Q15063 (POSTN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Periostin
Short name=PN

Alternative name(s):
Osteoblast-specific factor 2
Short name=OSF-2

Gene names

Name:	POSTN
Synonyms:	OSF2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	836 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX By similarity. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. Ref.2 Ref.11
Subunit structure	Interacts with BMP1 and fibronectin By similarity.
Subcellular location	Golgi apparatus By similarity. Secreted › extracellular space › extracellular matrix. Note: Co-localizes with BMP1 in the Golgi By similarity. Ref.2
Tissue specificity	Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers. Ref.2 Ref.7 Ref.9
Post-translational modification	Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
Sequence similarities	Contains 1 EMI domain. Contains 4 FAS1 domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Extracellular matrix Golgi apparatus Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal
Ligand	Heparin-binding
PTM	Disulfide bond Gamma-carboxyglutamic acid Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from direct assay Ref.2. Source: UniProtKB extracellular matrix organization Inferred from electronic annotation. Source: Compara regulation of Notch signaling pathway Inferred from electronic annotation. Source: Compara skeletal system development Traceable author statement Ref.1. Source: ProtInc tissue development Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell proteinaceous extracellular matrix Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	heparin binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 (identifier: Q15063-1)

Also known as: OSF-2OS;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.1 (identifier: Q15063-2)

Also known as: OSF-2p1;

The sequence of this isoform differs from the canonical sequence as follows:
     670-727: TTKIITKVVEPKIKVIEGSLQPIIKTEGPTLTKVKIEGEPEFRLIKEGETITEVIHGE → K

Isoform 3 Ref.2 (identifier: Q15063-3)

The sequence of this isoform differs from the canonical sequence as follows:
     670-697: TTKIITKVVEPKIKVIEGSLQPIIKTEG → R
     783-810: Missing.

Isoform 4 (identifier: Q15063-4)

The sequence of this isoform differs from the canonical sequence as follows:
     670-727: TTKIITKVVEPKIKVIEGSLQPIIKTEGPTLTKVKIEGEPEFRLIKEGETITEVIHGE → K
     783-810: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 836	815	Periostin		PRO_0000008789
Regions
	Domain	40 – 94	55	EMI
	Domain	97 – 230	134	FAS1 1
	Domain	234 – 365	132	FAS1 2
	Domain	368 – 492	125	FAS1 3
	Domain	496 – 628	133	FAS1 4
Amino acid modifications
	Modified residue	124	1	4-carboxyglutamate Potential
	Modified residue	125	1	4-carboxyglutamate Potential
	Modified residue	127	1	4-carboxyglutamate Potential
	Modified residue	140	1	4-carboxyglutamate Potential
	Modified residue	154	1	4-carboxyglutamate Potential
	Modified residue	160	1	4-carboxyglutamate Potential
	Modified residue	242	1	4-carboxyglutamate Potential
	Modified residue	244	1	4-carboxyglutamate Potential
	Modified residue	261	1	4-carboxyglutamate Potential
	Modified residue	277	1	4-carboxyglutamate Potential
	Modified residue	280	1	4-carboxyglutamate Potential
	Modified residue	288	1	4-carboxyglutamate Potential
	Modified residue	298	1	4-carboxyglutamate Potential
	Modified residue	313	1	4-carboxyglutamate Potential
	Modified residue	322	1	4-carboxyglutamate Potential
	Modified residue	325	1	4-carboxyglutamate Potential
	Modified residue	496	1	4-carboxyglutamate Potential
	Modified residue	501	1	4-carboxyglutamate Potential
	Modified residue	517	1	4-carboxyglutamate Potential
	Modified residue	523	1	4-carboxyglutamate Potential
	Modified residue	547	1	4-carboxyglutamate Potential
	Modified residue	548	1	4-carboxyglutamate Potential
	Modified residue	550	1	4-carboxyglutamate Potential
	Modified residue	578	1	4-carboxyglutamate Potential
	Glycosylation	599	1	N-linked (GlcNAc...) Ref.1 Ref.10 Ref.12
	Disulfide bond	44 ↔ 80		By similarity
	Disulfide bond	60 ↔ 69		By similarity
	Disulfide bond	79 ↔ 92		By similarity
Natural variations
	Alternative sequence	670 – 727	58	TTKII…VIHGE → K in isoform 2 and isoform 4. Ref.1		VSP_050005
	Alternative sequence	670 – 697	28	TTKII…IKTEG → R in isoform 3. Ref.2		VSP_050669
	Alternative sequence	783 – 810	28	Missing in isoform 3 and isoform 4.		VSP_050670
	Natural variant	339	1	T → I. Corresponds to variant rs9594223 [ dbSNP | Ensembl ].		VAR_049115
	Natural variant	814	1	V → M. Corresponds to variant rs9547952 [ dbSNP | Ensembl ].		VAR_049116
Experimental info
	Sequence conflict	290	1	I → F in BAA02836. Ref.1
	Sequence conflict	290	1	I → F in BAA02837. Ref.1
	Sequence conflict	290	1	I → F in AAY15840. Ref.3
	Sequence conflict	421	1	D → V in BAA02836. Ref.1
	Sequence conflict	421	1	D → V in BAA02837. Ref.1
	Sequence conflict	421	1	D → V in AAY15840. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (OSF-2OS) [UniParc]. Last modified March 7, 2006. Version 2. Checksum: 55E7B82D094824FD	FASTA	836	93,314
	10 20 30 40 50 60 MIPFLPMFSL LLLLIVNPIN ANNHYDKILA HSRIRGRDQG PNVCALQQIL GTKKKYFSTC 70 80 90 100 110 120 KNWYKKSICG QKTTVLYECC PGYMRMEGMK GCPAVLPIDH VYGTLGIVGA TTTQRYSDAS 130 140 150 160 170 180 KLREEIEGKG SFTYFAPSNE AWDNLDSDIR RGLESNVNVE LLNALHSHMI NKRMLTKDLK 190 200 210 220 230 240 NGMIIPSMYN NLGLFINHYP NGVVTVNCAR IIHGNQIATN GVVHVIDRVL TQIGTSIQDF 250 260 270 280 290 300 IEAEDDLSSF RAAAITSDIL EALGRDGHFT LFAPTNEAFE KLPRGVLERI MGDKVASEAL 310 320 330 340 350 360 MKYHILNTLQ CSESIMGGAV FETLEGNTIE IGCDGDSITV NGIKMVNKKD IVTNNGVIHL 370 380 390 400 410 420 IDQVLIPDSA KQVIELAGKQ QTTFTDLVAQ LGLASALRPD GEYTLLAPVN NAFSDDTLSM 430 440 450 460 470 480 DQRLLKLILQ NHILKVKVGL NELYNGQILE TIGGKQLRVF VYRTAVCIEN SCMEKGSKQG 490 500 510 520 530 540 RNGAIHIFRE IIKPAEKSLH EKLKQDKRFS TFLSLLEAAD LKELLTQPGD WTLFVPTNDA 550 560 570 580 590 600 FKGMTSEEKE ILIRDKNALQ NIILYHLTPG VFIGKGFEPG VTNILKTTQG SKIFLKEVND 610 620 630 640 650 660 TLLVNELKSK ESDIMTTNGV IHVVDKLLYP ADTPVGNDQL LEILNKLIKY IQIKFVRGST 670 680 690 700 710 720 FKEIPVTVYT TKIITKVVEP KIKVIEGSLQ PIIKTEGPTL TKVKIEGEPE FRLIKEGETI 730 740 750 760 770 780 TEVIHGEPII KKYTKIIDGV PVEITEKETR EERIITGPEI KYTRISTGGG ETEETLKKLL 790 800 810 820 830 QEEVTKVTKF IEGGDGHLFE DEEIKRLLQG DTPVRKLQAN KKVQGSRRRL REGRSQ
	Isoform 2 (OSF-2p1) [UniParc]. Checksum: C6936F32A42B8366	FASTA	779	87,021
	10 20 30 40 50 60 MIPFLPMFSL LLLLIVNPIN ANNHYDKILA HSRIRGRDQG PNVCALQQIL GTKKKYFSTC 70 80 90 100 110 120 KNWYKKSICG QKTTVLYECC PGYMRMEGMK GCPAVLPIDH VYGTLGIVGA TTTQRYSDAS 130 140 150 160 170 180 KLREEIEGKG SFTYFAPSNE AWDNLDSDIR RGLESNVNVE LLNALHSHMI NKRMLTKDLK 190 200 210 220 230 240 NGMIIPSMYN NLGLFINHYP NGVVTVNCAR IIHGNQIATN GVVHVIDRVL TQIGTSIQDF 250 260 270 280 290 300 IEAEDDLSSF RAAAITSDIL EALGRDGHFT LFAPTNEAFE KLPRGVLERI MGDKVASEAL 310 320 330 340 350 360 MKYHILNTLQ CSESIMGGAV FETLEGNTIE IGCDGDSITV NGIKMVNKKD IVTNNGVIHL 370 380 390 400 410 420 IDQVLIPDSA KQVIELAGKQ QTTFTDLVAQ LGLASALRPD GEYTLLAPVN NAFSDDTLSM 430 440 450 460 470 480 DQRLLKLILQ NHILKVKVGL NELYNGQILE TIGGKQLRVF VYRTAVCIEN SCMEKGSKQG 490 500 510 520 530 540 RNGAIHIFRE IIKPAEKSLH EKLKQDKRFS TFLSLLEAAD LKELLTQPGD WTLFVPTNDA 550 560 570 580 590 600 FKGMTSEEKE ILIRDKNALQ NIILYHLTPG VFIGKGFEPG VTNILKTTQG SKIFLKEVND 610 620 630 640 650 660 TLLVNELKSK ESDIMTTNGV IHVVDKLLYP ADTPVGNDQL LEILNKLIKY IQIKFVRGST 670 680 690 700 710 720 FKEIPVTVYK PIIKKYTKII DGVPVEITEK ETREERIITG PEIKYTRIST GGGETEETLK 730 740 750 760 770 KLLQEEVTKV TKFIEGGDGH LFEDEEIKRL LQGDTPVRKL QANKKVQGSR RRLREGRSQ
	Isoform 3 [UniParc]. Checksum: D082BC8F86ABAC37	FASTA	781	87,254
	10 20 30 40 50 60 MIPFLPMFSL LLLLIVNPIN ANNHYDKILA HSRIRGRDQG PNVCALQQIL GTKKKYFSTC 70 80 90 100 110 120 KNWYKKSICG QKTTVLYECC PGYMRMEGMK GCPAVLPIDH VYGTLGIVGA TTTQRYSDAS 130 140 150 160 170 180 KLREEIEGKG SFTYFAPSNE AWDNLDSDIR RGLESNVNVE LLNALHSHMI NKRMLTKDLK 190 200 210 220 230 240 NGMIIPSMYN NLGLFINHYP NGVVTVNCAR IIHGNQIATN GVVHVIDRVL TQIGTSIQDF 250 260 270 280 290 300 IEAEDDLSSF RAAAITSDIL EALGRDGHFT LFAPTNEAFE KLPRGVLERI MGDKVASEAL 310 320 330 340 350 360 MKYHILNTLQ CSESIMGGAV FETLEGNTIE IGCDGDSITV NGIKMVNKKD IVTNNGVIHL 370 380 390 400 410 420 IDQVLIPDSA KQVIELAGKQ QTTFTDLVAQ LGLASALRPD GEYTLLAPVN NAFSDDTLSM 430 440 450 460 470 