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Protein

TNFAIP3-interacting protein 1

Gene

TNIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.5 Publications

GO - Molecular functioni

  • mitogen-activated protein kinase binding Source: UniProtKB

GO - Biological processi

  • defense response Source: ProtInc
  • glycoprotein biosynthetic process Source: UniProtKB
  • inflammatory response Source: UniProtKB-KW
  • leukocyte cell-cell adhesion Source: UniProtKB
  • modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade Source: UniProtKB
  • MyD88-dependent toll-like receptor signaling pathway Source: UniProtKB
  • negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • negative regulation of viral genome replication Source: UniProtKB
  • positive regulation of inflammatory response Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • proteolysis Source: GOC
  • translation Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-5689896. Ovarian tumor domain proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
TNFAIP3-interacting protein 1
Alternative name(s):
A20-binding inhibitor of NF-kappa-B activation 1
Short name:
ABIN-1
HIV-1 Nef-interacting protein
Nef-associated factor 1
Short name:
Naf1
Nip40-1
Virion-associated nuclear shuttling protein
Short name:
VAN
Short name:
hVAN
Gene namesi
Name:TNIP1
Synonyms:KIAA0113, NAF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:16903. TNIP1.

Subcellular locationi

  • Cytoplasm
  • Nucleus

  • Note: Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.

GO - Cellular componenti

  • cytoplasm Source: HPA
  • intracellular Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi472D → N: Abolishes binding to polyubiquitin ('K-63'-linked and linear). 1 Publication1
Mutagenesisi552Y → F: Abolishes interaction with PI3K p85 regulatory subunit and abolishes interaction between SELPLG and PI3K p85 regulatory subunit. 1 Publication1

Organism-specific databases

DisGeNETi10318.
OpenTargetsiENSG00000145901.
Orphaneti536. Systemic lupus erythematosus.
PharmGKBiPA128394573.

Polymorphism and mutation databases

BioMutaiTNIP1.
DMDMi20138952.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966911 – 636TNFAIP3-interacting protein 1Add BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei438PhosphothreonineCombined sources1
Modified residuei442PhosphoserineCombined sources1
Modified residuei552Phosphotyrosine1 Publication1
Modified residuei571Asymmetric dimethylarginineBy similarity1
Modified residuei599Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei599Omega-N-methylarginine; alternateCombined sources1
Modified residuei627PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Tyr-552 by SRC-family kinases recruits phosphoinositide-3-kinase (PI3K) PIK3CD:p85 heterodimer which results in integrin activation and leukocyte adhesion to activated endothelium during inflammation.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ15025.
MaxQBiQ15025.
PaxDbiQ15025.
PeptideAtlasiQ15025.
PRIDEiQ15025.

PTM databases

iPTMnetiQ15025.
PhosphoSitePlusiQ15025.

Expressioni

Tissue specificityi

Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells.1 Publication

Gene expression databases

BgeeiENSG00000145901.
CleanExiHS_NAF1.
HS_TNIP1.
ExpressionAtlasiQ15025. baseline and differential.
GenevisibleiQ15025. HS.

Organism-specific databases

HPAiHPA037893.
HPA037894.
HPA071950.

Interactioni

Subunit structurei

Interacts with TNFAIP3 and IKBKG (polyubiquitinated); facilitates TNFAIP3-mediated de-ubiquitination of NEMO/IKBKG. Interacts with polyubiquitin. Interacts with MAPK1, SELPLG and PIK3CD. Interacts with IRAK1 (polyubiquitinated). Interacts with MYD88; the interaction is indicative for participation in an activated TLR-signaling complex. Interacts with HIV-1 matrix protein. Interacts with Shigella flexneri ipah9.8; the interaction promotes polyubiquitination of IKBKG.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-357849,EBI-357849
AP1M1Q9BXS53EBI-357849,EBI-541426
BYSLQ138957EBI-357849,EBI-358049
CCDC112Q8NEF33EBI-357849,EBI-745040
CCNG1P519597EBI-357849,EBI-3905829
CDIP1Q9H3054EBI-357849,EBI-2876678
CFAP53Q96M913EBI-357849,EBI-742422
EHHADHQ084263EBI-357849,EBI-2339219
FAM161AQ3B8205EBI-357849,EBI-719941
FAM168AQ925673EBI-357849,EBI-7957930
GABARAPL1Q9H0R85EBI-357849,EBI-746969
GABARAPL2P605205EBI-357849,EBI-720116
GIT2Q141613EBI-357849,EBI-1046878
GTF2BQ004035EBI-357849,EBI-389564
HDDC3Q8N4P33EBI-357849,EBI-750003
IKBKGQ9Y6K94EBI-357849,EBI-81279
ipaH9.8Q8VSC34EBI-357849,EBI-6125799From a different organism.
KIFC3Q9BVG83EBI-357849,EBI-2125614
MAGEB18Q96M615EBI-357849,EBI-741835
MAGEH1Q9H2133EBI-357849,EBI-473834
MAP1LC3AQ9H4925EBI-357849,EBI-720768
MAP1LC3BQ9GZQ83EBI-357849,EBI-373144
MOB1BQ7L9L43EBI-357849,EBI-2558745
MOB3CQ70IA83EBI-357849,EBI-9679267
MORF4L1Q9UBU83EBI-357849,EBI-399246
MORF4L2Q150143EBI-357849,EBI-399257
NDC80O147775EBI-357849,EBI-715849
NFKB1P198384EBI-357849,EBI-300010
NIFKQ9BYG33EBI-357849,EBI-2561019
NME7Q9Y5B87EBI-357849,EBI-744782
OPTNQ96CV98EBI-357849,EBI-748974
PIN1Q135266EBI-357849,EBI-714158
PNKPQ96T605EBI-357849,EBI-1045072
RALBP1Q153113EBI-357849,EBI-749285
SNIP1Q8TAD83EBI-357849,EBI-749336
SYT6Q5T7P8-23EBI-357849,EBI-10246152
TAX1BP1Q86VP15EBI-357849,EBI-529518
TCEA2Q155606EBI-357849,EBI-710310
TCEANC2Q96MN53EBI-357849,EBI-5462748
TNFAIP3P215806EBI-357849,EBI-527670
TNIP3Q96KP63EBI-357849,EBI-2509913
TXLNAP402225EBI-357849,EBI-359793
VPS33BQ9H2675EBI-357849,EBI-749072
ZBTB25P242785EBI-357849,EBI-739899
ZNHIT1O432573EBI-357849,EBI-347522

GO - Molecular functioni

  • mitogen-activated protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115602. 101 interactors.
DIPiDIP-27577N.
IntActiQ15025. 100 interactors.
MINTiMINT-200912.
STRINGi9606.ENSP00000317891.

Structurei

3D structure databases

ProteinModelPortaliQ15025.
SMRiQ15025.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 412Interaction with NefAdd BLAST319
Regioni351 – 367Interaction with Shigella flexneri ipah9.8Add BLAST17
Regioni431 – 588Required for inhibitory activity of TNF-induced NF-kappa-B activationBy similarityAdd BLAST158
Regioni452 – 510Ubiquitin-binding domain (UBD)Add BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili20 – 73Sequence analysisAdd BLAST54
Coiled coili196 – 258Sequence analysisAdd BLAST63
Coiled coili294 – 535Sequence analysisAdd BLAST242

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi524 – 530Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi539 – 636Pro-richAdd BLAST98

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEGE. Eukaryota.
ENOG411180D. LUCA.
GeneTreeiENSGT00510000046908.
HOGENOMiHOG000253048.
HOVERGENiHBG019072.
InParanoidiQ15025.
OMAiGSPKMEG.
OrthoDBiEOG091G04AX.
PhylomeDBiQ15025.
TreeFamiTF351138.

Family and domain databases

InterProiIPR033372. TNIP1.
[Graphical view]
PANTHERiPTHR31882:SF3. PTHR31882:SF3. 2 hits.

