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Protein

Zinc transporter ZIP14

Gene

SLC39A14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular zinc ion homeostasis Source: BHF-UCL
  • zinc II ion transmembrane import Source: BHF-UCL
  • zinc II ion transmembrane transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-HSA-442380. Zinc influx into cells by the SLC39 gene family.

Protein family/group databases

TCDBi2.A.5.4.5. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP14
Alternative name(s):
LIV-1 subfamily of ZIP zinc transporter 4
Short name:
LZT-Hs4
Solute carrier family 39 member 14
Zrt- and Irt-like protein 14
Short name:
ZIP-14
Gene namesi
Name:SLC39A14
Synonyms:KIAA0062, ZIP14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:20858. SLC39A14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 157127ExtracellularSequence analysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence analysisAdd
BLAST
Topological domaini179 – 1868CytoplasmicSequence analysis
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST
Topological domaini208 – 22417ExtracellularSequence analysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Topological domaini246 – 397152CytoplasmicSequence analysisAdd
BLAST
Transmembranei398 – 41821HelicalSequence analysisAdd
BLAST
Topological domaini419 – 4246ExtracellularSequence analysis
Transmembranei425 – 44521HelicalSequence analysisAdd
BLAST
Topological domaini446 – 46015CytoplasmicSequence analysisAdd
BLAST
Transmembranei461 – 48121HelicalSequence analysisAdd
BLAST
Topological domaini482 – 49211ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: HPA
  • Golgi apparatus Source: HPA
  • integral component of membrane Source: BHF-UCL
  • integral component of plasma membrane Source: BHF-UCL
  • lamellipodium Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134863701.

Polymorphism and mutation databases

BioMutaiSLC39A14.
DMDMi313104191.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 492462Zinc transporter ZIP14PRO_0000312194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...)2 Publications
Glycosylationi102 – 1021N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ15043.
MaxQBiQ15043.
PaxDbiQ15043.
PRIDEiQ15043.

PTM databases

iPTMnetiQ15043.
PhosphoSiteiQ15043.

Expressioni

Tissue specificityi

Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes.2 Publications

Gene expression databases

BgeeiQ15043.
CleanExiHS_SLC39A14.
ExpressionAtlasiQ15043. baseline and differential.
GenevisibleiQ15043. HS.

Organism-specific databases

HPAiHPA016508.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

BioGridi117063. 5 interactions.
IntActiQ15043. 4 interactions.
MINTiMINT-5004639.
STRINGi9606.ENSP00000289952.

Structurei

3D structure databases

ProteinModelPortaliQ15043.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi251 – 2588HHHGHXHX-motif
Motifi376 – 3816XEXPHE-motif

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000070225.
HOVERGENiHBG108450.
InParanoidiQ15043.
KOiK14720.
OMAiCANEIEM.
OrthoDBiEOG73BVD2.
PhylomeDBiQ15043.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15043-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLLLLHPAF QSCLLLTLLG LWRTTPEAHA SSLGAPAISA ASFLQDLIHR
60 70 80 90 100
YGEGDSLTLQ QLKALLNHLD VGVGRGNVTQ HVQGHRNLST CFSSGDLFTA
110 120 130 140 150
HNFSEQSRIG SSELQEFCPT ILQQLDSRAC TSENQENEEN EQTEEGRPSA
160 170 180 190 200
VEVWGYGLLC VTVISLCSLL GASVVPFMKK TFYKRLLLYF IALAIGTLYS
210 220 230 240 250
NALFQLIPEA FGFNPLEDYY VSKSAVVFGG FYLFFFTEKI LKILLKQKNE
260 270 280 290 300
HHHGHSHYAS ESLPSKKDQE EGVMEKLQNG DLDHMIPQHC SSELDGKAPM
310 320 330 340 350
VDEKVIVGSL SVQDLQASQS ACYWLKGVRY SDIGTLAWMI TLSDGLHNFI
360 370 380 390 400
DGLAIGASFT VSVFQGISTS VAILCEEFPH ELGDFVILLN AGMSIQQALF
410 420 430 440 450
FNFLSACCCY LGLAFGILAG SHFSANWIFA LAGGMFLYIS LADMFPEMNE
460 470 480 490
VCQEDERKGS ILIPFIIQNL GLLTGFTIMV VLTMYSGQIQ IG
Length:492
Mass (Da):54,212
Last modified:November 30, 2010 - v3
Checksum:iF2ACE1DA4656A5F0
GO
Isoform 2 (identifier: Q15043-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-492: FPEMNEVCQE...TMYSGQIQIG → MEFCSVAQAG...RLSCLSLPSN

