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Q15052

- ARHG6_HUMAN

UniProt

Q15052 - ARHG6_HUMAN

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Protein

Rho guanine nucleotide exchange factor 6

Gene
ARHGEF6, COOL2, KIAA0006, PIXA
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a RAC1 guanine nucleotide exchange factor (GEF).

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. Rho guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB
  2. apoptotic signaling pathway Source: Reactome
  3. cell junction assembly Source: Reactome
  4. JNK cascade Source: UniProtKB
  5. lamellipodium assembly Source: UniProtKB
  6. neurotrophin TRK receptor signaling pathway Source: Reactome
  7. positive regulation of apoptotic process Source: Reactome
  8. positive regulation of GTPase activity Source: GOC
  9. regulation of Rho GTPase activity Source: GOC
  10. regulation of small GTPase mediated signal transduction Source: Reactome
  11. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.
REACT_20580. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 6
Alternative name(s):
Alpha-Pix
COOL-2
PAK-interacting exchange factor alpha
Rac/Cdc42 guanine nucleotide exchange factor 6
Gene namesi
Name:ARHGEF6
Synonyms:COOL2, KIAA0006, PIXA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:685. ARHGEF6.

Subcellular locationi

Cell projectionlamellipodium By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. intracellular Source: UniProtKB
  3. lamellipodium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked 46 (MRX46) [MIM:300436]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Mental retardation

Organism-specific databases

MIMi300436. phenotype.
Orphaneti777. X-linked non-syndromic intellectual disability.
PharmGKBiPA24976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 776776Rho guanine nucleotide exchange factor 6PRO_0000080917Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei126 – 1261Phosphoserine1 Publication
Modified residuei144 – 1441Phosphoserine1 Publication
Modified residuei150 – 1501Phosphoserine2 Publications
Modified residuei488 – 4881Phosphoserine By similarity
Modified residuei640 – 6401Phosphoserine1 Publication
Modified residuei684 – 6841Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15052.
PaxDbiQ15052.
PRIDEiQ15052.

PTM databases

PhosphoSiteiQ15052.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ15052.
BgeeiQ15052.
CleanExiHS_ARHGEF6.
GenevestigatoriQ15052.

Organism-specific databases

HPAiHPA003578.

Interactioni

Subunit structurei

Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1 By similarity. Interacts with PARVB. Interacts with BIN2. Identified in a complex with BIN2 and GIT2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NAA10P412273EBI-1642523,EBI-747693
PAK2Q131772EBI-1642523,EBI-1045887
SH2D1AO608802EBI-1642523,EBI-6983382

Protein-protein interaction databases

BioGridi114847. 18 interactions.
IntActiQ15052. 15 interactions.
MINTiMINT-2791937.
STRINGi9606.ENSP00000250617.

Structurei

Secondary structure

1
776
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1411
Helixi27 – 3711
Helixi39 – 4810
Helixi63 – 8018
Helixi87 – 915
Helixi96 – 11015
Beta strandi163 – 1664
Beta strandi187 – 1915
Beta strandi194 – 1963
Beta strandi198 – 2025
Beta strandi205 – 2095
Turni211 – 2133
Beta strandi214 – 2163
Helixi219 – 2224

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UJYNMR-A160-222[»]
1WYRNMR-A4-111[»]
ProteinModelPortaliQ15052.
SMRiQ15052. Positions 4-111, 154-552, 711-762.

