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Q15072

- OZF_HUMAN

UniProt

Q15072 - OZF_HUMAN

Protein

Zinc finger protein OZF

Gene

ZNF146

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 3823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri44 – 6623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri72 – 9423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri100 – 12223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri128 – 15023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 17823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri184 – 20623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri212 – 23423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri240 – 26223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: ProtInc
    2. heparin binding Source: ProtInc
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome
    4. zinc ion binding Source: ProtInc

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein OZF
    Alternative name(s):
    Only zinc finger protein
    Zinc finger protein 146
    Gene namesi
    Name:ZNF146
    Synonyms:OZF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:12931. ZNF146.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleolus Source: HPA
    3. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi157 – 1571K → R: Induces a decrease in sumoylation. Induces a strong decrease but does not abolishes sumoylation; when associated with R-169. 1 Publication
    Mutagenesisi169 – 1691K → R: Induces a decrease in sumoylation. Induces a strong decrease but does not abolishes sumoylation; when associated with R-157. 1 Publication

    Organism-specific databases

    PharmGKBiPA37518.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Zinc finger protein OZFPRO_0000047276Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki157 – 157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Cross-linki169 – 169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

    Post-translational modificationi

    Sumoylated.1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ15072.
    PaxDbiQ15072.
    PRIDEiQ15072.

    PTM databases

    PhosphoSiteiQ15072.

    Expressioni

    Tissue specificityi

    Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers.2 Publications

    Gene expression databases

    BgeeiQ15072.
    CleanExiHS_ZNF146.
    GenevestigatoriQ15072.

    Organism-specific databases

    HPAiHPA003358.

    Interactioni

    Subunit structurei

    Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP.2 Publications

    Protein-protein interaction databases

    BioGridi113499. 4 interactions.
    STRINGi9606.ENSP00000301233.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15072.
    SMRiQ15072. Positions 41-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni212 – 29281Interaction with TERF2IPAdd
    BLAST

    Sequence similaritiesi

    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 3823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri44 – 6623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri72 – 9423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri100 – 12223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri128 – 15023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 17823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri184 – 20623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri212 – 23423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri240 – 26223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 29023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ15072.
    OMAiTEEAANQ.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ15072.
    TreeFamiTF337055.

    Family and domain databases

    Gene3Di3.30.160.60. 10 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15072-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHLSQQRIY SGENPFACKV CGKVFSHKSN LTEHEHFHTR EKPFECNECG    50
    KAFSQKQYVI KHQNTHTGEK LFECNECGKS FSQKENLLTH QKIHTGEKPF 100
    ECKDCGKAFI QKSNLIRHQR THTGEKPFVC KECGKTFSGK SNLTEHEKIH 150
    IGEKPFKCSE CGTAFGQKKY LIKHQNIHTG EKPYECNECG KAFSQRTSLI 200
    VHVRIHSGDK PYECNVCGKA FSQSSSLTVH VRSHTGEKPY GCNECGKAFS 250
    QFSTLALHLR IHTGKKPYQC SECGKAFSQK SHHIRHQKIH TH 292
    Length:292
    Mass (Da):33,308
    Last modified:March 6, 2007 - v2
    Checksum:iD5062375D261B971
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81R → K.3 Publications
    Corresponds to variant rs2070132 [ dbSNP | Ensembl ].
    VAR_023746

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70394 mRNA. Translation: CAA49844.1.
    AJ011806 Genomic DNA. Translation: CAB41967.1.
    AC012617 Genomic DNA. No translation available.
    BC110500 mRNA. Translation: AAI10501.1.
    BC110501 mRNA. Translation: AAI10502.1.
    CCDSiCCDS12492.1.
    PIRiS43826.
    RefSeqiNP_001093108.1. NM_001099638.1.
    NP_001093109.1. NM_001099639.1.
    NP_009076.2. NM_007145.2.
    XP_005259271.1. XM_005259214.1.
    UniGeneiHs.643436.

    Genome annotation databases

    EnsembliENST00000443387; ENSP00000392095; ENSG00000167635.
    ENST00000456324; ENSP00000400391; ENSG00000167635.
    GeneIDi7705.
    KEGGihsa:7705.
    UCSCiuc002odq.4. human.

