Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q15072 (OZF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein OZF
Alternative name(s):
Only zinc finger protein
Zinc finger protein 146
Gene names
Name:ZNF146
Synonyms:OZF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP. Ref.8 Ref.9

Subcellular location

Nucleus Ref.5.

Tissue specificity

Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers. Ref.1 Ref.5

Post-translational modification

Sumoylated. Ref.9

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 10 C2H2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Zinc finger protein OZF
PRO_0000047276

Regions

Zinc finger16 – 3823C2H2-type 1
Zinc finger44 – 6623C2H2-type 2
Zinc finger72 – 9423C2H2-type 3
Zinc finger100 – 12223C2H2-type 4
Zinc finger128 – 15023C2H2-type 5
Zinc finger156 – 17823C2H2-type 6
Zinc finger184 – 20623C2H2-type 7
Zinc finger212 – 23423C2H2-type 8
Zinc finger240 – 26223C2H2-type 9
Zinc finger268 – 29023C2H2-type 10
Region212 – 29281Interaction with TERF2IP

Amino acid modifications

Cross-link157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Cross-link169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity

Natural variations

Natural variant81R → K. Ref.1 Ref.2 Ref.4
Corresponds to variant rs2070132 [ dbSNP | Ensembl ].
VAR_023746

Experimental info

Mutagenesis1571K → R: Induces a decrease in sumoylation. Induces a strong decrease but does not abolishes sumoylation; when associated with R-169. Ref.9
Mutagenesis1691K → R: Induces a decrease in sumoylation. Induces a strong decrease but does not abolishes sumoylation; when associated with R-157. Ref.9

Sequences

Sequence LengthMass (Da)Tools
Q15072 [UniParc].

Last modified March 6, 2007. Version 2.
Checksum: D5062375D261B971

FASTA29233,308
        10         20         30         40         50         60 
MSHLSQQRIY SGENPFACKV CGKVFSHKSN LTEHEHFHTR EKPFECNECG KAFSQKQYVI 

        70         80         90        100        110        120 
KHQNTHTGEK LFECNECGKS FSQKENLLTH QKIHTGEKPF ECKDCGKAFI QKSNLIRHQR 

       130        140        150        160        170        180 
THTGEKPFVC KECGKTFSGK SNLTEHEKIH IGEKPFKCSE CGTAFGQKKY LIKHQNIHTG 

       190        200        210        220        230        240 
EKPYECNECG KAFSQRTSLI VHVRIHSGDK PYECNVCGKA FSQSSSLTVH VRSHTGEKPY 

       250        260        270        280        290 
GCNECGKAFS QFSTLALHLR IHTGKKPYQC SECGKAFSQK SHHIRHQKIH TH 

« Hide

References

« Hide 'large scale' references
[1]"The OZF gene encodes a protein consisting essentially of zinc finger motifs."
le Chalony C., Prosperi M.-T., Haluza R., Apiou F., Dutrillaux B., Goubin G.
J. Mol. Biol. 236:399-404(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT LYS-8.
Tissue: Mammary gland.
[2]"Genomic organization and promoter identification of ZNF146, a gene encoding a protein consisting solely of zinc finger domains."
Pibouin L., Villaudy J., Prosperi M.-T., Goubin G.
Cytogenet. Cell Genet. 92:80-84(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-8.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-8.
[5]"Identification, nuclear localization, and binding activities of OZF, a human protein solely composed of zinc-finger motifs."
Ferbus D., le Chalony C., Prosperi M.-T., Muleris M., Vincent-Salomon A., Goubin G.
Eur. J. Biochem. 236:991-995(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[6]"Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas."
Ferbus D., Flechon A., Muleris M., Li Y., Hanash S., Terris B., Hammel P., Pibouin L., Dutrillaux B., Goubin G.
Int. J. Cancer 80:369-372(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: OVEREXPRESSION IN PANCREATIC CANCER.
[7]"The zinc finger protein OZF (ZNF146) is overexpressed in colorectal cancer."
Ferbus D., Bovin C., Validire P., Goubin G.
J. Pathol. 200:177-182(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: OVEREXPRESSION IN COLORECTAL CANCER.
[8]"Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1."
Antoine K., Ferbus D., Kolahgar G., Prosperi M.-T., Goubin G.
J. Cell. Biochem. 95:763-768(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TERF2IP.
[9]"A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo."
Antoine K., Prosperi M.-T., Ferbus D., Boule C., Goubin G.
Mol. Cell. Biochem. 271:215-223(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UBE2I, SUMOYLATION AT LYS-157 AND LYS-169, MUTAGENESIS OF LYS-157 AND LYS-169.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X70394 mRNA. Translation: CAA49844.1.
AJ011806 Genomic DNA. Translation: CAB41967.1.
AC012617 Genomic DNA. No translation available.
BC110500 mRNA. Translation: AAI10501.1.
BC110501 mRNA. Translation: AAI10502.1.
CCDSCCDS12492.1.
PIRS43826.
RefSeqNP_001093108.1. NM_001099638.1.
NP_001093109.1. NM_001099639.1.
NP_009076.2. NM_007145.2.
XP_005259271.1. XM_005259214.1.
UniGeneHs.643436.

3D structure databases

ProteinModelPortalQ15072.
SMRQ15072. Positions 41-291.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113499. 5 interactions.
STRING9606.ENSP00000301233.

PTM databases

PhosphoSiteQ15072.

Polymorphism databases

DMDM134048495.

Proteomic databases

MaxQBQ15072.
PaxDbQ15072.
PRIDEQ15072.

Protocols and materials databases

DNASU7705.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000443387; ENSP00000392095; ENSG00000167635.
ENST00000456324; ENSP00000400391; ENSG00000167635.
GeneID7705.
KEGGhsa:7705.
UCSCuc002odq.4. human.

Organism-specific databases

CTD7705.
GeneCardsGC19P036705.
HGNCHGNC:12931. ZNF146.
HPAHPA003358.
MIM601505. gene.
neXtProtNX_Q15072.
PharmGKBPA37518.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ15072.
OMATEEAANQ.
OrthoDBEOG7KSX7Q.
PhylomeDBQ15072.
TreeFamTF337055.

Gene expression databases

BgeeQ15072.
CleanExHS_ZNF146.
GenevestigatorQ15072.

Family and domain databases

Gene3D3.30.160.60. 10 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF146.
GenomeRNAi7705.
NextBio29868.
PROQ15072.
SOURCESearch...

Entry information

Entry nameOZF_HUMAN
AccessionPrimary (citable) accession number: Q15072
Secondary accession number(s): Q2TB94
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 6, 2007
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM