Q15049 (MLC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane protein MLC1

Gene names

Name:	MLC1
Synonyms:	KIAA0027, WKL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. Ref.10
Subunit structure	Interacts with ATP1B1. Part of a complex containing ATP1B1, TRPV4, AQP4 and HEPACAM. Ref.10
Subcellular location	Membrane; Multi-pass membrane protein Potential. Cell membrane. Cytoplasm › perinuclear region. Endoplasmic reticulum Ref.10.
Tissue specificity	Expressed in the brain, with highest levels found in the amygdala, nucleus caudatus, thalamus and hippocampus. Ref.1
Involvement in disease	Leukoencephalopathy, megalencephalic, with subcortical cysts, 1 (MLC1) [MIM:604004]: A syndrome of cerebral leukoencephalopathy and megalencephaly characterized by ataxia, spasticity, seizures, delay in motor development and mild mental retardation. The brain appears swollen on magnetic resonance imaging, with diffuse white-matter abnormalities and the invariable presence of subcortical cysts in frontal and temporal lobes. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.11 Ref.12 Ref.13 Ref.14
Sequence caution	The sequence BAA04947.3 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Cytoplasm Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Disease	Disease mutation
Domain	Transmembrane Transmembrane helix
Molecular function	Ion channel
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	caveolin-mediated endocytosis Inferred from sequence or structural similarity. Source: UniProtKB cellular response to cholesterol Inferred from sequence or structural similarity. Source: UniProtKB ion transport Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of intracellular transport Inferred from direct assay PubMed 19931615. Source: UniProtKB protein oligomerization Inferred from direct assay PubMed 15367490. Source: UniProtKB regulation of response to osmotic stress Inferred from mutant phenotype Ref.10. Source: UniProtKB
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara basolateral plasma membrane Inferred from direct assay PubMed 18165104. Source: UniProtKB caveola Inferred from sequence or structural similarity. Source: UniProtKB cell-cell junction Inferred from electronic annotation. Source: Compara cytoplasmic vesicle Inferred from direct assay PubMed 15892299PubMed 19931615. Source: UniProtKB early endosome Inferred from sequence or structural similarity. Source: UniProtKB endoplasmic reticulum Inferred from direct assay PubMed 15367490Ref.10. Source: UniProtKB integral to membrane Inferred from direct assay PubMed 17628813. Source: UniProtKB lysosome Inferred from sequence or structural similarity. Source: UniProtKB perinuclear region of cytoplasm Inferred from direct assay PubMed 19931615Ref.10. Source: UniProtKB recycling endosome Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	protein complex binding Inferred from direct assay PubMed 17628813. Source: UniProtKB protein transporter activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.9
	Chain	2 – 377	376	Membrane protein MLC1		PRO_0000096496
Regions
	Transmembrane	52 – 72	21	Helical; Potential
	Transmembrane	82 – 100	19	Helical; Potential
	Transmembrane	111 – 131	21	Helical; Potential
	Transmembrane	144 – 164	21	Helical; Potential
	Transmembrane	199 – 219	21	Helical; Potential
	Transmembrane	230 – 250	21	Helical; Potential
	Transmembrane	257 – 277	21	Helical; Potential
	Transmembrane	304 – 324	21	Helical; Potential
	Compositional bias	173 – 176	4	Poly-Lys
Natural variations
	Natural variant	59	1	G → E in MLC1. Ref.13 Corresponds to variant rs80358242 [ dbSNP | Ensembl ].		VAR_017438
	Natural variant	69	1	S → L in MLC1. Ref.14		VAR_067762
	Natural variant	80	1	M → I in MLC1. Ref.14		VAR_067763
	Natural variant	84	1	R → C in MLC1. Ref.14		VAR_067764
	Natural variant	92	1	P → S in MLC1. Ref.12 Corresponds to variant rs121908345 [ dbSNP | Ensembl ].		VAR_017439
	Natural variant	93	1	S → L in MLC1. Ref.11 Corresponds to variant rs80358245 [ dbSNP | Ensembl ].		VAR_011699
	Natural variant	118	1	T → R in MLC1. Ref.11		VAR_011700
	Natural variant	125	1	C → R in MLC1; accumulates in the cytoplasmic perinuclear region and endoplasmic reticulum; affects interaction with ATP1B1. Ref.10 Ref.12		VAR_067765
	Natural variant	141	1	N → K in MLC1. Ref.12 Corresponds to variant rs121908343 [ dbSNP | Ensembl ].		VAR_017440
