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Protein

Mortality factor 4-like protein 2

Gene

MORF4L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processDNA damage, DNA repair, Growth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Mortality factor 4-like protein 2
Alternative name(s):
MORF-related gene X protein
Protein MSL3-2
Transcription factor-like protein MRGX
Gene namesi
Name:MORF4L2
Synonyms:KIAA0026, MRGX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:16849. MORF4L2.

Subcellular locationi

GO - Cellular componenti

  • NuA4 histone acetyltransferase complex Source: GO_Central
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: HPA
  • plasma membrane Source: HPA

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi132 – 136Missing : Abrogates both transcriptional activation and repression by MORF4L2. 1 Publication5
Mutagenesisi263L → A: Abrogates both transcriptional activation and repression by MORF4L2. 1 Publication1

Organism-specific databases

DisGeNETi9643.
OpenTargetsiENSG00000123562.
PharmGKBiPA134925837.

Polymorphism and mutation databases

BioMutaiMORF4L2.
DMDMi3123049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000887681 – 288Mortality factor 4-like protein 2Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15014.
MaxQBiQ15014.
PaxDbiQ15014.
PeptideAtlasiQ15014.
PRIDEiQ15014.

PTM databases

iPTMnetiQ15014.
PhosphoSitePlusiQ15014.

Expressioni

Gene expression databases

BgeeiENSG00000123562.
CleanExiHS_MORF4L2.
ExpressionAtlasiQ15014. baseline and differential.
GenevisibleiQ15014. HS.

Organism-specific databases

HPAiHPA031872.
HPA054102.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115001. 100 interactors.
IntActiQ15014. 61 interactors.
MINTiMINT-7944329.
STRINGi9606.ENSP00000353643.

Structurei

3D structure databases

ProteinModelPortaliQ15014.
SMRiQ15014.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 288MRGPROSITE-ProRule annotationAdd BLAST172

Phylogenomic databases

eggNOGiKOG3001. Eukaryota.
ENOG410XR9F. LUCA.
GeneTreeiENSGT00530000063018.
HOGENOMiHOG000190863.
HOVERGENiHBG052487.
InParanoidiQ15014.
KOiK11342.
OMAiWGGRSTE.
OrthoDBiEOG090B091V.
PhylomeDBiQ15014.
TreeFamiTF323400.

Family and domain databases

InterProiView protein in InterPro
IPR008676. MRG.
IPR026541. MRG_dom.
PANTHERiPTHR10880. PTHR10880. 1 hit.
PfamiView protein in Pfam
PF05712. MRG. 1 hit.
PROSITEiView protein in PROSITE
PS51640. MRG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRKQGSQP RGQQSAEEEN FKKPTRSNMQ RSKMRGASSG KKTAGPQQKN
60 70 80 90 100
LEPALPGRWG GRSAENPPSG SVRKTRKNKQ KTPGNGDGGS TSEAPQPPRK
110 120 130 140 150
KRARADPTVE SEEAFKNRME VKVKIPEELK PWLVEDWDLV TRQKQLFQLP
160 170 180 190 200
AKKNVDAILE EYANCKKSQG NVDNKEYAVN EVVAGIKEYF NVMLGTQLLY
210 220 230 240 250
KFERPQYAEI LLAHPDAPMS QVYGAPHLLR LFVRIGAMLA YTPLDEKSLA
260 270 280
LLLGYLHDFL KYLAKNSASL FTASDYKVAS AEYHRKAL
Length:288
Mass (Da):32,308
Last modified:November 1, 1996 - v1
Checksum:iC9EFF517C76A565D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100620 mRNA. Translation: AAD29873.1.
AF167174 mRNA. Translation: AAF80855.1.
D14812 mRNA. Translation: BAA03553.1.
AK056012 mRNA. Translation: BAG51604.1.
AL049610 Genomic DNA. Translation: CAB55701.1.
CH471190 Genomic DNA. Translation: EAW54698.1.
CH471190 Genomic DNA. Translation: EAW54699.1.
CH471190 Genomic DNA. Translation: EAW54700.1.
CH471190 Genomic DNA. Translation: EAW54701.1.
BC056899 mRNA. Translation: AAH56899.1.
BC093013 mRNA. Translation: AAH93013.1.
AB050778 mRNA. Translation: BAC22659.1.
CCDSiCCDS14512.1.
RefSeqiNP_001135890.1. NM_001142418.1.
NP_001135891.1. NM_001142419.1.
NP_001135892.1. NM_001142420.1.
NP_001135893.1. NM_001142421.1.
NP_001135894.1. NM_001142422.1.
NP_001135895.1. NM_001142423.1.
NP_001135896.1. NM_001142424.1.
NP_001135897.1. NM_001142425.1.
NP_001135898.1. NM_001142426.1.
NP_001135899.1. NM_001142427.1.
NP_001135900.1. NM_001142428.1.
NP_001135901.1. NM_001142429.1.
NP_001135902.1. NM_001142430.1.
NP_001135903.1. NM_001142431.1.
NP_001135904.1. NM_001142432.1.
NP_036418.1. NM_012286.2.
UniGeneiHs.326387.

