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Q15029

- U5S1_HUMAN

UniProt

Q15029 - U5S1_HUMAN

Protein

116 kDa U5 small nuclear ribonucleoprotein component

Gene

EFTUD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 166 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi136 – 1438GTPSequence Analysis
    Nucleotide bindingi204 – 2085GTPSequence Analysis
    Nucleotide bindingi258 – 2614GTPSequence Analysis

    GO - Molecular functioni

    1. GTPase activity Source: ProtInc
    2. GTP binding Source: UniProtKB-KW
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. gene expression Source: Reactome
    2. GTP catabolic process Source: GOC
    3. mRNA processing Source: ProtInc
    4. mRNA splicing, via spliceosome Source: UniProtKB
    5. RNA splicing Source: Reactome

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_1753. mRNA Splicing - Minor Pathway.
    REACT_467. mRNA Splicing - Major Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    116 kDa U5 small nuclear ribonucleoprotein component
    Alternative name(s):
    Elongation factor Tu GTP-binding domain-containing protein 2
    SNU114 homolog
    Short name:
    hSNU114
    U5 snRNP-specific protein, 116 kDa
    Short name:
    U5-116 kDa
    Gene namesi
    Name:EFTUD2
    Synonyms:KIAA0031, SNRP116
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:30858. EFTUD2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. Cajal body Source: BHF-UCL
    2. catalytic step 2 spliceosome Source: UniProtKB
    3. cytoplasm Source: HPA
    4. membrane Source: UniProtKB
    5. nuclear speck Source: BHF-UCL
    6. nucleoplasm Source: Reactome
    7. nucleus Source: HPA
    8. spliceosomal complex Source: ProtInc

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    Pathology & Biotechi

    Involvement in diseasei

    Mandibulofacial dysostosis with microcephaly (MFDM) [MIM:610536]: A rare syndrome characterized by progressive microcephaly, midface and malar hypoplasia, micrognathia, microtia, dysplastic ears, preauricular skin tags, significant developmental delay, and speech delay. Many patients have major sequelae, including choanal atresia that results in respiratory difficulties, conductive hearing loss, and cleft palate.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti262 – 2621R → W in MFDM. 1 Publication
    VAR_067580
    Natural varianti476 – 4761C → R in MFDM. 1 Publication
    VAR_067581
    Natural varianti637 – 6371L → R in MFDM. 1 Publication
    VAR_067582

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    MIMi610536. phenotype.
    Orphaneti79113. Mandibulofacial dysostosis-microcephaly syndrome.
    PharmGKBiPA142671915.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 972972116 kDa U5 small nuclear ribonucleoprotein componentPRO_0000091563Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine3 Publications
    Modified residuei19 – 191Phosphoserine3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ15029.
    PaxDbiQ15029.
    PeptideAtlasiQ15029.
    PRIDEiQ15029.

    PTM databases

    PhosphoSiteiQ15029.

    Expressioni

    Gene expression databases

    ArrayExpressiQ15029.
    BgeeiQ15029.
    CleanExiHS_EFTUD2.
    GenevestigatoriQ15029.

    Organism-specific databases

    HPAiHPA022021.

    Interactioni

    Subunit structurei

    Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Identified in the spliceosome C complex. Interacts with ERBB4 and PRPF8.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HSPB1P047922EBI-357897,EBI-352682
    IKQ131232EBI-357897,EBI-713456
    MYCP011065EBI-357897,EBI-447544
    PRPF8Q6P2Q92EBI-357897,EBI-538479
    SF3B4Q154272EBI-357897,EBI-348469

    Protein-protein interaction databases

    BioGridi114749. 115 interactions.
    IntActiQ15029. 41 interactions.
    MINTiMINT-1161890.
    STRINGi9606.ENSP00000262414.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15029.
    SMRiQ15029. Positions 114-954.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini127 – 409283tr-type GPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.PROSITE-ProRule annotation
    Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0480.
    HOGENOMiHOG000231589.
    HOVERGENiHBG001838.
    InParanoidiQ15029.
    KOiK12852.
    OMAiAFGPDEM.
    OrthoDBiEOG7WDN1S.
    PhylomeDBiQ15029.
    TreeFamiTF105703.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.240. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR009022. EFG_III-V.
    IPR000640. EFG_V.
    IPR027417. P-loop_NTPase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR005517. Transl_elong_EFG/EF2_IV.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PfamiPF00679. EFG_C. 1 hit.
    PF14492. EFG_II. 1 hit.
    PF03764. EFG_IV. 1 hit.
    PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SMARTiSM00838. EFG_C. 1 hit.
    SM00889. EFG_IV. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF54980. SSF54980. 2 hits.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15029-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDTDLYDEFG NYIGPELDSD EDDDELGRET KDLDEMDDDD DDDDVGDHDD    50
    DHPGMEVVLH EDKKYYPTAE EVYGPEVETI VQEEDTQPLT EPIIKPVKTK 100
    KFTLMEQTLP VTVYEMDFLA DLMDNSELIR NVTLCGHLHH GKTCFVDCLI 150
    EQTHPEIRKR YDQDLCYTDI LFTEQERGVG IKSTPVTVVL PDTKGKSYLF 200
    NIMDTPGHVN FSDEVTAGLR ISDGVVLFID AAEGVMLNTE RLIKHAVQER 250
    LAVTVCINKI DRLILELKLP PTDAYYKLRH IVDEVNGLIS MYSTDENLIL 300
    SPLLGNVCFS SSQYSICFTL GSFAKIYADT FGDINYQEFA KRLWGDIYFN 350
    PKTRKFTKKA PTSSSQRSFV EFILEPLYKI LAQVVGDVDT SLPRTLDELG 400
    IHLTKEELKL NIRPLLRLVC KKFFGEFTGF VDMCVQHIPS PKVGAKPKIE 450
    HTYTGGVDSD LGEAMSDCDP DGPLMCHTTK MYSTDDGVQF HAFGRVLSGT 500
    IHAGQPVKVL GENYTLEDEE DSQICTVGRL WISVARYHIE VNRVPAGNWV 550
    LIEGVDQPIV KTATITEPRG NEEAQIFRPL KFNTTSVIKI AVEPVNPSEL 600
    PKMLDGLRKV NKSYPSLTTK VEESGEHVIL GTGELYLDCV MHDLRKMYSE 650
    IDIKVADPVV TFCETVVETS SLKCFAETPN KKNKITMIAE PLEKGLAEDI 700
    ENEVVQITWN RKKLGEFFQT KYDWDLLAAR SIWAFGPDAT GPNILVDDTL 750
    PSEVDKALLG SVKDSIVQGF QWGTREGPLC DELIRNVKFK ILDAVVAQEP 800
    LHRGGGQIIP TARRVVYSAF LMATPRLMEP YYFVEVQAPA DCVSAVYTVL 850
    ARRRGHVTQD APIPGSPLYT IKAFIPAIDS FGFETDLRTH TQGQAFSLSV 900
    FHHWQIVPGD PLDKSIVIRP LEPQPAPHLA REFMIKTRRR KGLSEDVSIS 950
    KFFDDPMLLE LAKQDVVLNY PM 972
    Length:972
    Mass (Da):109,436
    Last modified:November 1, 1996 - v1
    Checksum:i862BD6CA7993F118
    GO
    Isoform 2 (identifier: Q15029-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-35: Missing.

    Show »
    Length:937
    Mass (Da):105,384
    Checksum:iC754AB346695B0C3
    GO
    Isoform 3 (identifier: Q15029-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         143-152: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:962
    Mass (Da):108,283
    Checksum:i6EF1ECDE3BDA0784
    GO

    Sequence cautioni

    The sequence BAA04699.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti321 – 3211G → V in AAH02360. (PubMed:15489334)Curated
    Sequence conflicti619 – 6191T → S in BAG59832. (PubMed:14702039)Curated
    Sequence conflicti955 – 9551D → G in BAG59832. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti262 – 2621R → W in MFDM. 1 Publication
    VAR_067580
    Natural varianti476 – 4761C → R in MFDM. 1 Publication
    VAR_067581
    Natural varianti637 – 6371L → R in MFDM. 1 Publication
    VAR_067582
    Natural varianti773 – 7731G → V.
    Corresponds to variant rs1056505 [ dbSNP | Ensembl ].
    VAR_014931

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3535Missing in isoform 2. 1 PublicationVSP_044282Add
    BLAST
    Alternative sequencei143 – 15210Missing in isoform 3. 1 PublicationVSP_055175

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21163 mRNA. Translation: BAA04699.2. Different initiation.
    AK296367 mRNA. Translation: BAG59042.1.
    AK297392 mRNA. Translation: BAG59832.1.
    AK316098 mRNA. Translation: BAH14469.1.
    AC015936 Genomic DNA. No translation available.
    CH471178 Genomic DNA. Translation: EAW51573.1.
    CH471178 Genomic DNA. Translation: EAW51574.1.
    BC002360 mRNA. Translation: AAH02360.1.
    CCDSiCCDS11489.1. [Q15029-1]
    CCDS45707.1. [Q15029-2]
    CCDS59295.1. [Q15029-3]
    RefSeqiNP_001136077.1. NM_001142605.1. [Q15029-2]
    NP_001245282.1. NM_001258353.1. [Q15029-1]
    NP_001245283.1. NM_001258354.1.
    NP_004238.3. NM_004247.3. [Q15029-1]
    UniGeneiHs.151787.

