Periostin precursor - Homo sapiens (Human)

Names and origin

Protein names

Recommended name:
    Periostin
      Short name=PN
Alternative name(s):
    Osteoblast-specific factor 2
      Short name=OSF-2

Gene names

Name:	POSTN
Synonyms:	OSF2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	836 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. Ref.2 Ref.11 UniProtKB Q62009
Subcellular location	Secreted › extracellular space › extracellular matrix. Ref.2
Tissue specificity	Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers. Ref.2 Ref.7 Ref.9
Post-translational modification	Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
Sequence similarities	Contains 1 EMI domain. Contains 4 FAS1 domains.

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Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal
Ligand	Heparin-binding
PTM	Disulfide bond Gamma-carboxyglutamic acid Glycoprotein
Gene Ontology (GO)
Biological process	cell adhesion Ref.2 Inferred from direct assay. Source: UniProtKB skeletal system development Ref.1 Traceable author statement. Source: ProtInc
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell proteinaceous extracellular matrix Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	heparin binding Inferred from sequence or structural similarity. Source: UniProtKB protein binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 (identifier: Q15063-1) Also known as: OSF-2OS; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.1 (identifier: Q15063-2) Also known as: OSF-2p1; The sequence of this isoform differs from the canonical sequence as follows: 670-727: TTKIITKVVEPKIKVIEGSLQPIIKTEGPTLTKVKIEGEPEFRLIKEGETITEVIHGE → K

Isoform 3 Ref.2 (identifier: Q15063-3) The sequence of this isoform differs from the canonical sequence as follows: 670-697: TTKIITKVVEPKIKVIEGSLQPIIKTEG → R 783-810: Missing.

Isoform 4 (identifier: Q15063-4) The sequence of this isoform differs from the canonical sequence as follows: 670-727: TTKIITKVVEPKIKVIEGSLQPIIKTEGPTLTKVKIEGEPEFRLIKEGETITEVIHGE → K 783-810: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

21

Potential

Chain

22 – 836

815

Periostin

PRO_0000008789

Regions

Domain

40 – 94

55

EMI

Domain

97 – 230

134

FAS1 1

Domain

234 – 365

132

FAS1 2

Domain

368 – 492

125

FAS1 3

Domain

496 – 628

133

FAS1 4

Amino acid modifications

Modified residue

124

1

4-carboxyglutamate Potential

Modified residue

125

1

4-carboxyglutamate Potential

Modified residue

127

1

4-carboxyglutamate Potential

Modified residue

140

1

4-carboxyglutamate Potential

Modified residue

154

1

4-carboxyglutamate Potential

Modified residue

160

1

4-carboxyglutamate Potential

Modified residue

242

1

4-carboxyglutamate Potential

Modified residue

244

1

4-carboxyglutamate Potential

Modified residue

261

1

4-carboxyglutamate Potential

Modified residue

277

1

4-carboxyglutamate Potential

Modified residue

280

1

4-carboxyglutamate Potential

Modified residue

288

1

4-carboxyglutamate Potential

Modified residue

298

1

4-carboxyglutamate Potential

Modified residue

313

1

4-carboxyglutamate Potential

Modified residue

322

1

4-carboxyglutamate Potential

Modified residue

325

1

4-carboxyglutamate Potential

Modified residue

496

1

4-carboxyglutamate Potential

Modified residue

501

1

4-carboxyglutamate Potential

Modified residue

517

1

4-carboxyglutamate Potential

Modified residue

523

1

4-carboxyglutamate Potential

Modified residue

547

1

4-carboxyglutamate Potential

Modified residue

548

1

4-carboxyglutamate Potential

Modified residue

550

1

4-carboxyglutamate Potential

Modified residue

578

1

4-carboxyglutamate Potential

Glycosylation

599

1

N-linked (GlcNAc...) Ref.10 UniProtKB Q62009

Disulfide bond

44 ↔ 80

By similarity

Disulfide bond

60 ↔ 69

By similarity

Disulfide bond

79 ↔ 92

By similarity

Natural variations

Alternative sequence

670 – 727

58

TTKII…VIHGE → K in isoform 2 and isoform 4. Ref.1

VSP_050005

Alternative sequence

670 – 697

28

TTKII…IKTEG → R in isoform 3. Ref.2

VSP_050669

Alternative sequence

783 – 810

28

Missing in isoform 3 and isoform 4.

VSP_050670

Natural variant

339

1

T → I: dbSNP rs9594223.

VAR_049115

Natural variant

814

1

V → M: dbSNP rs9547952.