Miscellaneous databases

EvolutionaryTraceiQ15052.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 110110CHAdd
BLAST
Domaini160 – 21960SH3Add
BLAST
Domaini241 – 421181DHAdd
BLAST
Domaini443 – 548106PHAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG314429.
HOGENOMiHOG000231381.
HOVERGENiHBG050569.
InParanoidiQ15052.
KOiK05729.
OMAiNKATEDQ.
OrthoDBiEOG708W04.
PhylomeDBiQ15052.
TreeFamiTF316105.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001715. CH-domain.
IPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q15052-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNPEEQIVTW LISLGVLESP KKTICDPEEF LKSSLKNGVV LCKLINRLMP    50
GSVEKFCLDP QTEADCINNI NDFLKGCATL QVEIFDPDDL YSGVNFSKVL 100
STLLAVNKAT EDQLSERPCG RSSSLSAANT SQTNPQGAVS STVSGLQRQS 150
KTVEMTENGS HQLIVKARFN FKQTNEDELS VCKGDIIYVT RVEEGGWWEG 200
TLNGRTGWFP SNYVREIKSS ERPLSPKAVK GFETAPLTKN YYTVVLQNIL 250
DTEKEYAKEL QSLLVTYLRP LQSNNNLSTV EVTSLLGNFE EVCTFQQTLC 300
QALEECSKFP ENQHKVGGCL LSLMPHFKSM YLAYCANHPS AVNVLTQHSD 350
ELEQFMENQG ASSPGILILT TNLSKPFMRL EKYVTLLQEL ERHMEDTHPD 400
HQDILKAIVA FKTLMGQCQD LRKRKQLELQ ILSEPIQAWE GEDIKNLGNV 450
IFMSQVMVQY GACEEKEERY LMLFSNVLIM LSASPRMSGF IYQGKIPIAG 500
TVVTRLDEIE GNDCTFEITG NTVERIVVHC NNNQDFQEWL EQLNRLIRGP 550
ASCSSLSKTS SSSCSAHSSF SSTGQPRGPL EPPQIIKPWS LSCLRPAPPL 600
RPSAALGYKE RMSYILKESS KSPKTMKKFL HKRKTERKPS EEEYVIRKST 650
AALEEDAQIL KVIEAYCTSA NFQQGHGSST RKDSIPQVLL PEEEKLIIEE 700
TRSNGQTIME EKSLVDTVYA LKDEVRELKQ ENKRMKQCLE EELKSRRDLE 750
KLVRRLLKQT DECIRGESSS KTSILP 776
Length:776
Mass (Da):87,499
Last modified:September 26, 2001 - v2
Checksum:i5D2622314E46341B
GO
Isoform 2 (identifier: Q15052-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.

Show »
Length:622
Mass (Da):70,791
Checksum:iB336793DC9A235ED
GO

Sequence cautioni

The sequence BAA02796.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti297 – 2971Q → H.
Corresponds to variant rs5974620 [ dbSNP | Ensembl ].
VAR_051981

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 154154Missing in isoform 2. VSP_015782Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti199 – 1991E → G in CAD97632. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK291742 mRNA. Translation: BAF84431.1.
AK294929 mRNA. Translation: BAH11929.1.
BX537390 mRNA. Translation: CAD97632.1.
AL683813, AL135783 Genomic DNA. Translation: CAI39443.1.
AL135783, AL683813 Genomic DNA. Translation: CAI42899.1.
AL135783 Genomic DNA. Translation: CAI42903.1.
CH471150 Genomic DNA. Translation: EAW88460.1.
CH471150 Genomic DNA. Translation: EAW88461.1.
BC039856 mRNA. Translation: AAH39856.1.
BC043505 mRNA. Translation: AAH43505.1. Different termination.
AF207831 mRNA. Translation: AAG27169.1.
D13631 mRNA. Translation: BAA02796.1. Different initiation.
D25304 mRNA. Translation: BAA04985.1.
CCDSiCCDS14660.1. [Q15052-1]
RefSeqiNP_004831.1. NM_004840.2. [Q15052-1]
XP_005262558.1. XM_005262501.1. [Q15052-2]
UniGeneiHs.522795.

Genome annotation databases

EnsembliENST00000250617; ENSP00000250617; ENSG00000129675. [Q15052-1]
ENST00000370620; ENSP00000359654; ENSG00000129675. [Q15052-2]
ENST00000370622; ENSP00000359656; ENSG00000129675. [Q15052-2]
GeneIDi9459.
KEGGihsa:9459.
UCSCiuc004fab.3. human. [Q15052-1]

Polymorphism databases

DMDMi17371603.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK291742 mRNA. Translation: BAF84431.1 .
AK294929 mRNA. Translation: BAH11929.1 .
BX537390 mRNA. Translation: CAD97632.1 .
AL683813 , AL135783 Genomic DNA. Translation: CAI39443.1 .
AL135783 , AL683813 Genomic DNA. Translation: CAI42899.1 .
AL135783 Genomic DNA. Translation: CAI42903.1 .
CH471150 Genomic DNA. Translation: EAW88460.1 .
CH471150 Genomic DNA. Translation: EAW88461.1 .
BC039856 mRNA. Translation: AAH39856.1 .
BC043505 mRNA. Translation: AAH43505.1 . Different termination.
AF207831 mRNA. Translation: AAG27169.1 .
D13631 mRNA. Translation: BAA02796.1 . Different initiation.
D25304 mRNA. Translation: BAA04985.1 .
CCDSi CCDS14660.1. [Q15052-1 ]
RefSeqi NP_004831.1. NM_004840.2. [Q15052-1 ]
XP_005262558.1. XM_005262501.1. [Q15052-2 ]
UniGenei Hs.522795.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UJY NMR - A 160-222 [» ]
1WYR NMR - A 4-111 [» ]
ProteinModelPortali Q15052.
SMRi Q15052. Positions 4-111, 154-552, 711-762.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114847. 18 interactions.
IntActi Q15052. 15 interactions.
MINTi MINT-2791937.
STRINGi 9606.ENSP00000250617.

