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Protein

Lysosomal-associated transmembrane protein 4A

Gene

LAPTM4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 4A
Alternative name(s):
Golgi 4-transmembrane-spanning transporter MTP
Gene namesi
Name:LAPTM4A
Synonyms:KIAA0108, LAPTM4, MBNT, MTRP
ORF Names:UNQ1846/PRO3574
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6924. LAPTM4A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921HelicalSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30295.

Polymorphism and mutation databases

BioMutaiLAPTM4A.
DMDMi3122413.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Lysosomal-associated transmembrane protein 4APRO_0000096637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ15012.
PRIDEiQ15012.

PTM databases

iPTMnetiQ15012.
PhosphoSiteiQ15012.
SwissPalmiQ15012.

Expressioni

Gene expression databases

BgeeiQ15012.
CleanExiHS_LAPTM4A.
ExpressionAtlasiQ15012. baseline and differential.
GenevisibleiQ15012. HS.

Organism-specific databases

HPAiHPA031402.
HPA031404.

Interactioni

Protein-protein interaction databases

BioGridi115089. 9 interactions.
IntActiQ15012. 2 interactions.
STRINGi9606.ENSP00000175091.

Structurei

3D structure databases

ProteinModelPortaliQ15012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi226 – 2294Poly-Pro

Domaini

The C-terminal domain is necessary for retention within intracellular membranes.By similarity

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEGH. Eukaryota.
ENOG4111K1Z. LUCA.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ15012.
KOiK12387.
OMAiDFPYKDN.
OrthoDBiEOG7QC7X3.
PhylomeDBiQ15012.
TreeFamiTF330843.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PfamiPF03821. Mtp. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSMSFKRNR SDRFYSTRCC GCCHVRTGTI ILGTWYMVVN LLMAILLTVE
60 70 80 90 100
VTHPNSMPAV NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG
110 120 130 140 150
AISYQVGWLI PFFCYRLFDF VLSCLVAISS LTYLPRIKEY LDQLPDFPYK
160 170 180 190 200
DDLLALDSSC LLFIVLVFFA LFIIFKAYLI NCVWNCYKYI NNRNVPEIAV
210 220 230
YPAFEAPPQY VLPTYEMAVK MPEKEPPPPY LPA
Length:233
Mass (Da):26,801
Last modified:November 1, 1996 - v1
Checksum:i9BB76152B6E1365E
GO

Sequence cautioni

The sequence AAQ89387.1 differs from that shown. Reason: Frameshift at position 206. Curated
The sequence BAA03522.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14696 mRNA. Translation: BAA03522.2. Different initiation.
AY359028 mRNA. Translation: AAQ89387.1. Frameshift.
BC000421 mRNA. Translation: AAH00421.1.
CCDSiCCDS1696.1.
RefSeqiNP_055528.1. NM_014713.4.
UniGeneiHs.467807.

Genome annotation databases

EnsembliENST00000175091; ENSP00000175091; ENSG00000068697.
GeneIDi9741.
KEGGihsa:9741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14696 mRNA. Translation: BAA03522.2. Different initiation.
AY359028 mRNA. Translation: AAQ89387.1. Frameshift.
BC000421 mRNA. Translation: AAH00421.1.
CCDSiCCDS1696.1.
RefSeqiNP_055528.1. NM_014713.4.
UniGeneiHs.467807.

3D structure databases

ProteinModelPortaliQ15012.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115089. 9 interactions.
IntActiQ15012. 2 interactions.
STRINGi9606.ENSP00000175091.

PTM databases

iPTMnetiQ15012.
PhosphoSiteiQ15012.
SwissPalmiQ15012.

Polymorphism and mutation databases

BioMutaiLAPTM4A.
DMDMi3122413.

Proteomic databases

PaxDbiQ15012.
PRIDEiQ15012.

Protocols and materials databases

DNASUi9741.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000175091; ENSP00000175091; ENSG00000068697.
GeneIDi9741.
KEGGihsa:9741.

Organism-specific databases

CTDi9741.
GeneCardsiLAPTM4A.
HGNCiHGNC:6924. LAPTM4A.
HPAiHPA031402.
HPA031404.
neXtProtiNX_Q15012.
PharmGKBiPA30295.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEGH. Eukaryota.
ENOG4111K1Z. LUCA.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ15012.
KOiK12387.
OMAiDFPYKDN.
OrthoDBiEOG7QC7X3.
PhylomeDBiQ15012.
TreeFamiTF330843.

Miscellaneous databases

ChiTaRSiLAPTM4A. human.
GenomeRNAii9741.
NextBioi36655.
PROiQ15012.

Gene expression databases

BgeeiQ15012.
CleanExiHS_LAPTM4A.
ExpressionAtlasiQ15012. baseline and differential.
GenevisibleiQ15012. HS.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PfamiPF03821. Mtp. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
    DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLAP4A_HUMAN
AccessioniPrimary (citable) accession number: Q15012
Secondary accession number(s): Q6UW22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.