Q15048 (LRC14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine-rich repeat-containing protein 14

Gene names

Name:	LRRC14
Synonyms:	KIAA0014

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the PRAME family. Contains 5 LRR (leucine-rich) repeats.
Sequence caution	The sequence BAA04946.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Leucine-rich repeat-containing protein 14		PRO_0000156974
Regions
	Repeat	285 – 307	23	LRR 1
	Repeat	310 – 330	21	LRR 2
	Repeat	337 – 360	24	LRR 3
	Repeat	366 – 387	22	LRR 4
	Repeat	394 – 414	21	LRR 5
Natural variations
	Natural variant	437	1	G → D. Corresponds to variant rs3735854 [ dbSNP | Ensembl ].		VAR_053603
Experimental info
	Sequence conflict	230	1	N → S in BAF82162. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q15048 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1B02E6D0FAF06A88	FASTA	493	54,513
	10 20 30 40 50 60 MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTVVLREL VHTWPFPLLS 70 80 90 100 110 120 FQQLLQECAH CSRALLQERP STESMQAVIL GLTARLHTSE PGASTQPLCR KHALRVLDMT 130 140 150 160 170 180 GLLDDGVEQD PGTMSMWDCT AAVARTCIAQ QQGGAAEPGP APIPVEVRVD LRVNRASYAF 190 200 210 220 230 240 LREALRSSVG SPLRLCCRDL RAEDLPMRNT VALLQLLDAG CLRRVDLRFN NLGLRGLSVI 250 260 270 280 290 300 IPHVARFQHL ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFTCLRELS MGSSLLSGRL 310 320 330 340 350 360 DQLLSTLQSP LESLELAFCA LLPEDLRFLA RSPHAAHLKK LDLSGNDLSG SQLAPFQGLL 370 380 390 400 410 420 QASAATLLHL ELTECQLADT QLLATLPILT QCASLRYLGL YGNPLSMAGL KELLRDSVAQ 430 440 450 460 470 480 AELRTVVHPF PVDCYEGLPW PPPASVLLEA SINEEKFARV EAELHQLLLA SGRAHVLWTT 490 DIYGRLAADY FSL

References

[1]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D25216 mRNA. Translation: BAA04946.2. Different initiation. AK289473 mRNA. Translation: BAF82162.1. CH471162 Genomic DNA. Translation: EAW82066.1. CH471162 Genomic DNA. Translation: EAW82067.1. CH471162 Genomic DNA. Translation: EAW82068.1. CH471162 Genomic DNA. Translation: EAW82069.1. BC011377 mRNA. Translation: AAH11377.1.
IPI	IPI00014239.
RefSeq	NP_001258965.1. NM_001272036.1. NP_055480.1. NM_014665.3.
UniGene	Hs.459391.
3D structure databases
ProteinModelPortal	Q15048.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15048. 2 interactions.
STRING	9606.ENSP00000292524.
PTM databases
PhosphoSite	Q15048.
Polymorphism databases
DMDM	6686102.
Proteomic databases
PaxDb	Q15048.
PRIDE	Q15048.
Protocols and materials databases
DNASU	9684.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292524; ENSP00000292524; ENSG00000160959. ENST00000529022; ENSP00000434768; ENSG00000160959.
GeneID	9684.
KEGG	hsa:9684.
UCSC	uc003zdk.2. human.
Organism-specific databases
CTD	9684.
GeneCards	GC08P145743.
H-InvDB	HIX0007861.
HGNC	HGNC:20419. LRRC14.
HPA	HPA021047.
neXtProt	NX_Q15048.
PharmGKB	PA134914089.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44653.
HOGENOM	HOG000113363.
HOVERGEN	HBG052342.
InParanoid	Q15048.
OMA	GTQPLCR.
OrthoDB	EOG4GQQ4W.
PhylomeDB	Q15048.
Gene expression databases
ArrayExpress	Q15048.
Bgee	Q15048.
CleanEx	HS_LRRC14.
Genevestigator	Q15048.
GermOnline	ENSG00000160959. Homo sapiens.
Family and domain databases
InterPro	IPR026292. PRAME/Leu_rich_rep-con_p14. [Graphical view]
PANTHER	PTHR14224. PTHR14224. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	9684.
NextBio	36368.

Entry information

Entry name

LRC14_HUMAN

Accession

Primary (citable) accession number: Q15048
Secondary accession number(s): A8K0A8, D3DWM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.