	Natural variant	141	1	N → S in MLC1. Ref.12 Corresponds to variant rs121908344 [ dbSNP | Ensembl ].		VAR_017441
	Natural variant	171	1	C → F. Corresponds to variant rs6010260 [ dbSNP | Ensembl ].		VAR_051186
	Natural variant	212	1	G → R in MLC1. Ref.11		VAR_011701
	Natural variant	245	1	A → P in MLC1. Ref.14		VAR_067766
	Natural variant	246	1	S → R in MLC1; does not affect subcellular location. Ref.10 Ref.12		VAR_067767
	Natural variant	280	1	S → L in MLC1; accumulates in the cytoplasmic perinuclear region and endoplasmic reticulum; affects the interaction with ATP1B1, TRPV4, AQP4 and HEPACAM. Ref.10 Ref.11 Corresponds to variant rs121908341 [ dbSNP | Ensembl ].		VAR_011702
	Natural variant	309	1	L → M in a pedigree affected by schizophrenia. Ref.1 Corresponds to variant rs80358240 [ dbSNP | Ensembl ].		VAR_012731
	Natural variant	320	1	T → K in MLC1. Ref.14		VAR_067768
	Natural variant	344	1	N → S. Corresponds to variant rs11568188 [ dbSNP | Ensembl ].		VAR_051187
Experimental info
	Sequence conflict	25	1	P → H in AAH28425. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Q15049 [UniParc]. Last modified January 23, 2007. Version 5. Checksum: 9AF70B87D979F459	FASTA	377	41,141
	10 20 30 40 50 60 MTQEPFREEL AYDRMPTLER GRQDPASYAP DAKPSDLQLS KRLPPCFSHK TWVFSVLMGS 70 80 90 100 110 120 CLLVTSGFSL YLGNVFPAEM DYLRCAAGSC IPSAIVSFTV SRRNANVIPN FQILFVSTFA 130 140 150 160 170 180 VTTTCLIWFG CKLVLNPSAI NINFNLILLL LLELLMAATV IIAARSSEED CKKKKGSMSD 190 200 210 220 230 240 SANILDEVPF PARVLKSYSV VEVIAGISAV LGGIIALNVD DSVSGPHLSV TFFWILVACF 250 260 270 280 290 300 PSAIASHVAA ECPSKCLVEV LIAISSLTSP LLFTASGYLS FSIMRIVEMF KDYPPAIKPS 310 320 330 340 350 360 YDVLLLLLLL VLLLQAGLNT GTAIQCVRFK VSARLQGASW DTQNGPQERL AGEVARSPLK 370 EFDKEKAWRA VVVQMAQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree." Meyer J., Huberth A., Ortega G., Syagailo Y.V., Jatzke S., Moessner R., Strom T.M., Ulzheimer-Teuber I., Stoeber G., Schmitt A., Lesch K.P. Mol. Psychiatry 6:302-306(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, VARIANT MET-309. Tissue: Hippocampus.
[2]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[6]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[9]	"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-14. Tissue: Platelet.
[10]	"Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations." Lanciotti A., Brignone M.S., Molinari P., Visentin S., De Nuccio C., Macchia G., Aiello C., Bertini E., Aloisi F., Petrucci T.C., Ambrosini E. Hum. Mol. Genet. 21:2166-2180(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH ATP1B1, CHARACTERIZATION OF VARIANTS MLC1 ARG-125; ARG-246 AND LEU-280.
[11]	"Mutations of MLC1 (KIAA0027), encoding a putative membrane protein, cause megalencephalic leukoencephalopathy with subcortical cysts." Leegwater P.A.J., Yuan B.Q., van der Steen J., Mulders J., Koenst A.A.M., Ilja Boor P.K., Mejaski-Bosnjak V., van der Maarel S.M., Frants R.R., Oudejans C.B.M., Schutgens R.B.H., Pronk J.C., van der Knapp M.S. Am. J. Hum. Genet. 68:831-838(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MLC1 LEU-93; ARG-118; ARG-212 AND LEU-280.
[12]	"Identification of novel mutations in MLC1 responsible for megalencephalic leukoencephalopathy with subcortical cysts." Leegwater P.A.J., Boor P.K.I., Yuan B.Q., van der Steen J., Visser A., Konst A.A.M., Oudejans C.B.M., Schutgens R.B.H., Pronk J.C., van der Knaap M.S. Hum. Genet. 110:279-283(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MLC1 SER-92; ARG-125; LYS-141; SER-141 AND ARG-246.
[13]	"Megalencephalic leukoencephalopathy with subcortical cysts; a founder effect in Israeli patients and a higher than expected carrier rate among Libyan Jews." Ben-Zeev B., Levy-Nissenbaum E., Lahat H., Anikster Y., Shinar Y., Brand N., Gross-Tzur V., MacGregor D., Sidi R., Kleta R., Frydman M., Pras E. Hum. Genet. 111:214-218(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MLC1 GLU-59.
[14]	"Megalencephalic leukoencephalopathy with subcortical cysts: an update and extended mutation analysis of MLC1." Ilja Boor P.K., de Groot K., Mejaski-Bosnjak V., Brenner C., van der Knaap M.S., Scheper G.C., Pronk J.C. Hum. Mutat. 27:505-512(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MLC1 LEU-69; ILE-80; CYS-84; PRO-245 AND LYS-320.
+	Additional computationally mapped references.

