Q15029 (U5S1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
116 kDa U5 small nuclear ribonucleoprotein component

Alternative name(s):
Elongation factor Tu GTP-binding domain-containing protein 2
SNU114 homolog
Short name=hSNU114
U5 snRNP-specific protein, 116 kDa
Short name=U5-116 kDa

Gene names

Name:	EFTUD2
Synonyms:	KIAA0031, SNRP116

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	972 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP.
Subunit structure	Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Identified in the spliceosome C complex. Interacts with ERBB4 and PRPF8. Ref.7 Ref.8 Ref.10 Ref.12
Subcellular location	Nucleus Ref.12.
Involvement in disease	Mandibulofacial dysostosis with microcephaly (MFDM) [MIM:610536]: A rare syndrome characterized by progressive microcephaly, midface and malar hypoplasia, micrognathia, microtia, dysplastic ears, preauricular skin tags, significant developmental delay, and speech delay. Many patients have major sequelae, including choanal atresia that results in respiratory difficulties, conductive hearing loss, and cleft palate. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.16
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
Sequence caution	The sequence BAA04699.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus Spliceosome
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Mental retardation
Ligand	GTP-binding Nucleotide-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA splicing, via spliceosome Inferred by curator Ref.8. Source: UniProtKB
Cellular_component	Cajal body Inferred from direct assay PubMed 15257298. Source: BHF-UCL catalytic step 2 spliceosome Inferred from direct assay Ref.8. Source: UniProtKB cytoplasm Inferred from direct assay. Source: HPA nuclear speck Inferred from direct assay PubMed 15257298. Source: BHF-UCL
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Traceable author statement Ref.6. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MYC	P01106	5	EBI-357897,EBI-447544
PRPF8	Q6P2Q9	2	EBI-357897,EBI-538479