    Polymorphism databases

    DMDMi134048495.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70394 mRNA. Translation: CAA49844.1 .
    AJ011806 Genomic DNA. Translation: CAB41967.1 .
    AC012617 Genomic DNA. No translation available.
    BC110500 mRNA. Translation: AAI10501.1 .
    BC110501 mRNA. Translation: AAI10502.1 .
    CCDSi CCDS12492.1.
    PIRi S43826.
    RefSeqi NP_001093108.1. NM_001099638.1.
    NP_001093109.1. NM_001099639.1.
    NP_009076.2. NM_007145.2.
    XP_005259271.1. XM_005259214.1.
    UniGenei Hs.643436.

    3D structure databases

    ProteinModelPortali Q15072.
    SMRi Q15072. Positions 41-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113499. 4 interactions.
    STRINGi 9606.ENSP00000301233.

    PTM databases

    PhosphoSitei Q15072.

    Polymorphism databases

    DMDMi 134048495.

    Proteomic databases

    MaxQBi Q15072.
    PaxDbi Q15072.
    PRIDEi Q15072.

    Protocols and materials databases

    DNASUi 7705.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000443387 ; ENSP00000392095 ; ENSG00000167635 .
    ENST00000456324 ; ENSP00000400391 ; ENSG00000167635 .
    GeneIDi 7705.
    KEGGi hsa:7705.
    UCSCi uc002odq.4. human.

    Organism-specific databases

    CTDi 7705.
    GeneCardsi GC19P036705.
    HGNCi HGNC:12931. ZNF146.
    HPAi HPA003358.
    MIMi 601505. gene.
    neXtProti NX_Q15072.
    PharmGKBi PA37518.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q15072.
    OMAi TEEAANQ.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q15072.
    TreeFami TF337055.

    Miscellaneous databases

    GeneWikii ZNF146.
    GenomeRNAii 7705.
    NextBioi 29868.
    PROi Q15072.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q15072.
    CleanExi HS_ZNF146.
    Genevestigatori Q15072.

    Family and domain databases

    Gene3Di 3.30.160.60. 10 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The OZF gene encodes a protein consisting essentially of zinc finger motifs."
      le Chalony C., Prosperi M.-T., Haluza R., Apiou F., Dutrillaux B., Goubin G.
      J. Mol. Biol. 236:399-404(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT LYS-8.
      Tissue: Mammary gland.
    2. "Genomic organization and promoter identification of ZNF146, a gene encoding a protein consisting solely of zinc finger domains."
      Pibouin L., Villaudy J., Prosperi M.-T., Goubin G.
      Cytogenet. Cell Genet. 92:80-84(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-8.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-8.
    5. "Identification, nuclear localization, and binding activities of OZF, a human protein solely composed of zinc-finger motifs."
      Ferbus D., le Chalony C., Prosperi M.-T., Muleris M., Vincent-Salomon A., Goubin G.
      Eur. J. Biochem. 236:991-995(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    6. "Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas."
      Ferbus D., Flechon A., Muleris M., Li Y., Hanash S., Terris B., Hammel P., Pibouin L., Dutrillaux B., Goubin G.
      Int. J. Cancer 80:369-372(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: OVEREXPRESSION IN PANCREATIC CANCER.
    7. "The zinc finger protein OZF (ZNF146) is overexpressed in colorectal cancer."
      Ferbus D., Bovin C., Validire P., Goubin G.
      J. Pathol. 200:177-182(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: OVEREXPRESSION IN COLORECTAL CANCER.
    8. "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1."
      Antoine K., Ferbus D., Kolahgar G., Prosperi M.-T., Goubin G.
      J. Cell. Biochem. 95:763-768(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TERF2IP.
    9. "A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo."
      Antoine K., Prosperi M.-T., Ferbus D., Boule C., Goubin G.
      Mol. Cell. Biochem. 271:215-223(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UBE2I, SUMOYLATION AT LYS-157 AND LYS-169, MUTAGENESIS OF LYS-157 AND LYS-169.

    Entry informationi

    Entry nameiOZF_HUMAN
    AccessioniPrimary (citable) accession number: Q15072
    Secondary accession number(s): Q2TB94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3