ID   PSMD6_HUMAN             Reviewed;         389 AA.
AC   Q15008;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   07-JUL-2009, entry version 83.
DE   RecName: Full=26S proteasome non-ATPase regulatory subunit 6;
DE   AltName: Full=26S proteasome regulatory subunit S10;
DE   AltName: Full=p42A;
DE   AltName: Full=Proteasome regulatory particle subunit p44S10;
DE   AltName: Full=Phosphonoformate immuno-associated protein 4;
DE   AltName: Full=Breast cancer-associated protein SGA-113M;
GN   Name=PSMD6; Synonyms=KIAA0107, PFAAP4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary cancer;
RX   MEDLINE=20190095; PubMed=10723133; DOI=10.1038/sj.onc.1203462;
RA   Ren S., Smith M.J., Louro I.D., McKie-Bell P., Bani M.R., Wagner M.,
RA   Zochodne B., Redden D.T., Grizzle W.E., Wang N.D., Smith D.I.,
RA   Herbst R.A., Bardenheuer W., Opalka B., Schutte J., Trent J.M.,
RA   Ben-David Y., Ruppert J.M.;
RT   "The p44S10 locus, encoding a subunit of the proteasome regulatory
RT   particle, is amplified during progression of cutaneous malignant
RT   melanoma.";
RL   Oncogene 19:1419-1427(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Liu Y., Cheng J., Lu Y.;
RT   "Screening and cloning of a new immuno-associated gene regulated by
RT   phosphonoformate.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Petroziello J.M.;
RT   "Breast cancer associated protein.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow;
RX   MEDLINE=95308325; PubMed=7788527; DOI=10.1093/dnares/2.1.37;
RA   Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S.,
RA   Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.;
RT   "Prediction of the coding sequences of unidentified human genes. III.
RT   The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by
RT   analysis of cDNA clones from human cell line KG-1.";
RL   DNA Res. 2:37-43(1995).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lymph, Ovary, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], AND MASS
RP   SPECTROMETRY.
RX   PubMed=17323924; DOI=10.1021/bi061994u;
RA   Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L.;
RT   "Mass spectrometric characterization of the affinity-purified human
RT   26S proteasome complex.";
RL   Biochemistry 46:3553-3565(2007).
RN   [7]
RP   IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
RA   Colinge J., Superti-Furga G., Bennett K.L.;
RL   Submitted (OCT-2008) to UniProtKB.
CC   -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which
CC       is involved in the ATP-dependent degradation of ubiquitinated
CC       proteins.
CC   -!- SUBUNIT: Component of the PA700 complex.
CC   -!- INTERACTION:
CC       Q9BRP4:PAAF1; NbExp=1; IntAct=EBI-359701, EBI-1056358;
CC       P25787:PSMA2; NbExp=1; IntAct=EBI-359701, EBI-603262;
CC       P28074:PSMB5; NbExp=1; IntAct=EBI-359701, EBI-357828;
CC       P62191:PSMC1; NbExp=1; IntAct=EBI-359701, EBI-357598;
CC       P35998:PSMC2; NbExp=1; IntAct=EBI-359701, EBI-359710;
CC       P17980:PSMC3; NbExp=1; IntAct=EBI-359701, EBI-359720;
CC       P43686:PSMC4; NbExp=1; IntAct=EBI-359701, EBI-743997;
CC       P62195:PSMC5; NbExp=1; IntAct=EBI-359701, EBI-357745;
CC       P62333:PSMC6; NbExp=1; IntAct=EBI-359701, EBI-357669;
CC       Q99460:PSMD1; NbExp=1; IntAct=EBI-359701, EBI-357874;
CC       O75832:PSMD10; NbExp=1; IntAct=EBI-359701, EBI-752185;
CC       O00231:PSMD11; NbExp=1; IntAct=EBI-359701, EBI-357816;
CC       O00232:PSMD12; NbExp=1; IntAct=EBI-359701, EBI-359733;
CC       Q9UNM6:PSMD13; NbExp=1; IntAct=EBI-359701, EBI-356070;
CC       O00487:PSMD14; NbExp=1; IntAct=EBI-359701, EBI-722193;
CC       Q13200:PSMD2; NbExp=1; IntAct=EBI-359701, EBI-357648;
CC       O43242:PSMD3; NbExp=1; IntAct=EBI-359701, EBI-357622;
CC       P55036:PSMD4; NbExp=1; IntAct=EBI-359701, EBI-359318;
CC       P51665:PSMD7; NbExp=1; IntAct=EBI-359701, EBI-357659;
CC       P48556:PSMD8; NbExp=1; IntAct=EBI-359701, EBI-359304;
CC       Q9Y4R8:TELO2; NbExp=1; IntAct=EBI-359701, EBI-1043674;
CC   -!- SIMILARITY: Belongs to the proteasome subunit S10 family.
