Q15059 (BRD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bromodomain-containing protein 3

Alternative name(s):
RING3-like protein

Gene names

Name:	BRD3
Synonyms:	KIAA0043, RING3L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	726 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets By similarity. Regulates transcription of the CCND1 gene. Ref.7
Subunit structure	Interacts (via bromo domain 1) with GATA1 acetylated at 'Lys-312' and 'Lys-315'. Interacts (via bromo domain 1) with GATA2 acetylated on lysine residues By similarity. Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro). Ref.7 Ref.14
Subcellular location	Nucleus Probable. Note: Detected on chromatin By similarity.
Tissue specificity	Ubiquitous.
Involvement in disease	A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.
Sequence similarities	Contains 2 bromo domains. Contains 1 NET domain.
Sequence caution	The sequence BAA05393.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Domain	Bromodomain Coiled coil Repeat
Molecular function	Chromatin regulator
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.7. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	chromatin binding Inferred from direct assay Ref.7. Source: UniProtKB histone acetyl-lysine binding Inferred from direct assay Ref.14. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MYC	P01106	3	EBI-1383460,EBI-447544

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15059-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15059-2)

The sequence of this isoform differs from the canonical sequence as follows:
     549-556: QLKKGGKQ → DHFLTCGV
     557-726: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 726

726

Bromodomain-containing protein 3

PRO_0000211181

Regions

Domain

51 – 123

73

Bromo 1

Domain

326 – 398

73

Bromo 2

Domain

562 – 644

83

NET

Coiled coil

453 – 524

72

Potential

Coiled coil

645 – 684

40

Potential

Compositional bias

487 – 555

69

Lys-rich

Compositional bias

676 – 725

50

Ser-rich

Sites

Site

647 – 648

2

Breakpoint for translocation to form BDR3-NUT fusion protein

Amino acid modifications

Modified residue

263

1

Phosphoserine Ref.9 Ref.11 Ref.12

Modified residue

563

1

Phosphoserine Ref.9 Ref.12

Natural variations

Alternative sequence

549 – 556

8

QLKKGGKQ → DHFLTCGV in isoform 2.

VSP_010247

Alternative sequence

557 – 726

170

Missing in isoform 2.

VSP_010248

Natural variant

36

1

T → N in a renal clear cell carcinoma sample; somatic mutation. Ref.15

VAR_041913

Natural variant

161

1

A → T in a gastric adenocarcinoma sample; somatic mutation. Ref.15

VAR_041914

Natural variant

172

1

A → V. Ref.15
Corresponds to variant rs34609592 [ dbSNP | Ensembl ].

VAR_041915

Natural variant

435

1

K → Q. Ref.15
Corresponds to variant rs36093130 [ dbSNP | Ensembl ].

VAR_041916

Natural variant

441

1

R → H. Ref.15
Corresponds to variant rs56017928 [ dbSNP | Ensembl ].

VAR_041917

Natural variant

447

1

S → P. Ref.15
Corresponds to variant rs55754444 [ dbSNP | Ensembl ].

VAR_041918

Secondary structure

1

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726

Helix Strand Turn

Details...

