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Protein

Sorting nexin-17

Gene

SNX17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei38Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei62Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei75Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • low-density lipoprotein particle receptor binding Source: UniProtKB
  • phosphatidylinositol binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

  • aorta development Source: Ensembl
  • cardiac septum development Source: Ensembl
  • cholesterol catabolic process Source: UniProtKB
  • coronary vasculature development Source: Ensembl
  • endosomal transport Source: UniProtKB
  • intracellular protein transport Source: UniProtKB
  • receptor-mediated endocytosis Source: Ensembl
  • regulation of endocytosis Source: UniProtKB
  • retrograde transport, endosome to plasma membrane Source: GO_Central
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115234-MONOMER.
SignaLinkiQ15036.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-17
Gene namesi
Name:SNX17
Synonyms:KIAA0064
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14979. SNX17.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • cytosol Source: UniProtKB
  • early endosome Source: UniProtKB
  • endosome Source: MGI
  • endosome membrane Source: MGI
  • Golgi apparatus Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi62K → A: No association with endosomes. 1 Publication1

Organism-specific databases

DisGeNETi9784.
OpenTargetsiENSG00000115234.
PharmGKBiPA37954.

Polymorphism and mutation databases

BioMutaiSNX17.
DMDMi3123050.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138651 – 470Sorting nexin-17Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15036.
MaxQBiQ15036.
PaxDbiQ15036.
PeptideAtlasiQ15036.
PRIDEiQ15036.

PTM databases

iPTMnetiQ15036.
PhosphoSitePlusiQ15036.

Expressioni

Gene expression databases

BgeeiENSG00000115234.
CleanExiHS_SNX17.
ExpressionAtlasiQ15036. baseline and differential.
GenevisibleiQ15036. HS.

Organism-specific databases

HPAiHPA043867.

Interactioni

Subunit structurei

Monomer. Interacts with APP (via cytoplasmic YXNPXY motif). Interacts with KIF1B (By similarity). Interacts with the C-termini of P-selectin, PTC, LDLR, VLDLR, LRP1 and LRP8. Interacts with KRIT1 (via N-terminus). Interacts with HRAS. Interacts with ITGB1 and ITGB5 (via NPxY motif).By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-1752620,EBI-389883
PLCG1P191742EBI-1752620,EBI-79387

GO - Molecular functioni

  • low-density lipoprotein particle receptor binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115128. 33 interactors.
DIPiDIP-52265N.
IntActiQ15036. 16 interactors.
MINTiMINT-1188067.
STRINGi9606.ENSP00000233575.

Structurei

Secondary structure

1470
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 11Combined sources9
Beta strandi20 – 27Combined sources8
Beta strandi30 – 36Combined sources7
Helixi37 – 51Combined sources15
Turni53 – 55Combined sources3
Helixi69 – 88Combined sources20
Helixi90 – 94Combined sources5
Helixi96 – 109Combined sources14
Beta strandi116 – 123Combined sources8
Beta strandi128 – 134Combined sources7
Helixi139 – 150Combined sources12
Helixi154 – 159Combined sources6
Beta strandi160 – 167Combined sources8
Beta strandi173 – 178Combined sources6
Helixi185 – 190Combined sources6
Turni191 – 193Combined sources3
Beta strandi197 – 203Combined sources7
Helixi208 – 210Combined sources3
Helixi211 – 214Combined sources4
Helixi218 – 233Combined sources16
Beta strandi236 – 238Combined sources3
Helixi241 – 253Combined sources13
Helixi256 – 263Combined sources8
Turni268 – 270Combined sources3
Beta strandi277 – 283Combined sources7
Beta strandi286 – 293Combined sources8
Beta strandi296 – 300Combined sources5
Beta strandi310 – 314Combined sources5
Helixi315 – 317Combined sources3
Beta strandi318 – 325Combined sources8
Beta strandi346 – 355Combined sources10
Beta strandi358 – 365Combined sources8
Helixi369 – 387Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FOGX-ray2.80A1-108[»]
3LUIX-ray1.80A/B/C1-112[»]
4GXBX-ray1.80A111-388[»]
4TKNX-ray3.00A/B/C108-391[»]
ProteinModelPortaliQ15036.
SMRiQ15036.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15036.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 109PXPROSITE-ProRule annotationAdd BLAST109
Domaini115 – 206Ras-associatingPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 432FERM-likeAdd BLAST318
Regioni270 – 432PTB-like F3 moduleAdd BLAST163

