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Protein

Probable E3 ubiquitin-protein ligase HERC3

Gene

HERC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1018Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase HERC3 (EC:2.3.2.26)
Alternative name(s):
HECT domain and RCC1-like domain-containing protein 3
HECT-type E3 ubiquitin transferase HERC3
Gene namesi
Name:HERC3
Synonyms:KIAA0032
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138641.15
HGNCiHGNC:4876 HERC3
MIMi605200 gene
neXtProtiNX_Q15034

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi8916
OpenTargetsiENSG00000138641
PharmGKBiPA29251

Polymorphism and mutation databases

DMDMi2495699

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066511 – 1050Probable E3 ubiquitin-protein ligase HERC3Add BLAST1050

Post-translational modificationi

Ubiquitinated; which promotes degradation by the proteasome.

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ15034
MaxQBiQ15034
PaxDbiQ15034
PeptideAtlasiQ15034
PRIDEiQ15034

PTM databases

iPTMnetiQ15034
PhosphoSitePlusiQ15034

Expressioni

Gene expression databases

BgeeiENSG00000138641
CleanExiHS_HERC3
ExpressionAtlasiQ15034 baseline and differential
GenevisibleiQ15034 HS

Organism-specific databases

HPAiHPA039170

Interactioni

Protein-protein interaction databases

BioGridi114430, 51 interactors
IntActiQ15034, 3 interactors
MINTiQ15034
STRINGi9606.ENSP00000264345

Structurei

3D structure databases

ProteinModelPortaliQ15034
SMRiQ15034
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 51RCC1 1Add BLAST51
Repeati52 – 101RCC1 2Add BLAST50
Repeati102 – 154RCC1 3Add BLAST53
Repeati156 – 207RCC1 4Add BLAST52
Repeati208 – 259RCC1 5Add BLAST52
Repeati261 – 311RCC1 6Add BLAST51
Repeati313 – 366RCC1 7Add BLAST54
Domaini951 – 1050HECTPROSITE-ProRule annotationAdd BLAST100

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0941 Eukaryota
COG5021 LUCA
COG5184 LUCA
GeneTreeiENSGT00910000144004
HOGENOMiHOG000208452
HOVERGENiHBG050878
InParanoidiQ15034
KOiK10614
OMAiVLDNWWS
OrthoDBiEOG091G028I
PhylomeDBiQ15034
TreeFamiTF315189

