ID   LRC14_HUMAN             Reviewed;         493 AA.
AC   Q15048; A8K0A8; D3DWM8;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 177.
DE   RecName: Full=Leucine-rich repeat-containing protein 14 {ECO:0000305};
GN   Name=LRRC14 {ECO:0000312|HGNC:HGNC:20419};
GN   Synonyms=KIAA0014 {ECO:0000303|PubMed:7584026};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=7584026; DOI=10.1093/dnares/1.1.27;
RA   Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S.,
RA   Nagase T., Seki N., Ishikawa K., Tabata S.;
RT   "Prediction of the coding sequences of unidentified human genes. I. The
RT   coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of
RT   randomly sampled cDNA clones from human immature myeloid cell line KG-1.";
RL   DNA Res. 1:27-35(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cerebellum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   INDUCTION, SUBCELLULAR LOCATION, INTERACTION WITH CHUK AND IKBKB, AND
RP   FUNCTION.
RX   PubMed=27426725; DOI=10.1016/j.yexcr.2016.07.011;
RA   Wu C., Yang Y., Ou J., Zhu L., Zhao W., Cui J.;
RT   "LRRC14 attenuates Toll-like receptor-mediated NF-kappa-B signaling through
RT   disruption of IKK complex.";
RL   Exp. Cell Res. 347:65-73(2016).
CC   -!- FUNCTION: Negatively regulates Toll-like receptor-mediated NF-kappa-B
CC       signaling by disrupting IKK core complex formation through interaction
CC       with IKBKB. {ECO:0000269|PubMed:27426725}.
CC   -!- SUBUNIT: Interacts with IKBKB; disrupts IKBKB-IKBKG interaction
CC       preventing I-kappa-B-kinase (IKK) core complex formation and leading to
CC       a decrease of IKBKB phosphorylation and NF-kappaB activation
CC       (PubMed:27426725). Interacts with CHUK (PubMed:27426725).
CC       {ECO:0000269|PubMed:27426725}.
CC   -!- INTERACTION:
CC       Q15048; Q13617: CUL2; NbExp=6; IntAct=EBI-2510124, EBI-456179;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27426725}.
CC   -!- INDUCTION: Down-regulated in response to toll-like receptor ligand.
CC       {ECO:0000269|PubMed:27426725}.
CC   -!- SIMILARITY: Belongs to the PRAME family. LRRC14 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA04946.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D25216; BAA04946.2; ALT_INIT; mRNA.
DR   EMBL; AK289473; BAF82162.1; -; mRNA.
DR   EMBL; CH471162; EAW82066.1; -; Genomic_DNA.
DR   EMBL; CH471162; EAW82067.1; -; Genomic_DNA.
DR   EMBL; CH471162; EAW82068.1; -; Genomic_DNA.
DR   EMBL; CH471162; EAW82069.1; -; Genomic_DNA.
DR   EMBL; BC011377; AAH11377.1; -; mRNA.
DR   CCDS; CCDS6432.1; -.
DR   RefSeq; NP_001258965.1; NM_001272036.1.
DR   RefSeq; NP_055480.1; NM_014665.3.
DR   RefSeq; XP_005272415.1; XM_005272358.4.
DR   RefSeq; XP_005272416.1; XM_005272359.4.
DR   AlphaFoldDB; Q15048; -.
DR   SMR; Q15048; -.
DR   BioGRID; 115037; 14.
DR   IntAct; Q15048; 5.
DR   STRING; 9606.ENSP00000292524; -.
DR   GlyGen; Q15048; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q15048; -.
DR   PhosphoSitePlus; Q15048; -.
DR   BioMuta; LRRC14; -.
DR   DMDM; 6686102; -.
DR   EPD; Q15048; -.
DR   jPOST; Q15048; -.
DR   MassIVE; Q15048; -.
DR   MaxQB; Q15048; -.
DR   PaxDb; 9606-ENSP00000292524; -.
DR   PeptideAtlas; Q15048; -.
DR   ProteomicsDB; 60400; -.
DR   Pumba; Q15048; -.
DR   TopDownProteomics; Q15048; -.
DR   Antibodypedia; 14965; 66 antibodies from 17 providers.
DR   DNASU; 9684; -.
DR   Ensembl; ENST00000292524.6; ENSP00000292524.1; ENSG00000160959.8.
