Q15038 (DAZP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DAZ-associated protein 2

Alternative name(s):
Deleted in azoospermia-associated protein 2

Gene names

Name:	DAZAP2
Synonyms:	KIAA0058

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with SOX6 By similarity. Interacts with DAZ and DAZL. Ref.6
Tissue specificity	Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Down-regulated in multiple myeloma. Ref.6
Sequence caution	The sequence BAA06545.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	WW domain binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATXN1	P54253	2	EBI-724310,EBI-930964
BATF2	Q8N1L9	3	EBI-724310,EBI-742695
EXD3	Q9NX53	3	EBI-724310,EBI-750745
PEF1	Q9UBV8	3	EBI-724310,EBI-724639
POLI	Q9UNA4	3	EBI-724310,EBI-741774
RHOXF2	Q9BQY4	3	EBI-724310,EBI-372094
TOLLIP	Q9H0E2	3	EBI-724310,EBI-74615
ZFAND2B	Q8WV99	3	EBI-724310,EBI-747823

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	DAZ-associated protein 2		PRO_0000079788
Regions
	Compositional bias	8 – 134	127	Pro-rich
Natural variations
	Natural variant	102	1	S → A. Corresponds to variant rs57917280 [ dbSNP | Ensembl ].		VAR_061639
Experimental info
	Sequence conflict	47	1	R → S in AAR11454. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q15038 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 49F1B6D281E24AAC	FASTA	168	17,319
	10 20 30 40 50 60 MNSKGQYPTQ PTYPVQPPGN PVYPQTLHLP QAPPYTDAPP AYSELYRPSF VHPGAATVPT 70 80 90 100 110 120 MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP GSTVLVEGGY DAGARFGAGA 130 140 150 160 TAGNIPPPPP GCPPNAAQLA VMQGANVLVT QRKGNFFMGG SDGGYTIW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DAZAP2 is highly down-regulated in multiple myeloma." Hu W.-X., Shi Y.-W., Shen R., Luo S.-Q., Tan D.-R. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone marrow.
[2]	"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1." Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S. DNA Res. 1:223-229(1994) [PubMed: 7584044] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell and Brain.
[6]	"Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1." Tsui S., Dai T., Roettger S., Schempp W., Salido E.C., Yen P.H. Genomics 65:266-273(2000) [PubMed: 10857750] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH DAZ AND DAZL. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY430097 mRNA. Translation: AAR11454.1. D31767 mRNA. Translation: BAA06545.2. Different initiation. AK290119 mRNA. Translation: BAF82808.1. CH471111 Genomic DNA. Translation: EAW58181.1. BC002334 mRNA. Translation: AAH02334.1. BC007900 mRNA. Translation: AAH07900.1.
IPI	IPI00006115.
RefSeq	NP_001129736.1. NM_001136264.1. NP_055579.1. NM_014764.3.
UniGene	Hs.369761.
3D structure databases
ProteinModelPortal	Q15038.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15038. 48 interactions.
MINT	MINT-1179995.
STRING	Q15038.
PTM databases
PhosphoSite	Q15038.
Polymorphism databases
DMDM	44887865.
Proteomic databases
PRIDE	Q15038.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000412716; ENSP00000394699; ENSG00000183283.
GeneID	9802.
KEGG	hsa:9802.
UCSC	uc001ryb.1. human.
Organism-specific databases
CTD	9802.
GeneCards	GC12P051634.
H-InvDB	HIX0021611.
HGNC	HGNC:2684. DAZAP2.
MIM	607431. gene.
neXtProt	NX_Q15038.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20071.
GeneTree	ENSGT00390000000685.
HOVERGEN	HBG051300.
InParanoid	Q15038.
OMA	VPMAYYP.
Gene expression databases
ArrayExpress	Q15038.
Bgee	Q15038.
CleanEx	HS_DAZAP2.
Genevestigator	Q15038.
GermOnline	ENSG00000183283. Homo sapiens.
Family and domain databases
InterPro	IPR022730. DAZ_assoc-2. [Graphical view]
Pfam	PF11029. DAZAP2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	36908.
SOURCE	Search...

Entry information

Entry name

DAZP2_HUMAN

Accession

Primary (citable) accession number: Q15038
Secondary accession number(s): A8K254

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.