Family and domain databases

CDDicd00078 HECTc, 1 hit
Gene3Di2.130.10.30, 2 hits
InterProiView protein in InterPro
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
PfamiView protein in Pfam
PF00632 HECT, 1 hit
PF00415 RCC1, 6 hits
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SUPFAMiSSF50985 SSF50985, 1 hit
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit
PS00626 RCC1_2, 3 hits
PS50012 RCC1_3, 7 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15034-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCWGYWSLG QPGISTNLQG IVAEPQVCGF ISDRSVKEVA CGGNHSVFLL
60 70 80 90 100
EDGEVYTCGL NTKGQLGHER EGNKPEQIGA LADQHIIHVA CGESHSLALS
110 120 130 140 150
DRGQLFSWGA GSDGQLGLMT TEDSVAVPRL IQKLNQQTIL QVSCGNWHCL
160 170 180 190 200
ALAADGQFFT WGKNSHGQLG LGKEFPSQAS PQRVRSLEGI PLAQVAAGGA
210 220 230 240 250
HSFALSLSGA VFGWGMNNAG QLGLSDEKDR ESPCHVKLLR TQKVVYISCG
260 270 280 290 300
EEHTAVLTKS GGVFTFGAGS CGQLGHDSMN DEVNPRRVLE LMGSEVTQIA
310 320 330 340 350
CGRQHTLAFV PSSGLIYAFG CGARGQLGTG HTCNVKCPSP VKGYWAAHSG
360 370 380 390 400
QLSARADRFK YHIVKQIFSG GDQTFVLCSK YENYSPAVDF RTMNQAHYTS
410 420 430 440 450
LINDETIAVW RQKLSEHNNA NTINGVVQIL SSAACWNGSF LEKKIDEHFK
460 470 480 490 500
TSPKIPGIDL NSTRVLFEKL MNSQHSMILE QILNSFESCL IPQLSSSPPD
510 520 530 540 550
VEAMRIYLIL PEFPLLQDSK YYITLTIPLA MAILRLDTNP SKVLDNWWSQ
560 570 580 590 600
VCPKYFMKLV NLYKGAVLYL LRGRKTFLIP VLFNNYITAA LKLLEKLYKV
610 620 630 640 650
NLKVKHVEYD TFYIPEISNL VDIQEDYLMW FLHQAGMKAR PSIIQDTVTL
660 670 680 690 700
CSYPFIFDAQ AKTKMLQTDA ELQMQVAVNG ANLQNVFMLL TLEPLLARSP
710 720 730 740 750
FLVLHVRRNN LVGDALRELS IHSDIDLKKP LKVIFDGEEA VDAGGVTKEF
760 770 780 790 800
FLLLLKELLN PIYGMFTYYQ DSNLLWFSDT CFVEHNWFHL IGITCGLAIY
810 820 830 840 850
NSTVVDLHFP LALYKKLLNV KPGLEDLKEL SPTEGRSLQE LLDYPGEDVE
860 870 880 890 900
ETFCLNFTIC RESYGVIEQK KLIPGGDNVT VCKDNRQEFV DAYVNYVFQI
910 920 930 940 950
SVHEWYTAFS SGFLKVCGGK VLELFQPSEL RAMMVGNSNY NWEELEETAI
960 970 980 990 1000
YKGDYSATHP TVKLFWETFH EFPLEKKKKF LLFLTGSDRI PIYGMASLQI
1010 1020 1030 1040 1050
VIQSTASGEE YLPVAHTCYN LLDLPKYSSK EILSARLTQA LDNYEGFSLA
Length:1,050
Mass (Da):117,188
Last modified:November 1, 1997 - v1
Checksum:i5F08A1DE1F40B912
GO
Isoform 2 (identifier: Q15034-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-368: DRFKYHIVKQIF → GKNDCLWNLKVF
     369-1050: Missing.

Note: No experimental confirmation available.
Show »
Length:368
Mass (Da):39,051
Checksum:iAFCCAE32308B91CB
GO

Sequence cautioni

The sequence BAA04945 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051729946E → Q. Corresponds to variant dbSNP:rs1804080Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056343357 – 368DRFKY…VKQIF → GKNDCLWNLKVF in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_056344369 – 1050Missing in isoform 2. 1 PublicationAdd BLAST682

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25215 mRNA Translation: BAA04945.2 Different initiation.
AK289990 mRNA Translation: BAF82679.1
AC083829 Genomic DNA No translation available.
AC098582 Genomic DNA No translation available.
AC108065 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06024.1
BC038960 mRNA Translation: AAH38960.1
CCDSiCCDS34028.1 [Q15034-1]
CCDS82939.1 [Q15034-2]
RefSeqiNP_001258531.1, NM_001271602.1
NP_001305434.1, NM_001318505.1 [Q15034-2]
NP_055421.1, NM_014606.2 [Q15034-1]
XP_005263384.1, XM_005263327.3 [Q15034-1]
UniGeneiHs.35804

Genome annotation databases

EnsembliENST00000264345; ENSP00000264345; ENSG00000138641 [Q15034-1]
ENST00000402738; ENSP00000385684; ENSG00000138641 [Q15034-1]
ENST00000407637; ENSP00000384005; ENSG00000138641 [Q15034-2]
GeneIDi8916
KEGGihsa:8916
UCSCiuc003hrv.5 human [Q15034-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHERC3_HUMAN
AccessioniPrimary (citable) accession number: Q15034
Secondary accession number(s): A8K1S5, Q8IXX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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