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q15025-1) [UniParc]FASTAAdd to basket
Also known as: Alpha, FL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGRGPYRIY DPGGSVPSGE ASAAFERLVK ENSRLKEKMQ GIKMLGELLE
60 70 80 90 100
ESQMEATRLR QKAEELVKDN ELLPPPSPSL GSFDPLAELT GKDSNVTASP
110 120 130 140 150
TAPACPSDKP APVQKPPSSG TSSEFEVVTP EEQNSPESSS HANAMALGPL
160 170 180 190 200
PREDGNLMLH LQRLETTLSV CAEEPDHGQL FTHLGRMALE FNRLASKVHK
210 220 230 240 250
NEQRTSILQT LCEQLRKENE ALKAKLDKGL EQRDQAAERL REENLELKKL
260 270 280 290 300
LMSNGNKEGA SGRPGSPKME GTGKKAVAGQ QQASVTAGKV PEVVALGAAE
310 320 330 340 350
KKVKMLEQQR SELLEVNKQW DQHFRSMKQQ YEQKITELRQ KLADLQKQVT
360 370 380 390 400
DLEAEREQKQ RDFDRKLLLA KSKIEMEETD KEQLTAEAKE LRQKVKYLQD
410 420 430 440 450
QLSPLTRQRE YQEKEIQRLN KALEEALSIQ TPPSSPPTAF GSPEGAGALL
460 470 480 490 500
RKQELVTQNE LLKQQVKIFE EDFQRERSDR ERMNEEKEEL KKQVEKLQAQ
510 520 530 540 550
VTLSNAQLKA FKDEEKAREA LRQQKRKAKA SGERYHVEPH PEHLCGAYPY
560 570 580 590 600
AYPPMPAMVP HHGFEDWSQI RYPPPPMAME HPPPLPNSRL FHLPEYTWRL
610 620 630
PCGGVRNPNQ SSQVMDPPTA RPTEPESPKN DREGPQ
Length:636
Mass (Da):71,864
Last modified:August 1, 1999 - v2
Checksum:iD81B96BEAD50D871
GO
Isoform 2 (identifier: Q15025-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     627-636: SPKNDREGPQ → PADLRLPRN

Show »
Length:635
Mass (Da):71,788
Checksum:iFE65D2CE6E7B185B
GO
Isoform 3 (identifier: Q15025-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:583
Mass (Da):66,012
Checksum:iA97F0EB85F9F39DE
GO
Isoform 4 (identifier: Q15025-4) [UniParc]FASTAAdd to basket
Also known as: Alpha2

The sequence of this isoform differs from the canonical sequence as follows:
     530-593: Missing.

Show »
Length:572
Mass (Da):64,500
Checksum:iD1E76C1FBBA59E63
GO
Isoform 5 (identifier: Q15025-5) [UniParc]FASTAAdd to basket
Also known as: Alpha4

The sequence of this isoform differs from the canonical sequence as follows:
     530-556: ASGERYHVEPHPEHLCGAYPYAYPPMP → SLQKMTVRGLSETRLCHLAPPSSCRAS
     557-636: Missing.

Note: Less effective in the NF-kappa-B inhibitory effect.
Show »
Length:556
Mass (Da):62,609
Checksum:i757B3E9B83C35F42
GO
Isoform 6 (identifier: Q15025-6) [UniParc]FASTAAdd to basket
Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     530-593: Missing.
     627-636: SPKNDREGPQ → PADLRLPRN

Show »
Length:571
Mass (Da):64,424
Checksum:i929F73D89B3D0A54
GO
Isoform 7 (identifier: Q15025-7) [UniParc]FASTAAdd to basket
Also known as: Alpha3, Beta3

The sequence of this isoform differs from the canonical sequence as follows:
     530-545: ASGERYHVEPHPEHLC → GTHRGCPRRLPERKVK
     546-636: Missing.

Show »
Length:545
Mass (Da):61,570
Checksum:i7F4AD5363F28608B
GO
Isoform 8 (identifier: Q15025-8) [UniParc]FASTAAdd to basket
Also known as: Beta4

The sequence of this isoform differs from the canonical sequence as follows:
     530-552: ASGERYHVEPHPEHLCGAYPYAY → SQLISDCQETRSHLHGVARASAG
     553-636: Missing.

Show »
Length:552
Mass (Da):62,103
Checksum:i699AD04365381366
GO

Sequence cautioni

The sequence AAB41438 differs from that shown. Reason: Frameshift at positions 152 and 154.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148G → D in AAH12133 (PubMed:15489334).Curated1
Sequence conflicti178G → S in BAH13185 (PubMed:14702039).Curated1
Sequence conflicti299A → P in AAG42154 (PubMed:11090181).Curated1
Sequence conflicti299A → P in BAF34946 (PubMed:17016622).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051453103P → S.Corresponds to variant rs2303018dbSNPEnsembl.1
Natural variantiVAR_051454146A → V.Corresponds to variant rs2233289dbSNPEnsembl.1
Natural variantiVAR_051455151P → A.Corresponds to variant rs2233290dbSNPEnsembl.1
Natural variantiVAR_051456233R → Q.Corresponds to variant rs2233292dbSNPEnsembl.1
Natural variantiVAR_051457260A → V.Corresponds to variant rs2233295dbSNPEnsembl.1
Natural variantiVAR_067965263R → W in patients with gastrointestinal diffuse large cell lymphoma. 1 PublicationCorresponds to variant rs117663772dbSNPEnsembl.1
Natural variantiVAR_067966286T → M in patients with gastrointestinal diffuse large cell lymphoma; somatic mutation. 1 PublicationCorresponds to variant rs185683917dbSNPEnsembl.1
Natural variantiVAR_067967374I → T in patients with gastrointestinal diffuse large cell lymphoma. 1 PublicationCorresponds to variant rs748495842dbSNPEnsembl.1
Natural variantiVAR_067968476E → K in patients with gastrointestinal diffuse large cell lymphoma; somatic mutation; loss of inhibitory activity on CARD11- and TNF-induced NF-kappa-B activation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0452961 – 53Missing in isoform 3. 3 PublicationsAdd BLAST53
Alternative sequenceiVSP_055208530 – 593Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_055209530 – 556ASGER…YPPMP → SLQKMTVRGLSETRLCHLAP PSSCRAS in isoform 5. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_055210530 – 552ASGER…YPYAY → SQLISDCQETRSHLHGVARA SAG in isoform 8. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_055211530 – 545ASGER…PEHLC → GTHRGCPRRLPERKVK in isoform 7. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_055212546 – 636Missing in isoform 7. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_055213553 – 636Missing in isoform 8. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_055214557 – 636Missing in isoform 5. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_003913627 – 636SPKNDREGPQ → PADLRLPRN in isoform 2 and isoform 6. 3 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011895 mRNA. Translation: CAA09855.1.
AJ011896 mRNA. Translation: CAA09856.1.
AY012155 mRNA. Translation: AAG42154.1.
AB177543 mRNA. Translation: BAF34946.1.
AB177544 mRNA. Translation: BAF34947.1.
AB252970 mRNA. Translation: BAF48787.1.
AB252971 mRNA. Translation: BAF48788.1.
AB252972 mRNA. Translation: BAF48789.1.
AB252973 mRNA. Translation: BAF48790.1.
AB252974 mRNA. Translation: BAF48791.1.
AB252975 mRNA. Translation: BAF48792.1.
AB252976 mRNA. Translation: BAF48793.1.
AB252977 mRNA. Translation: BAF48794.1.
AB252978 mRNA. Translation: BAF48795.1.
AB252979 mRNA. Translation: BAF48796.1.
AB252980 mRNA. Translation: BAF48797.1.
AB252981 mRNA. Translation: BAF48798.1.
D30755 mRNA. Translation: BAA06416.2.
AK299975 mRNA. Translation: BAH13185.1.
BX640647 mRNA. Translation: CAE45793.1.
AC008641 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61688.1.
CH471062 Genomic DNA. Translation: EAW61689.1.
CH471062 Genomic DNA. Translation: EAW61690.1.
CH471062 Genomic DNA. Translation: EAW61691.1.
BC012133 mRNA. Translation: AAH12133.1.
BC014008 mRNA. Translation: AAH14008.1.
U39403 mRNA. Translation: AAC99999.1.
U83844 mRNA. Translation: AAB41438.1. Frameshift.
CCDSiCCDS34280.1. [Q15025-1]
CCDS58982.1. [Q15025-3]
CCDS58983.1. [Q15025-5]
CCDS58984.1. [Q15025-4]
CCDS58985.1. [Q15025-2]
RefSeqiNP_001239314.1. NM_001252385.1.
NP_001239315.1. NM_001252386.1. [Q15025-3]
NP_001239319.1. NM_001252390.1. [Q15025-1]
NP_001239320.1. NM_001252391.1. [Q15025-1]
NP_001239321.1. NM_001252392.1. [Q15025-2]
NP_001239322.1. NM_001252393.1. [Q15025-2]
NP_001245383.1. NM_001258454.1. [Q15025-1]
NP_001245384.1. NM_001258455.1. [Q15025-4]
NP_001245385.1. NM_001258456.1. [Q15025-5]
NP_006049.3. NM_006058.4. [Q15025-1]
XP_006714814.1. XM_006714751.1. [Q15025-4]
XP_006714815.1. XM_006714752.2. [Q15025-6]
UniGeneiHs.355141.
Hs.731557.

