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Protein

Probable E3 ubiquitin-protein ligase HERC3

Gene

HERC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1018Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138641-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase HERC3 (EC:2.3.2.26)
Alternative name(s):
HECT domain and RCC1-like domain-containing protein 3
HECT-type E3 ubiquitin transferase HERC3
Gene namesi
Name:HERC3
Synonyms:KIAA0032
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4876. HERC3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi8916.
OpenTargetsiENSG00000138641.
PharmGKBiPA29251.

Polymorphism and mutation databases

DMDMi2495699.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066511 – 1050Probable E3 ubiquitin-protein ligase HERC3Add BLAST1050

Post-translational modificationi

Ubiquitinated; which promotes degradation by the proteasome.

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ15034.
MaxQBiQ15034.
PaxDbiQ15034.
PeptideAtlasiQ15034.
PRIDEiQ15034.

PTM databases

iPTMnetiQ15034.
PhosphoSitePlusiQ15034.

Expressioni

Gene expression databases

BgeeiENSG00000138641.
CleanExiHS_HERC3.
ExpressionAtlasiQ15034. baseline and differential.
GenevisibleiQ15034. HS.

Organism-specific databases

HPAiHPA039170.

Interactioni

Protein-protein interaction databases

BioGridi114430. 45 interactors.
IntActiQ15034. 3 interactors.
MINTiMINT-158126.
STRINGi9606.ENSP00000264345.

Structurei

3D structure databases

ProteinModelPortaliQ15034.
SMRiQ15034.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 51RCC1 1Add BLAST51
Repeati52 – 101RCC1 2Add BLAST50
Repeati102 – 154RCC1 3Add BLAST53
Repeati156 – 207RCC1 4Add BLAST52
Repeati208 – 259RCC1 5Add BLAST52
Repeati261 – 311RCC1 6Add BLAST51
Repeati313 – 366RCC1 7Add BLAST54
Domaini951 – 1050HECTPROSITE-ProRule annotationAdd BLAST100

Sequence similaritiesi

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation
Contains 7 RCC1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0941. Eukaryota.
COG5021. LUCA.
COG5184. LUCA.
GeneTreeiENSGT00860000133671.
HOGENOMiHOG000208452.
HOVERGENiHBG050878.
InParanoidiQ15034.
KOiK10614.
OMAiHYTSLIN.
OrthoDBiEOG091G028I.
PhylomeDBiQ15034.
TreeFamiTF315189.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
Gene3Di2.130.10.30. 1 hit.
InterProiIPR000569. HECT_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
PF00415. RCC1. 6 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS00626. RCC1_2. 3 hits.
PS50012. RCC1_3. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15034-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCWGYWSLG QPGISTNLQG IVAEPQVCGF ISDRSVKEVA CGGNHSVFLL
60 70 80 90 100
EDGEVYTCGL NTKGQLGHER EGNKPEQIGA LADQHIIHVA CGESHSLALS
110 120 130 140 150
DRGQLFSWGA GSDGQLGLMT TEDSVAVPRL IQKLNQQTIL QVSCGNWHCL
160 170 180 190 200
ALAADGQFFT WGKNSHGQLG LGKEFPSQAS PQRVRSLEGI PLAQVAAGGA
210 220 230 240 250
HSFALSLSGA VFGWGMNNAG QLGLSDEKDR ESPCHVKLLR TQKVVYISCG
260 270 280 290 300
EEHTAVLTKS GGVFTFGAGS CGQLGHDSMN DEVNPRRVLE LMGSEVTQIA
310 320 330 340 350
CGRQHTLAFV PSSGLIYAFG CGARGQLGTG HTCNVKCPSP VKGYWAAHSG
360 370 380 390 400
QLSARADRFK YHIVKQIFSG GDQTFVLCSK YENYSPAVDF RTMNQAHYTS
410 420 430 440 450
LINDETIAVW RQKLSEHNNA NTINGVVQIL SSAACWNGSF LEKKIDEHFK
460 470 480 490 500
TSPKIPGIDL NSTRVLFEKL MNSQHSMILE QILNSFESCL IPQLSSSPPD
510 520 530 540 550
VEAMRIYLIL PEFPLLQDSK YYITLTIPLA MAILRLDTNP SKVLDNWWSQ
560 570 580 590 600
VCPKYFMKLV NLYKGAVLYL LRGRKTFLIP VLFNNYITAA LKLLEKLYKV
610 620 630 640 650
NLKVKHVEYD TFYIPEISNL VDIQEDYLMW FLHQAGMKAR PSIIQDTVTL
660 670 680 690 700
CSYPFIFDAQ AKTKMLQTDA ELQMQVAVNG ANLQNVFMLL TLEPLLARSP
710 720 730 740 750
FLVLHVRRNN LVGDALRELS IHSDIDLKKP LKVIFDGEEA VDAGGVTKEF
760 770 780 790 800
FLLLLKELLN PIYGMFTYYQ DSNLLWFSDT CFVEHNWFHL IGITCGLAIY
810 820 830 840 850
NSTVVDLHFP LALYKKLLNV KPGLEDLKEL SPTEGRSLQE LLDYPGEDVE
860 870 880 890 900
ETFCLNFTIC RESYGVIEQK KLIPGGDNVT VCKDNRQEFV DAYVNYVFQI
910 920 930 940 950
SVHEWYTAFS SGFLKVCGGK VLELFQPSEL RAMMVGNSNY NWEELEETAI
960 970 980 990 1000
YKGDYSATHP TVKLFWETFH EFPLEKKKKF LLFLTGSDRI PIYGMASLQI
1010 1020 1030 1040 1050
VIQSTASGEE YLPVAHTCYN LLDLPKYSSK EILSARLTQA LDNYEGFSLA
Length:1,050
Mass (Da):117,188
Last modified:November 1, 1997 - v1
Checksum:i5F08A1DE1F40B912
GO
Isoform 2 (identifier: Q15034-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-368: DRFKYHIVKQIF → GKNDCLWNLKVF
     369-1050: Missing.

Note: No experimental confirmation available.
Show »
Length:368
Mass (Da):39,051
Checksum:iAFCCAE32308B91CB
GO

Sequence cautioni

The sequence BAA04945 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051729946E → Q.Corresponds to variant rs1804080dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056343357 – 368DRFKY…VKQIF → GKNDCLWNLKVF in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_056344369 – 1050Missing in isoform 2. 1 PublicationAdd BLAST682

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25215 mRNA. Translation: BAA04945.2. Different initiation.
AK289990 mRNA. Translation: BAF82679.1.
AC083829 Genomic DNA. No translation available.
AC098582 Genomic DNA. No translation available.
AC108065 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06024.1.
BC038960 mRNA. Translation: AAH38960.1.
CCDSiCCDS34028.1. [Q15034-1]
CCDS82939.1. [Q15034-2]
RefSeqiNP_001258531.1. NM_001271602.1.
NP_001305434.1. NM_001318505.1. [Q15034-2]
NP_055421.1. NM_014606.2. [Q15034-1]
XP_005263384.1. XM_005263327.3. [Q15034-1]
UniGeneiHs.35804.

Genome annotation databases

EnsembliENST00000264345; ENSP00000264345; ENSG00000138641. [Q15034-1]
ENST00000402738; ENSP00000385684; ENSG00000138641. [Q15034-1]
ENST00000407637; ENSP00000384005; ENSG00000138641. [Q15034-2]
GeneIDi8916.
KEGGihsa:8916.
UCSCiuc003hrv.5. human. [Q15034-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25215 mRNA. Translation: BAA04945.2. Different initiation.
AK289990 mRNA. Translation: BAF82679.1.
AC083829 Genomic DNA. No translation available.
AC098582 Genomic DNA. No translation available.
AC108065 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06024.1.
BC038960 mRNA. Translation: AAH38960.1.
CCDSiCCDS34028.1. [Q15034-1]
CCDS82939.1. [Q15034-2]
RefSeqiNP_001258531.1. NM_001271602.1.
NP_001305434.1. NM_001318505.1. [Q15034-2]
NP_055421.1. NM_014606.2. [Q15034-1]
XP_005263384.1. XM_005263327.3. [Q15034-1]
UniGeneiHs.35804.

3D structure databases

ProteinModelPortaliQ15034.
SMRiQ15034.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114430. 45 interactors.
IntActiQ15034. 3 interactors.
MINTiMINT-158126.
STRINGi9606.ENSP00000264345.

PTM databases

iPTMnetiQ15034.
PhosphoSitePlusiQ15034.

Polymorphism and mutation databases

DMDMi2495699.

Proteomic databases

EPDiQ15034.
MaxQBiQ15034.
PaxDbiQ15034.
PeptideAtlasiQ15034.
PRIDEiQ15034.

Protocols and materials databases

DNASUi8916.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264345; ENSP00000264345; ENSG00000138641. [Q15034-1]
ENST00000402738; ENSP00000385684; ENSG00000138641. [Q15034-1]
ENST00000407637; ENSP00000384005; ENSG00000138641. [Q15034-2]
GeneIDi8916.
KEGGihsa:8916.
UCSCiuc003hrv.5. human. [Q15034-1]

Organism-specific databases

CTDi8916.
DisGeNETi8916.
GeneCardsiHERC3.
HGNCiHGNC:4876. HERC3.
HPAiHPA039170.
MIMi605200. gene.
neXtProtiNX_Q15034.
OpenTargetsiENSG00000138641.
PharmGKBiPA29251.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0941. Eukaryota.
COG5021. LUCA.
COG5184. LUCA.
GeneTreeiENSGT00860000133671.
HOGENOMiHOG000208452.
HOVERGENiHBG050878.
InParanoidiQ15034.
KOiK10614.
OMAiHYTSLIN.
OrthoDBiEOG091G028I.
PhylomeDBiQ15034.
TreeFamiTF315189.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:ENSG00000138641-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiHERC3. human.
GenomeRNAii8916.
PROiQ15034.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138641.
CleanExiHS_HERC3.
ExpressionAtlasiQ15034. baseline and differential.
GenevisibleiQ15034. HS.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
Gene3Di2.130.10.30. 1 hit.
InterProiIPR000569. HECT_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
PF00415. RCC1. 6 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS00626. RCC1_2. 3 hits.
PS50012. RCC1_3. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHERC3_HUMAN
AccessioniPrimary (citable) accession number: Q15034
Secondary accession number(s): A8K1S5, Q8IXX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.