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15029-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15029-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 972	972	116 kDa U5 small nuclear ribonucleoprotein component		PRO_0000091563
Regions
	Nucleotide binding	136 – 143	8	GTP Potential
	Nucleotide binding	204 – 208	5	GTP Potential
	Nucleotide binding	258 – 261	4	GTP Potential
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.13 Ref.15
	Modified residue	19	1	Phosphoserine Ref.9 Ref.13 Ref.15
Natural variations
	Alternative sequence	1 – 35	35	Missing in isoform 2.		VSP_044282
	Natural variant	262	1	R → W in MFDM. Ref.16		VAR_067580
	Natural variant	476	1	C → R in MFDM. Ref.16		VAR_067581
	Natural variant	637	1	L → R in MFDM. Ref.16		VAR_067582
	Natural variant	773	1	G → V. Corresponds to variant rs1056505 [ dbSNP | Ensembl ].		VAR_014931
Experimental info
	Sequence conflict	321	1	G → V in AAH02360. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 862BD6CA7993F118	FASTA	972	109,436
	10 20 30 40 50 60 MDTDLYDEFG NYIGPELDSD EDDDELGRET KDLDEMDDDD DDDDVGDHDD DHPGMEVVLH 70 80 90 100 110 120 EDKKYYPTAE EVYGPEVETI VQEEDTQPLT EPIIKPVKTK KFTLMEQTLP VTVYEMDFLA 130 140 150 160 170 180 DLMDNSELIR NVTLCGHLHH GKTCFVDCLI EQTHPEIRKR YDQDLCYTDI LFTEQERGVG 190 200 210 220 230 240 IKSTPVTVVL PDTKGKSYLF NIMDTPGHVN FSDEVTAGLR ISDGVVLFID AAEGVMLNTE 250 260 270 280 290 300 RLIKHAVQER LAVTVCINKI DRLILELKLP PTDAYYKLRH IVDEVNGLIS MYSTDENLIL 310 320 330 340 350 360 SPLLGNVCFS SSQYSICFTL GSFAKIYADT FGDINYQEFA KRLWGDIYFN PKTRKFTKKA 370 380 390 400 410 420 PTSSSQRSFV EFILEPLYKI LAQVVGDVDT SLPRTLDELG IHLTKEELKL NIRPLLRLVC 430 440 450 460 470 480 KKFFGEFTGF VDMCVQHIPS PKVGAKPKIE HTYTGGVDSD LGEAMSDCDP DGPLMCHTTK 490 500 510 520 530 540 MYSTDDGVQF HAFGRVLSGT IHAGQPVKVL GENYTLEDEE DSQICTVGRL WISVARYHIE 550 560 570 580 590 600 VNRVPAGNWV LIEGVDQPIV KTATITEPRG NEEAQIFRPL KFNTTSVIKI AVEPVNPSEL 610 620 630 640 650 660 PKMLDGLRKV NKSYPSLTTK VEESGEHVIL GTGELYLDCV MHDLRKMYSE IDIKVADPVV 670 680 690 700 710 720 TFCETVVETS SLKCFAETPN KKNKITMIAE PLEKGLAEDI ENEVVQITWN RKKLGEFFQT 730 740 750 760 770 780 KYDWDLLAAR SIWAFGPDAT GPNILVDDTL PSEVDKALLG SVKDSIVQGF QWGTREGPLC 790 800 810 820 830 840 DELIRNVKFK ILDAVVAQEP LHRGGGQIIP TARRVVYSAF LMATPRLMEP YYFVEVQAPA 850 860 870 880 890 900 DCVSAVYTVL ARRRGHVTQD APIPGSPLYT IKAFIPAIDS FGFETDLRTH TQGQAFSLSV 910 920 930 940 950 960 FHHWQIVPGD PLDKSIVIRP LEPQPAPHLA REFMIKTRRR KGLSEDVSIS KFFDDPMLLE 970 LAKQDVVLNY PM
	Isoform 2 [UniParc]. Checksum: C754AB346695B0C3	FASTA	937	105,384
	10 20 30 40 50 60 MDDDDDDDDV GDHDDDHPGM EVVLHEDKKY YPTAEEVYGP EVETIVQEED TQPLTEPIIK 70 80 90 100 110 120 PVKTKKFTLM EQTLPVTVYE MDFLADLMDN SELIRNVTLC GHLHHGKTCF VDCLIEQTHP 130 140 150 160 170 180 EIRKRYDQDL CYTDILFTEQ ERGVGIKSTP VTVVLPDTKG KSYLFNIMDT PGHVNFSDEV 190 200 210 220 230 240 TAGLRISDGV VLFIDAAEGV MLNTERLIKH AVQERLAVTV CINKIDRLIL ELKLPPTDAY 250 260 270 280 290 300 YKLRHIVDEV NGLISMYSTD ENLILSPLLG NVCFSSSQYS ICFTLGSFAK IYADTFGDIN 310 320 330 340 350 360 YQEFAKRLWG DIYFNPKTRK FTKKAPTSSS QRSFVEFILE PLYKILAQVV GDVDTSLPRT 370 380 390 400 410 420 LDELGIHLTK EELKLNIRPL LRLVCKKFFG EFTGFVDMCV QHIPSPKVGA KPKIEHTYTG 430 440 450 460 470 480 GVDSDLGEAM SDCDPDGPLM CHTTKMYSTD DGVQFHAFGR VLSGTIHAGQ PVKVLGENYT 490 500 510 520 530 540 LEDEEDSQIC TVGRLWISVA RYHIEVNRVP AGNWVLIEGV DQPIVKTATI TEPRGNEEAQ 550 560 570 580 590 600 IFRPLKFNTT SVIKIAVEPV NPSELPKMLD GLRKVNKSYP SLTTKVEESG EHVILGTGEL 610 620 630 640 650 660 YLDCVMHDLR KMYSEIDIKV ADPVVTFCET VVETSSLKCF AETPNKKNKI TMIAEPLEKG 670 680 690 700 710 720 LAEDIENEVV QITWNRKKLG EFFQTKYDWD LLAARSIWAF GPDATGPNIL VDDTLPSEVD 730 740 750 760 770 780 KALLGSVKDS IVQGFQWGTR EGPLCDELIR NVKFKILDAV VAQEPLHRGG GQIIPTARRV 790 800 810 820 830 840 VYSAFLMATP RLMEPYYFVE VQAPADCVSA VYTVLARRRG HVTQDAPIPG SPLYTIKAFI 850 860 870 880 890 900 PAIDSFGFET DLRTHTQGQA FSLSVFHHWQ IVPGDPLDKS IVIRPLEPQP APHLAREFMI 910 920 930 KTRRRKGLSE DVSISKFFDD PMLLELAKQD VVLNYPM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Thalamus.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle.