CC   -!- SIMILARITY: Contains 1 PCI domain.
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DR   EMBL; AF215935; AAF65540.1; -; mRNA.
DR   EMBL; AF530062; AAQ09946.1; -; mRNA.
DR   EMBL; AY568086; AAS68366.1; -; mRNA.
DR   EMBL; D14663; BAA03497.1; -; mRNA.
DR   EMBL; BC000630; AAH00630.1; -; mRNA.
DR   EMBL; BC000904; AAH00904.1; -; mRNA.
DR   EMBL; BC012369; AAH12369.1; -; mRNA.
DR   IPI; IPI00014151; -.
DR   RefSeq; NP_055629.1; -.
DR   UniGene; Hs.152536; -.
DR   DIP; DIP:27590N; -.
DR   IntAct; Q15008; 50.
DR   PRIDE; Q15008; -.
DR   Ensembl; ENSG00000163636; Homo sapiens.
DR   GeneID; 9861; -.
DR   KEGG; hsa:9861; -.
DR   UCSC; uc003dma.1; human.
DR   GeneCards; GC03M063973; -.
DR   H-InvDB; HIX0003420; -.
DR   HGNC; HGNC:9564; PSMD6.
DR   PharmGKB; PA33910; -.
DR   HOVERGEN; Q15008; -.
DR   OMA; Q15008; HDLITRN.
DR   Reactome; REACT_11045; Signaling by Wnt.
DR   Reactome; REACT_13; Metabolism of amino acids.
DR   Reactome; REACT_13635; Regulation of activated PAK-2p34 by proteasome mediated degradation.
DR   Reactome; REACT_152; Cell Cycle, Mitotic.
DR   Reactome; REACT_1538; Cell Cycle Checkpoints.
DR   Reactome; REACT_383; DNA Replication.
DR   Reactome; REACT_578; Apoptosis.
DR   Reactome; REACT_6185; HIV Infection.
DR   Reactome; REACT_6850; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR   Reactome; REACT_9035; APC/C:Cdh1-mediated degradation of Skp2.
DR   NextBio; 37172; -.
DR   ArrayExpress; Q15008; -.
DR   Bgee; Q15008; -.
DR   CleanEx; HS_PSMD6; -.
DR   GermOnline; ENSG00000163636; Homo sapiens.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-KW.
DR   GO; GO:0000502; C:proteasome complex; NAS:UniProtKB.
DR   GO; GO:0016887; F:ATPase activity; NAS:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent protea...; EXP:Reactome.
DR   GO; GO:0051436; P:negative regulation of ubiquitin-protein li...; EXP:Reactome.
DR   GO; GO:0051437; P:positive regulation of ubiquitin-protein li...; EXP:Reactome.
DR   InterPro; IPR019585; 26S_proteasome_reg_su-Rpn7.
DR   InterPro; IPR000717; PCI.
DR   Pfam; PF01399; PCI; 1.
DR   Pfam; PF10602; RPN7; 1.
DR   SMART; SM00088; PINT; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Proteasome.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    389       26S proteasome non-ATPase regulatory
FT                                subunit 6.
FT                                /FTId=PRO_0000173838.
FT   DOMAIN      191    358       PCI.
SQ   SEQUENCE   389 AA;  45531 MW;  8843E6684AE91ACD CRC64;
     MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNM APYYEALCKS
     LDWQIDVDLL NKMKKANEDE LKRLDEELED AEKNLGESEI RDAMMAKAEY LCRIGDKEGA
     LTAFRKTYDK TVALGHRLDI VFYLLRIGLF YMDNDLITRN TEKAKSLIEE GGDWDRRNRL
     KVYQGLYCVA IRDFKQAAEL FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV
     IKGAEILEVL HSLPAVRQYL FSLYECRYSV FFQSLAVVEQ EMKKDWLFAP HYRYYVREMR
     IHAYSQLLES YRSLTLGYMA EAFGVGVEFI DQELSRFIAA GRLHCKIDKV NEIVETNRPD
     SKNWQYQETI KKGDLLLNRV QKLSRVINM
//