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Q15059

- BRD3_HUMAN

UniProt

Q15059 - BRD3_HUMAN

Protein

Bromodomain-containing protein 3

Gene

BRD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets By similarity. Regulates transcription of the CCND1 gene.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei647 – 6482Breakpoint for translocation to form BDR3-NUT fusion protein

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. lysine-acetylated histone binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bromodomain-containing protein 3
    Alternative name(s):
    RING3-like protein
    Gene namesi
    Name:BRD3
    Synonyms:KIAA0043, RING3L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:1104. BRD3.

    Subcellular locationi

    Nucleus Curated
    Note: Detected on chromatin.By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.

    Organism-specific databases

    PharmGKBiPA25415.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 726725Bromodomain-containing protein 3PRO_0000211181Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei263 – 2631Phosphoserine3 Publications
    Modified residuei563 – 5631Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ15059.
    PaxDbiQ15059.
    PRIDEiQ15059.

    PTM databases

    PhosphoSiteiQ15059.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ15059.
    BgeeiQ15059.
    CleanExiHS_BRD3.
    GenevestigatoriQ15059.

    Organism-specific databases

    HPAiHPA051830.

    Interactioni

    Subunit structurei

    Interacts (via bromo domain 1) with GATA1 acetylated at 'Lys-312' and 'Lys-315'. Interacts (via bromo domain 1) with GATA2 acetylated on lysine residues By similarity. Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro).By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MYCP011063EBI-1383460,EBI-447544

    Protein-protein interaction databases

    BioGridi113715. 9 interactions.
    DIPiDIP-39755N.
    IntActiQ15059. 3 interactions.
    MINTiMINT-3030809.
    STRINGi9606.ENSP00000305918.

    Structurei

    Secondary structure

    1
    726
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 313
    Helixi37 – 448
    Helixi46 – 527
    Helixi57 – 593
    Turni65 – 695
    Helixi73 – 764
    Helixi83 – 919
    Helixi98 – 11518
    Helixi121 – 13717
    Helixi310 – 32314
    Helixi325 – 3273
    Helixi328 – 3314
    Helixi332 – 3343
    Turni340 – 3445
    Helixi348 – 3514
    Helixi358 – 3669
    Helixi373 – 39018
    Helixi396 – 41318

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2E7NNMR-A306-415[»]
    2NXBX-ray1.40A/B24-144[»]
    2OO1X-ray1.70A/B/C/D307-416[»]
    2YW5NMR-A25-155[»]
    3S91X-ray2.06A24-144[»]
    3S92X-ray1.36A306-416[»]
    ProteinModelPortaliQ15059.
    SMRiQ15059. Positions 25-155, 307-416, 571-644.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ15059.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 12373Bromo 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini326 – 39873Bromo 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini562 – 64483NETPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili453 – 52472Sequence AnalysisAdd
    BLAST
    Coiled coili645 – 68440Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi487 – 55569Lys-richAdd
    BLAST
    Compositional biasi676 – 72550Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 bromo domains.PROSITE-ProRule annotation
    Contains 1 NET domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Bromodomain, Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG5076.
    HOGENOMiHOG000231200.
    HOVERGENiHBG004896.
    InParanoidiQ15059.
    KOiK11721.
    OMAiRHCDSIL.
    OrthoDBiEOG7TTQ86.
    PhylomeDBiQ15059.
    TreeFamiTF317345.