    Genome annotation databases

    EnsembliENST00000402521; ENSP00000385873; ENSG00000108883. [Q15029-2]
    ENST00000426333; ENSP00000392094; ENSG00000108883. [Q15029-1]
    ENST00000591382; ENSP00000467805; ENSG00000108883. [Q15029-1]
    ENST00000592576; ENSP00000465058; ENSG00000108883. [Q15029-3]
    GeneIDi9343.
    KEGGihsa:9343.
    UCSCiuc002ihn.2. human. [Q15029-1]

    Polymorphism databases

    DMDMi18202501.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21163 mRNA. Translation: BAA04699.2 . Different initiation.
    AK296367 mRNA. Translation: BAG59042.1 .
    AK297392 mRNA. Translation: BAG59832.1 .
    AK316098 mRNA. Translation: BAH14469.1 .
    AC015936 Genomic DNA. No translation available.
    CH471178 Genomic DNA. Translation: EAW51573.1 .
    CH471178 Genomic DNA. Translation: EAW51574.1 .
    BC002360 mRNA. Translation: AAH02360.1 .
    CCDSi CCDS11489.1. [Q15029-1 ]
    CCDS45707.1. [Q15029-2 ]
    CCDS59295.1. [Q15029-3 ]
    RefSeqi NP_001136077.1. NM_001142605.1. [Q15029-2 ]
    NP_001245282.1. NM_001258353.1. [Q15029-1 ]
    NP_001245283.1. NM_001258354.1.
    NP_004238.3. NM_004247.3. [Q15029-1 ]
    UniGenei Hs.151787.

    3D structure databases

    ProteinModelPortali Q15029.
    SMRi Q15029. Positions 114-954.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114749. 115 interactions.
    IntActi Q15029. 41 interactions.
    MINTi MINT-1161890.
    STRINGi 9606.ENSP00000262414.

    PTM databases

    PhosphoSitei Q15029.

    Polymorphism databases

    DMDMi 18202501.

    Proteomic databases

    MaxQBi Q15029.
    PaxDbi Q15029.
    PeptideAtlasi Q15029.
    PRIDEi Q15029.

    Protocols and materials databases

    DNASUi 9343.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000402521 ; ENSP00000385873 ; ENSG00000108883 . [Q15029-2 ]
    ENST00000426333 ; ENSP00000392094 ; ENSG00000108883 . [Q15029-1 ]
    ENST00000591382 ; ENSP00000467805 ; ENSG00000108883 . [Q15029-1 ]
    ENST00000592576 ; ENSP00000465058 ; ENSG00000108883 . [Q15029-3 ]
    GeneIDi 9343.
    KEGGi hsa:9343.
    UCSCi uc002ihn.2. human. [Q15029-1 ]

    Organism-specific databases

    CTDi 9343.
    GeneCardsi GC17M042927.
    H-InvDB HIX0135614.
    HGNCi HGNC:30858. EFTUD2.
    HPAi HPA022021.
    MIMi 603892. gene.
    610536. phenotype.
    neXtProti NX_Q15029.
    Orphaneti 79113. Mandibulofacial dysostosis-microcephaly syndrome.
    PharmGKBi PA142671915.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0480.
    HOGENOMi HOG000231589.
    HOVERGENi HBG001838.
    InParanoidi Q15029.
    KOi K12852.
    OMAi AFGPDEM.
    OrthoDBi EOG7WDN1S.
    PhylomeDBi Q15029.
    TreeFami TF105703.

    Enzyme and pathway databases

    Reactomei REACT_1753. mRNA Splicing - Minor Pathway.
    REACT_467. mRNA Splicing - Major Pathway.

    Miscellaneous databases

    ChiTaRSi EFTUD2. human.
    GeneWikii EFTUD2.
    GenomeRNAii 9343.
    NextBioi 34995.
    PROi Q15029.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15029.
    Bgeei Q15029.
    CleanExi HS_EFTUD2.
    Genevestigatori Q15029.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.240. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR009022. EFG_III-V.
    IPR000640. EFG_V.
    IPR027417. P-loop_NTPase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR005517. Transl_elong_EFG/EF2_IV.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    Pfami PF00679. EFG_C. 1 hit.
    PF14492. EFG_II. 1 hit.
    PF03764. EFG_IV. 1 hit.
    PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SMARTi SM00838. EFG_C. 1 hit.
    SM00889. EFG_IV. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF54980. SSF54980. 2 hits.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
      DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Thalamus.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Muscle.
    6. "An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2."
      Fabrizio P., Laggerbauer B., Lauber J., Lane W.S., Luehrmann R.
      EMBO J. 16:4092-4106(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    7. "The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein."
      Achsel T., Ahrens K., Brahms H., Teigelkamp S., Luehrmann R.
      Mol. Cell. Biol. 18:6756-6766(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PRPF8.
    8. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
      Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
      RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."
      Liu S., Rauhut R., Vornlocher H.-P., Luehrmann R.
      RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways."
      Gilmore-Hebert M., Ramabhadran R., Stern D.F.
      Mol. Cancer Res. 8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH ERBB4, SUBCELLULAR LOCATION.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. Cited for: VARIANTS MFDM TRP-262; ARG-476 AND ARG-637.

    Entry informationi

    Entry nameiU5S1_HUMAN
    AccessioniPrimary (citable) accession number: Q15029
    Secondary accession number(s): B4DK30
    , B4DMC0, D3DX58, K7EJ81, Q9BUR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 166 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3