Genome annotation databases

EnsembliENST00000315050; ENSP00000317891; ENSG00000145901. [Q15025-1]
ENST00000518977; ENSP00000430971; ENSG00000145901. [Q15025-2]
ENST00000520931; ENSP00000429891; ENSG00000145901. [Q15025-3]
ENST00000521591; ENSP00000430760; ENSG00000145901. [Q15025-1]
ENST00000522226; ENSP00000428187; ENSG00000145901. [Q15025-1]
ENST00000523200; ENSP00000431105; ENSG00000145901. [Q15025-4]
ENST00000523338; ENSP00000428243; ENSG00000145901. [Q15025-2]
ENST00000524280; ENSP00000429912; ENSG00000145901. [Q15025-5]
ENST00000610535; ENSP00000483944; ENSG00000145901. [Q15025-4]
ENST00000610874; ENSP00000484665; ENSG00000145901. [Q15025-5]
GeneIDi10318.
KEGGihsa:10318.
UCSCiuc003ltg.5. human. [Q15025-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011895 mRNA. Translation: CAA09855.1.
AJ011896 mRNA. Translation: CAA09856.1.
AY012155 mRNA. Translation: AAG42154.1.
AB177543 mRNA. Translation: BAF34946.1.
AB177544 mRNA. Translation: BAF34947.1.
AB252970 mRNA. Translation: BAF48787.1.
AB252971 mRNA. Translation: BAF48788.1.
AB252972 mRNA. Translation: BAF48789.1.
AB252973 mRNA. Translation: BAF48790.1.
AB252974 mRNA. Translation: BAF48791.1.
AB252975 mRNA. Translation: BAF48792.1.
AB252976 mRNA. Translation: BAF48793.1.
AB252977 mRNA. Translation: BAF48794.1.
AB252978 mRNA. Translation: BAF48795.1.
AB252979 mRNA. Translation: BAF48796.1.
AB252980 mRNA. Translation: BAF48797.1.
AB252981 mRNA. Translation: BAF48798.1.
D30755 mRNA. Translation: BAA06416.2.
AK299975 mRNA. Translation: BAH13185.1.
BX640647 mRNA. Translation: CAE45793.1.
AC008641 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61688.1.
CH471062 Genomic DNA. Translation: EAW61689.1.
CH471062 Genomic DNA. Translation: EAW61690.1.
CH471062 Genomic DNA. Translation: EAW61691.1.
BC012133 mRNA. Translation: AAH12133.1.
BC014008 mRNA. Translation: AAH14008.1.
U39403 mRNA. Translation: AAC99999.1.
U83844 mRNA. Translation: AAB41438.1. Frameshift.
CCDSiCCDS34280.1. [Q15025-1]
CCDS58982.1. [Q15025-3]
CCDS58983.1. [Q15025-5]
CCDS58984.1. [Q15025-4]
CCDS58985.1. [Q15025-2]
RefSeqiNP_001239314.1. NM_001252385.1.
NP_001239315.1. NM_001252386.1. [Q15025-3]
NP_001239319.1. NM_001252390.1. [Q15025-1]
NP_001239320.1. NM_001252391.1. [Q15025-1]
NP_001239321.1. NM_001252392.1. [Q15025-2]
NP_001239322.1. NM_001252393.1. [Q15025-2]
NP_001245383.1. NM_001258454.1. [Q15025-1]
NP_001245384.1. NM_001258455.1. [Q15025-4]
NP_001245385.1. NM_001258456.1. [Q15025-5]
NP_006049.3. NM_006058.4. [Q15025-1]
XP_006714814.1. XM_006714751.1. [Q15025-4]
XP_006714815.1. XM_006714752.2. [Q15025-6]
UniGeneiHs.355141.
Hs.731557.