VAR_049116

Experimental info

Sequence conflict

290

1

I → F in BAA02836. Ref.1

Sequence conflict

290

1

I → F in BAA02837. Ref.1

Sequence conflict

290

1

I → F in AAY15840. Ref.3

Sequence conflict

421

1

D → V in BAA02836. Ref.1

Sequence conflict

421

1

D → V in BAA02837. Ref.1

Sequence conflict

421

1

D → V in AAY15840. Ref.3

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 (OSF-2OS) [UniParc]. Last modified March 7, 2006. Version 2. Checksum: 55E7B82D094824FD Show »	FASTA	836	93,314
10 20 30 40 50 60 MIPFLPMFSL LLLLIVNPIN ANNHYDKILA HSRIRGRDQG PNVCALQQIL GTKKKYFSTC 70 80 90 100 110 120 KNWYKKSICG QKTTVLYECC PGYMRMEGMK GCPAVLPIDH VYGTLGIVGA TTTQRYSDAS 130 140 150 160 170 180 KLREEIEGKG SFTYFAPSNE AWDNLDSDIR RGLESNVNVE LLNALHSHMI NKRMLTKDLK 190 200 210 220 230 240 NGMIIPSMYN NLGLFINHYP NGVVTVNCAR IIHGNQIATN GVVHVIDRVL TQIGTSIQDF 250 260 270 280 290 300 IEAEDDLSSF RAAAITSDIL EALGRDGHFT LFAPTNEAFE KLPRGVLERI MGDKVASEAL 310 320 330 340 350 360 MKYHILNTLQ CSESIMGGAV FETLEGNTIE IGCDGDSITV NGIKMVNKKD IVTNNGVIHL 370 380 390 400 410 420 IDQVLIPDSA KQVIELAGKQ QTTFTDLVAQ LGLASALRPD GEYTLLAPVN NAFSDDTLSM 430 440 450 460 470 480 DQRLLKLILQ NHILKVKVGL NELYNGQILE TIGGKQLRVF VYRTAVCIEN SCMEKGSKQG 490 500 510 520 530 540 RNGAIHIFRE IIKPAEKSLH EKLKQDKRFS TFLSLLEAAD LKELLTQPGD WTLFVPTNDA 550 560 570 580 590 600 FKGMTSEEKE ILIRDKNALQ NIILYHLTPG VFIGKGFEPG VTNILKTTQG SKIFLKEVND 610 620 630 640 650 660 TLLVNELKSK ESDIMTTNGV IHVVDKLLYP ADTPVGNDQL LEILNKLIKY IQIKFVRGST 670 680 690 700 710 720 FKEIPVTVYT TKIITKVVEP KIKVIEGSLQ PIIKTEGPTL TKVKIEGEPE FRLIKEGETI 730 740 750 760 770 780 TEVIHGEPII KKYTKIIDGV PVEITEKETR EERIITGPEI KYTRISTGGG ETEETLKKLL 790 800 810 820 830 QEEVTKVTKF IEGGDGHLFE DEEIKRLLQG DTPVRKLQAN KKVQGSRRRL REGRSQ « Hide
Isoform 2 (OSF-2p1). Checksum: C6936F32A42B8366 Show »	FASTA	779	87,021
10 20 30 40 50 60 MIPFLPMFSL LLLLIVNPIN ANNHYDKILA HSRIRGRDQG PNVCALQQIL GTKKKYFSTC 70 80 90 100 110 120 KNWYKKSICG QKTTVLYECC PGYMRMEGMK GCPAVLPIDH VYGTLGIVGA TTTQRYSDAS 130 140 150 160 170 180 KLREEIEGKG SFTYFAPSNE AWDNLDSDIR RGLESNVNVE LLNALHSHMI NKRMLTKDLK 190 200 210 220 230 240 NGMIIPSMYN NLGLFINHYP NGVVTVNCAR IIHGNQIATN GVVHVIDRVL TQIGTSIQDF 250 260 270 280 290 300 IEAEDDLSSF RAAAITSDIL EALGRDGHFT LFAPTNEAFE KLPRGVLERI MGDKVASEAL 310 320 330 340 350 360 MKYHILNTLQ CSESIMGGAV FETLEGNTIE IGCDGDSITV NGIKMVNKKD IVTNNGVIHL 370 380 390 400 410 420 IDQVLIPDSA KQVIELAGKQ QTTFTDLVAQ LGLASALRPD GEYTLLAPVN NAFSDDTLSM 430 440 450 460 470 480 DQRLLKLILQ NHILKVKVGL NELYNGQILE TIGGKQLRVF VYRTAVCIEN SCMEKGSKQG 490 500 510 520 530 540 RNGAIHIFRE IIKPAEKSLH EKLKQDKRFS TFLSLLEAAD LKELLTQPGD WTLFVPTNDA 550 560 570 580 590 600 FKGMTSEEKE ILIRDKNALQ NIILYHLTPG VFIGKGFEPG VTNILKTTQG SKIFLKEVND 610 620 630 640 650 660 TLLVNELKSK ESDIMTTNGV IHVVDKLLYP ADTPVGNDQL LEILNKLIKY IQIKFVRGST 670 680 690 700 710 720 FKEIPVTVYK PIIKKYTKII DGVPVEITEK ETREERIITG PEIKYTRIST GGGETEETLK 730 740 750 760 770 KLLQEEVTKV TKFIEGGDGH LFEDEEIKRL LQGDTPVRKL QANKKVQGSR RRLREGRSQ « Hide
Isoform 3. Checksum: D082BC8F86ABAC37 Show »	FASTA	781	87,254
