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Q15011

- HERP1_HUMAN

UniProt

Q15011 - HERP1_HUMAN

Protein

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Gene

HERPUD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation.1 Publication

    GO - Biological processi

    1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
    2. cellular calcium ion homeostasis Source: Ensembl
    3. cellular protein metabolic process Source: Reactome
    4. endoplasmic reticulum unfolded protein response Source: Reactome
    5. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    6. positive regulation of protein binding Source: Ensembl
    7. regulation of protein ubiquitination Source: Ensembl
    8. response to unfolded protein Source: UniProtKB
    9. ubiquitin-dependent protein catabolic process Source: Ensembl

    Keywords - Biological processi

    Unfolded protein response

    Enzyme and pathway databases

    ReactomeiREACT_18355. ATF4 activates genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    Alternative name(s):
    Methyl methanesulfonate (MMF)-inducible fragment protein 1
    Gene namesi
    Name:HERPUD1
    Synonyms:HERP, KIAA0025, MIF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:13744. HERPUD1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29252.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 proteinPRO_0000114920Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ15011.
    PaxDbiQ15011.
    PRIDEiQ15011.

    PTM databases

    PhosphoSiteiQ15011.

    Expressioni

    Tissue specificityi

    Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.

    Inductioni

    Up-regulated by endoplasmic reticulum stress and CREB3.2 Publications

    Gene expression databases

    ArrayExpressiQ15011.
    BgeeiQ15011.
    CleanExiHS_HERPUD1.
    GenevestigatoriQ15011.

    Organism-specific databases

    HPAiCAB037041.
    CAB037104.
    HPA040754.
    HPA041219.

    Interactioni

    Subunit structurei

    Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6.3 Publications

    Protein-protein interaction databases

    BioGridi115060. 27 interactions.
    DIPiDIP-46662N.
    IntActiQ15011. 10 interactions.
    MINTiMINT-2867283.
    STRINGi9606.ENSP00000300302.

    Structurei

    Secondary structure

    1
    391
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi11 – 155
    Beta strandi17 – 204
    Beta strandi24 – 274
    Helixi34 – 4411
    Turni51 – 533
    Beta strandi55 – 584
    Beta strandi65 – 673
    Helixi69 – 724
    Beta strandi75 – 773
    Beta strandi79 – 857

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WGDNMR-A10-90[»]
    ProteinModelPortaliQ15011.
    SMRiQ15011. Positions 10-90.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ15011.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 263263CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini285 – 2895LumenalSequence Analysis
    Topological domaini311 – 39181CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 7263Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259558.
    HOGENOMiHOG000252989.
    HOVERGENiHBG051899.
    InParanoidiQ15011.
    KOiK14027.
    OMAiPLYTRIT.
    OrthoDBiEOG7QRQWK.
    PhylomeDBiQ15011.
    TreeFamiTF324319.

    Family and domain databases

    InterProiIPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: Q15011-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESETEPEPV TLLVKSPNQR HRDLELSGDR GWSVGHLKAH LSRVYPERPR    50
    PEDQRLIYSG KLLLDHQCLR DLLPKQEKRH VLHLVCNVKS PSKMPEINAK 100
    VAESTEEPAG SNRGQYPEDS SSDGLRQREV LRNLSSPGWE NISRPEAAQQ 150
    AFQGLGPGFS GYTPYGWLQL SWFQQIYARQ YYMQYLAATA ASGAFVPPPS 200
    AQEIPVVSAP APAPIHNQFP AENQPANQNA APQVVVNPGA NQNLRMNAQG 250
    GPIVEEDDEI NRDWLDWTYS AATFSVFLSI LYFYSSLSRF LMVMGATVVM 300
    YLHHVGWFPF RPRPVQNFPN DGPPPDVVNQ DPNNNLQEGT DPETEDPNHL 350
    PPDRDVLDGE QTSPSFMSTA WLVFKTFFAS LLPEGPPAIA N 391
    Length:391
    Mass (Da):43,720
    Last modified:November 1, 1996 - v1
    Checksum:i3CA827DC7EF0ED22
    GO
    Isoform 2 (identifier: Q15011-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         76-76: Missing.

