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Protein

Condensin complex subunit 1

Gene

NCAPD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain.1 Publication

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • histone binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2514853. Condensation of Prometaphase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin complex subunit 1
Alternative name(s):
Chromosome condensation-related SMC-associated protein 1
Chromosome-associated protein D2
Short name:
hCAP-D2
Non-SMC condensin I complex subunit D2
XCAP-D2 homolog
Gene namesi
Name:NCAPD2
Synonyms:CAPD2, CNAP1, KIAA0159
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000010292.12.
HGNCiHGNC:24305. NCAPD2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1343 – 1348RRTTRR → AATTAA: Abolishes localization to the nucleus, while it only reduces chromosome binding. 1 Publication6
Mutagenesisi1358 – 1360KKK → AAA: Abolishes localization to the nucleus, while it only reduces chromosome binding. 1 Publication3

Organism-specific databases

DisGeNETi9918.
OpenTargetsiENSG00000010292.
PharmGKBiPA162397021.

Polymorphism and mutation databases

BioMutaiNCAPD2.
DMDMi259016362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000950351 – 1401Condensin complex subunit 1Add BLAST1401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineCombined sources1
Modified residuei585PhosphoserineCombined sources1
Modified residuei1310PhosphoserineCombined sources1
Modified residuei1315PhosphoserineCombined sources1
Modified residuei1330PhosphoserineCombined sources1
Modified residuei1331PhosphothreonineCombined sources1
Modified residuei1333PhosphoserineCombined sources1
Modified residuei1339PhosphothreonineCombined sources1
Modified residuei1366PhosphoserineCombined sources1
Modified residuei1367PhosphoserineCombined sources1
Modified residuei1370PhosphoserineCombined sources1
Modified residuei1371PhosphoserineCombined sources1
Modified residuei1376PhosphoserineCombined sources1
Modified residuei1384Phosphothreonine; by CDK1By similarity1
Modified residuei1389Phosphothreonine; by CDK1By similarity1
Modified residuei1395PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15021.
MaxQBiQ15021.
PaxDbiQ15021.
PeptideAtlasiQ15021.
PRIDEiQ15021.

PTM databases

iPTMnetiQ15021.
PhosphoSitePlusiQ15021.

Expressioni

Gene expression databases

BgeeiENSG00000010292.
CleanExiHS_NCAPD2.
ExpressionAtlasiQ15021. baseline and differential.
GenevisibleiQ15021. HS.

Organism-specific databases

HPAiCAB012423.
HPA036947.
HPA037363.

Interactioni

Subunit structurei

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and H3.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NCAPHQ150034EBI-1044041,EBI-1046410

GO - Molecular functioni

  • histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115246. 54 interactors.
CORUMiQ15021.
IntActiQ15021. 16 interactors.
MINTiMINT-3030640.
STRINGi9606.ENSP00000325017.

Structurei

3D structure databases

ProteinModelPortaliQ15021.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 603Interactions with SMC2 and SMC4Add BLAST603

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1342 – 1362Bipartite nuclear localization signalAdd BLAST21

Domaini

The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal, although they are contained within the same region.

Sequence similaritiesi

Belongs to the CND1 (condensin subunit 1) family.Curated

Phylogenomic databases

eggNOGiKOG0414. Eukaryota.
COG5098. LUCA.
GeneTreeiENSGT00390000017108.
HOGENOMiHOG000068001.
HOVERGENiHBG038048.
InParanoidiQ15021.
KOiK06677.
OMAiHLDGENY.
OrthoDBiEOG091G00PU.
PhylomeDBiQ15021.
TreeFamiTF105712.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR026971. CND1/NCAPD3.
IPR032682. Cnd1_C.
IPR007673. Condensin_cplx_su1.
IPR024324. Condensin_cplx_su1_N.
PANTHERiPTHR14222. PTHR14222. 1 hit.
PTHR14222:SF4. PTHR14222:SF4. 1 hit.
PfamiView protein in Pfam
PF12717. Cnd1. 1 hit.
PF12922. Cnd1_N. 1 hit.
PIRSFiPIRSF017127. Condensin_D2. 1 hit.
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequencei

Sequence statusi: Complete.

