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Q15020

- SART3_HUMAN

UniProt

Q15020 - SART3_HUMAN

Protein

Squamous cell carcinoma antigen recognized by T-cells 3

Gene

SART3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.1 Publication

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. regulation of gene expression Source: MGI
    2. RNA processing Source: InterPro

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Squamous cell carcinoma antigen recognized by T-cells 3
    Short name:
    SART-3
    Short name:
    hSART-3
    Alternative name(s):
    Tat-interacting protein of 110 kDa
    Short name:
    Tip110
    Gene namesi
    Name:SART3
    Synonyms:KIAA0156, TIP110
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:16860. SART3.

    Subcellular locationi

    Cytoplasm. Nucleus speckle
    Note: Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nuclear speck Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Disseminated superficial actinic porokeratosis 1 (DSAP1) [MIM:175900]: Autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti591 – 5911V → M in DSAP1. 1 Publication
    VAR_038683

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi175900. phenotype.
    PharmGKBiPA34948.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed7 Publications
    Chaini2 – 963962Squamous cell carcinoma antigen recognized by T-cells 3PRO_0000223313Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine7 Publications
    Modified residuei10 – 101Phosphoserine1 Publication
    Modified residuei16 – 161Phosphoserine1 Publication
    Modified residuei852 – 8521Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ15020.
    PaxDbiQ15020.
    PeptideAtlasiQ15020.
    PRIDEiQ15020.

    PTM databases

    PhosphoSiteiQ15020.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ15020.
    BgeeiQ15020.
    CleanExiHS_SART3.
    GenevestigatoriQ15020.

    Organism-specific databases

    HPAiHPA044322.

    Interactioni

    Subunit structurei

    Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with HIV-1 Tat. Interacts with AGO1 and AGO2.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RNPS1Q152875EBI-308619,EBI-395959

    Protein-protein interaction databases

    BioGridi115082. 64 interactions.
    IntActiQ15020. 32 interactions.
    MINTiMINT-2867335.
    STRINGi9606.ENSP00000228284.

    Structurei

    Secondary structure

    1
    963
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi803 – 8075
    Helixi814 – 8218
    Turni822 – 8243
    Beta strandi827 – 8348
    Beta strandi840 – 85011
    Helixi851 – 86111
    Beta strandi864 – 8685
    Beta strandi870 – 8756

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DO4NMR-A791-877[»]
    ProteinModelPortaliQ15020.
    SMRiQ15020. Positions 102-360, 702-877.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ15020.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati126 – 15833HAT 1Add
    BLAST
    Repeati164 – 19532HAT 2Add
    BLAST
    Repeati201 – 23737HAT 3Add
    BLAST
    Repeati242 – 27534HAT 4Add
    BLAST
    Repeati324 – 35633HAT 5Add
    BLAST
    Repeati359 – 39133HAT 6Add
    BLAST
    Repeati394 – 43037HAT 7Add
    BLAST
    Repeati487 – 52034HAT 8Add
    BLAST
    Domaini704 – 78279RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini801 – 87878RRM 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni600 – 67071Required for nuclear localizationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili21 – 4626Sequence AnalysisAdd
    BLAST
    Coiled coili82 – 11029Sequence AnalysisAdd
    BLAST
    Coiled coili559 – 61961Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi601 – 61717Nuclear localization signalSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi89 – 924Poly-Glu
    Compositional biasi612 – 6165Poly-Lys

    Sequence similaritiesi

    Contains 8 HAT repeats.Curated
    Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG321927.
    HOGENOMiHOG000063708.
    HOVERGENiHBG053888.
    InParanoidiQ15020.
    OMAiMERTEGS.
    OrthoDBiEOG72ZCDB.
    PhylomeDBiQ15020.
    TreeFamiTF317554.