    Show »
    Length:390
    Mass (Da):43,592
    Checksum:i7BCA8854403C71AF
    GO
    Isoform 3 (identifier: Q15011-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         76-76: Missing.
         145-302: Missing.

    Show »
    Length:232
    Mass (Da):26,220
    Checksum:iBE916EB3E3CD79C0
    GO
    Isoform 4 (identifier: Q15011-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         75-99: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:366
    Mass (Da):40,851
    Checksum:iDD39A053E4D46626
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501R → H.
    Corresponds to variant rs2217332 [ dbSNP | Ensembl ].
    VAR_024277

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei75 – 9925Missing in isoform 4. CuratedVSP_047333Add
    BLAST
    Alternative sequencei76 – 761Missing in isoform 2 and isoform 3. 2 PublicationsVSP_006708
    Alternative sequencei145 – 302158Missing in isoform 3. 1 PublicationVSP_006709Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB034989 mRNA. Translation: BAB07891.1.
    D14695 mRNA. Translation: BAA03521.1.
    AF055001 mRNA. Translation: AAC09355.1.
    AF055003 mRNA. Translation: AAC09357.1.
    AB034990 Genomic DNA. Translation: BAB19010.1.
    CR457116 mRNA. Translation: CAG33397.1.
    AC012181 Genomic DNA. No translation available.
    BC000086 mRNA. Translation: AAH00086.1.
    BC008320 mRNA. Translation: AAH08320.1.
    BC009739 mRNA. Translation: AAH09739.1.
    BC032673 mRNA. Translation: AAH32673.1.
    CCDSiCCDS10771.1. [Q15011-1]
    CCDS45492.1. [Q15011-2]
    RefSeqiNP_001010989.1. NM_001010989.2. [Q15011-2]
    NP_001259032.1. NM_001272103.1.
    NP_055500.1. NM_014685.3. [Q15011-1]
    UniGeneiHs.146393.

    Genome annotation databases

    EnsembliENST00000300302; ENSP00000300302; ENSG00000051108. [Q15011-2]
    ENST00000344114; ENSP00000340931; ENSG00000051108. [Q15011-3]
    ENST00000379792; ENSP00000369118; ENSG00000051108. [Q15011-4]
    ENST00000439977; ENSP00000409555; ENSG00000051108. [Q15011-1]
    GeneIDi9709.
    KEGGihsa:9709.
    UCSCiuc002eke.2. human. [Q15011-1]
    uc002ekf.2. human. [Q15011-2]
    uc031qwh.1. human. [Q15011-3]

    Polymorphism databases

    DMDMi3123034.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB034989 mRNA. Translation: BAB07891.1 .
    D14695 mRNA. Translation: BAA03521.1 .
    AF055001 mRNA. Translation: AAC09355.1 .
    AF055003 mRNA. Translation: AAC09357.1 .
    AB034990 Genomic DNA. Translation: BAB19010.1 .
    CR457116 mRNA. Translation: CAG33397.1 .
    AC012181 Genomic DNA. No translation available.
    BC000086 mRNA. Translation: AAH00086.1 .
    BC008320 mRNA. Translation: AAH08320.1 .
    BC009739 mRNA. Translation: AAH09739.1 .
    BC032673 mRNA. Translation: AAH32673.1 .
    CCDSi CCDS10771.1. [Q15011-1 ]
    CCDS45492.1. [Q15011-2 ]
    RefSeqi NP_001010989.1. NM_001010989.2. [Q15011-2 ]
    NP_001259032.1. NM_001272103.1.
    NP_055500.1. NM_014685.3. [Q15011-1 ]
    UniGenei Hs.146393.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WGD NMR - A 10-90 [» ]
    ProteinModelPortali Q15011.
    SMRi Q15011. Positions 10-90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115060. 27 interactions.
    DIPi DIP-46662N.
    IntActi Q15011. 10 interactions.
    MINTi MINT-2867283.
    STRINGi 9606.ENSP00000300302.

    PTM databases

    PhosphoSitei Q15011.

    Polymorphism databases

    DMDMi 3123034.

    Proteomic databases

    MaxQBi Q15011.
    PaxDbi Q15011.
    PRIDEi Q15011.

    Protocols and materials databases

    DNASUi 9709.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300302 ; ENSP00000300302 ; ENSG00000051108 . [Q15011-2 ]
    ENST00000344114 ; ENSP00000340931 ; ENSG00000051108 . [Q15011-3 ]
    ENST00000379792 ; ENSP00000369118 ; ENSG00000051108 . [Q15011-4 ]
    ENST00000439977 ; ENSP00000409555 ; ENSG00000051108 . [Q15011-1 ]
    GeneIDi 9709.
    KEGGi hsa:9709.
    UCSCi uc002eke.2. human. [Q15011-1 ]
    uc002ekf.2. human. [Q15011-2 ]
    uc031qwh.1. human. [Q15011-3 ]

    Organism-specific databases

    CTDi 9709.
    GeneCardsi GC16P056965.
    HGNCi HGNC:13744. HERPUD1.
    HPAi CAB037041.
    CAB037104.
    HPA040754.
    HPA041219.
    MIMi 608070. gene.
    neXtProti NX_Q15011.
    PharmGKBi PA29252.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259558.
    HOGENOMi HOG000252989.
    HOVERGENi HBG051899.
    InParanoidi Q15011.
    KOi K14027.
    OMAi PLYTRIT.
    OrthoDBi EOG7QRQWK.
    PhylomeDBi Q15011.
    TreeFami TF324319.

    Enzyme and pathway databases

    Reactomei REACT_18355. ATF4 activates genes.

    Miscellaneous databases

    ChiTaRSi HERPUD1. human.
    EvolutionaryTracei Q15011.
    GeneWikii HERPUD1.
    GenomeRNAii 9709.
    NextBioi 36487.
    PROi Q15011.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15011.
    Bgeei Q15011.
    CleanExi HS_HERPUD1.
    Genevestigatori Q15011.

    Family and domain databases

    InterProi IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress."
      Kokame K., Agarwala K.L., Kato H., Miyata T.
      J. Biol. Chem. 275:32846-32853(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.
      Tissue: Umbilical vein endothelial cell.
    2. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
      DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    3. Yu W., Gibbs R.A.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    4. "Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response."
      Kokame K., Kato H., Miyata T.
      J. Biol. Chem. 276:9199-9205(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain, Eye, Placenta and Testis.
    8. "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein."
      Sai X., Kawamura Y., Kokame K., Yamaguchi H., Shiraishi H., Suzuki R., Suzuki T., Kawaichi M., Miyata T., Kitamura T., De Strooper B., Yanagisawa K., Komano H.
      J. Biol. Chem. 277:12915-12920(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PSEN1 AND PSEN2.
    9. "The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway."
      van Laar T., Schouten T., Hoogervorst E., van Eck M., van der Eb A.J., Terleth C.
      FEBS Lett. 469:123-131(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
      Tissue: Skin fibroblast.
    10. "The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway."
      Schulze A., Standera S., Buerger E., Kikkert M., van Voorden S., Wiertz E., Koning F., Kloetzel P.-M., Seeger M.
      J. Mol. Biol. 354:1021-1027(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SYVN1.
    11. "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element."
      Liang G., Audas T.E., Li Y., Cockram G.P., Dean J.D., Martyn A.C., Kokame K., Lu R.
      Mol. Cell. Biol. 26:7999-8010(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    12. Cited for: INTERACTION WITH UBXN6.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Solution structure of the UBL-domain of HERP."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 10-90.

    Entry informationi

    Entry nameiHERP1_HUMAN
    AccessioniPrimary (citable) accession number: Q15011
    Secondary accession number(s): E9PGD1
    , O60644, Q6IAN8, Q96D92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Although the precise topology is not known, experimental data suggest that both the N- and C-termini face the cytosol.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3