##gff-version 3 Q15025 UniProtKB Chain 1 636 . . . ID=PRO_0000096691;Note=TNFAIP3-interacting protein 1 Q15025 UniProtKB Region 61 151 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q15025 UniProtKB Region 94 412 . . . Note=Interaction with Nef Q15025 UniProtKB Region 252 283 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q15025 UniProtKB Region 351 367 . . . Note=Interaction with Shigella flexneri ipah9.8 Q15025 UniProtKB Region 431 588 . . . Note=Required for inhibitory activity of TNF-induced NF-kappa-B activation;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q15025 UniProtKB Region 452 510 . . . Note=Ubiquitin-binding domain (UBD) Q15025 UniProtKB Region 603 636 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q15025 UniProtKB Coiled coil 20 73 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q15025 UniProtKB Coiled coil 196 258 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q15025 UniProtKB Coiled coil 294 535 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q15025 UniProtKB Motif 524 530 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q15025 UniProtKB Compositional bias 114 142 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q15025 UniProtKB Compositional bias 604 618 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q15025 UniProtKB Modified residue 77 77 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q15025 UniProtKB Modified residue 284 284 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q15025 UniProtKB Modified residue 403 403 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:18669648,PMID:20068231,PMID:23186163 Q15025 UniProtKB Modified residue 438 438 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Q15025 UniProtKB Modified residue 442 442 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Q15025 UniProtKB Modified residue 552 552 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17632516;Dbxref=PMID:17632516 Q15025 UniProtKB Modified residue 571 571 . . . Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WUU8 Q15025 UniProtKB Modified residue 599 599 . . . Note=Asymmetric dimethylarginine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 Q15025 UniProtKB Modified residue 599 599 . . . Note=Omega-N-methylarginine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 Q15025 UniProtKB Modified residue 627 627 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q15025 UniProtKB Alternative sequence 1 53 . . . ID=VSP_045296;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:17016622,ECO:0000303|PubMed:17974005;Dbxref=PMID:14702039,PMID:17016622,PMID:17974005 Q15025 UniProtKB Alternative sequence 530 593 . . . ID=VSP_055208;Note=In isoform 4 and isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17016622;Dbxref=PMID:17016622 Q15025 UniProtKB Alternative sequence 530 556 . . . ID=VSP_055209;Note=In isoform 5. ASGERYHVEPHPEHLCGAYPYAYPPMP->SLQKMTVRGLSETRLCHLAPPSSCRAS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17016622;Dbxref=PMID:17016622 Q15025 UniProtKB Alternative sequence 530 552 . . . ID=VSP_055210;Note=In isoform 8. ASGERYHVEPHPEHLCGAYPYAY->SQLISDCQETRSHLHGVARASAG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17016622;Dbxref=PMID:17016622 Q15025 UniProtKB Alternative sequence 530 545 . . . ID=VSP_055211;Note=In isoform 7. ASGERYHVEPHPEHLC->GTHRGCPRRLPERKVK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17016622;Dbxref=PMID:17016622 Q15025 UniProtKB Alternative sequence 546 636 . . . ID=VSP_055212;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17016622;Dbxref=PMID:17016622 Q15025 UniProtKB Alternative sequence 553 636 . . . ID=VSP_055213;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17016622;Dbxref=PMID:17016622 Q15025 UniProtKB Alternative sequence 557 636 . . . ID=VSP_055214;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17016622;Dbxref=PMID:17016622 Q15025 UniProtKB Alternative sequence 627 636 . . . ID=VSP_003913;Note=In isoform 2 and isoform 6. SPKNDREGPQ->PADLRLPRN;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:17016622,ECO:0000303|PubMed:8681136,ECO:0000303|PubMed:9923610;Dbxref=PMID:17016622,PMID:8681136,PMID:9923610 Q15025 UniProtKB Natural variant 103 103 . . . ID=VAR_051453;Note=P->S;Dbxref=dbSNP:rs2303018 Q15025 UniProtKB Natural variant 146 146 . . . ID=VAR_051454;Note=A->V;Dbxref=dbSNP:rs2233289 Q15025 UniProtKB Natural variant 151 151 . . . ID=VAR_051455;Note=P->A;Dbxref=dbSNP:rs2233290 Q15025 UniProtKB Natural variant 233 233 . . . ID=VAR_051456;Note=R->Q;Dbxref=dbSNP:rs2233292 Q15025 UniProtKB Natural variant 260 260 . . . ID=VAR_051457;Note=A->V;Dbxref=dbSNP:rs2233295 Q15025 UniProtKB Natural variant 263 263 . . . ID=VAR_067965;Note=In patients with gastrointestinal diffuse large cell lymphoma. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21266526;Dbxref=dbSNP:rs117663772,PMID:21266526 Q15025 UniProtKB Natural variant 286 286 . . . ID=VAR_067966;Note=In patients with gastrointestinal diffuse large cell lymphoma%3B somatic mutation. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21266526;Dbxref=dbSNP:rs185683917,PMID:21266526 Q15025 UniProtKB Natural variant 374 374 . . . ID=VAR_067967;Note=In patients with gastrointestinal diffuse large cell lymphoma. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21266526;Dbxref=dbSNP:rs748495842,PMID:21266526 Q15025 UniProtKB Natural variant 476 476 . . . ID=VAR_067968;Note=In patients with gastrointestinal diffuse large cell lymphoma%3B somatic mutation%3B loss of inhibitory activity on CARD11- and TNF-induced NF-kappa-B activation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21266526;Dbxref=PMID:21266526 Q15025 UniProtKB Mutagenesis 472 472 . . . Note=Abolishes binding to polyubiquitin ('K-63'-linked and linear). D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21606507;Dbxref=PMID:21606507 Q15025 UniProtKB Mutagenesis 552 552 . . . Note=Abolishes interaction with PI3K p85 regulatory subunit and abolishes interaction between SELPLG and PI3K p85 regulatory subunit. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17632516;Dbxref=PMID:17632516 Q15025 UniProtKB Sequence conflict 148 148 . . . Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q15025 UniProtKB Sequence conflict 178 178 . . . Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q15025 UniProtKB Sequence conflict 299 299 . . . Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q15025 UniProtKB Helix 448 451 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EB9 Q15025 UniProtKB Helix 455 510 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EAL