480 DQRLLKLILQ NHILKVKVGL NELYNGQILE TIGGKQLRVF VYRTAVCIEN SCMEKGSKQG 490 500 510 520 530 540 RNGAIHIFRE IIKPAEKSLH EKLKQDKRFS TFLSLLEAAD LKELLTQPGD WTLFVPTNDA 550 560 570 580 590 600 FKGMTSEEKE ILIRDKNALQ NIILYHLTPG VFIGKGFEPG VTNILKTTQG SKIFLKEVND 610 620 630 640 650 660 TLLVNELKSK ESDIMTTNGV IHVVDKLLYP ADTPVGNDQL LEILNKLIKY IQIKFVRGST 670 680 690 700 710 720 FKEIPVTVYR PTLTKVKIEG EPEFRLIKEG ETITEVIHGE PIIKKYTKII DGVPVEITEK 730 740 750 760 770 780 ETREERIITG PEIKYTRIST GGGETEETLK KLLQEDTPVR KLQANKKVQG SRRRLREGRS Q
	Isoform 4 [UniParc]. Checksum: 7241170E4CDC18D3	FASTA	751	83,850
	10 20 30 40 50 60 MIPFLPMFSL LLLLIVNPIN ANNHYDKILA HSRIRGRDQG PNVCALQQIL GTKKKYFSTC 70 80 90 100 110 120 KNWYKKSICG QKTTVLYECC PGYMRMEGMK GCPAVLPIDH VYGTLGIVGA TTTQRYSDAS 130 140 150 160 170 180 KLREEIEGKG SFTYFAPSNE AWDNLDSDIR RGLESNVNVE LLNALHSHMI NKRMLTKDLK 190 200 210 220 230 240 NGMIIPSMYN NLGLFINHYP NGVVTVNCAR IIHGNQIATN GVVHVIDRVL TQIGTSIQDF 250 260 270 280 290 300 IEAEDDLSSF RAAAITSDIL EALGRDGHFT LFAPTNEAFE KLPRGVLERI MGDKVASEAL 310 320 330 340 350 360 MKYHILNTLQ CSESIMGGAV FETLEGNTIE IGCDGDSITV NGIKMVNKKD IVTNNGVIHL 370 380 390 400 410 420 IDQVLIPDSA KQVIELAGKQ QTTFTDLVAQ LGLASALRPD GEYTLLAPVN NAFSDDTLSM 430 440 450 460 470 480 DQRLLKLILQ NHILKVKVGL NELYNGQILE TIGGKQLRVF VYRTAVCIEN SCMEKGSKQG 490 500 510 520 530 540 RNGAIHIFRE IIKPAEKSLH EKLKQDKRFS TFLSLLEAAD LKELLTQPGD WTLFVPTNDA 550 560 570 580 590 600 FKGMTSEEKE ILIRDKNALQ NIILYHLTPG VFIGKGFEPG VTNILKTTQG SKIFLKEVND 610 620 630 640 650 660 TLLVNELKSK ESDIMTTNGV IHVVDKLLYP ADTPVGNDQL LEILNKLIKY IQIKFVRGST 670 680 690 700 710 720 FKEIPVTVYK PIIKKYTKII DGVPVEITEK ETREERIITG PEIKYTRIST GGGETEETLK 730 740 750 KLLQEDTPVR KLQANKKVQG SRRRLREGRS Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I." Takeshita S., Kikuno R., Tezuka K., Amann E. Biochem. J. 294:271-278(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Osteosarcoma and Placenta.
[2]	"Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility." Gillan L., Matei D., Fishman D.A., Gerbin C.S., Karlan B.Y., Chang D.D. Cancer Res. 62:5358-5364(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]	"Identification and characterization of a novel periodontal ligament-specific periostin isoform." Yamada S., Maeda K., Matsubara K., Murakami S. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Periodontal ligament.
[4]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[7]	"Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas." Sasaki H., Dai M., Auclair D., Fukai I., Kiriyama M., Yamakawa Y., Fujii Y., Chen L.B. Cancer 92:843-848(2001) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	Erratum Sasaki H., Dai M., Auclair D., Fukai I., Kiriyama M., Yamakawa Y., Fujii Y., Chen L.B. Cancer 95:2580-2580(2002)
[9]	"Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression." Shao R., Bao S., Bai X., Blanchette C., Anderson R.M., Dang T., Gishizky M.L., Marks J.R., Wang X.-F. Mol. Cell. Biol. 24:3992-4003(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[10]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-599, MASS SPECTROMETRY. Tissue: Plasma.