Domaini

The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes.1 Publication
The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS.1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3784. Eukaryota.
ENOG410XT9I. LUCA.
GeneTreeiENSGT00530000063147.
HOGENOMiHOG000007722.
HOVERGENiHBG061207.
InParanoidiQ15036.
KOiK17929.
OMAiAVFFRND.
OrthoDBiEOG091G0BES.
PhylomeDBiQ15036.
TreeFamiTF318398.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR000159. RA_dom.
IPR028666. SNX17.
[Graphical view]
PANTHERiPTHR12431:SF16. PTHR12431:SF16. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15036-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHFSIPETES RSGDSGGSAY VAYNIHVNGV LHCRVRYSQL LGLHEQLRKE
60 70 80 90 100
YGANVLPAFP PKKLFSLTPA EVEQRREQLE KYMQAVRQDP LLGSSETFNS
110 120 130 140 150
FLRRAQQETQ QVPTEEVSLE VLLSNGQKVL VNVLTSDQTE DVLEAVAAKL
160 170 180 190 200
DLPDDLIGYF SLFLVREKED GAFSFVRKLQ EFELPYVSVT SLRSQEYKIV
210 220 230 240 250
LRKSYWDSAY DDDVMENRVG LNLLYAQTVS DIERGWILVT KEQHRQLKSL
260 270 280 290 300
QEKVSKKEFL RLAQTLRHYG YLRFDACVAD FPEKDCPVVV SAGNSELSLQ
310 320 330 340 350
LRLPGQQLRE GSFRVTRMRC WRVTSSVPLP SGSTSSPGRG RGEVRLELAF
360 370 380 390 400
EYLMSKDRLQ WVTITSPQAI MMSICLQSMV DELMVKKSGG SIRKMLRRRV
410 420 430 440 450
GGTLRRSDSQ QAVKSPPLLE SPDATRESMV KLSSKLSAVS LRGIGSPSTD
460 470
ASASDVHGNF AFEGIGDEDL
Length:470
Mass (Da):52,901
Last modified:November 1, 1996 - v1
Checksum:iB1C8650CB8AFB5EE
GO
Isoform 2 (identifier: Q15036-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-46: Missing.

Note: No experimental confirmation available.
Show »
Length:445
Mass (Da):49,999
Checksum:iA2D07008B80114CE
GO

Sequence cautioni

The sequence BAA06542 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti429M → V in BAD96263 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04493522 – 46Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31764 mRNA. Translation: BAA06542.2. Different initiation.
AJ404855, AJ404856 Genomic DNA. Translation: CAC12897.1.
BT007167 mRNA. Translation: AAP35831.1.
AK298869 mRNA. Translation: BAG60989.1.
CR457081 mRNA. Translation: CAG33362.1.
AK222543 mRNA. Translation: BAD96263.1.
AC074117 Genomic DNA. Translation: AAY14844.1.
BC002524 mRNA. Translation: AAH02524.1.
BC002610 mRNA. Translation: AAH02610.1.
BC014620 mRNA. Translation: AAH14620.1.
BC050590 mRNA. Translation: AAH50590.1.
CCDSiCCDS1750.1. [Q15036-1]
CCDS58704.1. [Q15036-2]
RefSeqiNP_001253989.1. NM_001267060.1. [Q15036-2]
NP_055563.1. NM_014748.3. [Q15036-1]
UniGeneiHs.278569.

