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Q15048

- LRC14_HUMAN

UniProt

Q15048 - LRC14_HUMAN

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Protein

Leucine-rich repeat-containing protein 14

Gene

LRRC14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 14
Gene namesi
Name:LRRC14
Synonyms:KIAA0014
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:20419. LRRC14.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914089.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Leucine-rich repeat-containing protein 14PRO_0000156974Add
BLAST

Proteomic databases

MaxQBiQ15048.
PaxDbiQ15048.
PRIDEiQ15048.

PTM databases

PhosphoSiteiQ15048.

Expressioni

Gene expression databases

BgeeiQ15048.
CleanExiHS_LRRC14.
ExpressionAtlasiQ15048. baseline and differential.
GenevestigatoriQ15048.

Organism-specific databases

HPAiHPA021047.

Interactioni

Protein-protein interaction databases

BioGridi115037. 10 interactions.
IntActiQ15048. 2 interactions.
STRINGi9606.ENSP00000292524.

Structurei

3D structure databases

ProteinModelPortaliQ15048.
SMRiQ15048. Positions 216-428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati285 – 30723LRR 1Add
BLAST
Repeati310 – 33021LRR 2Add
BLAST
Repeati337 – 36024LRR 3Add
BLAST
Repeati366 – 38722LRR 4Add
BLAST
Repeati394 – 41421LRR 5Add
BLAST

Sequence similaritiesi

Belongs to the PRAME family.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG44653.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000113363.
HOVERGENiHBG052342.
InParanoidiQ15048.
OMAiGTQPLCR.
PhylomeDBiQ15048.
TreeFamiTF332708.

Family and domain databases

InterProiIPR026292. PRAME/Leu_rich_rep-con_p14.
[Graphical view]
PANTHERiPTHR14224. PTHR14224. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15048-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTVVLREL
60 70 80 90 100
VHTWPFPLLS FQQLLQECAH CSRALLQERP STESMQAVIL GLTARLHTSE
110 120 130 140 150
PGASTQPLCR KHALRVLDMT GLLDDGVEQD PGTMSMWDCT AAVARTCIAQ
160 170 180 190 200
QQGGAAEPGP APIPVEVRVD LRVNRASYAF LREALRSSVG SPLRLCCRDL
210 220 230 240 250
RAEDLPMRNT VALLQLLDAG CLRRVDLRFN NLGLRGLSVI IPHVARFQHL
260 270 280 290 300
ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFTCLRELS MGSSLLSGRL
310 320 330 340 350
DQLLSTLQSP LESLELAFCA LLPEDLRFLA RSPHAAHLKK LDLSGNDLSG
360 370 380 390 400
SQLAPFQGLL QASAATLLHL ELTECQLADT QLLATLPILT QCASLRYLGL
410 420 430 440 450
YGNPLSMAGL KELLRDSVAQ AELRTVVHPF PVDCYEGLPW PPPASVLLEA
460 470 480 490
SINEEKFARV EAELHQLLLA SGRAHVLWTT DIYGRLAADY FSL
Length:493
Mass (Da):54,513
Last modified:November 1, 1996 - v1
Checksum:i1B02E6D0FAF06A88
GO

Sequence cautioni

The sequence BAA04946.2 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti230 – 2301N → S in BAF82162. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti437 – 4371G → D.
Corresponds to variant rs3735854 [ dbSNP | Ensembl ].
VAR_053603

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D25216 mRNA. Translation: BAA04946.2. Different initiation.
AK289473 mRNA. Translation: BAF82162.1.
CH471162 Genomic DNA. Translation: EAW82066.1.
CH471162 Genomic DNA. Translation: EAW82067.1.
CH471162 Genomic DNA. Translation: EAW82068.1.
CH471162 Genomic DNA. Translation: EAW82069.1.
BC011377 mRNA. Translation: AAH11377.1.
CCDSiCCDS6432.1.
RefSeqiNP_001258965.1. NM_001272036.1.
NP_055480.1. NM_014665.3.
XP_005272415.1. XM_005272358.2.
XP_005272416.1. XM_005272359.2.
UniGeneiHs.459391.

Genome annotation databases

EnsembliENST00000292524; ENSP00000292524; ENSG00000160959.
ENST00000529022; ENSP00000434768; ENSG00000160959.
GeneIDi9684.
KEGGihsa:9684.
UCSCiuc003zdk.3. human.

Polymorphism databases

DMDMi6686102.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D25216 mRNA. Translation: BAA04946.2 . Different initiation.
AK289473 mRNA. Translation: BAF82162.1 .
CH471162 Genomic DNA. Translation: EAW82066.1 .
CH471162 Genomic DNA. Translation: EAW82067.1 .
CH471162 Genomic DNA. Translation: EAW82068.1 .
CH471162 Genomic DNA. Translation: EAW82069.1 .
BC011377 mRNA. Translation: AAH11377.1 .
CCDSi CCDS6432.1.
RefSeqi NP_001258965.1. NM_001272036.1.
NP_055480.1. NM_014665.3.
XP_005272415.1. XM_005272358.2.
XP_005272416.1. XM_005272359.2.
UniGenei Hs.459391.

3D structure databases

ProteinModelPortali Q15048.
SMRi Q15048. Positions 216-428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115037. 10 interactions.
IntActi Q15048. 2 interactions.
STRINGi 9606.ENSP00000292524.

PTM databases

PhosphoSitei Q15048.

Polymorphism databases

DMDMi 6686102.

Proteomic databases

MaxQBi Q15048.
PaxDbi Q15048.
PRIDEi Q15048.

Protocols and materials databases

DNASUi 9684.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292524 ; ENSP00000292524 ; ENSG00000160959 .
ENST00000529022 ; ENSP00000434768 ; ENSG00000160959 .
GeneIDi 9684.
KEGGi hsa:9684.
UCSCi uc003zdk.3. human.

Organism-specific databases

CTDi 9684.
GeneCardsi GC08P145743.
H-InvDB HIX0007861.
HGNCi HGNC:20419. LRRC14.
HPAi HPA021047.
neXtProti NX_Q15048.
PharmGKBi PA134914089.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44653.
GeneTreei ENSGT00760000119028.
HOGENOMi HOG000113363.
HOVERGENi HBG052342.
InParanoidi Q15048.
OMAi GTQPLCR.
PhylomeDBi Q15048.
TreeFami TF332708.

Miscellaneous databases

GenomeRNAii 9684.
NextBioi 36368.
PROi Q15048.

Gene expression databases

Bgeei Q15048.
CleanExi HS_LRRC14.
ExpressionAtlasi Q15048. baseline and differential.
Genevestigatori Q15048.

Family and domain databases

InterProi IPR026292. PRAME/Leu_rich_rep-con_p14.
[Graphical view ]
PANTHERi PTHR14224. PTHR14224. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
    Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
    DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiLRC14_HUMAN
AccessioniPrimary (citable) accession number: Q15048
Secondary accession number(s): A8K0A8, D3DWM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3