Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribosome biogenesis regulatory protein homolog

Gene

RRS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in ribosome biogenesis.By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. hematopoietic progenitor cell differentiation Source: Ensembl
  2. mitotic metaphase plate congression Source: UniProtKB
  3. ribosome biogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis regulatory protein homolog
Gene namesi
Name:RRS1
Synonyms:KIAA0112, RRR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:17083. RRS1.

Subcellular locationi

  1. Nucleusnucleolus 2 Publications

GO - Cellular componenti

  1. condensed nuclear chromosome Source: UniProtKB
  2. endoplasmic reticulum Source: Ensembl
  3. nucleolus Source: UniProtKB
  4. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134993138.

Polymorphism and mutation databases

BioMutaiRRS1.
DMDMi21431847.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Ribosome biogenesis regulatory protein homologPRO_0000185374Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine4 Publications
Modified residuei273 – 2731CitrullineBy similarity

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination

Proteomic databases

MaxQBiQ15050.
PaxDbiQ15050.
PeptideAtlasiQ15050.
PRIDEiQ15050.

2D gel databases

SWISS-2DPAGEQ15050.

PTM databases

PhosphoSiteiQ15050.

Expressioni

Gene expression databases

BgeeiQ15050.
CleanExiHS_RRS1.
GenevestigatoriQ15050.

Organism-specific databases

HPAiHPA055549.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926244EBI-749186,EBI-743771

Protein-protein interaction databases

BioGridi116819. 70 interactions.
IntActiQ15050. 3 interactions.
MINTiMINT-1485279.
STRINGi9606.ENSP00000322396.

Structurei

3D structure databases

ProteinModelPortaliQ15050.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi302 – 36564Arg/Gly/Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the RRS1 family.Curated

Phylogenomic databases

eggNOGiCOG5225.
GeneTreeiENSGT00390000005213.
HOGENOMiHOG000017552.
HOVERGENiHBG036121.
InParanoidiQ15050.
KOiK14852.
OMAiRRRWGYK.
OrthoDBiEOG73NG4D.
PhylomeDBiQ15050.
TreeFamiTF313067.

Family and domain databases

InterProiIPR007023. Ribosom_reg.
[Graphical view]
PANTHERiPTHR17602. PTHR17602. 1 hit.
PfamiPF04939. RRS1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGQSVEELL AKAEQDEAEK LQRITVHKEL ELQFDLGNLL ASDRNPPTGL
60 70 80 90 100
RCAGPTPEAE LQALARDNTQ LLINQLWQLP TERVEEAIVA RLPEPTTRLP
110 120 130 140 150
REKPLPRPRP LTRWQQFARL KGIRPKKKTN LVWDEVSGQW RRRWGYQRAR
160 170 180 190 200
DDTKEWLIEV PGNADPLEDQ FAKRIQAKKE RVAKNELNRL RNLARAHKMQ
210 220 230 240 250
LPSAAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP KEKVPRGSGK
260 270 280 290 300
KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP QLDVTRATNK QMREEDQEEA
310 320 330 340 350
AKRRKMSQKG KRKGGRQGPG GKRKGGPPSQ GGKRKGGLGG KMNSGPPGLG
360
GKRKGGQRPG GKRRK
Length:365
Mass (Da):41,193
Last modified:June 6, 2002 - v2
Checksum:i061C3A6174C2E7C2
GO

Sequence cautioni

The sequence BAA04948.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti116 – 1161Q → H.
Corresponds to variant rs34077648 [ dbSNP | Ensembl ].
VAR_051887
Natural varianti126 – 1261K → R.
Corresponds to variant rs3739335 [ dbSNP | Ensembl ].
VAR_051888
Natural varianti191 – 1911R → L.
Corresponds to variant rs3739336 [ dbSNP | Ensembl ].
VAR_020484

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25218 mRNA. Translation: BAA04948.1. Different initiation.
BC001811 mRNA. Translation: AAH01811.1.
BC013043 mRNA. Translation: AAH13043.1.
CCDSiCCDS6189.1.
RefSeqiNP_055984.1. NM_015169.3.
UniGeneiHs.71827.

Genome annotation databases

EnsembliENST00000320270; ENSP00000322396; ENSG00000179041.
GeneIDi23212.
KEGGihsa:23212.
UCSCiuc003xwa.3. human.

Polymorphism and mutation databases

BioMutaiRRS1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25218 mRNA. Translation: BAA04948.1. Different initiation.
BC001811 mRNA. Translation: AAH01811.1.
BC013043 mRNA. Translation: AAH13043.1.
CCDSiCCDS6189.1.
RefSeqiNP_055984.1. NM_015169.3.
UniGeneiHs.71827.

3D structure databases

ProteinModelPortaliQ15050.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116819. 70 interactions.
IntActiQ15050. 3 interactions.
MINTiMINT-1485279.
STRINGi9606.ENSP00000322396.

PTM databases

PhosphoSiteiQ15050.

Polymorphism and mutation databases

BioMutaiRRS1.
DMDMi21431847.

2D gel databases

SWISS-2DPAGEQ15050.

Proteomic databases

MaxQBiQ15050.
PaxDbiQ15050.
PeptideAtlasiQ15050.
PRIDEiQ15050.

Protocols and materials databases

DNASUi23212.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320270; ENSP00000322396; ENSG00000179041.
GeneIDi23212.
KEGGihsa:23212.
UCSCiuc003xwa.3. human.

Organism-specific databases

CTDi23212.
GeneCardsiGC08P067341.
HGNCiHGNC:17083. RRS1.
HPAiHPA055549.
neXtProtiNX_Q15050.
PharmGKBiPA134993138.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5225.
GeneTreeiENSGT00390000005213.
HOGENOMiHOG000017552.
HOVERGENiHBG036121.
InParanoidiQ15050.
KOiK14852.
OMAiRRRWGYK.
OrthoDBiEOG73NG4D.
PhylomeDBiQ15050.
TreeFamiTF313067.

Miscellaneous databases

GeneWikiiRRS1.
GenomeRNAii23212.
NextBioi44767.
PROiQ15050.

Gene expression databases

BgeeiQ15050.
CleanExiHS_RRS1.
GenevestigatoriQ15050.

Family and domain databases

InterProiIPR007023. Ribosom_reg.
[Graphical view]
PANTHERiPTHR17602. PTHR17602. 1 hit.
PfamiPF04939. RRS1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
    DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Uterus.
  3. Bienvenut W.V.
    Submitted (AUG-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-12; 92-98; 129-141; 254-265; 267-273 AND 342-352, ACETYLATION AT MET-1, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRRS1_HUMAN
AccessioniPrimary (citable) accession number: Q15050
Secondary accession number(s): Q9BUX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 6, 2002
Last modified: April 29, 2015
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.