Beta strand

29 – 31

3

Helix

37 – 44

8

Helix

46 – 52

7

Helix

57 – 59

3

Turn

65 – 69

5

Helix

73 – 76

4

Helix

83 – 91

9

Helix

98 – 115

18

Helix

121 – 137

17

Helix

310 – 323

14

Helix

325 – 327

3

Helix

328 – 331

4

Helix

332 – 334

3

Turn

340 – 344

5

Helix

348 – 351

4

Helix

358 – 366

9

Helix

373 – 390

18

Helix

396 – 413

18

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 64F526FC3C1033AA	FASTA	726	79,542
	10 20 30 40 50 60 MSTATTVAPA GIPATPGPVN PPPPEVSNPS KPGRKTNQLQ YMQNVVVKTL WKHQFAWPFY 70 80 90 100 110 120 QPVDAIKLNL PDYHKIIKNP MDMGTIKKRL ENNYYWSASE CMQDFNTMFT NCYIYNKPTD 130 140 150 160 170 180 DIVLMAQALE KIFLQKVAQM PQEEVELLPP APKGKGRKPA AGAQSAGTQQ VAAVSSVSPA 190 200 210 220 230 240 TPFQSVPPTV SQTPVIAATP VPTITANVTS VPVPPAAAPP PPATPIVPVV PPTPPVVKKK 250 260 270 280 290 300 GVKRKADTTT PTTSAITASR SESPPPLSDP KQAKVVARRE SGGRPIKPPK KDLEDGEVPQ 310 320 330 340 350 360 HAGKKGKLSE HLRYCDSILR EMLSKKHAAY AWPFYKPVDA EALELHDYHD IIKHPMDLST 370 380 390 400 410 420 VKRKMDGREY PDAQGFAADV RLMFSNCYKY NPPDHEVVAM ARKLQDVFEM RFAKMPDEPV 430 440 450 460 470 480 EAPALPAPAA PMVSKGAESS RSSEESSSDS GSSDSEEERA TRLAELQEQL KAVHEQLAAL 490 500 510 520 530 540 SQAPVNKPKK KKEKKEKEKK KKDKEKEKEK HKVKAEEEKK AKVAPPAKQA QQKKAPAKKA 550 560 570 580 590 600 NSTTTAGRQL KKGGKQASAS YDSEEEEEGL PMSYDEKRQL SLDINRLPGE KLGRVVHIIQ 610 620 630 640 650 660 SREPSLRDSN PDEIEIDFET LKPTTLRELE RYVKSCLQKK QRKPFSASGK KQAAKSKEEL 670 680 690 700 710 720 AQEKKKELEK RLQDVSGQLS SSKKPARKEK PGSAPSGGPS RLSSSSSSES GSSSSSGSSS DSSDSE
	Isoform 2 [UniParc]. Checksum: 8352F5DF1801A793	FASTA	556	60,942
	10 20 30 40 50 60 MSTATTVAPA GIPATPGPVN PPPPEVSNPS KPGRKTNQLQ YMQNVVVKTL WKHQFAWPFY 70 80 90 100 110 120 QPVDAIKLNL PDYHKIIKNP MDMGTIKKRL ENNYYWSASE CMQDFNTMFT NCYIYNKPTD 130 140 150 160 170 180 DIVLMAQALE KIFLQKVAQM PQEEVELLPP APKGKGRKPA AGAQSAGTQQ VAAVSSVSPA 190 200 210 220 230 240 TPFQSVPPTV SQTPVIAATP VPTITANVTS VPVPPAAAPP PPATPIVPVV PPTPPVVKKK 250 260 270 280 290 300 GVKRKADTTT PTTSAITASR SESPPPLSDP KQAKVVARRE SGGRPIKPPK KDLEDGEVPQ 310 320 330 340 350 360 HAGKKGKLSE HLRYCDSILR EMLSKKHAAY AWPFYKPVDA EALELHDYHD IIKHPMDLST 370 380 390 400 410 420 VKRKMDGREY PDAQGFAADV RLMFSNCYKY NPPDHEVVAM ARKLQDVFEM RFAKMPDEPV 430 440 450 460 470 480 EAPALPAPAA PMVSKGAESS RSSEESSSDS GSSDSEEERA TRLAELQEQL KAVHEQLAAL 490 500 510 520 530 540 SQAPVNKPKK KKEKKEKEKK KKDKEKEKEK HKVKAEEEKK AKVAPPAKQA QQKKAPAKKA 550 NSTTTAGRDH FLTCGV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1." Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S. DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[2]	"Differentially expressed genes in endothelial differentiation." Ishii H., Mimori K., Mori M., Vecchione A. DNA Cell Biol. 24:432-437(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Colon.
[6]	"Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene." Thorpe K.L., Gorman P., Thomas C., Sheer D., Trowsdale J., Beck S. Gene 200:177-183(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 363-726.
[7]	"The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription." LeRoy G., Rickards B., Flint S.J. Mol. Cell 30:51-60(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH ACETYLATED CHROMATIN.
[8]	"BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells." French C.A., Ramirez C.L., Kolmakova J., Hickman T.T., Cameron M.J., Thyne M.E., Kutok J.L., Toretsky J.A., Tadavarthy A.K., Kees U.R., Fletcher J.A., Aster J.C. Oncogene 27:2237-2242(2008) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH NUT.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263 AND SER-563, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263 AND SER-563, MASS SPECTROMETRY.
[13]	"Solution structure of the first and second bromodomain from human bromodomain containing protein 3." RIKEN structural genomics initiative (RSGI) Submitted (FEB-2009) to the PDB data bank Cited for: STRUCTURE BY NMR OF 25-415.
[14]	"Histone recognition and large-scale structural analysis of the human bromodomain family." Filippakopoulos P., Picaud S., Mangos M., Keates T., Lambert J.P., Barsyte-Lovejoy D., Felletar I., Volkmer R., Muller S., Pawson T., Gingras A.C., Arrowsmith C.H., Knapp S. Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.36 ANGSTROMS) OF 24-416, SUBUNIT, DOMAIN.
[15]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-36; THR-161; VAL-172; GLN-435; HIS-441 AND PRO-447.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D26362 mRNA. Translation: BAA05393.2. Different initiation.
AY513270 mRNA. Translation: AAS82952.1.
AL445931 Genomic DNA. Translation: CAI13726.1.
AL445931 Genomic DNA. Translation: CAI13727.1.
CH471090 Genomic DNA. Translation: EAW88113.1.
CH471090 Genomic DNA. Translation: EAW88114.1.
BC032124 mRNA. Translation: AAH32124.1.
Z81330 Genomic DNA. No translation available.

