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Protein

Ribosome biogenesis regulatory protein homolog

Gene

RRS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.1 Publication

GO - Molecular functioni

  • 5S rRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
  • hematopoietic progenitor cell differentiation Source: Ensembl
  • mitotic metaphase plate congression Source: UniProtKB
  • protein localization to nucleolus Source: UniProtKB
  • regulation of signal transduction by p53 class mediator Source: UniProtKB
  • ribosomal large subunit assembly Source: UniProtKB
  • ribosomal large subunit biogenesis Source: UniProtKB
  • ribosomal large subunit export from nucleus Source: GO_Central

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis regulatory protein homolog
Gene namesi
Name:RRS1
Synonyms:KIAA0112, RRR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000179041.3.
HGNCiHGNC:17083. RRS1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23212.
OpenTargetsiENSG00000179041.
PharmGKBiPA134993138.

Polymorphism and mutation databases

BioMutaiRRS1.
DMDMi21431847.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001853741 – 365Ribosome biogenesis regulatory protein homologAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei5PhosphoserineCombined sources1
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei273CitrullineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15050.
MaxQBiQ15050.
PaxDbiQ15050.
PeptideAtlasiQ15050.
PRIDEiQ15050.
TopDownProteomicsiQ15050.

2D gel databases

SWISS-2DPAGEiQ15050.

PTM databases

iPTMnetiQ15050.
PhosphoSitePlusiQ15050.

Expressioni

Gene expression databases

BgeeiENSG00000179041.
CleanExiHS_RRS1.
GenevisibleiQ15050. HS.

Organism-specific databases

HPAiHPA055549.
HPA060937.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926248EBI-749186,EBI-743771

Protein-protein interaction databases

BioGridi116819. 193 interactors.
IntActiQ15050. 8 interactors.
MINTiMINT-1485279.
STRINGi9606.ENSP00000322396.

Structurei

3D structure databases

ProteinModelPortaliQ15050.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi302 – 365Arg/Gly/Lys-richAdd BLAST64

Sequence similaritiesi

Belongs to the RRS1 family.Curated

Phylogenomic databases

eggNOGiKOG1765. Eukaryota.
COG5225. LUCA.
GeneTreeiENSGT00390000005213.
HOGENOMiHOG000017552.
HOVERGENiHBG036121.
InParanoidiQ15050.
KOiK14852.
OMAiKWEKFAK.
OrthoDBiEOG091G0I2Z.
PhylomeDBiQ15050.
TreeFamiTF313067.

Family and domain databases

InterProiView protein in InterPro
IPR007023. Ribosom_reg.
PANTHERiPTHR17602. PTHR17602. 1 hit.
PfamiView protein in Pfam
PF04939. RRS1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGQSVEELL AKAEQDEAEK LQRITVHKEL ELQFDLGNLL ASDRNPPTGL
60 70 80 90 100
RCAGPTPEAE LQALARDNTQ LLINQLWQLP TERVEEAIVA RLPEPTTRLP
110 120 130 140 150
REKPLPRPRP LTRWQQFARL KGIRPKKKTN LVWDEVSGQW RRRWGYQRAR
160 170 180 190 200
DDTKEWLIEV PGNADPLEDQ FAKRIQAKKE RVAKNELNRL RNLARAHKMQ
210 220 230 240 250
LPSAAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP KEKVPRGSGK
260 270 280 290 300
KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP QLDVTRATNK QMREEDQEEA
310 320 330 340 350
AKRRKMSQKG KRKGGRQGPG GKRKGGPPSQ GGKRKGGLGG KMNSGPPGLG
360
GKRKGGQRPG GKRRK
Length:365
Mass (Da):41,193
Last modified:June 6, 2002 - v2
Checksum:i061C3A6174C2E7C2
GO

Sequence cautioni

The sequence BAA04948 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051887116Q → H. Corresponds to variant dbSNP:rs34077648Ensembl.1
Natural variantiVAR_051888126K → R. Corresponds to variant dbSNP:rs3739335Ensembl.1
Natural variantiVAR_020484191R → L. Corresponds to variant dbSNP:rs3739336Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25218 mRNA. Translation: BAA04948.1. Different initiation.
BC001811 mRNA. Translation: AAH01811.1.
BC013043 mRNA. Translation: AAH13043.1.
CCDSiCCDS6189.1.
RefSeqiNP_055984.1. NM_015169.3.
UniGeneiHs.71827.

Genome annotation databases

EnsembliENST00000320270; ENSP00000322396; ENSG00000179041.
GeneIDi23212.
KEGGihsa:23212.
UCSCiuc003xwa.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRRS1_HUMAN
AccessioniPrimary (citable) accession number: Q15050
Secondary accession number(s): Q9BUX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 6, 2002
Last modified: September 27, 2017
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families