heparin binding Source: ProtInc
  • sequence-specific DNA binding transcription factor activity Source: GO_Central
  • zinc ion binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein OZF
Alternative name(s):
Only zinc finger protein
Zinc finger protein 146
Gene namesi
Name:ZNF146
Synonyms:OZF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12931. ZNF146.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleolus Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi157 – 1571K → R: Induces a decrease in sumoylation. Induces a strong decrease but does not abolishes sumoylation; when associated with R-169. 1 Publication
Mutagenesisi169 – 1691K → R: Induces a decrease in sumoylation. Induces a strong decrease but does not abolishes sumoylation; when associated with R-157. 1 Publication

Organism-specific databases

PharmGKBiPA37518.

Polymorphism and mutation databases

BioMutaiZNF146.
DMDMi134048495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Zinc finger protein OZFPRO_0000047276Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki157 – 157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki169 – 169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ15072.
PaxDbiQ15072.
PRIDEiQ15072.

PTM databases

PhosphoSiteiQ15072.

Expressioni

Tissue specificityi

Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers.2 Publications

Gene expression databases

BgeeiQ15072.
CleanExiHS_ZNF146.
GenevestigatoriQ15072.

Organism-specific databases

HPAiHPA003358.

Interactioni

Subunit structurei

Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP.2 Publications

Protein-protein interaction databases

BioGridi113499. 8 interactions.
STRINGi9606.ENSP00000301233.

Structurei

3D structure databases

ProteinModelPortaliQ15072.
SMRiQ15072. Positions 41-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni212 – 29281Interaction with TERF2IPAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 3823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri44 – 6623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri72 – 9423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri100 – 12223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri128 – 15023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri156 – 17823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00790000123112.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ15072.
OMAiTEEAANQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ15072.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLSQQRIY SGENPFACKV CGKVFSHKSN LTEHEHFHTR EKPFECNECG
60 70 80 90 100
KAFSQKQYVI KHQNTHTGEK LFECNECGKS FSQKENLLTH QKIHTGEKPF
110 120 130 140 150
ECKDCGKAFI QKSNLIRHQR THTGEKPFVC KECGKTFSGK SNLTEHEKIH
160 170 180 190 200
IGEKPFKCSE CGTAFGQKKY LIKHQNIHTG EKPYECNECG KAFSQRTSLI
210 220 230 240 250
VHVRIHSGDK PYECNVCGKA FSQSSSLTVH VRSHTGEKPY GCNECGKAFS
260 270 280 290
QFSTLALHLR IHTGKKPYQC SECGKAFSQK SHHIRHQKIH TH
Length:292
Mass (Da):33,308
Last modified:March 6, 2007 - v2
Checksum:iD5062375D261B971
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81R → K.3 Publications
Corresponds to variant rs2070132 [ dbSNP | Ensembl ].
VAR_023746

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70394 mRNA. Translation: CAA49844.1.
AJ011806 Genomic DNA. Translation: CAB41967.1.
AC012617 Genomic DNA. No translation available.
BC110500 mRNA. Translation: AAI10501.1.
BC110501 mRNA. Translation: AAI10502.1.
CCDSiCCDS12492.1.
PIRiS43826.
RefSeqiNP_001093108.1. NM_001099638.1.
NP_001093109.1. NM_001099639.1.
NP_009076.2. NM_007145.2.
XP_005259271.1. XM_005259214.1.
UniGeneiHs.643436.

Genome annotation databases

EnsembliENST00000443387; ENSP00000392095; ENSG00000167635.
ENST00000456324; ENSP00000400391; ENSG00000167635.
GeneIDi7705.
KEGGihsa:7705.
UCSCiuc002odq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70394 mRNA. Translation: CAA49844.1.
AJ011806 Genomic DNA. Translation: CAB41967.1.
AC012617 Genomic DNA. No translation available.
BC110500 mRNA. Translation: AAI10501.1.
BC110501 mRNA. Translation: AAI10502.1.
CCDSiCCDS12492.1.
PIRiS43826.
RefSeqiNP_001093108.1. NM_001099638.1.
NP_001093109.1. NM_001099639.1.
NP_009076.2. NM_007145.2.
XP_005259271.1. XM_005259214.1.
UniGeneiHs.643436.

3D structure databases

ProteinModelPortaliQ15072.
SMRiQ15072. Positions 41-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113499. 8 interactions.
STRINGi9606.ENSP00000301233.

PTM databases

PhosphoSiteiQ15072.

Polymorphism and mutation databases

BioMutaiZNF146.
DMDMi134048495.

Proteomic databases

MaxQBiQ15072.
PaxDbiQ15072.
PRIDEiQ15072.

Protocols and materials databases

DNASUi7705.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000443387; ENSP00000392095; ENSG00000167635.
ENST00000456324; ENSP00000400391; ENSG00000167635.
GeneIDi7705.
KEGGihsa:7705.
UCSCiuc002odq.4. human.

Organism-specific databases

CTDi7705.
GeneCardsiGC19P036705.
HGNCiHGNC:12931. ZNF146.
HPAiHPA003358.
MIMi601505. gene.
neXtProtiNX_Q15072.
PharmGKBiPA37518.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00790000123112.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ15072.
OMAiTEEAANQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ15072.
TreeFamiTF337055.

Miscellaneous databases

GeneWikiiZNF146.
GenomeRNAii7705.
NextBioi29868.
PROiQ15072.
SOURCEiSearch...

Gene expression databases

BgeeiQ15072.
CleanExiHS_ZNF146.
GenevestigatoriQ15072.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The OZF gene encodes a protein consisting essentially of zinc finger motifs."
    le Chalony C., Prosperi M.-T., Haluza R., Apiou F., Dutrillaux B., Goubin G.
    J. Mol. Biol. 236:399-404(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT LYS-8.
    Tissue: Mammary gland.
  2. "Genomic organization and promoter identification of ZNF146, a gene encoding a protein consisting solely of zinc finger domains."
    Pibouin L., Villaudy J., Prosperi M.-T., Goubin G.
    Cytogenet. Cell Genet. 92:80-84(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-8.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-8.
  5. "Identification, nuclear localization, and binding activities of OZF, a human protein solely composed of zinc-finger motifs."
    Ferbus D., le Chalony C., Prosperi M.-T., Muleris M., Vincent-Salomon A., Goubin G.
    Eur. J. Biochem. 236:991-995(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas."
    Ferbus D., Flechon A., Muleris M., Li Y., Hanash S., Terris B., Hammel P., Pibouin L., Dutrillaux B., Goubin G.
    Int. J. Cancer 80:369-372(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: OVEREXPRESSION IN PANCREATIC CANCER.
  7. "The zinc finger protein OZF (ZNF146) is overexpressed in colorectal cancer."
    Ferbus D., Bovin C., Validire P., Goubin G.
    J. Pathol. 200:177-182(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: OVEREXPRESSION IN COLORECTAL CANCER.
  8. "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1."
    Antoine K., Ferbus D., Kolahgar G., Prosperi M.-T., Goubin G.
    J. Cell. Biochem. 95:763-768(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TERF2IP.
  9. "A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo."
    Antoine K., Prosperi M.-T., Ferbus D., Boule C., Goubin G.
    Mol. Cell. Biochem. 271:215-223(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBE2I, SUMOYLATION AT LYS-157 AND LYS-169, MUTAGENESIS OF LYS-157 AND LYS-169.

Entry informationi

Entry nameiOZF_HUMAN
AccessioniPrimary (citable) accession number: Q15072
Secondary accession number(s): Q2TB94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 6, 2007
Last modified: May 27, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.