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Q15050 (RRS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribosome biogenesis regulatory protein homolog
Gene names
Name:RRS1
Synonyms:KIAA0112, RRR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in ribosome biogenesis By similarity.

Subcellular location

Nucleusnucleolus Ref.3 Ref.4.

Post-translational modification

Citrullinated by PADI4 By similarity.

Sequence similarities

Belongs to the RRS1 family.

Sequence caution

The sequence BAA04948.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Ribosome biogenesis regulatory protein homolog
PRO_0000185374

Regions

Compositional bias302 – 36564Arg/Gly/Lys-rich

Amino acid modifications

Modified residue11N-acetylmethionine Ref.3 Ref.5 Ref.6 Ref.7
Modified residue2731Citrulline By similarity

Natural variations

Natural variant1161Q → H.
Corresponds to variant rs34077648 [ dbSNP | Ensembl ].
VAR_051887
Natural variant1261K → R.
Corresponds to variant rs3739335 [ dbSNP | Ensembl ].
VAR_051888
Natural variant1911R → L.
Corresponds to variant rs3739336 [ dbSNP | Ensembl ].
VAR_020484

Sequences

Sequence LengthMass (Da)Tools
Q15050 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: 061C3A6174C2E7C2

FASTA36541,193
        10         20         30         40         50         60 
MEGQSVEELL AKAEQDEAEK LQRITVHKEL ELQFDLGNLL ASDRNPPTGL RCAGPTPEAE 

        70         80         90        100        110        120 
LQALARDNTQ LLINQLWQLP TERVEEAIVA RLPEPTTRLP REKPLPRPRP LTRWQQFARL 

       130        140        150        160        170        180 
KGIRPKKKTN LVWDEVSGQW RRRWGYQRAR DDTKEWLIEV PGNADPLEDQ FAKRIQAKKE 

       190        200        210        220        230        240 
RVAKNELNRL RNLARAHKMQ LPSAAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP 

       250        260        270        280        290        300 
KEKVPRGSGK KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP QLDVTRATNK QMREEDQEEA 

       310        320        330        340        350        360 
AKRRKMSQKG KRKGGRQGPG GKRKGGPPSQ GGKRKGGLGG KMNSGPPGLG GKRKGGQRPG 


GKRRK 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Uterus.
[3]Bienvenut W.V.
Submitted (AUG-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 1-12; 92-98; 129-141; 254-265; 267-273 AND 342-352, ACETYLATION AT MET-1, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[4]"Functional proteomic analysis of human nucleolus."
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D25218 mRNA. Translation: BAA04948.1. Different initiation.
BC001811 mRNA. Translation: AAH01811.1.
BC013043 mRNA. Translation: AAH13043.1.
CCDSCCDS6189.1.
RefSeqNP_055984.1. NM_015169.3.
UniGeneHs.71827.

3D structure databases

ProteinModelPortalQ15050.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116819. 47 interactions.
IntActQ15050. 3 interactions.
MINTMINT-1485279.
STRING9606.ENSP00000322396.

PTM databases

PhosphoSiteQ15050.

Polymorphism databases

DMDM21431847.

2D gel databases

SWISS-2DPAGEQ15050.

Proteomic databases

MaxQBQ15050.
PaxDbQ15050.
PeptideAtlasQ15050.
PRIDEQ15050.

Protocols and materials databases

DNASU23212.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320270; ENSP00000322396; ENSG00000179041.
GeneID23212.
KEGGhsa:23212.
UCSCuc003xwa.3. human.

Organism-specific databases

CTD23212.
GeneCardsGC08P067341.
HGNCHGNC:17083. RRS1.
HPAHPA055549.
neXtProtNX_Q15050.
PharmGKBPA134993138.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5225.
HOGENOMHOG000017552.
HOVERGENHBG036121.
InParanoidQ15050.
KOK14852.
OMARWGYKRA.
OrthoDBEOG73NG4D.
PhylomeDBQ15050.
TreeFamTF313067.

Gene expression databases

BgeeQ15050.
CleanExHS_RRS1.
GenevestigatorQ15050.

Family and domain databases

InterProIPR007023. Ribosom_reg.
[Graphical view]
PANTHERPTHR17602. PTHR17602. 1 hit.
PfamPF04939. RRS1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRRS1. human.
GeneWikiRRS1.
GenomeRNAi23212.
NextBio44767.
PROQ15050.

Entry information

Entry nameRRS1_HUMAN
AccessionPrimary (citable) accession number: Q15050
Secondary accession number(s): Q9BUX8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 6, 2002
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM