Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Squamous cell carcinoma antigen recognized by T-cells 3

Gene

SART3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity).By similarity4 Publications
Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.1 Publication

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • U4 snRNA binding Source: UniProtKB
  • U6atac snRNA binding Source: UniProtKB
  • U6 snRNA binding Source: UniProtKB
  • ubiquitin-specific protease binding Source: UniProtKB

GO - Biological processi

  • cell morphogenesis Source: Ensembl
  • hematopoietic stem cell proliferation Source: Ensembl
  • homeostasis of number of cells Source: Ensembl
  • mRNA splicing, via spliceosome Source: UniProtKB
  • nucleosome assembly Source: UniProtKB
  • positive regulation of histone deubiquitination Source: UniProtKB
  • regulation of gene expression Source: MGI
  • spliceosomal complex assembly Source: GO_Central
  • spliceosomal snRNP assembly Source: UniProtKB
  • spliceosomal tri-snRNP complex assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075856-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Squamous cell carcinoma antigen recognized by T-cells 3Curated
Short name:
SART-3Imported
Alternative name(s):
Tat-interacting protein of 110 kDa1 Publication
Short name:
Tip1101 Publication
p110 nuclear RNA-binding protein1 Publication
Gene namesi
Name:SART3Imported
Synonyms:KIAA0156Imported, TIP1101 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:16860. SART3.

Subcellular locationi

GO - Cellular componenti

  • Cajal body Source: UniProtKB
  • cytoplasm Source: UniProtKB-SubCell
  • nuclear speck Source: UniProtKB-SubCell
  • nucleoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9733.
MalaCardsiSART3.
OpenTargetsiENSG00000075856.
PharmGKBiPA34948.

Polymorphism and mutation databases

BioMutaiSART3.
DMDMi74762140.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002233132 – 963Squamous cell carcinoma antigen recognized by T-cells 3Add BLAST962

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei10PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei650PhosphoserineCombined sources1
Modified residuei657PhosphothreonineCombined sources1
Modified residuei769PhosphoserineCombined sources1
Modified residuei795PhosphoserineCombined sources1
Modified residuei852PhosphoserineCombined sources1
Modified residuei906Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ15020.
MaxQBiQ15020.
PaxDbiQ15020.
PeptideAtlasiQ15020.
PRIDEiQ15020.

PTM databases

iPTMnetiQ15020.
PhosphoSitePlusiQ15020.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000075856.
CleanExiHS_SART3.
ExpressionAtlasiQ15020. baseline and differential.
GenevisibleiQ15020. HS.

Organism-specific databases

HPAiHPA044322.

Interactioni

Subunit structurei

Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:17643375). Interacts with AGO1 and AGO2 (PubMed:17932509). Interacts with PRPF3 and USP4; the interaction with PRPF3 is direct and recruits USP4 to its substrate PRPF3 (PubMed:15314151, PubMed:20595234). Interacts with USP15; the interaction is direct (PubMed:24526689). Interacts with HIV-1 Tat (PubMed:11959860).6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RNPS1Q152875EBI-308619,EBI-395959

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • ubiquitin-specific protease binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115082. 155 interactors.
IntActiQ15020. 39 interactors.
MINTiMINT-2867335.
STRINGi9606.ENSP00000228284.

Structurei

Secondary structure

1963
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi91 – 107Combined sources17
Helixi112 – 124Combined sources13
Helixi128 – 141Combined sources14
Helixi146 – 159Combined sources14
Helixi163 – 176Combined sources14
Helixi183 – 195Combined sources13
Turni196 – 198Combined sources3
Helixi202 – 217Combined sources16
Turni221 – 223Combined sources3
Helixi225 – 236Combined sources12
Beta strandi240 – 242Combined sources3
Helixi245 – 255Combined sources11
Helixi262 – 272Combined sources11
Helixi279 – 304Combined sources26
Helixi310 – 323Combined sources14
Helixi326 – 339Combined sources14
Helixi344 – 354Combined sources11
Helixi361 – 374Combined sources14
Helixi379 – 392Combined sources14
Helixi396 – 409Combined sources14
Helixi414 – 429Combined sources16
Beta strandi436 – 438Combined sources3
Helixi440 – 457Combined sources18
Helixi459 – 464Combined sources6
Helixi473 – 484Combined sources12
Helixi489 – 501Combined sources13
Turni502 – 506Combined sources5
Helixi508 – 521Combined sources14
Helixi524 – 537Combined sources14
Helixi542 – 556Combined sources15
Helixi559 – 603Combined sources45
Beta strandi803 – 807Combined sources5
Helixi814 – 821Combined sources8
Turni822 – 824Combined sources3
Beta strandi827 – 834Combined sources8
Beta strandi840 – 850Combined sources11
Helixi851 – 861Combined sources11
Beta strandi864 – 868Combined sources5
Beta strandi870 – 875Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DO4NMR-A791-877[»]
5CTQX-ray2.60A/B/C/D94-611[»]
5CTRX-ray3.01A/B278-611[»]
5CTTX-ray1.70B601-649[»]
5JJWX-ray3.01A280-578[»]
5JJXX-ray2.00A81-393[»]
5JPZX-ray3.04A/B96-574[»]
ProteinModelPortaliQ15020.
SMRiQ15020.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15020.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati126 – 158HAT 1Add BLAST33
Repeati164 – 195HAT 2Add BLAST32
Repeati201 – 237HAT 3Add BLAST37
Repeati242 – 275HAT 4Add BLAST34
Repeati324 – 356HAT 5Add BLAST33
Repeati359 – 391HAT 6Add BLAST33
Repeati394 – 430HAT 7Add BLAST37
Repeati487 – 520HAT 8Add BLAST34
Domaini704 – 782RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini801 – 878RRM 2PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 351Mediates interaction with PRPF31 PublicationAdd BLAST350
Regioni487 – 520Required for interaction with USP41 PublicationAdd BLAST34
Regioni537 – 953Necessary and sufficient for U6 snRNA binding1 PublicationAdd BLAST417
Regioni600 – 670Required for nuclear localization1 PublicationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 46Sequence analysisAdd BLAST26
Coiled coili82 – 110Sequence analysisAdd BLAST29
Coiled coili559 – 619Sequence analysisAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi601 – 617Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 92Poly-Glu4
Compositional biasi612 – 616Poly-Lys5

Sequence similaritiesi

Contains 8 HAT repeats.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0128. Eukaryota.
ENOG410XP88. LUCA.
GeneTreeiENSGT00830000128394.
HOGENOMiHOG000063708.
HOVERGENiHBG053888.
InParanoidiQ15020.
OMAiMDRKSVE.
OrthoDBiEOG091G041L.
PhylomeDBiQ15020.
TreeFamiTF317554.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR003107. HAT.
IPR008669. LSM_interact.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF05391. Lsm_interact. 1 hit.
PF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00386. HAT. 7 hits.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15020-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAAETSAS EPEAESKAGP KADGEEDEVK AARTRRKVLS RAVAAATYKT
60 70 80 90 100
MGPAWDQQEE GVSESDGDEY AMASSAESSP GEYEWEYDEE EEKNQLEIER
110 120 130 140 150
LEEQLSINVY DYNCHVDLIR LLRLEGELTK VRMARQKMSE IFPLTEELWL
160 170 180 190 200
EWLHDEISMA QDGLDREHVY DLFEKAVKDY ICPNIWLEYG QYSVGGIGQK
210 220 230 240 250
GGLEKVRSVF ERALSSVGLH MTKGLALWEA YREFESAIVE AARLEKVHSL
260 270 280 290 300
FRRQLAIPLY DMEATFAEYE EWSEDPIPES VIQNYNKALQ QLEKYKPYEE
310 320 330 340 350
ALLQAEAPRL AEYQAYIDFE MKIGDPARIQ LIFERALVEN CLVPDLWIRY
360 370 380 390 400
SQYLDRQLKV KDLVLSVHNR AIRNCPWTVA LWSRYLLAME RHGVDHQVIS
410 420 430 440 450
VTFEKALNAG FIQATDYVEI WQAYLDYLRR RVDFKQDSSK ELEELRAAFT
460 470 480 490 500
RALEYLKQEV EERFNESGDP SCVIMQNWAR IEARLCNNMQ KARELWDSIM
510 520 530 540 550
TRGNAKYANM WLEYYNLERA HGDTQHCRKA LHRAVQCTSD YPEHVCEVLL
560 570 580 590 600
TMERTEGSLE DWDIAVQKTE TRLARVNEQR MKAAEKEAAL VQQEEEKAEQ
610 620 630 640 650
RKRARAEKKA LKKKKKIRGP EKRGADEDDE KEWGDDEEEQ PSKRRRVENS
660 670 680 690 700
IPAAGETQNV EVAAGPAGKC AAVDVEPPSK QKEKAASLKR DMPKVLHDSS
710 720 730 740 750
KDSITVFVSN LPYSMQEPDT KLRPLFEACG EVVQIRPIFS NRGDFRGYCY
760 770 780 790 800
VEFKEEKSAL QALEMDRKSV EGRPMFVSPC VDKSKNPDFK VFRYSTSLEK
810 820 830 840 850
HKLFISGLPF SCTKEELEEI CKAHGTVKDL RLVTNRAGKP KGLAYVEYEN
860 870 880 890 900
ESQASQAVMK MDGMTIKENI IKVAISNPPQ RKVPEKPETR KAPGGPMLLP
910 920 930 940 950
QTYGARGKGR TQLSLLPRAL QRPSAAAPQA ENGPAAAPAV AAPAATEAPK
960
MSNADFAKLF LRK
Length:963
Mass (Da):109,935
Last modified:November 1, 1996 - v1
Checksum:i06B26CEB8B19102A
GO
Isoform 2 (identifier: Q15020-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-364: SQYLDRQLKVKDLV → RSTTESKGFGFICT
     365-963: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Inactive in U4/U6 snRNP recycling.1 Publication
Show »
Length:364
Mass (Da):41,829
Checksum:iD86B2562A7FA2E4E
GO
Isoform 3 (identifier: Q15020-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-129: LSINVYDYNCHVDLIRLLRLEGELT → VGPGVGSGHLPVFQVLGSPCPGPPP
     130-963: Missing.

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):13,773
Checksum:iB41FC49C1C5E4C33
GO
Isoform 4 (identifier: Q15020-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-436: Missing.

Note: No experimental confirmation available.
Show »
Length:927
Mass (Da):105,584
Checksum:iA4D08EF2F14CFC93
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03880223D → E.1 PublicationCorresponds to variant rs2072579dbSNPEnsembl.1
Natural variantiVAR_038683591V → M Found in a patient with disseminated superficial actinic porokeratosis; unknown pathological significance. 1 PublicationCorresponds to variant rs118203954dbSNPEnsembl.1
Natural variantiVAR_038684621E → D.Corresponds to variant rs2287546dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017248105 – 129LSINV…EGELT → VGPGVGSGHLPVFQVLGSPC PGPPP in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_017249130 – 963Missing in isoform 3. 1 PublicationAdd BLAST834
Alternative sequenceiVSP_017250351 – 364SQYLD…VKDLV → RSTTESKGFGFICT in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_017251365 – 963Missing in isoform 2. 1 PublicationAdd BLAST599
Alternative sequenceiVSP_057284401 – 436Missing in isoform 4. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020880 mRNA. Translation: BAA78384.1.
AF387506 mRNA. Translation: AAK69347.1.
D63879 mRNA. Translation: BAA09929.1.
AK290209 mRNA. Translation: BAF82898.1.
AC008119 Genomic DNA. No translation available.
AC010206 Genomic DNA. No translation available.
KF455716 Genomic DNA. No translation available.
KF511170 Genomic DNA. No translation available.
BC032601 mRNA. Translation: AAH32601.1.
BC041638 mRNA. Translation: AAH41638.1.
BC093784 mRNA. Translation: AAH93784.1.
BC103706 mRNA. Translation: AAI03707.1.
BC111983 mRNA. Translation: AAI11984.1.
BC143253 mRNA. Translation: AAI43254.1.
CCDSiCCDS9117.1. [Q15020-1]
RefSeqiNP_055521.1. NM_014706.3. [Q15020-1]
UniGeneiHs.584842.

