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Q15041 (AR6P1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP-ribosylation factor-like protein 6-interacting protein 1

Short name=ARL-6-interacting protein 1
Short name=Aip-1
Gene names
Name:ARL6IP1
Synonyms:ARL6IP, KIAA0069
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.

Subunit structure

Interacts with ARL6 By similarity.

Subcellular location

Endomembrane system; Multi-pass membrane protein. Note: Predominantly localized to intracytoplasmic membranes. Ref.3

Tissue specificity

Expressed in all hematopoietic cell lineages, but the highest level of expression is found in early myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in liver, kidney and spleen. Not detected in heart. Ref.3

Developmental stage

Down-regulated during myeloid differentiation.

Sequence similarities

Belongs to the ARL6ip family.

Sequence caution

The sequence BAA06683.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FXR2P511163EBI-714543,EBI-740459

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203ADP-ribosylation factor-like protein 6-interacting protein 1
PRO_0000064655

Regions

Transmembrane42 – 6221Helical; Potential
Transmembrane66 – 8621Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane155 – 17521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q15041 [UniParc].

Last modified June 20, 2001. Version 2.
Checksum: CE914D8FC9609FC6

FASTA20323,363
        10         20         30         40         50         60 
MAEGDNRSTN LLAAETASLE EQLQGWGEVM LMADKVLRWE RAWFPPAIMG VVSLVFLIIY 

        70         80         90        100        110        120 
YLDPSVLSGV SCFVMFLCLA DYLVPILAPR IFGSNKWTTE QQQRFHEICS NLVKTRRRAV 

       130        140        150        160        170        180 
GWWKRLFTLK EEKPKMYFMT MIVSLAAVAW VGQQVHNLLL TYLIVTSLLL LPGLNQHGII 

       190        200 
LKYIGMAKRE INKLLKQKEK KNE 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[3]"Characterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP-ribosylation-like factor-6 interacting protein (ARL6)."
Pettersson M., Bessonova M., Gu H.F., Groop L.C., Jonsson J.I.
Genomics 68:351-354(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D31885 mRNA. Translation: BAA06683.1. Different initiation.
BC010281 mRNA. Translation: AAH10281.1.
CCDSCCDS10572.1.
RefSeqNP_055976.1. NM_015161.1.
UniGeneHs.634882.

3D structure databases

ProteinModelPortalQ15041.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116812. 10 interactions.
IntActQ15041. 10 interactions.
MINTMINT-1378119.
STRING9606.ENSP00000306788.

PTM databases

PhosphoSiteQ15041.

Polymorphism databases

DMDM14424435.

Proteomic databases

MaxQBQ15041.
PaxDbQ15041.
PeptideAtlasQ15041.
PRIDEQ15041.

Protocols and materials databases

DNASU23204.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304414; ENSP00000306788; ENSG00000170540.
GeneID23204.
KEGGhsa:23204.
UCSCuc002dfl.1. human.

Organism-specific databases

CTD23204.
GeneCardsGC16M018802.
HGNCHGNC:697. ARL6IP1.
HPAHPA045307.
MIM607669. gene.
neXtProtNX_Q15041.
PharmGKBPA162376894.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46676.
HOGENOMHOG000034032.
HOVERGENHBG050558.
InParanoidQ15041.
OMAWLAPKKL.
OrthoDBEOG7CZK70.
PhylomeDBQ15041.
TreeFamTF105477.

Gene expression databases

ArrayExpressQ15041.
BgeeQ15041.
CleanExHS_ARL6IP1.
GenevestigatorQ15041.

Family and domain databases

InterProIPR003388. Reticulon.
[Graphical view]
PfamPF02453. Reticulon. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiARL6IP1.
GenomeRNAi23204.
NextBio44727.
PROQ15041.
SOURCESearch...

Entry information

Entry nameAR6P1_HUMAN
AccessionPrimary (citable) accession number: Q15041
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 20, 2001
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM