Q15032 (R3HD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
R3H domain-containing protein 1

Gene names

Name:	R3HDM1
Synonyms:	KIAA0029, R3HDM

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1099 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Contains 1 R3H domain.
Sequence caution	The sequence BAA04878.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15032-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15032-2)

The sequence of this isoform differs from the canonical sequence as follows:
     57-100: Missing.
     406-490: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1099	1099	R3H domain-containing protein 1		PRO_0000097139
Regions
	Domain	168 – 231	64	R3H
	Compositional bias	89 – 94	6	Poly-Pro
	Compositional bias	589 – 608	20	Poly-Pro
	Compositional bias	822 – 826	5	Poly-Pro
Amino acid modifications
	Modified residue	138	1	Phosphoserine Ref.7
	Modified residue	187	1	Phosphoserine Ref.5
	Modified residue	337	1	Phosphoserine Ref.3
	Modified residue	381	1	Phosphoserine Ref.6
	Modified residue	973	1	Phosphoserine Ref.4 Ref.7
Natural variations
	Alternative sequence	57 – 100	44	Missing in isoform 2.		VSP_017344
	Alternative sequence	406 – 490	85	Missing in isoform 2.		VSP_017345
	Natural variant	270	1	M → V. Ref.2 Corresponds to variant rs961360 [ dbSNP | Ensembl ].		VAR_025423
	Natural variant	632	1	Q → P. Corresponds to variant rs2305165 [ dbSNP | Ensembl ].		VAR_025424
Experimental info
	Sequence conflict	541	1	Q → QQ in BAA04878. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 7, 2006. Version 3. Checksum: 67782B9163702174	FASTA	1,099	120,696
	10 20 30 40 50 60 MRMSDTVTVK DETATMKDLE AEVKDTTRVE NLIKSENYGK ILVEKNEHCI ENNIDLQRPL 70 80 90 100 110 120 QSFGQTGKRS KSSSKLKLVR SLAVCEESPP PPAPEISQEN QEKIQIQLTQ SFEKEEKPSK 130 140 150 160 170 180 DEAEKEKASD KLPRKMLSRD SSQEYTDSTG IDLHEFLVNT LKNNPRDRMM LLKLEQEILD 190 200 210 220 230 240 FIGNNESPRK KFPPMTSYHR MLLHRVAAYF GLDHNVDQSG KSVIVNKTSN TRIPDQKFNE 250 260 270 280 290 300 HIKDDKGEDF QKRYILKRDN SSFDKDDNQM RIRLKDDRRS KSIEEREEEY QRARDRIFSQ 310 320 330 340 350 360 DSLCSQENYI IDKRLQDEDA SSTQQRRQIF RVNKDASGRS TNSHQSSTEN ELKYSEPRPW 370 380 390 400 410 420 SSTDSDSSLR NLKPAVTKAS SFSGISVLTR GDSSGSSKSI GRLSKTGSES SGSVGSSTGS 430 440 450 460 470 480 LSHIQQPLPG TALSQSSHGA PVVYPTVSTH SSLSFDGGLN GQVASPSTSF FLLPLEAAGI 490 500 510 520 530 540 PPGSILINPQ TGQPFINPDG SPVVYNPPMT QQPVRSQVPG PPQPPLPAPP QQPAANHIFS 550 560 570 580 590 600 QDNLGSQFSH MSLARQPSAD GSDPHAAMFQ STVVLQSPQQ SGYIMTAAPP PHPPPPPPPP 610 620 630 640 650 660 PPPPPLPPGQ PVPTAGYPAS GHPVSQPVLQ QQGYIQQPSP QMPACYCAPG HYHSSQPQYR 670 680 690 700 710 720 PVPSVHYNSH LNQPLPQPAQ QTGYQVIPNQ QQNYQGIVGV QQPQSQSLVS GQPNSIGNQI 730 740 750 760 770 780 QGVVIPYTSV PTYQVSLPQG SQGIPHQTYQ QPVMFPNQSN QGSMPTTGMP VYYSVIPPGQ 790 800 810 820 830 840 QNNLSSSVGY LQHPGSEQVQ FPRTTSPCSS QQLQGHQCTA GPPPPPGGGM VMMQLSVPNN 850 860 870 880 890 900 PQSCAHSPPQ WKQNKYYCDH QRGQKCVEFS SVDNIVQHSP QLSSPIISPA QSPAPAQLST 910 920 930 940 950 960 LKTVRPSGPP LSIMPQFSRP FVPGQGDSRY PLLGQPLQYN PPAVLHGHIP NQQGQPGSRH 970 980 990 1000 1010 1020 GNRGRRQAKK AASTDLGAGE TVVGKVLEIT ELPDGITRME AEKLFGELFK IGAKIRWLRD 1030 1040 1050 1060 1070 1080 PQSQPRRHPL CCGSGDNTAN PERSKPSDLA STYTVLATFP SISAAQNALK KQINSVNKFK 1090 LRTSKKHYDF HILERASSQ
	Isoform 2 [UniParc]. Checksum: A3C38DE59AB874D9	FASTA	970	107,577
	10 20 30 40 50 60 MRMSDTVTVK DETATMKDLE AEVKDTTRVE NLIKSENYGK ILVEKNEHCI ENNIDLQEKI 70 80 90 100 110 120 QIQLTQSFEK EEKPSKDEAE KEKASDKLPR KMLSRDSSQE YTDSTGIDLH EFLVNTLKNN 130 140 150 160 170 180 PRDRMMLLKL EQEILDFIGN NESPRKKFPP MTSYHRMLLH RVAAYFGLDH NVDQSGKSVI 190 200 210 220 230 240 VNKTSNTRIP DQKFNEHIKD DKGEDFQKRY ILKRDNSSFD KDDNQMRIRL KDDRRSKSIE 250 260 270 280 290 300 EREEEYQRAR DRIFSQDSLC SQENYIIDKR LQDEDASSTQ QRRQIFRVNK DASGRSTNSH 310 320 330 340 350 360 QSSTENELKY SEPRPWSSTD SDSSLRNLKP AVTKASSFSG ISVLTRGDSS GSSKSIGRLS 370 380 390 400 410 420 KTGQPFINPD GSPVVYNPPM TQQPVRSQVP GPPQPPLPAP PQQPAANHIF SQDNLGSQFS 430 440 450 460 470 480 HMSLARQPSA DGSDPHAAMF QSTVVLQSPQ QSGYIMTAAP PPHPPPPPPP PPPPPPLPPG 490 500 510 520 530 540 QPVPTAGYPA SGHPVSQPVL QQQGYIQQPS PQMPACYCAP GHYHSSQPQY RPVPSVHYNS 550 560 570 580 590 600 HLNQPLPQPA QQTGYQVIPN QQQNYQGIVG VQQPQSQSLV SGQPNSIGNQ IQGVVIPYTS 610 620 630 640 650 660 VPTYQVSLPQ GSQGIPHQTY QQPVMFPNQS NQGSMPTTGM PVYYSVIPPG QQNNLSSSVG 670 680 690 700 710 720 YLQHPGSEQV QFPRTTSPCS SQQLQGHQCT AGPPPPPGGG MVMMQLSVPN NPQSCAHSPP 730 740 750 760 770 780 QWKQNKYYCD HQRGQKCVEF SSVDNIVQHS PQLSSPIISP AQSPAPAQLS TLKTVRPSGP 790 800 810 820 830 840 PLSIMPQFSR PFVPGQGDSR YPLLGQPLQY NPPAVLHGHI PNQQGQPGSR HGNRGRRQAK 850 860 870 880 890 900 KAASTDLGAG ETVVGKVLEI TELPDGITRM EAEKLFGELF KIGAKIRWLR DPQSQPRRHP 910 920 930 940 950 960 LCCGSGDNTA NPERSKPSDL ASTYTVLATF PSISAAQNAL KKQINSVNKF KLRTSKKHYD 970 FHILERASSQ