PTM databases

PhosphoSitei Q15052.

Polymorphism databases

DMDMi 17371603.

Proteomic databases

MaxQBi Q15052.
PaxDbi Q15052.
PRIDEi Q15052.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000250617 ; ENSP00000250617 ; ENSG00000129675 . [Q15052-1 ]
ENST00000370620 ; ENSP00000359654 ; ENSG00000129675 . [Q15052-2 ]
ENST00000370622 ; ENSP00000359656 ; ENSG00000129675 . [Q15052-2 ]
GeneIDi 9459.
KEGGi hsa:9459.
UCSCi uc004fab.3. human. [Q15052-1 ]

Organism-specific databases

CTDi 9459.
GeneCardsi GC0XM135747.
HGNCi HGNC:685. ARHGEF6.
HPAi HPA003578.
MIMi 300267. gene.
300436. phenotype.
neXtProti NX_Q15052.
Orphaneti 777. X-linked non-syndromic intellectual disability.
PharmGKBi PA24976.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314429.
HOGENOMi HOG000231381.
HOVERGENi HBG050569.
InParanoidi Q15052.
KOi K05729.
OMAi NKATEDQ.
OrthoDBi EOG708W04.
PhylomeDBi Q15052.
TreeFami TF316105.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.
REACT_20580. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.

Miscellaneous databases

ChiTaRSi ARHGEF6. human.
EvolutionaryTracei Q15052.
GeneWikii ARHGEF6.
GenomeRNAii 9459.
NextBioi 35442.
PROi Q15052.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15052.
Bgeei Q15052.
CleanExi HS_ARHGEF6.
Genevestigatori Q15052.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR001715. CH-domain.
IPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
IPR003096. SM22_calponin.
[Graphical view ]
Pfami PF00307. CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
PR00888. SM22CALPONIN.
SMARTi SM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50021. CH. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adipose tissue.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  6. "Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation."
    Kutsche K., Yntema H., Brandt A., Jantke I., Nothwang H.G., Orth U., Boavida M.G., David D., Chelly J., Fryns J.-P., Moraine C., Ropers H.-H., Hamel B.C.J., van Bokhoven H., Gal A.
    Nat. Genet. 26:247-250(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-3 (ISOFORM 1), DISEASE.
  7. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
    Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
    DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-776 (ISOFORM 1).
    Tissue: Bone marrow.
  8. "Characterization of ARHGEF6, a guanine nucleotide exchange factor for Rho GTPases and a candidate gene for X-linked mental retardation: mutation screening in Borjeson-Forssman-Lehmann syndrome and MRX27."
    Lower K.M., Gecz J.
    Am. J. Med. Genet. 100:43-48(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  9. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-150, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor."
    Mishima W., Suzuki A., Yamaji S., Yoshimi R., Ueda A., Kaneko T., Tanaka J., Miwa Y., Ohno S., Ishigatsubo Y.
    Genes Cells 9:193-204(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PARVB.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126; SER-144; SER-150; SER-640 AND SER-684, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis."
    Sanchez-Barrena M.J., Vallis Y., Clatworthy M.R., Doherty G.J., Veprintsev D.B., Evans P.R., McMahon H.T.
    PLoS ONE 7:E52401-E52401(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BIN2, IDENTIFICATION IN A COMPLEX WITH BIN2 AND GIT2.
  13. "Solution structure of the CH domain and the SH3 domain in RAC/CDC42 guanine nucleotide exchange factor (GEF) 6."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 4-222.

Entry informationi

Entry nameiARHG6_HUMAN
AccessioniPrimary (citable) accession number: Q15052
Secondary accession number(s): A6NMW9
, A8K6S7, B1AL37, Q15396, Q5JQ66, Q7Z3W1, Q86XH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: September 3, 2014
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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