Reviewed, UniProtKB/Swiss-Prot Q15041 (AR6P1_HUMAN)

Names and origin

Protein names

Recommended name:
    ADP-ribosylation factor-like protein 6-interacting protein 1
      Short name=ARL-6-interacting protein 1
      Short name=Aip-1

Gene names

Name:	ARL6IP1
Synonyms:	ARL6IP, KIAA0069

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.
Subunit structure	Interacts with ARL6 By similarity.
Subcellular location	Endomembrane system; Multi-pass membrane protein. Note: Predominantly localized to intracytoplasmic membranes. Ref.3
Tissue specificity	Expressed in all hematopoietic cell lineages, but the highest level of expression is found in early myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in liver, kidney and spleen. Not detected in heart. Ref.3
Developmental stage	Down-regulated during myeloid differentiation.
Sequence similarities	Belongs to the ARL6ip family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FXR2	P51116	2	EBI-714543,EBI-740459

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	ADP-ribosylation factor-like protein 6-interacting protein 1		PRO_0000064655
Regions
	Transmembrane	42 – 62	21	Potential
	Transmembrane	66 – 86	21	Potential
	Transmembrane	134 – 154	21	Potential
	Transmembrane	155 – 175	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q15041-1 [UniParc]. Last modified June 20, 2001. Version 2. Checksum: CE914D8FC9609FC6	FASTA	203	23,363
	10 20 30 40 50 60 MAEGDNRSTN LLAAETASLE EQLQGWGEVM LMADKVLRWE RAWFPPAIMG VVSLVFLIIY 70 80 90 100 110 120 YLDPSVLSGV SCFVMFLCLA DYLVPILAPR IFGSNKWTTE QQQRFHEICS NLVKTRRRAV 130 140 150 160 170 180 GWWKRLFTLK EEKPKMYFMT MIVSLAAVAW VGQQVHNLLL TYLIVTSLLL LPGLNQHGII 190 200 LKYIGMAKRE INKLLKQKEK KNE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1." Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S. DNA Res. 1:223-229(1994) [PubMed: 7584044] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"Characterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP-ribosylation-like factor-6 interacting protein (ARL6)." Pettersson M., Bessonova M., Gu H.F., Groop L.C., Jonsson J.I. Genomics 68:351-354(2000) [PubMed: 10995579] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D31885 mRNA. Translation: BAA06683.1. Different initiation. BC010281 mRNA. Translation: AAH10281.1.
IPI	IPI00014232.
RefSeq	NP_055976.1.
UniGene	Hs.634882
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15041. 4 interactions.
STRING	Q15041.
Proteomic databases
PeptideAtlas	Q15041.
PRIDE	Q15041.
Genome annotation databases
Ensembl	ENST00000304414; ENSP00000306788; ENSG00000170540; Homo sapiens. [Genome view]
GeneID	23204.
KEGG	hsa:23204.
UCSC	uc002dfl.1. human.
Organism-specific databases
CTD	23204.
GeneCards	GC16M018711.
H-InvDB	HIX0012847.
HGNC	HGNC:697. ARL6IP1.
MIM	607669. gene.
PharmGKB	PA24990.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q15041.
HOVERGEN	Q15041.
OMA	FLMIYYL
OrthoDB	EOG9KM1PJ
Gene expression databases
ArrayExpress	Q15041.
Bgee	Q15041.
CleanEx	HS_ARL6IP1.
Genevestigator	Q15041.
GermOnline	ENSG00000170540. Homo sapiens.
Family and domain databases
InterPro	IPR003388. Reticulon. [Graphical view]
Pfam	PF02453. Reticulon. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	44727.
SOURCE	Search...

Entry information

Entry name

AR6P1_HUMAN

Accession

Primary (citable) accession number: Q15041

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	June 20, 2001
Last modified:	November 24, 2009
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.