    Family and domain databases

    Gene3Di1.20.920.10. 2 hits.
    InterProiIPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR027353. NET_dom.
    [Graphical view]
    PfamiPF00439. Bromodomain. 2 hits.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 2 hits.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 2 hits.
    PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
    PS50014. BROMODOMAIN_2. 2 hits.
    PS51525. NET. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15059-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTATTVAPA GIPATPGPVN PPPPEVSNPS KPGRKTNQLQ YMQNVVVKTL    50
    WKHQFAWPFY QPVDAIKLNL PDYHKIIKNP MDMGTIKKRL ENNYYWSASE 100
    CMQDFNTMFT NCYIYNKPTD DIVLMAQALE KIFLQKVAQM PQEEVELLPP 150
    APKGKGRKPA AGAQSAGTQQ VAAVSSVSPA TPFQSVPPTV SQTPVIAATP 200
    VPTITANVTS VPVPPAAAPP PPATPIVPVV PPTPPVVKKK GVKRKADTTT 250
    PTTSAITASR SESPPPLSDP KQAKVVARRE SGGRPIKPPK KDLEDGEVPQ 300
    HAGKKGKLSE HLRYCDSILR EMLSKKHAAY AWPFYKPVDA EALELHDYHD 350
    IIKHPMDLST VKRKMDGREY PDAQGFAADV RLMFSNCYKY NPPDHEVVAM 400
    ARKLQDVFEM RFAKMPDEPV EAPALPAPAA PMVSKGAESS RSSEESSSDS 450
    GSSDSEEERA TRLAELQEQL KAVHEQLAAL SQAPVNKPKK KKEKKEKEKK 500
    KKDKEKEKEK HKVKAEEEKK AKVAPPAKQA QQKKAPAKKA NSTTTAGRQL 550
    KKGGKQASAS YDSEEEEEGL PMSYDEKRQL SLDINRLPGE KLGRVVHIIQ 600
    SREPSLRDSN PDEIEIDFET LKPTTLRELE RYVKSCLQKK QRKPFSASGK 650
    KQAAKSKEEL AQEKKKELEK RLQDVSGQLS SSKKPARKEK PGSAPSGGPS 700
    RLSSSSSSES GSSSSSGSSS DSSDSE 726
    Length:726
    Mass (Da):79,542
    Last modified:November 1, 1996 - v1
    Checksum:i64F526FC3C1033AA
    GO
    Isoform 2 (identifier: Q15059-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         549-556: QLKKGGKQ → DHFLTCGV
         557-726: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:556
    Mass (Da):60,942
    Checksum:i8352F5DF1801A793
    GO

    Sequence cautioni

    The sequence BAA05393.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti36 – 361T → N in a renal clear cell carcinoma sample; somatic mutation. 1 Publication
    VAR_041913
    Natural varianti161 – 1611A → T in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041914
    Natural varianti172 – 1721A → V.1 Publication
    Corresponds to variant rs34609592 [ dbSNP | Ensembl ].
    VAR_041915
    Natural varianti435 – 4351K → Q.1 Publication
    Corresponds to variant rs36093130 [ dbSNP | Ensembl ].
    VAR_041916
    Natural varianti441 – 4411R → H.1 Publication
    Corresponds to variant rs56017928 [ dbSNP | Ensembl ].
    VAR_041917
    Natural varianti447 – 4471S → P.1 Publication
    Corresponds to variant rs55754444 [ dbSNP | Ensembl ].
    VAR_041918

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei549 – 5568QLKKGGKQ → DHFLTCGV in isoform 2. 1 PublicationVSP_010247
    Alternative sequencei557 – 726170Missing in isoform 2. 1 PublicationVSP_010248Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26362 mRNA. Translation: BAA05393.2. Different initiation.
    AY513270 mRNA. Translation: AAS82952.1.
    AL445931 Genomic DNA. Translation: CAI13726.1.
    AL445931 Genomic DNA. Translation: CAI13727.1.
    CH471090 Genomic DNA. Translation: EAW88113.1.
    CH471090 Genomic DNA. Translation: EAW88114.1.
    BC032124 mRNA. Translation: AAH32124.1.
    Z81330 Genomic DNA. No translation available.
    CCDSiCCDS6980.1. [Q15059-1]
    RefSeqiNP_031397.1. NM_007371.3. [Q15059-1]
    XP_006717354.1. XM_006717291.1. [Q15059-1]
    UniGeneiHs.522472.
    Hs.654869.

    Genome annotation databases

    EnsembliENST00000303407; ENSP00000305918; ENSG00000169925. [Q15059-1]
    ENST00000371834; ENSP00000360900; ENSG00000169925. [Q15059-2]
    GeneIDi8019.
    KEGGihsa:8019.
    UCSCiuc004cew.3. human. [Q15059-1]
    uc004cex.2. human. [Q15059-2]