Q15021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPQMYEFHL PLSPEELLKS GGVNQYVVQE VLSIKHLPPQ LRAFQAAFRA
60 70 80 90 100
QGPLAMLQHF DTIYSILHHF RSIDPGLKED TLQFLIKVVS RHSQELPAIL
110 120 130 140 150
DDTTLSGSDR NAHLNALKMN CYALIRLLES FETMASQTNL VDLDLGGKGK
160 170 180 190 200
KARTKAAHGF DWEEERQPIL QLLTQLLQLD IRHLWNHSII EEEFVSLVTG
210 220 230 240 250
CCYRLLENPT INHQKNRPTR EAITHLLGVA LTRYNHMLSA TVKIIQMLQH
260 270 280 290 300
FEHLAPVLVA AVSLWATDYG MKSIVGEIVR EIGQKCPQEL SRDPSGTKGF
310 320 330 340 350
AAFLTELAER VPAILMSSMC ILLDHLDGEN YMMRNAVLAA MAEMVLQVLS
360 370 380 390 400
GDQLEAAARD TRDQFLDTLQ AHGHDVNSFV RSRVLQLFTR IVQQKALPLT
410 420 430 440 450
RFQAVVALAV GRLADKSVLV CKNAIQLLAS FLANNPFSCK LSDADLAGPL
460 470 480 490 500
QKETQKLQEM RAQRRTAAAS AVLDPEEEWE AMLPELKSTL QQLLQLPQGE
510 520 530 540 550
EEIPEQIANT ETTEDVKGRI YQLLAKASYK KAIILTREAT GHFQESEPFS
560 570 580 590 600
HIDPEESEET RLLNILGLIF KGPAASTQEK NPRESTGNMV TGQTVCKNKP
610 620 630 640 650
NMSDPEESRG NDELVKQEML VQYLQDAYSF SRKITEAIGI ISKMMYENTT
660 670 680 690 700
TVVQEVIEFF VMVFQFGVPQ ALFGVRRMLP LIWSKEPGVR EAVLNAYRQL
710 720 730 740 750
YLNPKGDSAR AKAQALIQNL SLLLVDASVG TIQCLEEILC EFVQKDELKP
760 770 780 790 800
AVTQLLWERA TEKVACCPLE RCSSVMLLGM MARGKPEIVG SNLDTLVSIG
810 820 830 840 850
LDEKFPQDYR LAQQVCHAIA NISDRRKPSL GKRHPPFRLP QEHRLFERLR
860 870 880 890 900
ETVTKGFVHP DPLWIPFKEV AVTLIYQLAE GPEVICAQIL QGCAKQALEK
910 920 930 940 950
LEEKRTSQED PKESPAMLPT FLLMNLLSLA GDVALQQLVH LEQAVSGELC
960 970 980 990 1000
RRRVLREEQE HKTKDPKEKN TSSETTMEEE LGLVGATADD TEAELIRGIC
1010 1020 1030 1040 1050
EMELLDGKQT LAAFVPLLLK VCNNPGLYSN PDLSAAASLA LGKFCMISAT
1060 1070 1080 1090 1100
FCDSQLRLLF TMLEKSPLPI VRSNLMVATG DLAIRFPNLV DPWTPHLYAR
1110 1120 1130 1140 1150
LRDPAQQVRK TAGLVMTHLI LKDMVKVKGQ VSEMAVLLID PEPQIAALAK
1160 1170 1180 1190 1200
NFFNELSHKG NAIYNLLPDI ISRLSDPELG VEEEPFHTIM KQLLSYITKD
1210 1220 1230 1240 1250
KQTESLVEKL CQRFRTSRTE RQQRDLAYCV SQLPLTERGL RKMLDNFDCF
1260 1270 1280 1290 1300
GDKLSDESIF SAFLSVVGKL RRGAKPEGKA IIDEFEQKLR ACHTRGLDGI
1310 1320 1330 1340 1350
KELEIGQAGS QRAPSAKKPS TGSRYQPLAS TASDNDFVTP EPRRTTRRHP
1360 1370 1380 1390 1400
NTQQRASKKK PKVVFSSDES SEEDLSAEMT EDETPKKTTP ILRASARRHR

S
Length:1,401
Mass (Da):157,182
Last modified:September 22, 2009 - v3
Checksum:i35E31642B94B513D
GO

Sequence cautioni

The sequence BAA09930 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1062M → I in BAA09930 (PubMed:8590280).Curated1
Sequence conflicti1218R → L in BAA09930 (PubMed:8590280).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02442183Q → ECombined sources3 PublicationsCorresponds to variant dbSNP:rs714774Ensembl.1
Natural variantiVAR_057511580K → R. Corresponds to variant dbSNP:rs17725914Ensembl.1
Natural variantiVAR_024422797V → M. Corresponds to variant dbSNP:rs10849482Ensembl.1
Natural variantiVAR_0587131321T → S1 PublicationCorresponds to variant dbSNP:rs2240871Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63880 mRNA. Translation: BAA09930.2. Different initiation.
AC006064 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88788.1.
CH471116 Genomic DNA. Translation: EAW88789.1.
BC028182 mRNA. Translation: AAH28182.1.
CCDSiCCDS8548.1.
RefSeqiNP_055680.3. NM_014865.3.
UniGeneiHs.5719.

Genome annotation databases

EnsembliENST00000315579; ENSP00000325017; ENSG00000010292.
GeneIDi9918.
KEGGihsa:9918.
UCSCiuc001qoo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCND1_HUMAN
AccessioniPrimary (citable) accession number: Q15021
Secondary accession number(s): D3DUR4, Q8N6U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: September 22, 2009
Last modified: September 27, 2017
This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families