[11]	"Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells." Coutu D.L., Wu J.H., Monette A., Rivard G.-E., Blostein M.D., Galipeau J. J. Biol. Chem. 283:17991-18001(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, GAMMA-CARBOXYGLUTAMATION.
[12]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-599, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13665 mRNA. Translation: BAA02836.1. D13666 mRNA. Translation: BAA02837.1. AY140646 mRNA. Translation: AAN17733.1. AY918092 mRNA. Translation: AAY15840.1. AL138679, AL646087 Genomic DNA. Translation: CAH70107.1. AL646087, AL138679 Genomic DNA. Translation: CAH73568.1. AL138679, AL646087 Genomic DNA. Translation: CAH70104.1. AL646087, AL138679 Genomic DNA. Translation: CAH73569.1. CH471075 Genomic DNA. Translation: EAX08590.1. BC106709 mRNA. Translation: AAI06710.1. BC106710 mRNA. Translation: AAI06711.1.
IPI	IPI00007960. IPI00218585. IPI00910262. IPI01009588.
PIR	S36110. S36111.
RefSeq	NP_001129406.1. NM_001135934.1. NP_001129407.1. NM_001135935.1. NP_001129408.1. NM_001135936.1. NP_006466.2. NM_006475.2.
UniGene	Hs.136348. Hs.721018.
3D structure databases
ProteinModelPortal	Q15063.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000369071.
PTM databases
PhosphoSite	Q15063.
Polymorphism databases
DMDM	93138709.
Proteomic databases
PaxDb	Q15063.
PRIDE	Q15063.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379742; ENSP00000369066; ENSG00000133110. ENST00000379747; ENSP00000369071; ENSG00000133110. ENST00000541179; ENSP00000437959; ENSG00000133110.
GeneID	10631.
KEGG	hsa:10631.
UCSC	uc001uwo.4. human. uc001uwp.4. human. uc001uwq.3. human. uc001uwr.3. human.
Organism-specific databases
CTD	10631.
GeneCards	GC13M038136.
HGNC	HGNC:16953. POSTN.
HPA	HPA012306.
MIM	608777. gene.
neXtProt	NX_Q15063.
PharmGKB	PA134900304.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2335.
HOGENOM	HOG000220865.
HOVERGEN	HBG000715.
InParanoid	Q15063.
OMA	IHGEPII.
PhylomeDB	Q15063.
Gene expression databases
ArrayExpress	Q15063.
Bgee	Q15063.
CleanEx	HS_POSTN.
Genevestigator	Q15063.
GermOnline	ENSG00000133110. Homo sapiens.
Family and domain databases
Gene3D	2.30.180.10. 4 hits.
InterPro	IPR011489. EMI_domain. IPR000782. FAS1_domain. IPR016666. TGFb-ind_bIGH3/osteoblast_fac2. [Graphical view]
Pfam	PF02469. Fasciclin. 4 hits. [Graphical view]
PIRSF	PIRSF016553. BIGH3_OSF2. 1 hit.
SMART	SM00554. FAS1. 4 hits. [Graphical view]
SUPFAM	SSF82153. BIgH3_FAS1. 4 hits.
PROSITE	PS51041. EMI. 1 hit. PS50213. FAS1. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	POSTN. human.
GenomeRNAi	10631.
NextBio	40399.
SOURCE	Search...

Entry information

Entry name

POSTN_HUMAN

Accession

Primary (citable) accession number: Q15063
Secondary accession number(s): Q15064 , Q29XZ0, Q3KPJ5, Q5VSY5, Q8IZF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	March 7, 2006
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.