    Polymorphism databases

    DMDMi12643726.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26362 mRNA. Translation: BAA05393.2 . Different initiation.
    AY513270 mRNA. Translation: AAS82952.1 .
    AL445931 Genomic DNA. Translation: CAI13726.1 .
    AL445931 Genomic DNA. Translation: CAI13727.1 .
    CH471090 Genomic DNA. Translation: EAW88113.1 .
    CH471090 Genomic DNA. Translation: EAW88114.1 .
    BC032124 mRNA. Translation: AAH32124.1 .
    Z81330 Genomic DNA. No translation available.
    CCDSi CCDS6980.1. [Q15059-1 ]
    RefSeqi NP_031397.1. NM_007371.3. [Q15059-1 ]
    XP_006717354.1. XM_006717291.1. [Q15059-1 ]
    UniGenei Hs.522472.
    Hs.654869.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2E7N NMR - A 306-415 [» ]
    2NXB X-ray 1.40 A/B 24-144 [» ]
    2OO1 X-ray 1.70 A/B/C/D 307-416 [» ]
    2YW5 NMR - A 25-155 [» ]
    3S91 X-ray 2.06 A 24-144 [» ]
    3S92 X-ray 1.36 A 306-416 [» ]
    ProteinModelPortali Q15059.
    SMRi Q15059. Positions 25-155, 307-416, 571-644.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113715. 9 interactions.
    DIPi DIP-39755N.
    IntActi Q15059. 3 interactions.
    MINTi MINT-3030809.
    STRINGi 9606.ENSP00000305918.

    Chemistry

    BindingDBi Q15059.
    ChEMBLi CHEMBL1795186.
    GuidetoPHARMACOLOGYi 2725.

    PTM databases

    PhosphoSitei Q15059.

    Polymorphism databases

    DMDMi 12643726.

    Proteomic databases

    MaxQBi Q15059.
    PaxDbi Q15059.
    PRIDEi Q15059.

    Protocols and materials databases

    DNASUi 8019.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303407 ; ENSP00000305918 ; ENSG00000169925 . [Q15059-1 ]
    ENST00000371834 ; ENSP00000360900 ; ENSG00000169925 . [Q15059-2 ]
    GeneIDi 8019.
    KEGGi hsa:8019.
    UCSCi uc004cew.3. human. [Q15059-1 ]
    uc004cex.2. human. [Q15059-2 ]

    Organism-specific databases

    CTDi 8019.
    GeneCardsi GC09M136897.
    HGNCi HGNC:1104. BRD3.
    HPAi HPA051830.
    MIMi 601541. gene.
    neXtProti NX_Q15059.
    PharmGKBi PA25415.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5076.
    HOGENOMi HOG000231200.
    HOVERGENi HBG004896.
    InParanoidi Q15059.
    KOi K11721.
    OMAi RHCDSIL.
    OrthoDBi EOG7TTQ86.
    PhylomeDBi Q15059.
    TreeFami TF317345.

    Miscellaneous databases

    EvolutionaryTracei Q15059.
    GeneWikii BRD3.
    GenomeRNAii 8019.
    NextBioi 30578.
    PROi Q15059.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15059.
    Bgeei Q15059.
    CleanExi HS_BRD3.
    Genevestigatori Q15059.

    Family and domain databases

    Gene3Di 1.20.920.10. 2 hits.
    InterProi IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR027353. NET_dom.
    [Graphical view ]
    Pfami PF00439. Bromodomain. 2 hits.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 2 hits.
    PROSITEi PS00633. BROMODOMAIN_1. 2 hits.
    PS50014. BROMODOMAIN_2. 2 hits.
    PS51525. NET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
      Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
      DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    2. "Differentially expressed genes in endothelial differentiation."
      Ishii H., Mimori K., Mori M., Vecchione A.
      DNA Cell Biol. 24:432-437(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Colon.
    6. "Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene."
      Thorpe K.L., Gorman P., Thomas C., Sheer D., Trowsdale J., Beck S.
      Gene 200:177-183(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 363-726.
    7. "The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription."
      LeRoy G., Rickards B., Flint S.J.
      Mol. Cell 30:51-60(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ACETYLATED CHROMATIN.
    8. "BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells."
      French C.A., Ramirez C.L., Kolmakova J., Hickman T.T., Cameron M.J., Thyne M.E., Kutok J.L., Toretsky J.A., Tadavarthy A.K., Kees U.R., Fletcher J.A., Aster J.C.
      Oncogene 27:2237-2242(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION WITH NUT.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263 AND SER-563, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263 AND SER-563, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Solution structure of the first and second bromodomain from human bromodomain containing protein 3."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 25-415.
    15. Cited for: X-RAY CRYSTALLOGRAPHY (1.36 ANGSTROMS) OF 24-416, SUBUNIT, DOMAIN.
    16. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-36; THR-161; VAL-172; GLN-435; HIS-441 AND PRO-447.

    Entry informationi

    Entry nameiBRD3_HUMAN
    AccessioniPrimary (citable) accession number: Q15059
    Secondary accession number(s): B1APD9
    , Q4G5Y3, Q5T1R7, Q8N5M3, Q92645
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3