    Family and domain databases

    Gene3Di3.30.70.330. 2 hits.
    InterProiIPR003107. HAT.
    IPR008669. LSM_interact.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF05391. Lsm_interact. 1 hit.
    PF00076. RRM_1. 2 hits.
    [Graphical view]
    SMARTiSM00386. HAT. 7 hits.
    SM00360. RRM. 2 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15020-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATAAETSAS EPEAESKAGP KADGEEDEVK AARTRRKVLS RAVAAATYKT    50
    MGPAWDQQEE GVSESDGDEY AMASSAESSP GEYEWEYDEE EEKNQLEIER 100
    LEEQLSINVY DYNCHVDLIR LLRLEGELTK VRMARQKMSE IFPLTEELWL 150
    EWLHDEISMA QDGLDREHVY DLFEKAVKDY ICPNIWLEYG QYSVGGIGQK 200
    GGLEKVRSVF ERALSSVGLH MTKGLALWEA YREFESAIVE AARLEKVHSL 250
    FRRQLAIPLY DMEATFAEYE EWSEDPIPES VIQNYNKALQ QLEKYKPYEE 300
    ALLQAEAPRL AEYQAYIDFE MKIGDPARIQ LIFERALVEN CLVPDLWIRY 350
    SQYLDRQLKV KDLVLSVHNR AIRNCPWTVA LWSRYLLAME RHGVDHQVIS 400
    VTFEKALNAG FIQATDYVEI WQAYLDYLRR RVDFKQDSSK ELEELRAAFT 450
    RALEYLKQEV EERFNESGDP SCVIMQNWAR IEARLCNNMQ KARELWDSIM 500
    TRGNAKYANM WLEYYNLERA HGDTQHCRKA LHRAVQCTSD YPEHVCEVLL 550
    TMERTEGSLE DWDIAVQKTE TRLARVNEQR MKAAEKEAAL VQQEEEKAEQ 600
    RKRARAEKKA LKKKKKIRGP EKRGADEDDE KEWGDDEEEQ PSKRRRVENS 650
    IPAAGETQNV EVAAGPAGKC AAVDVEPPSK QKEKAASLKR DMPKVLHDSS 700
    KDSITVFVSN LPYSMQEPDT KLRPLFEACG EVVQIRPIFS NRGDFRGYCY 750
    VEFKEEKSAL QALEMDRKSV EGRPMFVSPC VDKSKNPDFK VFRYSTSLEK 800
    HKLFISGLPF SCTKEELEEI CKAHGTVKDL RLVTNRAGKP KGLAYVEYEN 850
    ESQASQAVMK MDGMTIKENI IKVAISNPPQ RKVPEKPETR KAPGGPMLLP 900
    QTYGARGKGR TQLSLLPRAL QRPSAAAPQA ENGPAAAPAV AAPAATEAPK 950
    MSNADFAKLF LRK 963
    Length:963
    Mass (Da):109,935
    Last modified:November 1, 1996 - v1
    Checksum:i06B26CEB8B19102A
    GO
    Isoform 2 (identifier: Q15020-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         351-364: SQYLDRQLKVKDLV → RSTTESKGFGFICT
         365-963: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:364
    Mass (Da):41,829
    Checksum:iD86B2562A7FA2E4E
    GO
    Isoform 3 (identifier: Q15020-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         105-129: LSINVYDYNCHVDLIRLLRLEGELT → VGPGVGSGHLPVFQVLGSPCPGPPP
         130-963: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:129
    Mass (Da):13,773
    Checksum:iB41FC49C1C5E4C33
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231D → E.1 Publication
    Corresponds to variant rs2072579 [ dbSNP | Ensembl ].
    VAR_038802
    Natural varianti591 – 5911V → M in DSAP1. 1 Publication
    VAR_038683
    Natural varianti621 – 6211E → D.
    Corresponds to variant rs2287546 [ dbSNP | Ensembl ].
    VAR_038684

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei105 – 12925LSINV…EGELT → VGPGVGSGHLPVFQVLGSPC PGPPP in isoform 3. 1 PublicationVSP_017248Add
    BLAST
    Alternative sequencei130 – 963834Missing in isoform 3. 1 PublicationVSP_017249Add
    BLAST
    Alternative sequencei351 – 36414SQYLD…VKDLV → RSTTESKGFGFICT in isoform 2. 1 PublicationVSP_017250Add
    BLAST
    Alternative sequencei365 – 963599Missing in isoform 2. 1 PublicationVSP_017251Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF387506 mRNA. Translation: AAK69347.1.
    AB020880 mRNA. Translation: BAA78384.1.
    D63879 mRNA. Translation: BAA09929.1.
    AK290209 mRNA. Translation: BAF82898.1.
    BC032601 mRNA. Translation: AAH32601.1.
    BC041638 mRNA. Translation: AAH41638.1.
    BC093784 mRNA. Translation: AAH93784.1.
    BC103706 mRNA. Translation: AAI03707.1.
    BC111983 mRNA. Translation: AAI11984.1.
    CCDSiCCDS9117.1. [Q15020-1]
    RefSeqiNP_055521.1. NM_014706.3. [Q15020-1]
    UniGeneiHs.584842.

    Genome annotation databases

    EnsembliENST00000228284; ENSP00000228284; ENSG00000075856. [Q15020-1]
    ENST00000546611; ENSP00000448554; ENSG00000075856. [Q15020-3]
    ENST00000546728; ENSP00000449743; ENSG00000075856. [Q15020-2]
    GeneIDi9733.
    KEGGihsa:9733.
    UCSCiuc001tmy.1. human. [Q15020-1]
    uc001tnb.3. human. [Q15020-3]

    Polymorphism databases

    DMDMi74762140.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF387506 mRNA. Translation: AAK69347.1 .
    AB020880 mRNA. Translation: BAA78384.1 .
    D63879 mRNA. Translation: BAA09929.1 .
    AK290209 mRNA. Translation: BAF82898.1 .
    BC032601 mRNA. Translation: AAH32601.1 .
    BC041638 mRNA. Translation: AAH41638.1 .
    BC093784 mRNA. Translation: AAH93784.1 .
    BC103706 mRNA. Translation: AAI03707.1 .
    BC111983 mRNA. Translation: AAI11984.1 .
    CCDSi CCDS9117.1. [Q15020-1 ]
    RefSeqi NP_055521.1. NM_014706.3. [Q15020-1 ]
    UniGenei Hs.584842.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DO4 NMR - A 791-877 [» ]
    ProteinModelPortali Q15020.
    SMRi Q15020. Positions 102-360, 702-877.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115082. 64 interactions.
    IntActi Q15020. 32 interactions.
    MINTi MINT-2867335.
    STRINGi 9606.ENSP00000228284.

