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Q15048 (LRC14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeat-containing protein 14
Gene names
Name:LRRC14
Synonyms:KIAA0014
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the PRAME family.

Contains 5 LRR (leucine-rich) repeats.

Sequence caution

The sequence BAA04946.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainLeucine-rich repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 493493Leucine-rich repeat-containing protein 14
PRO_0000156974

Regions

Repeat285 – 30723LRR 1
Repeat310 – 33021LRR 2
Repeat337 – 36024LRR 3
Repeat366 – 38722LRR 4
Repeat394 – 41421LRR 5

Natural variations

Natural variant4371G → D.
Corresponds to variant rs3735854 [ dbSNP | Ensembl ].
VAR_053603

Experimental info

Sequence conflict2301N → S in BAF82162. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q15048 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 1B02E6D0FAF06A88

FASTA49354,513
        10         20         30         40         50         60 
MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTVVLREL VHTWPFPLLS 

        70         80         90        100        110        120 
FQQLLQECAH CSRALLQERP STESMQAVIL GLTARLHTSE PGASTQPLCR KHALRVLDMT 

       130        140        150        160        170        180 
GLLDDGVEQD PGTMSMWDCT AAVARTCIAQ QQGGAAEPGP APIPVEVRVD LRVNRASYAF 

       190        200        210        220        230        240 
LREALRSSVG SPLRLCCRDL RAEDLPMRNT VALLQLLDAG CLRRVDLRFN NLGLRGLSVI 

       250        260        270        280        290        300 
IPHVARFQHL ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFTCLRELS MGSSLLSGRL 

       310        320        330        340        350        360 
DQLLSTLQSP LESLELAFCA LLPEDLRFLA RSPHAAHLKK LDLSGNDLSG SQLAPFQGLL 

       370        380        390        400        410        420 
QASAATLLHL ELTECQLADT QLLATLPILT QCASLRYLGL YGNPLSMAGL KELLRDSVAQ 

       430        440        450        460        470        480 
AELRTVVHPF PVDCYEGLPW PPPASVLLEA SINEEKFARV EAELHQLLLA SGRAHVLWTT 

       490 
DIYGRLAADY FSL 

« Hide

References

[1]"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D25216 mRNA. Translation: BAA04946.2. Different initiation.
AK289473 mRNA. Translation: BAF82162.1.
CH471162 Genomic DNA. Translation: EAW82066.1.
CH471162 Genomic DNA. Translation: EAW82067.1.
CH471162 Genomic DNA. Translation: EAW82068.1.
CH471162 Genomic DNA. Translation: EAW82069.1.
BC011377 mRNA. Translation: AAH11377.1.
CCDSCCDS6432.1.
RefSeqNP_001258965.1. NM_001272036.1.
NP_055480.1. NM_014665.3.
XP_005272415.1. XM_005272358.2.
XP_005272416.1. XM_005272359.2.
UniGeneHs.459391.

3D structure databases

ProteinModelPortalQ15048.
SMRQ15048. Positions 218-435.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115037. 10 interactions.
IntActQ15048. 2 interactions.
STRING9606.ENSP00000292524.

PTM databases

PhosphoSiteQ15048.

Polymorphism databases

DMDM6686102.

Proteomic databases

MaxQBQ15048.
PaxDbQ15048.
PRIDEQ15048.

Protocols and materials databases

DNASU9684.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000292524; ENSP00000292524; ENSG00000160959.
ENST00000529022; ENSP00000434768; ENSG00000160959.
GeneID9684.
KEGGhsa:9684.
UCSCuc003zdk.3. human.

Organism-specific databases

CTD9684.
GeneCardsGC08P145743.
H-InvDBHIX0007861.
HGNCHGNC:20419. LRRC14.
HPAHPA021047.
neXtProtNX_Q15048.
PharmGKBPA134914089.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44653.
HOGENOMHOG000113363.
HOVERGENHBG052342.
InParanoidQ15048.
OMAGTQPLCR.
PhylomeDBQ15048.
TreeFamTF332708.

Gene expression databases

ArrayExpressQ15048.
BgeeQ15048.
CleanExHS_LRRC14.
GenevestigatorQ15048.

Family and domain databases

InterProIPR026292. PRAME/Leu_rich_rep-con_p14.
[Graphical view]
PANTHERPTHR14224. PTHR14224. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi9684.
NextBio36368.
PROQ15048.

Entry information

Entry nameLRC14_HUMAN
AccessionPrimary (citable) accession number: Q15048
Secondary accession number(s): A8K0A8, D3DWM8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM