Q15038 (DAZP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DAZ-associated protein 2

Alternative name(s):
Deleted in azoospermia-associated protein 2

Gene names

Name:	DAZAP2
Synonyms:	KIAA0058

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with SOX6 By similarity. Interacts with DAZ and DAZL. Interacts with IL17RB. May interact with FAM168B. Ref.9 Ref.10 Ref.11
Subcellular location	Cytoplasm. Nucleus. Note: Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm. Ref.1 Ref.11
Tissue specificity	Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Down-regulated in multiple myeloma. Ref.9
Post-translational modification	Ubiquitinated by SMURF2, leading to proteasomal degradation. Ref.11
Sequence caution	The sequence BAA06545.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATXN1	P54253	2	EBI-724310,EBI-930964
BATF2	Q8N1L9	3	EBI-724310,EBI-742695
EXD3	Q9NX53	3	EBI-724310,EBI-750745
PEF1	Q9UBV8	3	EBI-724310,EBI-724639
POLI	Q9UNA4	3	EBI-724310,EBI-741774
RHOXF2	Q9BQY4	3	EBI-724310,EBI-372094
TOLLIP	Q9H0E2	3	EBI-724310,EBI-74615
ZFAND2B	Q8WV99	3	EBI-724310,EBI-747823

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15038-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15038-2)

The sequence of this isoform differs from the canonical sequence as follows:
     127-168: PPPPGCPPNAAQLAVMQGANVLVTQRKGNFFMGGSDGGYTIW → VKEDQDHDREQGEEDNGDNNLERRGKM

Note: No experimental confirmation available.

Isoform 3 (identifier: Q15038-3)

The sequence of this isoform differs from the canonical sequence as follows:
     45-76: Missing.

Isoform 4 (identifier: Q15038-4)