    PTM databases

    PhosphoSitei Q15020.

    Polymorphism databases

    DMDMi 74762140.

    Proteomic databases

    MaxQBi Q15020.
    PaxDbi Q15020.
    PeptideAtlasi Q15020.
    PRIDEi Q15020.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000228284 ; ENSP00000228284 ; ENSG00000075856 . [Q15020-1 ]
    ENST00000546611 ; ENSP00000448554 ; ENSG00000075856 . [Q15020-3 ]
    ENST00000546728 ; ENSP00000449743 ; ENSG00000075856 . [Q15020-2 ]
    GeneIDi 9733.
    KEGGi hsa:9733.
    UCSCi uc001tmy.1. human. [Q15020-1 ]
    uc001tnb.3. human. [Q15020-3 ]

    Organism-specific databases

    CTDi 9733.
    GeneCardsi GC12M108915.
    HGNCi HGNC:16860. SART3.
    HPAi HPA044322.
    MIMi 175900. phenotype.
    611684. gene.
    neXtProti NX_Q15020.
    PharmGKBi PA34948.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG321927.
    HOGENOMi HOG000063708.
    HOVERGENi HBG053888.
    InParanoidi Q15020.
    OMAi MERTEGS.
    OrthoDBi EOG72ZCDB.
    PhylomeDBi Q15020.
    TreeFami TF317554.

    Miscellaneous databases

    ChiTaRSi SART3. human.
    EvolutionaryTracei Q15020.
    GeneWikii SART3.
    GenomeRNAii 9733.
    NextBioi 36616.
    PROi Q15020.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15020.
    Bgeei Q15020.
    CleanExi HS_SART3.
    Genevestigatori Q15020.

    Family and domain databases

    Gene3Di 3.30.70.330. 2 hits.
    InterProi IPR003107. HAT.
    IPR008669. LSM_interact.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF05391. Lsm_interact. 1 hit.
    PF00076. RRM_1. 2 hits.
    [Graphical view ]
    SMARTi SM00386. HAT. 7 hits.
    SM00360. RRM. 2 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients."
      Yang D., Nakao M., Shichijo S., Sasatomi T., Takasu H., Matsumoto H., Mori K., Hayashi A., Yamana H., Shirouzu K., Itoh K.
      Cancer Res. 59:4056-4063(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    2. "HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110."
      Liu Y., Li J., Kim B.O., Pace B.S., He J.J.
      J. Biol. Chem. 277:23854-23863(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH TAT.
      Tissue: Fetal brain.
    3. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
      DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-23.
      Tissue: Thalamus.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain, Eye, Skin and Uterus.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."
      Hoeck J., Weinmann L., Ender C., Ruedel S., Kremmer E., Raabe M., Urlaub H., Meister G.
      EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AGO1 AND AGO2.
    8. Bienvenut W.V., Dhillon A.S., Kolch W.
      Submitted (FEB-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-17; 121-130; 233-243; 295-322; 329-335; 350-356; 360-370; 452-463; 494-502; 555-568; 646-669; 758-768 AND 911-918, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Hepatoma.
    9. "Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme."
      Jeronimo C., Forget D., Bouchard A., Li Q., Chua G., Poitras C., Therien C., Bergeron D., Bourassa S., Greenblatt J., Chabot B., Poirier G.G., Hughes T.R., Blanchette M., Price D.H., Coulombe B.
      Mol. Cell 27:262-274(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE 7SK SNRNP COMPLEX.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-852, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Solution structure of the RNA binding domain of squamous cell carcinoma antigen recognized by T cells 3."
      RIKEN structural genomics initiative (RSGI)
      Submitted (APR-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 791-877.
    19. "A mutation in SART3 gene in a Chinese pedigree with disseminated superficial actinic porokeratosis."
      Zhang Z.H., Niu Z.M., Yuan W.T., Zhao J.J., Jiang F.X., Zhang J., Chai B., Cui F., Chen W., Lian C.H., Xiang L.H., Xu S.J., Liu W.D., Zheng Z.Z., Huang W.
      Br. J. Dermatol. 152:658-663(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT DSAP1 MET-591.

    Entry informationi

    Entry nameiSART3_HUMAN
    AccessioniPrimary (citable) accession number: Q15020
    Secondary accession number(s): A8K2E4
    , Q2M2H0, Q58F06, Q8IUS1, Q96J95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3