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Protein

WD repeat-containing protein 43

Gene

WDR43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • dynein binding Source: GO_Central
  • microtubule binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
SignaLinkiQ15061.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 43
Alternative name(s):
U3 small nucleolar RNA-associated protein 5 homolog
Gene namesi
Name:WDR43
Synonyms:KIAA0007, UTP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28945. WDR43.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: GO_Central
  • centrosome Source: GO_Central
  • fibrillar center Source: UniProtKB
  • kinetochore Source: GO_Central
  • microtubule Source: GO_Central
  • microtubule associated complex Source: GO_Central
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914163.

Polymorphism and mutation databases

BioMutaiWDR43.
DMDMi158518532.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677WD repeat-containing protein 43PRO_0000051392Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771PhosphoserineCombined sources
Modified residuei394 – 3941PhosphothreonineCombined sources
Modified residuei399 – 3991PhosphoserineCombined sources
Modified residuei431 – 4311PhosphoserineCombined sources
Modified residuei437 – 4371PhosphoserineCombined sources
Modified residuei590 – 5901PhosphoserineCombined sources
Modified residuei656 – 6561PhosphothreonineCombined sources
Modified residuei658 – 6581PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15061.
MaxQBiQ15061.
PaxDbiQ15061.
PRIDEiQ15061.

2D gel databases

SWISS-2DPAGEQ15061.

PTM databases

iPTMnetiQ15061.
PhosphoSiteiQ15061.
SwissPalmiQ15061.

Expressioni

Gene expression databases

BgeeiQ15061.
CleanExiHS_WDR43.
ExpressionAtlasiQ15061. baseline and differential.
GenevisibleiQ15061. HS.

Organism-specific databases

HPAiHPA044733.

Interactioni

Subunit structurei

Forms a complex with UTP4, NOL11, UTP15 and WDR75.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116772. 22 interactions.
IntActiQ15061. 9 interactions.
MINTiMINT-2807123.
STRINGi9606.ENSP00000384302.

Structurei

3D structure databases

ProteinModelPortaliQ15061.
SMRiQ15061. Positions 20-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 5141WD 1Add
BLAST
Repeati57 – 11963WD 2Add
BLAST
Repeati124 – 16340WD 3Add
BLAST
Repeati166 – 20540WD 4Add
BLAST
Repeati207 – 25953WD 5Add
BLAST
Repeati267 – 30943WD 6Add
BLAST

Sequence similaritiesi

Belongs to the UTP5 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4547. Eukaryota.
ENOG410XRY4. LUCA.
GeneTreeiENSGT00390000004254.
HOGENOMiHOG000006569.
HOVERGENiHBG060012.
InParanoidiQ15061.
KOiK14546.
OMAiWQVRSEN.
OrthoDBiEOG76472K.
PhylomeDBiQ15061.
TreeFamiTF313160.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR007148. SSU_processome_Utp12.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04003. Utp12. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGGGGSCD PLAPAGVPCA FSPHSQAYFA LASTDGHLRV WETANNRLHQ
60 70 80 90 100
EYVPSAHLSG TCTCLAWAPA RLQAKESPQR KKRKSEAVGM SNQTDLLALG
110 120 130 140 150
TAVGSILLYS TVKGELHSKL ISGGHDNRVN CIQWHQDSGC LYSCSDDKHI
160 170 180 190 200
VEWNVQTCKV KCKWKGDNSS VSSLCISPDG KMLLSAGRTI KLWVLETKEV
210 220 230 240 250
YRHFTGHATP VSSLMFTTIR PPNESQPFDG ITGLYFLSGA VHDRLLNVWQ
260 270 280 290 300
VRSENKEKSA VMSFTVTDEP VYIDLTLSEN KEEPVKLAVV CRDGQVHLFE
310 320 330 340 350
HILNGYCKKP LTSNCTIQIA TPGKGKKSTP KPIPILAAGF CSDKMSLLLV
360 370 380 390 400
YGSWFQPTIE RVALNSREPH MCLVRDISNC WAPKVETAIT KVRTPVMNSE
410 420 430 440 450
AKVLVPGIPG HHAAIKPAPP QTEQVESKRK SGGNEVSIEE RLGAMDIDTH
460 470 480 490 500
KKGKEDLQTN SFPVLLTQGL ESNDFEMLNK VLQTRNVNLI KKTVLRMPLH
510 520 530 540 550
TIIPLLQELT KRLQGHPNSA VLMVQWLKCV LTVHASYLST LPDLVPQLGT
560 570 580 590 600
LYQLMESRVK TFQKLSHLHG KLILLITQVT ASEKTKGATS PGQKAKLVYE
610 620 630 640 650
EESSEEESDD EIADKDSEDN WDEDEEESES EKDEDVEEED EDAEGKDEEN
660 670
GEDRDTASEK ELNGDSDLDP ENESEEE
Length:677
Mass (Da):74,891
Last modified:July 24, 2007 - v3
Checksum:i4EEAD92C30118ACD
GO

Sequence cautioni

The sequence BAA05499.1 differs from that shown. Reason: Frameshift at positions 614 and 617. Curated
The sequence BAA05499.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26488 mRNA. Translation: BAA05499.1. Different initiation.
D87716 mRNA. Translation: BAA13441.1. Frameshift.
CCDSiCCDS46251.1.
RefSeqiNP_055946.1. NM_015131.2.
UniGeneiHs.622982.
Hs.709228.

Genome annotation databases

EnsembliENST00000407426; ENSP00000384302; ENSG00000163811.
GeneIDi23160.
KEGGihsa:23160.
UCSCiuc002rmo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26488 mRNA. Translation: BAA05499.1. Different initiation.
D87716 mRNA. Translation: BAA13441.1. Frameshift.
CCDSiCCDS46251.1.
RefSeqiNP_055946.1. NM_015131.2.
UniGeneiHs.622982.
Hs.709228.

3D structure databases

ProteinModelPortaliQ15061.
SMRiQ15061. Positions 20-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116772. 22 interactions.
IntActiQ15061. 9 interactions.
MINTiMINT-2807123.
STRINGi9606.ENSP00000384302.

PTM databases

iPTMnetiQ15061.
PhosphoSiteiQ15061.
SwissPalmiQ15061.

Polymorphism and mutation databases

BioMutaiWDR43.
DMDMi158518532.

2D gel databases

SWISS-2DPAGEQ15061.

Proteomic databases

EPDiQ15061.
MaxQBiQ15061.
PaxDbiQ15061.
PRIDEiQ15061.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000407426; ENSP00000384302; ENSG00000163811.
GeneIDi23160.
KEGGihsa:23160.
UCSCiuc002rmo.3. human.

Organism-specific databases

CTDi23160.
GeneCardsiWDR43.
HGNCiHGNC:28945. WDR43.
HPAiHPA044733.
MIMi616195. gene.
neXtProtiNX_Q15061.
PharmGKBiPA134914163.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4547. Eukaryota.
ENOG410XRY4. LUCA.
GeneTreeiENSGT00390000004254.
HOGENOMiHOG000006569.
HOVERGENiHBG060012.
InParanoidiQ15061.
KOiK14546.
OMAiWQVRSEN.
OrthoDBiEOG76472K.
PhylomeDBiQ15061.
TreeFamiTF313160.

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
SignaLinkiQ15061.

Miscellaneous databases

ChiTaRSiWDR43. human.
GenomeRNAii23160.
PROiQ15061.
SOURCEiSearch...

Gene expression databases

BgeeiQ15061.
CleanExiHS_WDR43.
ExpressionAtlasiQ15061. baseline and differential.
GenevisibleiQ15061. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR007148. SSU_processome_Utp12.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04003. Utp12. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
    Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
    DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-431, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-431, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; THR-394; SER-399; SER-431; THR-656 AND SER-658, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-431; SER-437; SER-590; THR-656 AND SER-658, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing."
    Freed E.F., Prieto J.L., McCann K.L., McStay B., Baserga S.J.
    PLoS Genet. 8:E1002892-E1002892(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN COMPLEX WITH UTP4; NOL11; UTP15 AND WDR75.
  10. "Interaction, mobility, and phosphorylation of human orthologues of WD repeat-containing components of the yeast SSU processome t-UTP sub-complex."
    Sato M., Araki N., Kumeta M., Takeyasu K., Taguchi Y., Asai T., Furukawa K., Horigome T.
    Biochem. Cell Biol. 91:466-475(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH UTP4 AND UTP15.

Entry informationi

Entry nameiWDR43_HUMAN
AccessioniPrimary (citable) accession number: Q15061
Secondary accession number(s): Q15395, Q92577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 24, 2007
Last modified: June 8, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.