Genome annotation databases

EnsembliENST00000360458; ENSP00000353643; ENSG00000123562.
ENST00000422154; ENSP00000394417; ENSG00000123562.
ENST00000433176; ENSP00000415476; ENSG00000123562.
ENST00000441076; ENSP00000391969; ENSG00000123562.
ENST00000451301; ENSP00000410532; ENSG00000123562.
GeneIDi9643.
KEGGihsa:9643.
UCSCiuc004ekx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100620 mRNA. Translation: AAD29873.1.
AF167174 mRNA. Translation: AAF80855.1.
D14812 mRNA. Translation: BAA03553.1.
AK056012 mRNA. Translation: BAG51604.1.
AL049610 Genomic DNA. Translation: CAB55701.1.
CH471190 Genomic DNA. Translation: EAW54698.1.
CH471190 Genomic DNA. Translation: EAW54699.1.
CH471190 Genomic DNA. Translation: EAW54700.1.
CH471190 Genomic DNA. Translation: EAW54701.1.
BC056899 mRNA. Translation: AAH56899.1.
BC093013 mRNA. Translation: AAH93013.1.
AB050778 mRNA. Translation: BAC22659.1.
CCDSiCCDS14512.1.
RefSeqiNP_001135890.1. NM_001142418.1.
NP_001135891.1. NM_001142419.1.
NP_001135892.1. NM_001142420.1.
NP_001135893.1. NM_001142421.1.
NP_001135894.1. NM_001142422.1.
NP_001135895.1. NM_001142423.1.
NP_001135896.1. NM_001142424.1.
NP_001135897.1. NM_001142425.1.
NP_001135898.1. NM_001142426.1.
NP_001135899.1. NM_001142427.1.
NP_001135900.1. NM_001142428.1.
NP_001135901.1. NM_001142429.1.
NP_001135902.1. NM_001142430.1.
NP_001135903.1. NM_001142431.1.
NP_001135904.1. NM_001142432.1.
NP_036418.1. NM_012286.2.
UniGeneiHs.326387.

3D structure databases

ProteinModelPortaliQ15014.
SMRiQ15014.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115001. 100 interactors.
IntActiQ15014. 61 interactors.
MINTiMINT-7944329.
STRINGi9606.ENSP00000353643.

PTM databases

iPTMnetiQ15014.
PhosphoSitePlusiQ15014.

Polymorphism and mutation databases

BioMutaiMORF4L2.
DMDMi3123049.

Proteomic databases

EPDiQ15014.
MaxQBiQ15014.
PaxDbiQ15014.
PeptideAtlasiQ15014.
PRIDEiQ15014.

Protocols and materials databases

DNASUi9643.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360458; ENSP00000353643; ENSG00000123562.
ENST00000422154; ENSP00000394417; ENSG00000123562.
ENST00000433176; ENSP00000415476; ENSG00000123562.
ENST00000441076; ENSP00000391969; ENSG00000123562.
ENST00000451301; ENSP00000410532; ENSG00000123562.
GeneIDi9643.
KEGGihsa:9643.
UCSCiuc004ekx.4. human.

Organism-specific databases

CTDi9643.
DisGeNETi9643.
GeneCardsiMORF4L2.
HGNCiHGNC:16849. MORF4L2.
HPAiHPA031872.
HPA054102.
MIMi300409. gene.
neXtProtiNX_Q15014.
OpenTargetsiENSG00000123562.
PharmGKBiPA134925837.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3001. Eukaryota.
ENOG410XR9F. LUCA.
GeneTreeiENSGT00530000063018.
HOGENOMiHOG000190863.
HOVERGENiHBG052487.
InParanoidiQ15014.
KOiK11342.
OMAiWGGRSTE.
OrthoDBiEOG090B091V.
PhylomeDBiQ15014.
TreeFamiTF323400.

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Miscellaneous databases

ChiTaRSiMORF4L2. human.
GeneWikiiMORF4L2.
GenomeRNAii9643.
PROiQ15014.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123562.
CleanExiHS_MORF4L2.
ExpressionAtlasiQ15014. baseline and differential.
GenevisibleiQ15014. HS.

Family and domain databases

InterProiView protein in InterPro
IPR008676. MRG.
IPR026541. MRG_dom.
PANTHERiPTHR10880. PTHR10880. 1 hit.
PfamiView protein in Pfam
PF05712. MRG. 1 hit.
PROSITEiView protein in PROSITE
PS51640. MRG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMO4L2_HUMAN
AccessioniPrimary (citable) accession number: Q15014
Secondary accession number(s): B3KP92
, D3DXA5, Q567V0, Q8J026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 15, 2017
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.