IPI

IPI00014266.
IPI00410716.

RefSeq

NP_031397.1. NM_007371.3.

UniGene

Hs.522472.
Hs.654869.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2E7N	NMR	-	A	306-415	[»]
2NXB	X-ray	1.40	A/B	24-144	[»]
2OO1	X-ray	1.70	A/B/C/D	306-416	[»]
2YW5	NMR	-	A	25-155	[»]
3S91	X-ray	2.06	A	24-144	[»]
3S92	X-ray	1.36	A	306-416	[»]

ProteinModelPortal

Q15059.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q15059. 1 interaction.

STRING

9606.ENSP00000305918.

PTM databases

PhosphoSite

Q15059.

Polymorphism databases

DMDM

12643726.

Proteomic databases

PaxDb

Q15059.

PRIDE

Q15059.

Protocols and materials databases

DNASU

8019.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000303407; ENSP00000305918; ENSG00000169925.
ENST00000357885; ENSP00000350557; ENSG00000169925.
ENST00000371834; ENSP00000360900; ENSG00000169925.

GeneID

8019.

KEGG

hsa:8019.

UCSC

uc004cew.3. human.
uc004cex.2. human.

Organism-specific databases

CTD

8019.

GeneCards

GC09M136897.

HGNC

HGNC:1104. BRD3.

HPA

HPA051830.

MIM

601541. gene.

neXtProt

NX_Q15059.

PharmGKB

PA25415.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5076.

HOGENOM

HOG000231200.

HOVERGEN

HBG004896.

InParanoid

Q15059.

KO

K11721.

OMA

NNNKKPA.

OrthoDB

EOG476K03.

Gene expression databases

ArrayExpress

Q15059.

Bgee

Q15059.

CleanEx

HS_BRD3.

Genevestigator

Q15059.

GermOnline

ENSG00000169925. Homo sapiens.

Family and domain databases

Gene3D

1.20.920.10. 2 hits.

InterPro

IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027353. NET_dom.
[Graphical view]

Pfam

PF00439. Bromodomain. 2 hits.
[Graphical view]

PRINTS

PR00503. BROMODOMAIN.

SMART

SM00297. BROMO. 2 hits.
[Graphical view]

SUPFAM

SSF47370. Bromodomain. 2 hits.

PROSITE

PS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
PS51525. NET. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q15059.

ChEMBL

CHEMBL1795186.

EvolutionaryTrace

Q15059.

GenomeRNAi

8019.

NextBio

30578.

SOURCE

Search...

Entry information

Entry name

BRD3_HUMAN

Accession

Primary (citable) accession number: Q15059
Secondary accession number(s): B1APD9 , Q4G5Y3, Q5T1R7, Q8N5M3, Q92645

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 122 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.