Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat-containing protein 14

Gene

LRRC14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160959-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 14
Gene namesi
Name:LRRC14
Synonyms:KIAA0014
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:20419. LRRC14.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160959.
PharmGKBiPA134914089.

Polymorphism and mutation databases

DMDMi6686102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569741 – 493Leucine-rich repeat-containing protein 14Add BLAST493

Proteomic databases

EPDiQ15048.
MaxQBiQ15048.
PaxDbiQ15048.
PeptideAtlasiQ15048.
PRIDEiQ15048.
TopDownProteomicsiQ15048.

PTM databases

iPTMnetiQ15048.
PhosphoSitePlusiQ15048.

Expressioni

Gene expression databases

BgeeiENSG00000160959.
CleanExiHS_LRRC14.
ExpressionAtlasiQ15048. baseline and differential.
GenevisibleiQ15048. HS.

Organism-specific databases

HPAiHPA021047.
HPA063512.

Interactioni

Protein-protein interaction databases

BioGridi115037. 8 interactors.
IntActiQ15048. 2 interactors.
STRINGi9606.ENSP00000292524.

Structurei

3D structure databases

ProteinModelPortaliQ15048.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati285 – 307LRR 1Add BLAST23
Repeati310 – 330LRR 2Add BLAST21
Repeati337 – 360LRR 3Add BLAST24
Repeati366 – 387LRR 4Add BLAST22
Repeati394 – 414LRR 5Add BLAST21

Sequence similaritiesi

Belongs to the PRAME family. LRRC14 subfamily.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IIBA. Eukaryota.
ENOG4111FCX. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000113363.
HOVERGENiHBG052342.
InParanoidiQ15048.
OMAiPILTRCT.
OrthoDBiEOG091G05TB.
PhylomeDBiQ15048.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR026292. LRRC14.
[Graphical view]
PANTHERiPTHR14224:SF9. PTHR14224:SF9. 1 hit.
PfamiPF13516. LRR_6. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTVVLREL
60 70 80 90 100
VHTWPFPLLS FQQLLQECAH CSRALLQERP STESMQAVIL GLTARLHTSE
110 120 130 140 150
PGASTQPLCR KHALRVLDMT GLLDDGVEQD PGTMSMWDCT AAVARTCIAQ
160 170 180 190 200
QQGGAAEPGP APIPVEVRVD LRVNRASYAF LREALRSSVG SPLRLCCRDL
210 220 230 240 250
RAEDLPMRNT VALLQLLDAG CLRRVDLRFN NLGLRGLSVI IPHVARFQHL
260 270 280 290 300
ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFTCLRELS MGSSLLSGRL
310 320 330 340 350
DQLLSTLQSP LESLELAFCA LLPEDLRFLA RSPHAAHLKK LDLSGNDLSG
360 370 380 390 400
SQLAPFQGLL QASAATLLHL ELTECQLADT QLLATLPILT QCASLRYLGL
410 420 430 440 450
YGNPLSMAGL KELLRDSVAQ AELRTVVHPF PVDCYEGLPW PPPASVLLEA
460 470 480 490
SINEEKFARV EAELHQLLLA SGRAHVLWTT DIYGRLAADY FSL
Length:493
Mass (Da):54,513
Last modified:November 1, 1996 - v1
Checksum:i1B02E6D0FAF06A88
GO

Sequence cautioni

The sequence BAA04946 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti230N → S in BAF82162 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053603437G → D.Corresponds to variant rs3735854dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25216 mRNA. Translation: BAA04946.2. Different initiation.
AK289473 mRNA. Translation: BAF82162.1.
CH471162 Genomic DNA. Translation: EAW82066.1.
CH471162 Genomic DNA. Translation: EAW82067.1.
CH471162 Genomic DNA. Translation: EAW82068.1.
CH471162 Genomic DNA. Translation: EAW82069.1.
BC011377 mRNA. Translation: AAH11377.1.
CCDSiCCDS6432.1.
RefSeqiNP_001258965.1. NM_001272036.1.
NP_055480.1. NM_014665.3.
XP_005272415.1. XM_005272358.4.
XP_005272416.1. XM_005272359.4.
UniGeneiHs.459391.

Genome annotation databases

EnsembliENST00000292524; ENSP00000292524; ENSG00000160959.
ENST00000529022; ENSP00000434768; ENSG00000160959.
GeneIDi9684.
KEGGihsa:9684.
UCSCiuc003zdk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25216 mRNA. Translation: BAA04946.2. Different initiation.
AK289473 mRNA. Translation: BAF82162.1.
CH471162 Genomic DNA. Translation: EAW82066.1.
CH471162 Genomic DNA. Translation: EAW82067.1.
CH471162 Genomic DNA. Translation: EAW82068.1.
CH471162 Genomic DNA. Translation: EAW82069.1.
BC011377 mRNA. Translation: AAH11377.1.
CCDSiCCDS6432.1.
RefSeqiNP_001258965.1. NM_001272036.1.
NP_055480.1. NM_014665.3.
XP_005272415.1. XM_005272358.4.
XP_005272416.1. XM_005272359.4.
UniGeneiHs.459391.

3D structure databases

ProteinModelPortaliQ15048.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115037. 8 interactors.
IntActiQ15048. 2 interactors.
STRINGi9606.ENSP00000292524.

PTM databases

iPTMnetiQ15048.
PhosphoSitePlusiQ15048.

Polymorphism and mutation databases

DMDMi6686102.

Proteomic databases

EPDiQ15048.
MaxQBiQ15048.
PaxDbiQ15048.
PeptideAtlasiQ15048.
PRIDEiQ15048.
TopDownProteomicsiQ15048.

Protocols and materials databases

DNASUi9684.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292524; ENSP00000292524; ENSG00000160959.
ENST00000529022; ENSP00000434768; ENSG00000160959.
GeneIDi9684.
KEGGihsa:9684.
UCSCiuc003zdk.4. human.

Organism-specific databases

CTDi9684.
GeneCardsiLRRC14.
H-InvDBHIX0007861.
HGNCiHGNC:20419. LRRC14.
HPAiHPA021047.
HPA063512.
neXtProtiNX_Q15048.
OpenTargetsiENSG00000160959.
PharmGKBiPA134914089.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIBA. Eukaryota.
ENOG4111FCX. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000113363.
HOVERGENiHBG052342.
InParanoidiQ15048.
OMAiPILTRCT.
OrthoDBiEOG091G05TB.
PhylomeDBiQ15048.
TreeFamiTF332708.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160959-MONOMER.

Miscellaneous databases

ChiTaRSiLRRC14. human.
GenomeRNAii9684.
PROiQ15048.

Gene expression databases

BgeeiENSG00000160959.
CleanExiHS_LRRC14.
ExpressionAtlasiQ15048. baseline and differential.
GenevisibleiQ15048. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR026292. LRRC14.
[Graphical view]
PANTHERiPTHR14224:SF9. PTHR14224:SF9. 1 hit.
PfamiPF13516. LRR_6. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC14_HUMAN
AccessioniPrimary (citable) accession number: Q15048
Secondary accession number(s): A8K0A8, D3DWM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.