Genome annotation databases

EnsembliENST00000228284; ENSP00000228284; ENSG00000075856. [Q15020-1]
ENST00000431469; ENSP00000414453; ENSG00000075856. [Q15020-4]
ENST00000546611; ENSP00000448554; ENSG00000075856. [Q15020-3]
ENST00000546728; ENSP00000449743; ENSG00000075856. [Q15020-2]
GeneIDi9733.
KEGGihsa:9733.
UCSCiuc001tmz.2. human. [Q15020-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020880 mRNA. Translation: BAA78384.1.
AF387506 mRNA. Translation: AAK69347.1.
D63879 mRNA. Translation: BAA09929.1.
AK290209 mRNA. Translation: BAF82898.1.
AC008119 Genomic DNA. No translation available.
AC010206 Genomic DNA. No translation available.
KF455716 Genomic DNA. No translation available.
KF511170 Genomic DNA. No translation available.
BC032601 mRNA. Translation: AAH32601.1.
BC041638 mRNA. Translation: AAH41638.1.
BC093784 mRNA. Translation: AAH93784.1.
BC103706 mRNA. Translation: AAI03707.1.
BC111983 mRNA. Translation: AAI11984.1.
BC143253 mRNA. Translation: AAI43254.1.
CCDSiCCDS9117.1. [Q15020-1]
RefSeqiNP_055521.1. NM_014706.3. [Q15020-1]
UniGeneiHs.584842.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DO4NMR-A791-877[»]
5CTQX-ray2.60A/B/C/D94-611[»]
5CTRX-ray3.01A/B278-611[»]
5CTTX-ray1.70B601-649[»]
5JJWX-ray3.01A280-578[»]
5JJXX-ray2.00A81-393[»]
5JPZX-ray3.04A/B96-574[»]
ProteinModelPortaliQ15020.
SMRiQ15020.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115082. 155 interactors.
IntActiQ15020. 39 interactors.
MINTiMINT-2867335.
STRINGi9606.ENSP00000228284.

PTM databases

iPTMnetiQ15020.
PhosphoSitePlusiQ15020.

Polymorphism and mutation databases

BioMutaiSART3.
DMDMi74762140.

Proteomic databases

EPDiQ15020.
MaxQBiQ15020.
PaxDbiQ15020.
PeptideAtlasiQ15020.
PRIDEiQ15020.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228284; ENSP00000228284; ENSG00000075856. [Q15020-1]
ENST00000431469; ENSP00000414453; ENSG00000075856. [Q15020-4]
ENST00000546611; ENSP00000448554; ENSG00000075856. [Q15020-3]
ENST00000546728; ENSP00000449743; ENSG00000075856. [Q15020-2]
GeneIDi9733.
KEGGihsa:9733.
UCSCiuc001tmz.2. human. [Q15020-1]

Organism-specific databases

CTDi9733.
DisGeNETi9733.
GeneCardsiSART3.
HGNCiHGNC:16860. SART3.
HPAiHPA044322.
MalaCardsiSART3.
MIMi611684. gene.
neXtProtiNX_Q15020.
OpenTargetsiENSG00000075856.
PharmGKBiPA34948.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0128. Eukaryota.
ENOG410XP88. LUCA.
GeneTreeiENSGT00830000128394.
HOGENOMiHOG000063708.
HOVERGENiHBG053888.
InParanoidiQ15020.
OMAiMDRKSVE.
OrthoDBiEOG091G041L.
PhylomeDBiQ15020.
TreeFamiTF317554.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075856-MONOMER.

Miscellaneous databases

ChiTaRSiSART3. human.
EvolutionaryTraceiQ15020.
GeneWikiiSART3.
GenomeRNAii9733.
PROiQ15020.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075856.
CleanExiHS_SART3.
ExpressionAtlasiQ15020. baseline and differential.
GenevisibleiQ15020. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR003107. HAT.
IPR008669. LSM_interact.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF05391. Lsm_interact. 1 hit.
PF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00386. HAT. 7 hits.
SM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSART3_HUMAN
AccessioniPrimary (citable) accession number: Q15020
Secondary accession number(s): A8K2E4
, B7ZKM0, Q2M2H0, Q58F06, Q8IUS1, Q96J95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.