Q15012 (LAP4A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysosomal-associated transmembrane protein 4A

Alternative name(s):
Golgi 4-transmembrane-spanning transporter MTP

Gene names

Name:	LAPTM4A
Synonyms:	KIAA0108, LAPTM4, MBNT, MTRP
ORF Names:	UNQ1846/PRO3574

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment By similarity.
Subcellular location	Endomembrane system; Multi-pass membrane protein Potential. Note: May reside in an intracellular membrane-bound compartment Potential.
Domain	The C-terminal domain is necessary for retention within intracelllular membranes By similarity.
Sequence similarities	Belongs to the LAPTM4/LAPTM5 transporter family.
Sequence caution	The sequence AAQ89387.1 differs from that shown. Reason: Frameshift at position 206. The sequence BAA03522.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi apparatus Inferred from direct assay. Source: UniProtKB endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 233	233	Lysosomal-associated transmembrane protein 4A		PRO_0000096637
Regions
	Transmembrane	29 – 49	21	Helical; Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Transmembrane	108 – 128	21	Helical; Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Compositional bias	226 – 229	4	Poly-Pro
Amino acid modifications
	Modified residue	230	1	Phosphotyrosine Ref.4 Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q15012 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 9BB76152B6E1365E	FASTA	233	26,801
	10 20 30 40 50 60 MVSMSFKRNR SDRFYSTRCC GCCHVRTGTI ILGTWYMVVN LLMAILLTVE VTHPNSMPAV 70 80 90 100 110 120 NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG AISYQVGWLI PFFCYRLFDF 130 140 150 160 170 180 VLSCLVAISS LTYLPRIKEY LDQLPDFPYK DDLLALDSSC LLFIVLVFFA LFIIFKAYLI 190 200 210 220 230 NCVWNCYKYI NNRNVPEIAV YPAFEAPPQY VLPTYEMAVK MPEKEPPPPY LPA

References

[1]	"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N. DNA Res. 2:37-43(1995) [PubMed: 7788527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[4]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-230, MASS SPECTROMETRY. Tissue: Lung carcinoma.
[5]	"An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells." Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A., Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D., Wiley H.S., Qian W.-J. J. Proteome Res. 8:3852-3861(2009) [PubMed: 19534553] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-230, MASS SPECTROMETRY. Tissue: Mammary epithelium.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D14696 mRNA. Translation: BAA03522.2. Different initiation. AY359028 mRNA. Translation: AAQ89387.1. Frameshift. BC000421 mRNA. Translation: AAH00421.1.
IPI	IPI00014172.
RefSeq	NP_055528.1. NM_014713.4.
UniGene	Hs.467807.
3D structure databases
ProteinModelPortal	Q15012.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15012. 2 interactions.
STRING	Q15012.
PTM databases
PhosphoSite	Q15012.
Polymorphism databases
DMDM	3122413.
Proteomic databases
PRIDE	Q15012.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000175091; ENSP00000175091; ENSG00000068697.
GeneID	9741.
KEGG	hsa:9741.
UCSC	uc002rdm.1. human.
Organism-specific databases
CTD	9741.
GeneCards	GC02M020232.
H-InvDB	HIX0001855.
HGNC	HGNC:6924. LAPTM4A.
HPA	HPA031402. HPA031404.
neXtProt	NX_Q15012.
PharmGKB	PA30295.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17081.
HOGENOM	HBG713795.
HOVERGEN	HBG000908.
InParanoid	Q15012.
OMA	MMVYGAI.
OrthoDB	EOG4WQ139.
PhylomeDB	Q15012.
Gene expression databases
ArrayExpress	Q15012.
Bgee	Q15012.
CleanEx	HS_LAPTM4A.
Genevestigator	Q15012.
GermOnline	ENSG00000068697. Homo sapiens.
Family and domain databases
InterPro	IPR004687. LAPTM4/5. IPR018396. LAPTM_4A/5. [Graphical view]
KO	K12387.
PANTHER	PTHR12479. Mtp_transporter. 1 hit.
Pfam	PF03821. Mtp. 1 hit. [Graphical view]
TIGRFAMs	TIGR00799. Mtp. 1 hit.
ProtoNet	Search...
Other
NextBio	36655.

Entry information

Entry name

LAP4A_HUMAN

Accession

Primary (citable) accession number: Q15012
Secondary accession number(s): Q6UW22

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.