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Q15050

- RRS1_HUMAN

UniProt

Q15050 - RRS1_HUMAN

Protein

Ribosome biogenesis regulatory protein homolog

Gene

RRS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Involved in ribosome biogenesis.By similarity

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. mitotic metaphase plate congression Source: UniProtKB
    2. ribosome biogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Ribosome biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosome biogenesis regulatory protein homolog
    Gene namesi
    Name:RRS1
    Synonyms:KIAA0112, RRR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:17083. RRS1.

    Subcellular locationi

    Nucleusnucleolus 2 Publications

    GO - Cellular componenti

    1. condensed nuclear chromosome Source: UniProtKB
    2. endoplasmic reticulum Source: Ensembl
    3. nucleolus Source: UniProtKB
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134993138.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 365365Ribosome biogenesis regulatory protein homologPRO_0000185374Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine4 Publications
    Modified residuei273 – 2731CitrullineBy similarity

    Post-translational modificationi

    Citrullinated by PADI4.By similarity

    Keywords - PTMi

    Acetylation, Citrullination

    Proteomic databases

    MaxQBiQ15050.
    PaxDbiQ15050.
    PeptideAtlasiQ15050.
    PRIDEiQ15050.

    2D gel databases

    SWISS-2DPAGEQ15050.

    PTM databases

    PhosphoSiteiQ15050.

    Expressioni

    Gene expression databases

    BgeeiQ15050.
    CleanExiHS_RRS1.
    GenevestigatoriQ15050.

    Organism-specific databases

    HPAiHPA055549.

    Interactioni

    Protein-protein interaction databases

    BioGridi116819. 49 interactions.
    IntActiQ15050. 3 interactions.
    MINTiMINT-1485279.
    STRINGi9606.ENSP00000322396.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15050.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi302 – 36564Arg/Gly/Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RRS1 family.Curated

    Phylogenomic databases

    eggNOGiCOG5225.
    HOGENOMiHOG000017552.
    HOVERGENiHBG036121.
    InParanoidiQ15050.
    KOiK14852.
    OMAiRWGYKRA.
    OrthoDBiEOG73NG4D.
    PhylomeDBiQ15050.
    TreeFamiTF313067.

    Family and domain databases

    InterProiIPR007023. Ribosom_reg.
    [Graphical view]
    PANTHERiPTHR17602. PTHR17602. 1 hit.
    PfamiPF04939. RRS1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15050-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGQSVEELL AKAEQDEAEK LQRITVHKEL ELQFDLGNLL ASDRNPPTGL    50
    RCAGPTPEAE LQALARDNTQ LLINQLWQLP TERVEEAIVA RLPEPTTRLP 100
    REKPLPRPRP LTRWQQFARL KGIRPKKKTN LVWDEVSGQW RRRWGYQRAR 150
    DDTKEWLIEV PGNADPLEDQ FAKRIQAKKE RVAKNELNRL RNLARAHKMQ 200
    LPSAAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP KEKVPRGSGK 250
    KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP QLDVTRATNK QMREEDQEEA 300
    AKRRKMSQKG KRKGGRQGPG GKRKGGPPSQ GGKRKGGLGG KMNSGPPGLG 350
    GKRKGGQRPG GKRRK 365
    Length:365
    Mass (Da):41,193
    Last modified:June 6, 2002 - v2
    Checksum:i061C3A6174C2E7C2
    GO

    Sequence cautioni

    The sequence BAA04948.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti116 – 1161Q → H.
    Corresponds to variant rs34077648 [ dbSNP | Ensembl ].
    VAR_051887
    Natural varianti126 – 1261K → R.
    Corresponds to variant rs3739335 [ dbSNP | Ensembl ].
    VAR_051888
    Natural varianti191 – 1911R → L.
    Corresponds to variant rs3739336 [ dbSNP | Ensembl ].
    VAR_020484

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D25218 mRNA. Translation: BAA04948.1. Different initiation.
    BC001811 mRNA. Translation: AAH01811.1.
    BC013043 mRNA. Translation: AAH13043.1.
    CCDSiCCDS6189.1.
    RefSeqiNP_055984.1. NM_015169.3.
    UniGeneiHs.71827.

    Genome annotation databases

    EnsembliENST00000320270; ENSP00000322396; ENSG00000179041.
    GeneIDi23212.
    KEGGihsa:23212.
    UCSCiuc003xwa.3. human.

    Polymorphism databases

    DMDMi21431847.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D25218 mRNA. Translation: BAA04948.1 . Different initiation.
    BC001811 mRNA. Translation: AAH01811.1 .
    BC013043 mRNA. Translation: AAH13043.1 .
    CCDSi CCDS6189.1.
    RefSeqi NP_055984.1. NM_015169.3.
    UniGenei Hs.71827.

    3D structure databases

    ProteinModelPortali Q15050.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116819. 49 interactions.
    IntActi Q15050. 3 interactions.
    MINTi MINT-1485279.
    STRINGi 9606.ENSP00000322396.

    PTM databases

    PhosphoSitei Q15050.

    Polymorphism databases

    DMDMi 21431847.

    2D gel databases

    SWISS-2DPAGE Q15050.

    Proteomic databases

    MaxQBi Q15050.
    PaxDbi Q15050.
    PeptideAtlasi Q15050.
    PRIDEi Q15050.

    Protocols and materials databases

    DNASUi 23212.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320270 ; ENSP00000322396 ; ENSG00000179041 .
    GeneIDi 23212.
    KEGGi hsa:23212.
    UCSCi uc003xwa.3. human.

    Organism-specific databases

    CTDi 23212.
    GeneCardsi GC08P067341.
    HGNCi HGNC:17083. RRS1.
    HPAi HPA055549.
    neXtProti NX_Q15050.
    PharmGKBi PA134993138.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5225.
    HOGENOMi HOG000017552.
    HOVERGENi HBG036121.
    InParanoidi Q15050.
    KOi K14852.
    OMAi RWGYKRA.
    OrthoDBi EOG73NG4D.
    PhylomeDBi Q15050.
    TreeFami TF313067.

    Miscellaneous databases

    ChiTaRSi RRS1. human.
    GeneWikii RRS1.
    GenomeRNAii 23212.
    NextBioi 44767.
    PROi Q15050.

    Gene expression databases

    Bgeei Q15050.
    CleanExi HS_RRS1.
    Genevestigatori Q15050.

    Family and domain databases

    InterProi IPR007023. Ribosom_reg.
    [Graphical view ]
    PANTHERi PTHR17602. PTHR17602. 1 hit.
    Pfami PF04939. RRS1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
      DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Uterus.
    3. Bienvenut W.V.
      Submitted (AUG-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 1-12; 92-98; 129-141; 254-265; 267-273 AND 342-352, ACETYLATION AT MET-1, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRRS1_HUMAN
    AccessioniPrimary (citable) accession number: Q15050
    Secondary accession number(s): Q9BUX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3