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Q15041

- AR6P1_HUMAN

UniProt

Q15041 - AR6P1_HUMAN

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Protein
ADP-ribosylation factor-like protein 6-interacting protein 1
Gene
ARL6IP1, ARL6IP, KIAA0069
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. cotranslational protein targeting to membrane Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 6-interacting protein 1
Short name:
ARL-6-interacting protein 1
Short name:
Aip-1
Gene namesi
Name:ARL6IP1
Synonyms:ARL6IP, KIAA0069
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:697. ARL6IP1.

Subcellular locationi

Endomembrane system; Multi-pass membrane protein
Note: Predominantly localized to intracytoplasmic membranes.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221Helical; Reviewed prediction
Add
BLAST
Transmembranei66 – 8621Helical; Reviewed prediction
Add
BLAST
Transmembranei134 – 15421Helical; Reviewed prediction
Add
BLAST
Transmembranei155 – 17521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Sec61 translocon complex Source: Ensembl
  2. cytosol Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376894.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203ADP-ribosylation factor-like protein 6-interacting protein 1
PRO_0000064655Add
BLAST

Proteomic databases

MaxQBiQ15041.
PaxDbiQ15041.
PeptideAtlasiQ15041.
PRIDEiQ15041.

PTM databases

PhosphoSiteiQ15041.

Expressioni

Tissue specificityi

Expressed in all hematopoietic cell lineages, but the highest level of expression is found in early myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in liver, kidney and spleen. Not detected in heart.1 Publication

Developmental stagei

Down-regulated during myeloid differentiation.

Gene expression databases

ArrayExpressiQ15041.
BgeeiQ15041.
CleanExiHS_ARL6IP1.
GenevestigatoriQ15041.

Organism-specific databases

HPAiHPA045307.

Interactioni

Subunit structurei

Interacts with ARL6 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
FXR2P511163EBI-714543,EBI-740459

Protein-protein interaction databases

BioGridi116812. 10 interactions.
IntActiQ15041. 10 interactions.
MINTiMINT-1378119.
STRINGi9606.ENSP00000306788.

Structurei

3D structure databases

ProteinModelPortaliQ15041.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARL6ip family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46676.
HOGENOMiHOG000034032.
HOVERGENiHBG050558.
InParanoidiQ15041.
OMAiWLAPKKL.
OrthoDBiEOG7CZK70.
PhylomeDBiQ15041.
TreeFamiTF105477.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15041-1 [UniParc]FASTAAdd to Basket

« Hide

MAEGDNRSTN LLAAETASLE EQLQGWGEVM LMADKVLRWE RAWFPPAIMG    50
VVSLVFLIIY YLDPSVLSGV SCFVMFLCLA DYLVPILAPR IFGSNKWTTE 100
QQQRFHEICS NLVKTRRRAV GWWKRLFTLK EEKPKMYFMT MIVSLAAVAW 150
VGQQVHNLLL TYLIVTSLLL LPGLNQHGII LKYIGMAKRE INKLLKQKEK 200
KNE 203
Length:203
Mass (Da):23,363
Last modified:June 20, 2001 - v2
Checksum:iCE914D8FC9609FC6
GO

Sequence cautioni

The sequence BAA06683.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31885 mRNA. Translation: BAA06683.1. Different initiation.
BC010281 mRNA. Translation: AAH10281.1.
CCDSiCCDS10572.1.
RefSeqiNP_055976.1. NM_015161.1.
UniGeneiHs.634882.

Genome annotation databases

EnsembliENST00000304414; ENSP00000306788; ENSG00000170540.
GeneIDi23204.
KEGGihsa:23204.
UCSCiuc002dfl.1. human.

Polymorphism databases

DMDMi14424435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31885 mRNA. Translation: BAA06683.1 . Different initiation.
BC010281 mRNA. Translation: AAH10281.1 .
CCDSi CCDS10572.1.
RefSeqi NP_055976.1. NM_015161.1.
UniGenei Hs.634882.

3D structure databases

ProteinModelPortali Q15041.
ModBasei Search...

Protein-protein interaction databases

BioGridi 116812. 10 interactions.
IntActi Q15041. 10 interactions.
MINTi MINT-1378119.
STRINGi 9606.ENSP00000306788.

PTM databases

PhosphoSitei Q15041.

Polymorphism databases

DMDMi 14424435.

Proteomic databases

MaxQBi Q15041.
PaxDbi Q15041.
PeptideAtlasi Q15041.
PRIDEi Q15041.

Protocols and materials databases

DNASUi 23204.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304414 ; ENSP00000306788 ; ENSG00000170540 .
GeneIDi 23204.
KEGGi hsa:23204.
UCSCi uc002dfl.1. human.

Organism-specific databases

CTDi 23204.
GeneCardsi GC16M018802.
HGNCi HGNC:697. ARL6IP1.
HPAi HPA045307.
MIMi 607669. gene.
neXtProti NX_Q15041.
PharmGKBi PA162376894.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46676.
HOGENOMi HOG000034032.
HOVERGENi HBG050558.
InParanoidi Q15041.
OMAi WLAPKKL.
OrthoDBi EOG7CZK70.
PhylomeDBi Q15041.
TreeFami TF105477.

Miscellaneous databases

GeneWikii ARL6IP1.
GenomeRNAii 23204.
NextBioi 44727.
PROi Q15041.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15041.
Bgeei Q15041.
CleanExi HS_ARL6IP1.
Genevestigatori Q15041.

Family and domain databases

InterProi IPR003388. Reticulon.
[Graphical view ]
Pfami PF02453. Reticulon. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
    Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
    DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Characterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP-ribosylation-like factor-6 interacting protein (ARL6)."
    Pettersson M., Bessonova M., Gu H.F., Groop L.C., Jonsson J.I.
    Genomics 68:351-354(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAR6P1_HUMAN
AccessioniPrimary (citable) accession number: Q15041
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2001
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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