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Protein

Mortality factor 4-like protein 2

Gene

MORF4L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processDNA damage, DNA repair, Growth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Mortality factor 4-like protein 2
Alternative name(s):
MORF-related gene X protein
Protein MSL3-2
Transcription factor-like protein MRGX
Gene namesi
Name:MORF4L2
Synonyms:KIAA0026, MRGX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000123562.16
HGNCiHGNC:16849 MORF4L2
MIMi300409 gene
neXtProtiNX_Q15014

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi132 – 136Missing : Abrogates both transcriptional activation and repression by MORF4L2. 1 Publication5
Mutagenesisi263L → A: Abrogates both transcriptional activation and repression by MORF4L2. 1 Publication1

Organism-specific databases

DisGeNETi9643
OpenTargetsiENSG00000123562
PharmGKBiPA134925837

Polymorphism and mutation databases

BioMutaiMORF4L2
DMDMi3123049

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000887681 – 288Mortality factor 4-like protein 2Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15014
MaxQBiQ15014
PaxDbiQ15014
PeptideAtlasiQ15014
PRIDEiQ15014

PTM databases

iPTMnetiQ15014
PhosphoSitePlusiQ15014

Expressioni

Gene expression databases

BgeeiENSG00000123562
CleanExiHS_MORF4L2
ExpressionAtlasiQ15014 baseline and differential
GenevisibleiQ15014 HS

Organism-specific databases

HPAiHPA031872
HPA054102

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115001, 102 interactors
CORUMiQ15014
IntActiQ15014, 67 interactors
MINTiQ15014
STRINGi9606.ENSP00000353643

Structurei

3D structure databases

ProteinModelPortaliQ15014
SMRiQ15014
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 288MRGPROSITE-ProRule annotationAdd BLAST172

Phylogenomic databases

eggNOGiKOG3001 Eukaryota
ENOG410XR9F LUCA
GeneTreeiENSGT00530000063018
HOGENOMiHOG000190863
HOVERGENiHBG052487
InParanoidiQ15014
KOiK11342
OMAiRGNMQRS
OrthoDBiEOG091G0J32
PhylomeDBiQ15014
TreeFamiTF323400

Family and domain databases

Gene3Di1.10.274.30, 1 hit
InterProiView protein in InterPro
IPR008676 MRG
IPR038217 MRG_C_sf
IPR026541 MRG_dom
IPR038012 MRGX
PANTHERiPTHR10880 PTHR10880, 1 hit
PTHR10880:SF25 PTHR10880:SF25, 1 hit
PfamiView protein in Pfam
PF05712 MRG, 1 hit
PIRSFiPIRSF038133 HAT_Nua4_EAF3/MRG15, 1 hit
PROSITEiView protein in PROSITE
PS51640 MRG, 1 hit

Sequencei

Sequence statusi: Complete.

Q15014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRKQGSQP RGQQSAEEEN FKKPTRSNMQ RSKMRGASSG KKTAGPQQKN
60 70 80 90 100
LEPALPGRWG GRSAENPPSG SVRKTRKNKQ KTPGNGDGGS TSEAPQPPRK
110 120 130 140 150
KRARADPTVE SEEAFKNRME VKVKIPEELK PWLVEDWDLV TRQKQLFQLP
160 170 180 190 200
AKKNVDAILE EYANCKKSQG NVDNKEYAVN EVVAGIKEYF NVMLGTQLLY
210 220 230 240 250
KFERPQYAEI LLAHPDAPMS QVYGAPHLLR LFVRIGAMLA YTPLDEKSLA
260 270 280
LLLGYLHDFL KYLAKNSASL FTASDYKVAS AEYHRKAL
Length:288
Mass (Da):32,308
Last modified:November 1, 1996 - v1
Checksum:iC9EFF517C76A565D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100620 mRNA Translation: AAD29873.1
AF167174 mRNA Translation: AAF80855.1
D14812 mRNA Translation: BAA03553.1
AK056012 mRNA Translation: BAG51604.1
AL049610 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54698.1
CH471190 Genomic DNA Translation: EAW54699.1
CH471190 Genomic DNA Translation: EAW54700.1
CH471190 Genomic DNA Translation: EAW54701.1
BC056899 mRNA Translation: AAH56899.1
BC093013 mRNA Translation: AAH93013.1
AB050778 mRNA Translation: BAC22659.1
CCDSiCCDS14512.1
RefSeqiNP_001135890.1, NM_001142418.1
NP_001135891.1, NM_001142419.1
NP_001135892.1, NM_001142420.1
NP_001135893.1, NM_001142421.1
NP_001135894.1, NM_001142422.1
NP_001135895.1, NM_001142423.1
NP_001135896.1, NM_001142424.1
NP_001135897.1, NM_001142425.1
NP_001135898.1, NM_001142426.1
NP_001135899.1, NM_001142427.1
NP_001135900.1, NM_001142428.1
NP_001135901.1, NM_001142429.1
NP_001135902.1, NM_001142430.1
NP_001135903.1, NM_001142431.1
NP_001135904.1, NM_001142432.1
NP_036418.1, NM_012286.2
UniGeneiHs.326387

Genome annotation databases

EnsembliENST00000360458; ENSP00000353643; ENSG00000123562
ENST00000422154; ENSP00000394417; ENSG00000123562
ENST00000433176; ENSP00000415476; ENSG00000123562
ENST00000441076; ENSP00000391969; ENSG00000123562
ENST00000451301; ENSP00000410532; ENSG00000123562
GeneIDi9643
KEGGihsa:9643
UCSCiuc004ekx.4 human

Similar proteinsi

Entry informationi

Entry nameiMO4L2_HUMAN
AccessioniPrimary (citable) accession number: Q15014
Secondary accession number(s): B3KP92
, D3DXA5, Q567V0, Q8J026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health