Note: No experimental confirmation available.
Show »
Length:481
Mass (Da):52,839
Checksum:iDC2788F667F06D95
GO
Isoform 3 (identifier: Q15043-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-199: YGLLCVTVIS...FIALAIGTLY → FGFLSVSLIN...FIALSIGTLL

Show »
Length:492
Mass (Da):54,057
Checksum:i5D5503F24F952500
GO

Sequence cautioni

The sequence BAA06685.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571L → P in BAD18780 (PubMed:14702039).Curated
Sequence conflicti314 – 3141D → G in BAG58625 (PubMed:14702039).Curated
Sequence conflicti380 – 3801H → R in BAD18780 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331L → P.1 Publication
Corresponds to variant rs896378 [ dbSNP | Ensembl ].
VAR_037450

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei156 – 19944YGLLC…IGTLY → FGFLSVSLINLASLLGVLVL PCTEKAFFSRVLTYFIALSI GTLL in isoform 3. 1 PublicationVSP_040139Add
BLAST
Alternative sequencei445 – 49248FPEMN…QIQIG → MEFCSVAQAGVQWCHLSSLQ PLPLGLKRLSCLSLPSN in isoform 2. 1 PublicationVSP_029728Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31887 mRNA. Translation: BAA06685.1. Different initiation.
AK172810 mRNA. Translation: BAD18780.1.
AK295807 mRNA. Translation: BAG58625.1.
AC087854 Genomic DNA. No translation available.
AC105910 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63681.1.
CH471080 Genomic DNA. Translation: EAW63682.1.
CH471080 Genomic DNA. Translation: EAW63683.1.
BC015770 mRNA. Translation: AAH15770.1.
CCDSiCCDS47822.1. [Q15043-2]
CCDS47823.1. [Q15043-1]
CCDS6030.1. [Q15043-3]
RefSeqiNP_001121903.1. NM_001128431.2. [Q15043-1]
NP_001128625.1. NM_001135153.1. [Q15043-1]
NP_001128626.1. NM_001135154.1. [Q15043-2]
NP_056174.2. NM_015359.4. [Q15043-3]
XP_005273522.1. XM_005273465.1. [Q15043-1]
XP_005273523.1. XM_005273466.3. [Q15043-1]
XP_006716387.1. XM_006716324.1. [Q15043-1]
XP_011542779.1. XM_011544477.1. [Q15043-3]
XP_011542780.1. XM_011544478.1. [Q15043-1]
UniGeneiHs.491232.