Genome annotation databases

EnsembliENST00000233575; ENSP00000233575; ENSG00000115234. [Q15036-1]
ENST00000537606; ENSP00000439208; ENSG00000115234. [Q15036-2]
GeneIDi9784.
KEGGihsa:9784.
UCSCiuc002rkg.3. human. [Q15036-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31764 mRNA. Translation: BAA06542.2. Different initiation.
AJ404855, AJ404856 Genomic DNA. Translation: CAC12897.1.
BT007167 mRNA. Translation: AAP35831.1.
AK298869 mRNA. Translation: BAG60989.1.
CR457081 mRNA. Translation: CAG33362.1.
AK222543 mRNA. Translation: BAD96263.1.
AC074117 Genomic DNA. Translation: AAY14844.1.
BC002524 mRNA. Translation: AAH02524.1.
BC002610 mRNA. Translation: AAH02610.1.
BC014620 mRNA. Translation: AAH14620.1.
BC050590 mRNA. Translation: AAH50590.1.
CCDSiCCDS1750.1. [Q15036-1]
CCDS58704.1. [Q15036-2]
RefSeqiNP_001253989.1. NM_001267060.1. [Q15036-2]
NP_055563.1. NM_014748.3. [Q15036-1]
UniGeneiHs.278569.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FOGX-ray2.80A1-108[»]
3LUIX-ray1.80A/B/C1-112[»]
4GXBX-ray1.80A111-388[»]
4TKNX-ray3.00A/B/C108-391[»]
ProteinModelPortaliQ15036.
SMRiQ15036.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115128. 33 interactors.
DIPiDIP-52265N.
IntActiQ15036. 16 interactors.
MINTiMINT-1188067.
STRINGi9606.ENSP00000233575.

PTM databases

iPTMnetiQ15036.
PhosphoSitePlusiQ15036.

Polymorphism and mutation databases

BioMutaiSNX17.
DMDMi3123050.

Proteomic databases

EPDiQ15036.
MaxQBiQ15036.
PaxDbiQ15036.
PeptideAtlasiQ15036.
PRIDEiQ15036.

Protocols and materials databases

DNASUi9784.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233575; ENSP00000233575; ENSG00000115234. [Q15036-1]
ENST00000537606; ENSP00000439208; ENSG00000115234. [Q15036-2]
GeneIDi9784.
KEGGihsa:9784.
UCSCiuc002rkg.3. human. [Q15036-1]

Organism-specific databases

CTDi9784.
DisGeNETi9784.
GeneCardsiSNX17.
HGNCiHGNC:14979. SNX17.
HPAiHPA043867.
MIMi605963. gene.
neXtProtiNX_Q15036.
OpenTargetsiENSG00000115234.
PharmGKBiPA37954.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3784. Eukaryota.
ENOG410XT9I. LUCA.
GeneTreeiENSGT00530000063147.
HOGENOMiHOG000007722.
HOVERGENiHBG061207.
InParanoidiQ15036.
KOiK17929.
OMAiAVFFRND.
OrthoDBiEOG091G0BES.
PhylomeDBiQ15036.
TreeFamiTF318398.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115234-MONOMER.
SignaLinkiQ15036.

Miscellaneous databases

ChiTaRSiSNX17. human.
EvolutionaryTraceiQ15036.
GeneWikiiSNX17.
GenomeRNAii9784.
PROiQ15036.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115234.
CleanExiHS_SNX17.
ExpressionAtlasiQ15036. baseline and differential.
GenevisibleiQ15036. HS.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR000159. RA_dom.
IPR028666. SNX17.
[Graphical view]
PANTHERiPTHR12431:SF16. PTHR12431:SF16. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX17_HUMAN
AccessioniPrimary (citable) accession number: Q15036
Secondary accession number(s): B4DQM7, Q53HN7, Q6IAS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 166 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.