Web resources

GeneReviews

Mendelian genes megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1)

Leiden Open Variation Database (LOVD)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF319633 mRNA. Translation: AAK60119.1. D25217 mRNA. Translation: BAA04947.3. Different initiation. CR456460 mRNA. Translation: CAG30346.1. AL022327 Genomic DNA. Translation: CAI42687.1. AK124264 mRNA. Translation: BAG54023.1. CH471138 Genomic DNA. Translation: EAW73490.1. BC028425 mRNA. Translation: AAH28425.1.
IPI	IPI00014240.
RefSeq	NP_055981.1. NM_015166.3. NP_631941.1. NM_139202.2.
UniGene	Hs.517729.
3D structure databases
ProteinModelPortal	Q15049.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000310375.
PTM databases
PhosphoSite	Q15049.
Polymorphism databases
DMDM	20141590.
Proteomic databases
PaxDb	Q15049.
PRIDE	Q15049.
Protocols and materials databases
DNASU	23209.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311597; ENSP00000310375; ENSG00000100427. ENST00000395876; ENSP00000379216; ENSG00000100427.
GeneID	23209.
KEGG	hsa:23209.
UCSC	uc003bjg.1. human.
Organism-specific databases
CTD	23209.
GeneCards	GC22M050497.
HGNC	HGNC:17082. MLC1.
HPA	HPA003040.
MIM	604004. phenotype. 605908. gene.
neXtProt	NX_Q15049.
Orphanet	2478. Megalencephalic leukoencephalopathy with subcortical cysts.
PharmGKB	PA38199.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG48054.
HOGENOM	HOG000065767.
HOVERGEN	HBG049239.
InParanoid	Q15049.
OMA	VTFFWIL.
OrthoDB	EOG4QZ7MP.
PhylomeDB	Q15049.
Gene expression databases
ArrayExpress	Q15049.
Bgee	Q15049.
CleanEx	HS_MLC1.
Genevestigator	Q15049.
GermOnline	ENSG00000100427. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	MLC1. human.
GenomeRNAi	23209.
NextBio	44747.
SOURCE	Search...

Entry information

Entry name

MLC1_HUMAN

Accession

Primary (citable) accession number: Q15049
Secondary accession number(s): B3KW61 , Q5JZ83, Q8TAG4, Q96RP5, Q9UGY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 116 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.