Genome annotation databases

EnsembliENST00000240095; ENSP00000240095; ENSG00000104635. [Q15043-2]
ENST00000289952; ENSP00000289952; ENSG00000104635. [Q15043-1]
ENST00000359741; ENSP00000352779; ENSG00000104635. [Q15043-3]
ENST00000381237; ENSP00000370635; ENSG00000104635. [Q15043-1]
GeneIDi23516.
KEGGihsa:23516.
UCSCiuc003xbp.5. human. [Q15043-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31887 mRNA. Translation: BAA06685.1. Different initiation.
AK172810 mRNA. Translation: BAD18780.1.
AK295807 mRNA. Translation: BAG58625.1.
AC087854 Genomic DNA. No translation available.
AC105910 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63681.1.
CH471080 Genomic DNA. Translation: EAW63682.1.
CH471080 Genomic DNA. Translation: EAW63683.1.
BC015770 mRNA. Translation: AAH15770.1.
CCDSiCCDS47822.1. [Q15043-2]
CCDS47823.1. [Q15043-1]
CCDS6030.1. [Q15043-3]
RefSeqiNP_001121903.1. NM_001128431.2. [Q15043-1]
NP_001128625.1. NM_001135153.1. [Q15043-1]
NP_001128626.1. NM_001135154.1. [Q15043-2]
NP_056174.2. NM_015359.4. [Q15043-3]
XP_005273522.1. XM_005273465.1. [Q15043-1]
XP_005273523.1. XM_005273466.3. [Q15043-1]
XP_006716387.1. XM_006716324.1. [Q15043-1]
XP_011542779.1. XM_011544477.1. [Q15043-3]
XP_011542780.1. XM_011544478.1. [Q15043-1]
UniGeneiHs.491232.

3D structure databases

ProteinModelPortaliQ15043.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117063. 5 interactions.
IntActiQ15043. 4 interactions.
MINTiMINT-5004639.
STRINGi9606.ENSP00000289952.

Protein family/group databases

TCDBi2.A.5.4.5. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

iPTMnetiQ15043.
PhosphoSiteiQ15043.

Polymorphism and mutation databases

BioMutaiSLC39A14.
DMDMi313104191.

Proteomic databases

EPDiQ15043.
MaxQBiQ15043.
PaxDbiQ15043.
PRIDEiQ15043.

Protocols and materials databases

DNASUi23516.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240095; ENSP00000240095; ENSG00000104635. [Q15043-2]
ENST00000289952; ENSP00000289952; ENSG00000104635. [Q15043-1]
ENST00000359741; ENSP00000352779; ENSG00000104635. [Q15043-3]
ENST00000381237; ENSP00000370635; ENSG00000104635. [Q15043-1]
GeneIDi23516.
KEGGihsa:23516.
UCSCiuc003xbp.5. human. [Q15043-1]

Organism-specific databases

CTDi23516.
GeneCardsiSLC39A14.
HGNCiHGNC:20858. SLC39A14.
HPAiHPA016508.
MIMi608736. gene.
neXtProtiNX_Q15043.
PharmGKBiPA134863701.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000070225.
HOVERGENiHBG108450.
InParanoidiQ15043.
KOiK14720.
OMAiCANEIEM.
OrthoDBiEOG73BVD2.
PhylomeDBiQ15043.
TreeFamiTF318470.

Enzyme and pathway databases

ReactomeiR-HSA-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSiSLC39A14. human.
GenomeRNAii23516.
PROiQ15043.
SOURCEiSearch...

Gene expression databases

BgeeiQ15043.
CleanExiHS_SLC39A14.
ExpressionAtlasiQ15043. baseline and differential.
GenevisibleiQ15043. HS.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
    Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
    DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Bone marrow.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Hippocampus.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-33.
    Tissue: Colon.
  6. "The LZT proteins; the LIV-1 subfamily of zinc transporters."
    Taylor K.M., Nicholson R.I.
    Biochim. Biophys. Acta 1611:16-30(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, SUBCELLULAR LOCATION.
  7. "Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14."
    Taylor K.M., Morgan H.E., Johnson A., Nicholson R.I.
    FEBS Lett. 579:427-432(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION.
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-77.
    Tissue: Liver.
  9. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-77 AND ASN-102.
    Tissue: Leukemic T-cell.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiS39AE_HUMAN
AccessioniPrimary (citable) accession number: Q15043
Secondary accession number(s): A6NH98
, B4DIW3, B6EU88, D3DSR4, Q6ZME8, Q96BB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 30, 2010
Last modified: June 8, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.