3D structure databases

ProteinModelPortaliQ15025.
SMRiQ15025.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115602. 101 interactors.
DIPiDIP-27577N.
IntActiQ15025. 100 interactors.
MINTiMINT-200912.
STRINGi9606.ENSP00000317891.

PTM databases

iPTMnetiQ15025.
PhosphoSitePlusiQ15025.

Polymorphism and mutation databases

BioMutaiTNIP1.
DMDMi20138952.

Proteomic databases

EPDiQ15025.
MaxQBiQ15025.
PaxDbiQ15025.
PeptideAtlasiQ15025.
PRIDEiQ15025.

Protocols and materials databases

DNASUi10318.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315050; ENSP00000317891; ENSG00000145901. [Q15025-1]
ENST00000518977; ENSP00000430971; ENSG00000145901. [Q15025-2]
ENST00000520931; ENSP00000429891; ENSG00000145901. [Q15025-3]
ENST00000521591; ENSP00000430760; ENSG00000145901. [Q15025-1]
ENST00000522226; ENSP00000428187; ENSG00000145901. [Q15025-1]
ENST00000523200; ENSP00000431105; ENSG00000145901. [Q15025-4]
ENST00000523338; ENSP00000428243; ENSG00000145901. [Q15025-2]
ENST00000524280; ENSP00000429912; ENSG00000145901. [Q15025-5]
ENST00000610535; ENSP00000483944; ENSG00000145901. [Q15025-4]
ENST00000610874; ENSP00000484665; ENSG00000145901. [Q15025-5]
GeneIDi10318.
KEGGihsa:10318.
UCSCiuc003ltg.5. human. [Q15025-1]

Organism-specific databases

CTDi10318.
DisGeNETi10318.
GeneCardsiTNIP1.
HGNCiHGNC:16903. TNIP1.
HPAiHPA037893.
HPA037894.
HPA071950.
MIMi607714. gene.
neXtProtiNX_Q15025.
OpenTargetsiENSG00000145901.
Orphaneti536. Systemic lupus erythematosus.
PharmGKBiPA128394573.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEGE. Eukaryota.
ENOG411180D. LUCA.
GeneTreeiENSGT00510000046908.
HOGENOMiHOG000253048.
HOVERGENiHBG019072.
InParanoidiQ15025.
OMAiGSPKMEG.
OrthoDBiEOG091G04AX.
PhylomeDBiQ15025.
TreeFamiTF351138.

Enzyme and pathway databases

ReactomeiR-HSA-5689896. Ovarian tumor domain proteases.

Miscellaneous databases

ChiTaRSiTNIP1. human.
GeneWikiiTNIP1.
GenomeRNAii10318.
PROiQ15025.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145901.
CleanExiHS_NAF1.
HS_TNIP1.
ExpressionAtlasiQ15025. baseline and differential.
GenevisibleiQ15025. HS.

Family and domain databases

InterProiIPR033372. TNIP1.
[Graphical view]
PANTHERiPTHR31882:SF3. PTHR31882:SF3. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTNIP1_HUMAN
AccessioniPrimary (citable) accession number: Q15025
Secondary accession number(s): A4F1W8
, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q6N077, Q96EL9, Q99833, Q9H1J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 1, 1999
Last modified: November 30, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.