The sequence of this isoform differs from the canonical sequence as follows:
     45-126: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	DAZ-associated protein 2		PRO_0000079788
Regions
	Compositional bias	8 – 134	127	Pro-rich
Natural variations
	Alternative sequence	45 – 126	82	Missing in isoform 4.		VSP_045678
	Alternative sequence	45 – 76	32	Missing in isoform 3.		VSP_045679
	Alternative sequence	127 – 168	42	PPPPG…GYTIW → VKEDQDHDREQGEEDNGDNN LERRGKM in isoform 2.		VSP_042773
	Natural variant	102	1	S → A. Corresponds to variant rs57917280 [ dbSNP | Ensembl ].		VAR_061639
Experimental info
	Sequence conflict	47	1	R → S in AAR11454. Ref.1
	Sequence conflict	90	1	A → V in BU662353. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 49F1B6D281E24AAC	FASTA	168	17,319
	10 20 30 40 50 60 MNSKGQYPTQ PTYPVQPPGN PVYPQTLHLP QAPPYTDAPP AYSELYRPSF VHPGAATVPT 70 80 90 100 110 120 MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP GSTVLVEGGY DAGARFGAGA 130 140 150 160 TAGNIPPPPP GCPPNAAQLA VMQGANVLVT QRKGNFFMGG SDGGYTIW
	Isoform 2 [UniParc]. Checksum: FAF1904AF43CA4E4	FASTA	153	16,187
	10 20 30 40 50 60 MNSKGQYPTQ PTYPVQPPGN PVYPQTLHLP QAPPYTDAPP AYSELYRPSF VHPGAATVPT 70 80 90 100 110 120 MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP GSTVLVEGGY DAGARFGAGA 130 140 150 TAGNIPVKED QDHDREQGEE DNGDNNLERR GKM
	Isoform 3 [UniParc]. Checksum: 46E379CE7F8A3A04	FASTA	136	13,987
	10 20 30 40 50 60 MNSKGQYPTQ PTYPVQPPGN PVYPQTLHLP QAPPYTDAPP AYSESVAVGP LGSTIPMAYY 70 80 90 100 110 120 PVGPIYPPGS TVLVEGGYDA GARFGAGATA GNIPPPPPGC PPNAAQLAVM QGANVLVTQR 130 KGNFFMGGSD GGYTIW
	Isoform 4 [UniParc]. Checksum: 5A99269B0CBA9174	FASTA	86	9,167
	10 20 30 40 50 60 MNSKGQYPTQ PTYPVQPPGN PVYPQTLHLP QAPPYTDAPP AYSEPPPPGC PPNAAQLAVM 70 80 QGANVLVTQR KGNFFMGGSD GGYTIW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular features and expression of DAZAP2 in human multiple myeloma." Shi Y.-W., Shen R., Ren W., Tang L.J., Tan D.-R., Hu W.-X. Chin. Med. J. 120:1659-1665(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION. Tissue: Bone marrow.
[2]	"Gene expression in human erythroid precursor cells." Gubin A.N., Lee Y.T., Bouffard G.G., Miller J.L. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Erythroblast.
[3]	"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1." Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S. DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[4]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Fetal brain.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Mammary gland and Thalamus.
[6]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: B-cell and Brain.
[9]	"Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1." Tsui S., Dai T., Roettger S., Schempp W., Salido E.C., Yen P.H. Genomics 65:266-273(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH DAZ AND DAZL. Tissue: Testis.
[10]	"Characterizing the neurite outgrowth inhibitory effect of Mani." Mishra M., Lee S., Lin M.K., Yamashita T., Heese K. FEBS Lett. 586:3018-3023(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FAM168B.
[11]	"Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2." Popova A., Kzhyshkowska J., Nurgazieva D., Goerdt S., Gratchev A. Immunobiology 217:321-328(2012) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION BY SMURF2, SUBCELLULAR LOCATION, INTERACTION WITH IL17RB.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY430097 mRNA. Translation: AAR11454.1. BU662353 mRNA. No translation available. D31767 mRNA. Translation: BAA06545.2. Different initiation. BX441137 mRNA. No translation available. AK290119 mRNA. Translation: BAF82808.1. AK293330 mRNA. Translation: BAG56846.1. AC046135 Genomic DNA. No translation available. AC139768 Genomic DNA. No translation available. CH471111 Genomic DNA. Translation: EAW58181.1. BC002334 mRNA. Translation: AAH02334.1. BC007900 mRNA. Translation: AAH07900.1.
IPI	IPI00006115. IPI00790018. IPI00914856. IPI00914867.
RefSeq	NP_001129736.1. NM_001136264.1. NP_001129739.1. NM_001136267.1. NP_001129740.1. NM_001136268.1. NP_001129741.1. NM_001136269.1. NP_055579.1. NM_014764.3.
UniGene	Hs.369761.
3D structure databases
ProteinModelPortal	Q15038.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15038. 46 interactions.
MINT	MINT-1179995.
STRING	9606.ENSP00000404968.
PTM databases
PhosphoSite	Q15038.
Polymorphism databases
DMDM	44887865.
Proteomic databases
PRIDE	Q15038.
Protocols and materials databases
DNASU	9802.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000412716; ENSP00000394699; ENSG00000183283. ENST00000425012; ENSP00000408251; ENSG00000183283. ENST00000439799; ENSP00000398804; ENSG00000183283. ENST00000549732; ENSP00000446554; ENSG00000183283.
GeneID	9802.
KEGG	hsa:9802.
UCSC	uc001ryb.3. human.
Organism-specific databases
CTD	9802.
GeneCards	GC12P051634.
HGNC	HGNC:2684. DAZAP2.
MIM	607431. gene.
neXtProt	NX_Q15038.
PharmGKB	PA27154.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG286791.
HOGENOM	HOG000007683.
HOVERGEN	HBG051300.
InParanoid	Q15038.
OMA	AMQGANV.
Gene expression databases
ArrayExpress	Q15038.
Bgee	Q15038.
CleanEx	HS_DAZAP2.
Genevestigator	Q15038.
GermOnline	ENSG00000183283. Homo sapiens.
Family and domain databases
InterPro	IPR022730. DAZ_assoc-2. [Graphical view]
Pfam	PF11029. DAZAP2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DAZAP2. human.
GenomeRNAi	9802.
NextBio	36908.
SOURCE	Search...

Entry information

Entry name

DAZP2_HUMAN

Accession

Primary (citable) accession number: Q15038
Secondary accession number(s): A8K254 , B4DDT5, C9JA96, C9JP84

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.