Reviewed, UniProtKB/Swiss-Prot Q15008 (PSMD6_HUMAN)

Names and origin

Protein names

Recommended name:
    26S proteasome non-ATPase regulatory subunit 6
Alternative name(s):
    26S proteasome regulatory subunit S10
    p42A
    Proteasome regulatory particle subunit p44S10
    Phosphonoformate immuno-associated protein 4
    Breast cancer-associated protein SGA-113M

Gene names

Name:	PSMD6
Synonyms:	KIAA0107, PFAAP4

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Subunit structure	Component of the PA700 complex.
Sequence similarities	Belongs to the proteasome subunit S10 family. Contains 1 PCI domain.

Ontologies

Keywords
Cellular component	Proteasome
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Inferred from Experiment. Source: Reactome negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle Inferred from Experiment. Source: Reactome positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle Inferred from Experiment. Source: Reactome
Cellular component	proteasome complex Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	ATPase activity Ref.1 Non-traceable author statement. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PAAF1	Q9BRP4	1	EBI-359701,EBI-1056358
PSMA2	P25787	1	EBI-359701,EBI-603262
PSMB5	P28074	1	EBI-359701,EBI-357828
PSMC1	P62191	1	EBI-359701,EBI-357598
PSMC2	P35998	1	EBI-359701,EBI-359710
PSMC3	P17980	1	EBI-359701,EBI-359720
PSMC4	P43686	1	EBI-359701,EBI-743997
PSMC5	P62195	1	EBI-359701,EBI-357745
PSMC6	P62333	1	EBI-359701,EBI-357669
PSMD1	Q99460	1	EBI-359701,EBI-357874
PSMD10	O75832	1	EBI-359701,EBI-752185
PSMD11	O00231	1	EBI-359701,EBI-357816
PSMD12	O00232	1	EBI-359701,EBI-359733
PSMD13	Q9UNM6	1	EBI-359701,EBI-356070
PSMD14	O00487	1	EBI-359701,EBI-722193
PSMD2	Q13200	1	EBI-359701,EBI-357648
PSMD3	O43242	1	EBI-359701,EBI-357622
PSMD4	P55036	1	EBI-359701,EBI-359318
PSMD7	P51665	1	EBI-359701,EBI-357659
PSMD8	P48556	1	EBI-359701,EBI-359304
TELO2	Q9Y4R8	1	EBI-359701,EBI-1043674

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.8
	Chain	2 – 389	388	26S proteasome non-ATPase regulatory subunit 6		PRO_0000173838
Regions
	Domain	191 – 358	168	PCI

Sequences

	Sequence		Length	Mass (Da)
	Q15008-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 8843E6684AE91ACD	FASTA	389	45,531
	10 20 30 40 50 60 MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNM APYYEALCKS 70 80 90 100 110 120 LDWQIDVDLL NKMKKANEDE LKRLDEELED AEKNLGESEI RDAMMAKAEY LCRIGDKEGA 130 140 150 160 170 180 LTAFRKTYDK TVALGHRLDI VFYLLRIGLF YMDNDLITRN TEKAKSLIEE GGDWDRRNRL 190 200 210 220 230 240 KVYQGLYCVA IRDFKQAAEL FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV 250 260 270 280 290 300 IKGAEILEVL HSLPAVRQYL FSLYECRYSV FFQSLAVVEQ EMKKDWLFAP HYRYYVREMR 310 320 330 340 350 360 IHAYSQLLES YRSLTLGYMA EAFGVGVEFI DQELSRFIAA GRLHCKIDKV NEIVETNRPD 370 380 SKNWQYQETI KKGDLLLNRV QKLSRVINM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma." Ren S., Smith M.J., Louro I.D., McKie-Bell P., Bani M.R., Wagner M., Zochodne B., Redden D.T., Grizzle W.E., Wang N.D., Smith D.I., Herbst R.A., Bardenheuer W., Opalka B., Schutte J., Trent J.M., Ben-David Y., Ruppert J.M. Oncogene 19:1419-1427(2000) [PubMed: 10723133] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary cancer.
[2]	"Screening and cloning of a new immuno-associated gene regulated by phosphonoformate." Liu Y., Cheng J., Lu Y. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Breast cancer associated protein." Petroziello J.M. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N. DNA Res. 2:37-43(1995) [PubMed: 7788527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph, Ovary and Placenta.
[8]	"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex." Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L. Biochemistry 46:3553-3565(2007) [PubMed: 17323924] [Abstract] Cited for: CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[9]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF215935 mRNA. Translation: AAF65540.1. AF530062 mRNA. Translation: AAQ09946.1. AY568086 mRNA. Translation: AAS68366.1. D14663 mRNA. Translation: BAA03497.1. AK290205 mRNA. Translation: BAF82894.1. CH471055 Genomic DNA. Translation: EAW65424.1. BC000630 mRNA. Translation: AAH00630.1. BC000904 mRNA. Translation: AAH00904.1. BC012369 mRNA. Translation: AAH12369.1.
IPI	IPI00014151.
RefSeq	NP_055629.1.
UniGene	Hs.152536
3D structure databases
SMR	Q15008. Positions 296-361.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-27590N.
IntAct	Q15008. 53 interactions.
STRING	Q15008.
Proteomic databases
PRIDE	Q15008.
Genome annotation databases
Ensembl	ENST00000295901; ENSP00000295901; ENSG00000163636; Homo sapiens. [Genome view]
GeneID	9861.
KEGG	hsa:9861.
UCSC	uc003dma.1. human.
Organism-specific databases
CTD	9861.
GeneCards	GC03M063973.
H-InvDB	HIX0003420.
HGNC	HGNC:9564. PSMD6.
PharmGKB	PA33910.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08877.
HOGENOM	HBG318581.
HOVERGEN	Q15008.
InParanoid	Q15008.
OMA	ITRNIDK.
PhylomeDB	Q15008.
Enzyme and pathway databases
Reactome	REACT_11045. Signaling by Wnt. REACT_13. Metabolism of amino acids. REACT_13635. Regulation of activated PAK-2p34 by proteasome mediated degradation. REACT_152. Cell Cycle, Mitotic. REACT_1538. Cell Cycle Checkpoints. REACT_383. DNA Replication. REACT_578. Apoptosis. REACT_6185. HIV Infection. REACT_6850. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. REACT_9035. APC/C:Cdh1-mediated degradation of Skp2.
Gene expression databases
ArrayExpress	Q15008.
Bgee	Q15008.
CleanEx	HS_PSMD6.
Genevestigator	Q15008.
GermOnline	ENSG00000163636. Homo sapiens.
Family and domain databases
InterPro	IPR019585. 26S_proteasome_reg_su-Rpn7. IPR000717. PCI_dom. [Graphical view]
Pfam	PF01399. PCI. 1 hit. PF10602. RPN7. 1 hit. [Graphical view]
SMART	SM00088. PINT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	37172.

Entry information

Entry name

PSMD6_HUMAN

Accession

Primary (citable) accession number: Q15008
Secondary accession number(s): A8K2E0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	January 19, 2010
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.