DR   Ensembl; ENST00000529022.5; ENSP00000434768.1; ENSG00000160959.8.
DR   GeneID; 9684; -.
DR   KEGG; hsa:9684; -.
DR   MANE-Select; ENST00000292524.6; ENSP00000292524.1; NM_014665.4; NP_055480.1.
DR   UCSC; uc003zdk.4; human.
DR   AGR; HGNC:20419; -.
DR   CTD; 9684; -.
DR   DisGeNET; 9684; -.
DR   GeneCards; LRRC14; -.
DR   HGNC; HGNC:20419; LRRC14.
DR   HPA; ENSG00000160959; Low tissue specificity.
DR   MIM; 619368; gene.
DR   neXtProt; NX_Q15048; -.
DR   OpenTargets; ENSG00000160959; -.
DR   PharmGKB; PA134914089; -.
DR   VEuPathDB; HostDB:ENSG00000160959; -.
DR   eggNOG; ENOG502QWSJ; Eukaryota.
DR   GeneTree; ENSGT01030000234531; -.
DR   HOGENOM; CLU_039635_0_1_1; -.
DR   InParanoid; Q15048; -.
DR   OMA; VTECELM; -.
DR   OrthoDB; 5344588at2759; -.
DR   PhylomeDB; Q15048; -.
DR   TreeFam; TF332708; -.
DR   PathwayCommons; Q15048; -.
DR   Reactome; R-HSA-9758274; Regulation of NF-kappa B signaling.
DR   SignaLink; Q15048; -.
DR   BioGRID-ORCS; 9684; 15 hits in 1157 CRISPR screens.
DR   ChiTaRS; LRRC14; human.
DR   GenomeRNAi; 9684; -.
DR   Pharos; Q15048; Tdark.
DR   PRO; PR:Q15048; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q15048; Protein.
DR   Bgee; ENSG00000160959; Expressed in lower esophagus mucosa and 161 other cell types or tissues.
DR   ExpressionAtlas; Q15048; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0019900; F:kinase binding; IPI:UniProtKB.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
DR   GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; IDA:UniProtKB.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR14224:SF9; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14; 1.
DR   PANTHER; PTHR14224; SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3; 1.
DR   Pfam; PF13516; LRR_6; 2.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   Genevisible; Q15048; HS.
PE   1: Evidence at protein level;
KW   Cytoplasm; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..493
FT                   /note="Leucine-rich repeat-containing protein 14"
FT                   /id="PRO_0000156974"
FT   REPEAT          111..146
FT                   /note="LRR 1; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          194..218
FT                   /note="LRR 2; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          219..246
FT                   /note="LRR 3; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          247..282
FT                   /note="LRR 4; degenerate"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          283..307
FT                   /note="LRR 5"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          308..339
FT                   /note="LRR 6"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          340..360
FT                   /note="LRR 7"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          364..391
FT                   /note="LRR 8"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   REPEAT          392..416
FT                   /note="LRR 9"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT   VARIANT         437
FT                   /note="G -> D (in dbSNP:rs3735854)"
FT                   /id="VAR_053603"
FT   CONFLICT        230
FT                   /note="N -> S (in Ref. 2; BAF82162)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   493 AA;  54513 MW;  1B02E6D0FAF06A88 CRC64;
     MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTVVLREL VHTWPFPLLS
     FQQLLQECAH CSRALLQERP STESMQAVIL GLTARLHTSE PGASTQPLCR KHALRVLDMT
     GLLDDGVEQD PGTMSMWDCT AAVARTCIAQ QQGGAAEPGP APIPVEVRVD LRVNRASYAF
     LREALRSSVG SPLRLCCRDL RAEDLPMRNT VALLQLLDAG CLRRVDLRFN NLGLRGLSVI
     IPHVARFQHL ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFTCLRELS MGSSLLSGRL
     DQLLSTLQSP LESLELAFCA LLPEDLRFLA RSPHAAHLKK LDLSGNDLSG SQLAPFQGLL
     QASAATLLHL ELTECQLADT QLLATLPILT QCASLRYLGL YGNPLSMAGL KELLRDSVAQ
     AELRTVVHPF PVDCYEGLPW PPPASVLLEA SINEEKFARV EAELHQLLLA SGRAHVLWTT
     DIYGRLAADY FSL
//