References

[1]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed: 7584026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Bone marrow.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-270. Tissue: Uterus.
[3]	"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry." Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C. Anal. Chem. 76:2763-2772(2004) [PubMed: 15144186] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[4]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-973, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-381, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138 AND SER-973, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D21852 mRNA. Translation: BAA04878.2. Different initiation. BC041093 mRNA. Translation: AAH41093.1.
IPI	IPI00332932. IPI00847498.
RefSeq	NP_056176.2. NM_015361.2.
UniGene	Hs.412462.
3D structure databases
ProteinModelPortal	Q15032.
SMR	Q15032. Positions 151-261.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15032. 2 interactions.
MINT	MINT-2809589.
Polymorphism databases
DMDM	92086999.
Proteomic databases
PRIDE	Q15032.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264160; ENSP00000264160; ENSG00000048991.
GeneID	23518.
KEGG	hsa:23518.
UCSC	uc002tuo.1. human. uc002tuq.1. human.
Organism-specific databases
CTD	23518.
GeneCards	GC02P136289.
H-InvDB	HIX0002476.
HGNC	HGNC:9757. R3HDM1.
HPA	HPA030936.
neXtProt	NX_Q15032.
PharmGKB	PA34098.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17338.
HOVERGEN	HBG052192.
PhylomeDB	Q15032.
Gene expression databases
ArrayExpress	Q15032.
Bgee	Q15032.
CleanEx	HS_R3HDM1.
Genevestigator	Q15032.
Family and domain databases
InterPro	IPR001374. R3H_ss-bd. IPR024771. SUZ. [Graphical view]
Pfam	PF01424. R3H. 1 hit. PF12752. SUZ. 1 hit. [Graphical view]
SMART	SM00393. R3H. 1 hit. [Graphical view]
PROSITE	PS51061. R3H. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	45961.

Entry information

Entry name

R3HD1_HUMAN

Accession

Primary (citable) accession number: Q15032
Secondary accession number(s): Q8IW32

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 87 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.