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Q15048

- LRC14_HUMAN

UniProt

Q15048 - LRC14_HUMAN

Protein

Leucine-rich repeat-containing protein 14

Gene

LRRC14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeat-containing protein 14
    Gene namesi
    Name:LRRC14
    Synonyms:KIAA0014
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:20419. LRRC14.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134914089.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Leucine-rich repeat-containing protein 14PRO_0000156974Add
    BLAST

    Proteomic databases

    MaxQBiQ15048.
    PaxDbiQ15048.
    PRIDEiQ15048.

    PTM databases

    PhosphoSiteiQ15048.

    Expressioni

    Gene expression databases

    ArrayExpressiQ15048.
    BgeeiQ15048.
    CleanExiHS_LRRC14.
    GenevestigatoriQ15048.

    Organism-specific databases

    HPAiHPA021047.

    Interactioni

    Protein-protein interaction databases

    BioGridi115037. 10 interactions.
    IntActiQ15048. 2 interactions.
    STRINGi9606.ENSP00000292524.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15048.
    SMRiQ15048. Positions 218-435.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati285 – 30723LRR 1Add
    BLAST
    Repeati310 – 33021LRR 2Add
    BLAST
    Repeati337 – 36024LRR 3Add
    BLAST
    Repeati366 – 38722LRR 4Add
    BLAST
    Repeati394 – 41421LRR 5Add
    BLAST

    Sequence similaritiesi

    Belongs to the PRAME family.Curated
    Contains 5 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG44653.
    HOGENOMiHOG000113363.
    HOVERGENiHBG052342.
    InParanoidiQ15048.
    OMAiGTQPLCR.
    PhylomeDBiQ15048.
    TreeFamiTF332708.

    Family and domain databases

    InterProiIPR026292. PRAME/Leu_rich_rep-con_p14.
    [Graphical view]
    PANTHERiPTHR14224. PTHR14224. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q15048-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTVVLREL    50
    VHTWPFPLLS FQQLLQECAH CSRALLQERP STESMQAVIL GLTARLHTSE 100
    PGASTQPLCR KHALRVLDMT GLLDDGVEQD PGTMSMWDCT AAVARTCIAQ 150
    QQGGAAEPGP APIPVEVRVD LRVNRASYAF LREALRSSVG SPLRLCCRDL 200
    RAEDLPMRNT VALLQLLDAG CLRRVDLRFN NLGLRGLSVI IPHVARFQHL 250
    ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFTCLRELS MGSSLLSGRL 300
    DQLLSTLQSP LESLELAFCA LLPEDLRFLA RSPHAAHLKK LDLSGNDLSG 350
    SQLAPFQGLL QASAATLLHL ELTECQLADT QLLATLPILT QCASLRYLGL 400
    YGNPLSMAGL KELLRDSVAQ AELRTVVHPF PVDCYEGLPW PPPASVLLEA 450
    SINEEKFARV EAELHQLLLA SGRAHVLWTT DIYGRLAADY FSL 493
    Length:493
    Mass (Da):54,513
    Last modified:November 1, 1996 - v1
    Checksum:i1B02E6D0FAF06A88
    GO

    Sequence cautioni

    The sequence BAA04946.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti230 – 2301N → S in BAF82162. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti437 – 4371G → D.
    Corresponds to variant rs3735854 [ dbSNP | Ensembl ].
    VAR_053603

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D25216 mRNA. Translation: BAA04946.2. Different initiation.
    AK289473 mRNA. Translation: BAF82162.1.
    CH471162 Genomic DNA. Translation: EAW82066.1.
    CH471162 Genomic DNA. Translation: EAW82067.1.
    CH471162 Genomic DNA. Translation: EAW82068.1.
    CH471162 Genomic DNA. Translation: EAW82069.1.
    BC011377 mRNA. Translation: AAH11377.1.
    CCDSiCCDS6432.1.
    RefSeqiNP_001258965.1. NM_001272036.1.
    NP_055480.1. NM_014665.3.
    XP_005272415.1. XM_005272358.2.
    XP_005272416.1. XM_005272359.2.
    UniGeneiHs.459391.

    Genome annotation databases

    EnsembliENST00000292524; ENSP00000292524; ENSG00000160959.
    ENST00000529022; ENSP00000434768; ENSG00000160959.
    GeneIDi9684.
    KEGGihsa:9684.
    UCSCiuc003zdk.3. human.

    Polymorphism databases

    DMDMi6686102.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D25216 mRNA. Translation: BAA04946.2 . Different initiation.
    AK289473 mRNA. Translation: BAF82162.1 .
    CH471162 Genomic DNA. Translation: EAW82066.1 .
    CH471162 Genomic DNA. Translation: EAW82067.1 .
    CH471162 Genomic DNA. Translation: EAW82068.1 .
    CH471162 Genomic DNA. Translation: EAW82069.1 .
    BC011377 mRNA. Translation: AAH11377.1 .
    CCDSi CCDS6432.1.
    RefSeqi NP_001258965.1. NM_001272036.1.
    NP_055480.1. NM_014665.3.
    XP_005272415.1. XM_005272358.2.
    XP_005272416.1. XM_005272359.2.
    UniGenei Hs.459391.

    3D structure databases

    ProteinModelPortali Q15048.
    SMRi Q15048. Positions 218-435.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115037. 10 interactions.
    IntActi Q15048. 2 interactions.
    STRINGi 9606.ENSP00000292524.

    PTM databases

    PhosphoSitei Q15048.

    Polymorphism databases

    DMDMi 6686102.

    Proteomic databases

    MaxQBi Q15048.
    PaxDbi Q15048.
    PRIDEi Q15048.

    Protocols and materials databases

    DNASUi 9684.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292524 ; ENSP00000292524 ; ENSG00000160959 .
    ENST00000529022 ; ENSP00000434768 ; ENSG00000160959 .
    GeneIDi 9684.
    KEGGi hsa:9684.
    UCSCi uc003zdk.3. human.

    Organism-specific databases

    CTDi 9684.
    GeneCardsi GC08P145743.
    H-InvDB HIX0007861.
    HGNCi HGNC:20419. LRRC14.
    HPAi HPA021047.
    neXtProti NX_Q15048.
    PharmGKBi PA134914089.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44653.
    HOGENOMi HOG000113363.
    HOVERGENi HBG052342.
    InParanoidi Q15048.
    OMAi GTQPLCR.
    PhylomeDBi Q15048.
    TreeFami TF332708.

    Miscellaneous databases

    GenomeRNAii 9684.
    NextBioi 36368.
    PROi Q15048.

    Gene expression databases

    ArrayExpressi Q15048.
    Bgeei Q15048.
    CleanExi HS_LRRC14.
    Genevestigatori Q15048.

    Family and domain databases

    InterProi IPR026292. PRAME/Leu_rich_rep-con_p14.
    [Graphical view ]
    PANTHERi PTHR14224. PTHR14224. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
      DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.

    Entry informationi

    Entry nameiLRC14_HUMAN
    AccessioniPrimary (citable) accession number: Q15048
    Secondary accession number(s): A8K0A8, D3DWM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3