[6]	"An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2." Fabrizio P., Laggerbauer B., Lauber J., Lane W.S., Luehrmann R. EMBO J. 16:4092-4106(1997) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[7]	"The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein." Achsel T., Ahrens K., Brahms H., Teigelkamp S., Luehrmann R. Mol. Cell. Biol. 18:6756-6766(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PRPF8.
[8]	"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis." Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J. RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP." Liu S., Rauhut R., Vornlocher H.-P., Luehrmann R. RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[11]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Embryonic kidney.
[12]	"Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways." Gilmore-Hebert M., Ramabhadran R., Stern D.F. Mol. Cancer Res. 8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH ERBB4, SUBCELLULAR LOCATION.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, MASS SPECTROMETRY.
[16]	"Haploinsufficiency of a spliceosomal GTPase encoded by EFTUD2 causes mandibulofacial dysostosis with microcephaly." Lines M.A., Huang L., Schwartzentruber J., Douglas S.L., Lynch D.C., Beaulieu C., Guion-Almeida M.L., Zechi-Ceide R.M., Gener B., Gillessen-Kaesbach G., Nava C., Baujat G., Horn D., Kini U., Caliebe A., Alanay Y., Utine G.E., Lev D. , Kohlhase J., Grix A.W., Lohmann D.R., Hehr U., Bohm D., Majewski J., Bulman D.E., Wieczorek D., Boycott K.M. Am. J. Hum. Genet. 90:369-377(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MFDM TRP-262; ARG-476 AND ARG-637.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D21163 mRNA. Translation: BAA04699.2. Different initiation. AK296367 mRNA. Translation: BAG59042.1. AK316098 mRNA. Translation: BAH14469.1. AC015936 Genomic DNA. No translation available. CH471178 Genomic DNA. Translation: EAW51573.1. CH471178 Genomic DNA. Translation: EAW51574.1. BC002360 mRNA. Translation: AAH02360.1.
IPI	IPI00003519.
RefSeq	NP_001136077.1. NM_001142605.1. NP_001245282.1. NM_001258353.1. NP_004238.3. NM_004247.3.
UniGene	Hs.151787.
3D structure databases
ProteinModelPortal	Q15029.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15029. 25 interactions.
MINT	MINT-1161890.
STRING	9606.ENSP00000262414.
PTM databases
PhosphoSite	Q15029.
Polymorphism databases
DMDM	18202501.
Proteomic databases
PaxDb	Q15029.
PeptideAtlas	Q15029.
PRIDE	Q15029.
Protocols and materials databases
DNASU	9343.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000402521; ENSP00000385873; ENSG00000108883. ENST00000426333; ENSP00000392094; ENSG00000108883. ENST00000591382; ENSP00000467805; ENSG00000108883.
GeneID	9343.
KEGG	hsa:9343.
UCSC	uc002ihn.2. human.
Organism-specific databases
CTD	9343.
GeneCards	GC17M042927.
H-InvDB	HIX0135614.
HGNC	HGNC:30858. EFTUD2.
HPA	HPA022021.
MIM	603892. gene. 610536. phenotype.
neXtProt	NX_Q15029.
Orphanet	79113. Mandibulofacial dysostosis-microcephaly syndrome.
PharmGKB	PA142671915.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0480.
HOGENOM	HOG000231589.
HOVERGEN	HBG001838.
InParanoid	Q15029.
KO	K12852.
OMA	LGNVCFA.
OrthoDB	EOG4001HJ.
PhylomeDB	Q15029.
Enzyme and pathway databases
Reactome	REACT_1675. mRNA Processing. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q15029.
Bgee	Q15029.
CleanEx	HS_EFTUD2.
Genevestigator	Q15029.
GermOnline	ENSG00000108883. Homo sapiens.
Family and domain databases
Gene3D	3.30.230.10. 1 hit. 3.30.70.240. 1 hit.
InterPro	IPR000795. EF_GTP-bd_dom. IPR009022. EFG_III-V. IPR000640. EFG_V. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR005225. Small_GTP-bd_dom. IPR005517. Transl_elong_EFG/EF2_IV. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Pfam	PF00679. EFG_C. 1 hit. PF03764. EFG_IV. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. SM00889. EFG_IV. 1 hit. [Graphical view]
SUPFAM	SSF54980. EFG_III_V. 2 hits. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	EFTUD2. human.
GenomeRNAi	9343.
NextBio	34995.
SOURCE	Search...

Entry information

Entry name

U5S1_HUMAN

Accession

Primary (citable) accession number: Q15029
Secondary accession number(s): B4DK30, D3DX58, Q9BUR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 151 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.