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Protein

Sorting nexin-17

Gene

SNX17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei38Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei62Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei75Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • low-density lipoprotein particle receptor binding Source: UniProtKB
  • phosphatidylinositol binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Enzyme and pathway databases

SignaLinkiQ15036

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-17
Gene namesi
Name:SNX17
Synonyms:KIAA0064
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115234.10
HGNCiHGNC:14979 SNX17
MIMi605963 gene
neXtProtiNX_Q15036

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi62K → A: No association with endosomes. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000115234
PharmGKBiPA37954

Polymorphism and mutation databases

BioMutaiSNX17
DMDMi3123050

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138651 – 470Sorting nexin-17Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15036
MaxQBiQ15036
PaxDbiQ15036
PeptideAtlasiQ15036
PRIDEiQ15036

PTM databases

iPTMnetiQ15036
PhosphoSitePlusiQ15036

Expressioni

Gene expression databases

BgeeiENSG00000115234
CleanExiHS_SNX17
ExpressionAtlasiQ15036 baseline and differential
GenevisibleiQ15036 HS

Organism-specific databases

HPAiHPA043867

Interactioni

Subunit structurei

Monomer. Interacts with APP (via cytoplasmic YXNPXY motif). Interacts with KIF1B (By similarity). Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with KRIT1 (via N-terminus). Interacts with HRAS. Interacts with ITGB1 and ITGB5 (via NPxY motif).By similarity7 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • low-density lipoprotein particle receptor binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115128, 41 interactors
DIPiDIP-52265N
IntActiQ15036, 18 interactors
MINTiQ15036
STRINGi9606.ENSP00000233575

Structurei

Secondary structure

1470
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 11Combined sources9
Beta strandi20 – 27Combined sources8
Beta strandi30 – 36Combined sources7
Helixi37 – 51Combined sources15
Turni53 – 55Combined sources3
Helixi69 – 88Combined sources20
Helixi90 – 94Combined sources5
Helixi96 – 109Combined sources14
Beta strandi116 – 123Combined sources8
Beta strandi128 – 134Combined sources7
Helixi139 – 150Combined sources12
Helixi154 – 159Combined sources6
Beta strandi160 – 167Combined sources8
Beta strandi173 – 178Combined sources6
Helixi185 – 190Combined sources6
Turni191 – 193Combined sources3
Beta strandi197 – 203Combined sources7
Helixi208 – 210Combined sources3
Helixi211 – 214Combined sources4
Helixi218 – 233Combined sources16
Beta strandi236 – 238Combined sources3
Helixi241 – 253Combined sources13
Helixi256 – 263Combined sources8
Turni268 – 270Combined sources3
Beta strandi277 – 283Combined sources7
Beta strandi286 – 293Combined sources8
Beta strandi296 – 300Combined sources5
Beta strandi310 – 314Combined sources5
Helixi315 – 317Combined sources3
Beta strandi318 – 325Combined sources8
Beta strandi346 – 355Combined sources10
Beta strandi358 – 365Combined sources8
Helixi369 – 387Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FOGX-ray2.80A1-108[»]
3LUIX-ray1.80A/B/C1-112[»]
4GXBX-ray1.80A111-388[»]
4TKNX-ray3.00A/B/C108-391[»]
ProteinModelPortaliQ15036
SMRiQ15036
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15036

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 109PXPROSITE-ProRule annotationAdd BLAST109
Domaini115 – 206Ras-associatingPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 432FERM-likeAdd BLAST318
Regioni270 – 432PTB-like F3 moduleAdd BLAST163

Domaini

The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes.1 Publication
The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS.1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG3784 Eukaryota
ENOG410XT9I LUCA
GeneTreeiENSGT00530000063147
HOGENOMiHOG000007722
HOVERGENiHBG061207
InParanoidiQ15036
KOiK17929
OMAiSVCLQAM
OrthoDBiEOG091G0BES
PhylomeDBiQ15036
TreeFamiTF318398

Family and domain databases

CDDicd13337 FERM-like_C_SNX17, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR000159 RA_dom
IPR028666 SNX17
IPR037831 SNX17/27/31
IPR037836 SNX17_FERM-like_dom
PANTHERiPTHR12431 PTHR12431, 1 hit
PTHR12431:SF16 PTHR12431:SF16, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50200 RA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15036-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHFSIPETES RSGDSGGSAY VAYNIHVNGV LHCRVRYSQL LGLHEQLRKE
60 70 80 90 100
YGANVLPAFP PKKLFSLTPA EVEQRREQLE KYMQAVRQDP LLGSSETFNS
110 120 130 140 150
FLRRAQQETQ QVPTEEVSLE VLLSNGQKVL VNVLTSDQTE DVLEAVAAKL
160 170 180 190 200
DLPDDLIGYF SLFLVREKED GAFSFVRKLQ EFELPYVSVT SLRSQEYKIV
210 220 230 240 250
LRKSYWDSAY DDDVMENRVG LNLLYAQTVS DIERGWILVT KEQHRQLKSL
260 270 280 290 300
QEKVSKKEFL RLAQTLRHYG YLRFDACVAD FPEKDCPVVV SAGNSELSLQ
310 320 330 340 350
LRLPGQQLRE GSFRVTRMRC WRVTSSVPLP SGSTSSPGRG RGEVRLELAF
360 370 380 390 400
EYLMSKDRLQ WVTITSPQAI MMSICLQSMV DELMVKKSGG SIRKMLRRRV
410 420 430 440 450
GGTLRRSDSQ QAVKSPPLLE SPDATRESMV KLSSKLSAVS LRGIGSPSTD
460 470
ASASDVHGNF AFEGIGDEDL
Length:470
Mass (Da):52,901
Last modified:November 1, 1996 - v1
Checksum:iB1C8650CB8AFB5EE
GO
Isoform 2 (identifier: Q15036-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-46: Missing.

Note: No experimental confirmation available.
Show »
Length:445
Mass (Da):49,999
Checksum:iA2D07008B80114CE
GO

Sequence cautioni

The sequence BAA06542 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti429M → V in BAD96263 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04493522 – 46Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31764 mRNA Translation: BAA06542.2 Different initiation.
AJ404855, AJ404856 Genomic DNA Translation: CAC12897.1
BT007167 mRNA Translation: AAP35831.1
AK298869 mRNA Translation: BAG60989.1
CR457081 mRNA Translation: CAG33362.1
AK222543 mRNA Translation: BAD96263.1
AC074117 Genomic DNA Translation: AAY14844.1
BC002524 mRNA Translation: AAH02524.1
BC002610 mRNA Translation: AAH02610.1
BC014620 mRNA Translation: AAH14620.1
BC050590 mRNA Translation: AAH50590.1
CCDSiCCDS1750.1 [Q15036-1]
CCDS58704.1 [Q15036-2]
RefSeqiNP_001253989.1, NM_001267060.1 [Q15036-2]
NP_055563.1, NM_014748.3 [Q15036-1]
UniGeneiHs.278569

Genome annotation databases

EnsembliENST00000233575; ENSP00000233575; ENSG00000115234 [Q15036-1]
ENST00000537606; ENSP00000439208; ENSG00000115234 [Q15036-2]
GeneIDi9784
KEGGihsa:9784
UCSCiuc002rkg.3 human [Q15036-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSNX17_HUMAN
AccessioniPrimary (citable) accession number: Q15036
Secondary accession number(s): B4DQM7, Q53HN7, Q6IAS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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