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Q15050

- RRS1_HUMAN

UniProt

Q15050 - RRS1_HUMAN

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Protein
Ribosome biogenesis regulatory protein homolog
Gene
RRS1, KIAA0112, RRR
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in ribosome biogenesis By similarity.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. mitotic metaphase plate congression Source: UniProtKB
  2. ribosome biogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis regulatory protein homolog
Gene namesi
Name:RRS1
Synonyms:KIAA0112, RRR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:17083. RRS1.

Subcellular locationi

Nucleusnucleolus 2 Publications

GO - Cellular componenti

  1. condensed nuclear chromosome Source: UniProtKB
  2. endoplasmic reticulum Source: Ensembl
  3. nucleolus Source: UniProtKB
  4. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134993138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Ribosome biogenesis regulatory protein homolog
PRO_0000185374Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine4 Publications
Modified residuei273 – 2731Citrulline By similarity

Post-translational modificationi

Citrullinated by PADI4 By similarity.

Keywords - PTMi

Acetylation, Citrullination

Proteomic databases

MaxQBiQ15050.
PaxDbiQ15050.
PeptideAtlasiQ15050.
PRIDEiQ15050.

2D gel databases

SWISS-2DPAGEQ15050.

PTM databases

PhosphoSiteiQ15050.

Expressioni

Gene expression databases

BgeeiQ15050.
CleanExiHS_RRS1.
GenevestigatoriQ15050.

Organism-specific databases

HPAiHPA055549.

Interactioni

Protein-protein interaction databases

BioGridi116819. 49 interactions.
IntActiQ15050. 3 interactions.
MINTiMINT-1485279.
STRINGi9606.ENSP00000322396.

Structurei

3D structure databases

ProteinModelPortaliQ15050.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi302 – 36564Arg/Gly/Lys-rich
Add
BLAST

Sequence similaritiesi

Belongs to the RRS1 family.

Phylogenomic databases

eggNOGiCOG5225.
HOGENOMiHOG000017552.
HOVERGENiHBG036121.
InParanoidiQ15050.
KOiK14852.
OMAiRWGYKRA.
OrthoDBiEOG73NG4D.
PhylomeDBiQ15050.
TreeFamiTF313067.

Family and domain databases

InterProiIPR007023. Ribosom_reg.
[Graphical view]
PANTHERiPTHR17602. PTHR17602. 1 hit.
PfamiPF04939. RRS1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15050-1 [UniParc]FASTAAdd to Basket

« Hide

MEGQSVEELL AKAEQDEAEK LQRITVHKEL ELQFDLGNLL ASDRNPPTGL    50
RCAGPTPEAE LQALARDNTQ LLINQLWQLP TERVEEAIVA RLPEPTTRLP 100
REKPLPRPRP LTRWQQFARL KGIRPKKKTN LVWDEVSGQW RRRWGYQRAR 150
DDTKEWLIEV PGNADPLEDQ FAKRIQAKKE RVAKNELNRL RNLARAHKMQ 200
LPSAAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP KEKVPRGSGK 250
KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP QLDVTRATNK QMREEDQEEA 300
AKRRKMSQKG KRKGGRQGPG GKRKGGPPSQ GGKRKGGLGG KMNSGPPGLG 350
GKRKGGQRPG GKRRK 365
Length:365
Mass (Da):41,193
Last modified:June 6, 2002 - v2
Checksum:i061C3A6174C2E7C2
GO

Sequence cautioni

The sequence BAA04948.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti116 – 1161Q → H.
Corresponds to variant rs34077648 [ dbSNP | Ensembl ].
VAR_051887
Natural varianti126 – 1261K → R.
Corresponds to variant rs3739335 [ dbSNP | Ensembl ].
VAR_051888
Natural varianti191 – 1911R → L.
Corresponds to variant rs3739336 [ dbSNP | Ensembl ].
VAR_020484

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D25218 mRNA. Translation: BAA04948.1. Different initiation.
BC001811 mRNA. Translation: AAH01811.1.
BC013043 mRNA. Translation: AAH13043.1.
CCDSiCCDS6189.1.
RefSeqiNP_055984.1. NM_015169.3.
UniGeneiHs.71827.

Genome annotation databases

EnsembliENST00000320270; ENSP00000322396; ENSG00000179041.
GeneIDi23212.
KEGGihsa:23212.
UCSCiuc003xwa.3. human.

Polymorphism databases

DMDMi21431847.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D25218 mRNA. Translation: BAA04948.1 . Different initiation.
BC001811 mRNA. Translation: AAH01811.1 .
BC013043 mRNA. Translation: AAH13043.1 .
CCDSi CCDS6189.1.
RefSeqi NP_055984.1. NM_015169.3.
UniGenei Hs.71827.

3D structure databases

ProteinModelPortali Q15050.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116819. 49 interactions.
IntActi Q15050. 3 interactions.
MINTi MINT-1485279.
STRINGi 9606.ENSP00000322396.

PTM databases

PhosphoSitei Q15050.

Polymorphism databases

DMDMi 21431847.

2D gel databases

SWISS-2DPAGE Q15050.

Proteomic databases

MaxQBi Q15050.
PaxDbi Q15050.
PeptideAtlasi Q15050.
PRIDEi Q15050.

Protocols and materials databases

DNASUi 23212.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320270 ; ENSP00000322396 ; ENSG00000179041 .
GeneIDi 23212.
KEGGi hsa:23212.
UCSCi uc003xwa.3. human.

Organism-specific databases

CTDi 23212.
GeneCardsi GC08P067341.
HGNCi HGNC:17083. RRS1.
HPAi HPA055549.
neXtProti NX_Q15050.
PharmGKBi PA134993138.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5225.
HOGENOMi HOG000017552.
HOVERGENi HBG036121.
InParanoidi Q15050.
KOi K14852.
OMAi RWGYKRA.
OrthoDBi EOG73NG4D.
PhylomeDBi Q15050.
TreeFami TF313067.

Miscellaneous databases

ChiTaRSi RRS1. human.
GeneWikii RRS1.
GenomeRNAii 23212.
NextBioi 44767.
PROi Q15050.

Gene expression databases

Bgeei Q15050.
CleanExi HS_RRS1.
Genevestigatori Q15050.

Family and domain databases

InterProi IPR007023. Ribosom_reg.
[Graphical view ]
PANTHERi PTHR17602. PTHR17602. 1 hit.
Pfami PF04939. RRS1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
    DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Uterus.
  3. Bienvenut W.V.
    Submitted (AUG-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-12; 92-98; 129-141; 254-265; 267-273 AND 342-352, ACETYLATION AT MET-1, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRRS1_HUMAN
AccessioniPrimary (citable) accession number: Q15050
Secondary accession number(s): Q9BUX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 6, 2002
Last modified: September 3, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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