10 20 30 40 50 60 MIPFLPMFSL LLLLIVNPIN ANNHYDKILA HSRIRGRDQG PNVCALQQIL GTKKKYFSTC 70 80 90 100 110 120 KNWYKKSICG QKTTVLYECC PGYMRMEGMK GCPAVLPIDH VYGTLGIVGA TTTQRYSDAS 130 140 150 160 170 180 KLREEIEGKG SFTYFAPSNE AWDNLDSDIR RGLESNVNVE LLNALHSHMI NKRMLTKDLK 190 200 210 220 230 240 NGMIIPSMYN NLGLFINHYP NGVVTVNCAR IIHGNQIATN GVVHVIDRVL TQIGTSIQDF 250 260 270 280 290 300 IEAEDDLSSF RAAAITSDIL EALGRDGHFT LFAPTNEAFE KLPRGVLERI MGDKVASEAL 310 320 330 340 350 360 MKYHILNTLQ CSESIMGGAV FETLEGNTIE IGCDGDSITV NGIKMVNKKD IVTNNGVIHL 370 380 390 400 410 420 IDQVLIPDSA KQVIELAGKQ QTTFTDLVAQ LGLASALRPD GEYTLLAPVN NAFSDDTLSM 430 440 450 460 470 480 DQRLLKLILQ NHILKVKVGL NELYNGQILE TIGGKQLRVF VYRTAVCIEN SCMEKGSKQG 490 500 510 520 530 540 RNGAIHIFRE IIKPAEKSLH EKLKQDKRFS TFLSLLEAAD LKELLTQPGD WTLFVPTNDA 550 560 570 580 590 600 FKGMTSEEKE ILIRDKNALQ NIILYHLTPG VFIGKGFEPG VTNILKTTQG SKIFLKEVND 610 620 630 640 650 660 TLLVNELKSK ESDIMTTNGV IHVVDKLLYP ADTPVGNDQL LEILNKLIKY IQIKFVRGST 670 680 690 700 710 720 FKEIPVTVYR PTLTKVKIEG EPEFRLIKEG ETITEVIHGE PIIKKYTKII DGVPVEITEK 730 740 750 760 770 780 ETREERIITG PEIKYTRIST GGGETEETLK KLLQEDTPVR KLQANKKVQG SRRRLREGRS Q « Hide
Isoform 4. Checksum: 7241170E4CDC18D3 Show »	FASTA	751	83,850
10 20 30 40 50 60 MIPFLPMFSL LLLLIVNPIN ANNHYDKILA HSRIRGRDQG PNVCALQQIL GTKKKYFSTC 70 80 90 100 110 120 KNWYKKSICG QKTTVLYECC PGYMRMEGMK GCPAVLPIDH VYGTLGIVGA TTTQRYSDAS 130 140 150 160 170 180 KLREEIEGKG SFTYFAPSNE AWDNLDSDIR RGLESNVNVE LLNALHSHMI NKRMLTKDLK 190 200 210 220 230 240 NGMIIPSMYN NLGLFINHYP NGVVTVNCAR IIHGNQIATN GVVHVIDRVL TQIGTSIQDF 250 260 270 280 290 300 IEAEDDLSSF RAAAITSDIL EALGRDGHFT LFAPTNEAFE KLPRGVLERI MGDKVASEAL 310 320 330 340 350 360 MKYHILNTLQ CSESIMGGAV FETLEGNTIE IGCDGDSITV NGIKMVNKKD IVTNNGVIHL 370 380 390 400 410 420 IDQVLIPDSA KQVIELAGKQ QTTFTDLVAQ LGLASALRPD GEYTLLAPVN NAFSDDTLSM 430 440 450 460 470 480 DQRLLKLILQ NHILKVKVGL NELYNGQILE TIGGKQLRVF VYRTAVCIEN SCMEKGSKQG 490 500 510 520 530 540 RNGAIHIFRE IIKPAEKSLH EKLKQDKRFS TFLSLLEAAD LKELLTQPGD WTLFVPTNDA 550 560 570 580 590 600 FKGMTSEEKE ILIRDKNALQ NIILYHLTPG VFIGKGFEPG VTNILKTTQG SKIFLKEVND 610 620 630 640 650 660 TLLVNELKSK ESDIMTTNGV IHVVDKLLYP ADTPVGNDQL LEILNKLIKY IQIKFVRGST 670 680 690 700 710 720 FKEIPVTVYK PIIKKYTKII DGVPVEITEK ETREERIITG PEIKYTRIST GGGETEETLK 730 740 750 KLLQEDTPVR KLQANKKVQG SRRRLREGRS Q « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I." Takeshita S., Kikuno R., Tezuka K., Amann E. Biochem. J. 294:271-278(1993) [PubMed: 8363580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Osteosarcoma and Placenta.
[2]	"Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility." Gillan L., Matei D., Fishman D.A., Gerbin C.S., Karlan B.Y., Chang D.D. Cancer Res. 62:5358-5364(2002) [PubMed: 12235007] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]	"Identification and characterization of a novel periodontal ligament-specific periostin isoform." Yamada S., Maeda K., Matsubara K., Murakami S. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Periodontal ligament.
[4]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[7]	"Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas." Sasaki H., Dai M., Auclair D., Fukai I., Kiriyama M., Yamakawa Y., Fujii Y., Chen L.B. Cancer 92:843-848(2001) [PubMed: 11550156] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	Erratum Sasaki H., Dai M., Auclair D., Fukai I., Kiriyama M., Yamakawa Y., Fujii Y., Chen L.B. Cancer 95:2580-2580(2002)
[9]	"Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression." Shao R., Bao S., Bai X., Blanchette C., Anderson R.M., Dang T., Gishizky M.L., Marks J.R., Wang X.-F. Mol. Cell. Biol. 24:3992-4003(2004) [PubMed: 15082792] [Abstract] Cited for: TISSUE SPECIFICITY.
[10]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-599, MASS SPECTROMETRY. Tissue: Plasma.
[11]	"Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells." Coutu D.L., Wu J.H., Monette A., Rivard G.-E., Blostein M.D., Galipeau J. J. Biol. Chem. 283:17991-18001(2008) [PubMed: 18450759] [Abstract] Cited for: FUNCTION, GAMMA-CARBOXYGLUTAMATION.
[12]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-599, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	D13665 mRNA. Translation: BAA02836.1. D13666 mRNA. Translation: BAA02837.1. AY140646 mRNA. Translation: AAN17733.1. AY918092 mRNA. Translation: AAY15840.1. AL138679, AL646087 Genomic DNA. Translation: CAH70107.1. AL646087, AL138679 Genomic DNA. Translation: CAH73568.1. AL138679, AL646087 Genomic DNA. Translation: CAH70104.1. AL646087, AL138679 Genomic DNA. Translation: CAH73569.1. CH471075 Genomic DNA. Translation: EAX08590.1. BC106709 mRNA. Translation: AAI06710.1. BC106710 mRNA. Translation: AAI06711.1.
IPI	IPI00007960. IPI00218585. IPI00873848. IPI00910262.
PIR	S36110. S36111.
RefSeq	NP_001129406.1. NP_001129407.1. NP_001129408.1. NP_006466.2.
UniGene	Hs.136348 Hs.664318
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q15063.
Proteomic databases
PRIDE	Q15063.
Genome annotation databases
Ensembl	ENSG00000133110. Homo sapiens. [Contig view]
GeneID	10631.
NMPDR	fig\|9606.3.peg.8746.
Organism-specific databases
GeneCards	GC13M037034.
H-InvDB	HIX0011247.
HGNC	HGNC:16953. POSTN.
HPA	HPA012306.
MIM	608777. gene.
PharmGKB	PA134900304.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q15063.
HOVERGEN	Q15063.
OMA	Q15063. NLDSDIR.
Gene expression databases
ArrayExpress	Q15063.
Bgee	Q15063.
CleanEx	HS_POSTN.
GermOnline	ENSG00000133110. Homo sapiens.
Family and domain databases
InterPro	IPR011489. EMI_domain. IPR000782. FAS1_domain. IPR016666. TGFb-ind_bIGH3/osteoblast_fac2. [Graphical view]
Gene3D	G3DSA:2.30.180.10. BIgH3_FAS1. 4 hits.
Pfam	PF07546. EMI. 1 hit. PF02469. Fasciclin. 4 hits. [Graphical view]
PIRSF	PIRSF016553. BIGH3_OSF2. 1 hit.
SMART	SM00554. FAS1. 4 hits. [Graphical view]
PROSITE	PS51041. EMI. 1 hit. PS50213. FAS1. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	40399.
SOURCE	Search...

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Entry information

Entry name

POSTN_HUMAN

Accession

Primary (citable) accession number: Q15063
Secondary accession number(s): Q15064

Q8IZF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents