26S proteasome non-ATPase regulatory subunit 6

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Reviewed, UniProtKB/Swiss-Prot Q15008 (PSMD6_HUMAN)

Last modified November 25, 2008. Version 74. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    26S proteasome non-ATPase regulatory subunit 6
Alternative name(s):
    26S proteasome regulatory subunit S10
    p42A
    Proteasome regulatory particle subunit p44S10
    Phosphonoformate immuno-associated protein 4
    Breast cancer-associated protein SGA-113M

Gene names

Name:	PSMD6
Synonyms:	KIAA0107, PFAAP4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

Subunit structure

Component of the PA700 complex.

Sequence similarities

Belongs to the proteasome subunit S10 family.

Contains 1 PCI domain.

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Ontologies

Keywords
Cellular component	Proteasome
Gene Ontology (GO)
Biological process	ATP-dependent proteolysis Ref.1 Non-traceable author statement. Source: UniProtKB anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Inferred from Experiment. Source: Reactome negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle Inferred from Experiment. Source: Reactome positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle Inferred from Experiment. Source: Reactome
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-KW proteasome complex Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	ATPase activity Ref.1 Non-traceable author statement. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
PAAF1	Q9BRP4	1	EBI-359701,EBI-1056358
PSMA2	P25787	1	EBI-359701,EBI-603262
PSMB5	P28074	1	EBI-359701,EBI-357828
PSMC1	P62191	1	EBI-359701,EBI-357598
PSMC2	P35998	1	EBI-359701,EBI-359710
PSMC3	P17980	1	EBI-359701,EBI-359720
PSMC4	P43686	1	EBI-359701,EBI-743997
PSMC5	P62195	1	EBI-359701,EBI-357745
PSMC6	P62333	1	EBI-359701,EBI-357669
PSMD1	Q99460	1	EBI-359701,EBI-357874
PSMD10	O75832	1	EBI-359701,EBI-752185
PSMD11	O00231	1	EBI-359701,EBI-357816
PSMD12	O00232	1	EBI-359701,EBI-359733
PSMD13	Q9UNM6	1	EBI-359701,EBI-356070
PSMD14	O00487	1	EBI-359701,EBI-722193
PSMD2	Q13200	1	EBI-359701,EBI-357648
PSMD3	O43242	1	EBI-359701,EBI-357622
PSMD4	P55036	1	EBI-359701,EBI-359318
PSMD7	P51665	1	EBI-359701,EBI-357659
PSMD8	P48556	1	EBI-359701,EBI-359304
TELO2	Q9Y4R8	1	EBI-359701,EBI-1043674

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed

Chain

2 – 389

388

26S proteasome non-ATPase regulatory subunit 6

PRO_0000173838

Regions

Domain

191 – 358

168

PCI

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Sequences

Sequence

Length

Mass (Da)

Tools

Q15008-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8843E6684AE91ACD
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FASTA

389

45,531

        10         20         30         40         50         60 
MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNM APYYEALCKS 

        70         80         90        100        110        120 
LDWQIDVDLL NKMKKANEDE LKRLDEELED AEKNLGESEI RDAMMAKAEY LCRIGDKEGA 

       130        140        150        160        170        180 
LTAFRKTYDK TVALGHRLDI VFYLLRIGLF YMDNDLITRN TEKAKSLIEE GGDWDRRNRL 

       190        200        210        220        230        240 
KVYQGLYCVA IRDFKQAAEL FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV 

       250        260        270        280        290        300 
IKGAEILEVL HSLPAVRQYL FSLYECRYSV FFQSLAVVEQ EMKKDWLFAP HYRYYVREMR 

       310        320        330        340        350        360 
IHAYSQLLES YRSLTLGYMA EAFGVGVEFI DQELSRFIAA GRLHCKIDKV NEIVETNRPD 

       370        380 
SKNWQYQETI KKGDLLLNRV QKLSRVINM

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma." Ren S., Smith M.J., Louro I.D., McKie-Bell P., Bani M.R., Wagner M., Zochodne B., Redden D.T., Grizzle W.E., Wang N.D., Smith D.I., Herbst R.A., Bardenheuer W., Opalka B., Schutte J., Trent J.M., Ben-David Y., Ruppert J.M. Oncogene 19:1419-1427(2000) [PubMed: 10723133] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary cancer.
[2]	"Screening and cloning of a new immuno-associated gene regulated by phosphonoformate." Liu Y., Cheng J., Lu Y. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Breast cancer associated protein." Petroziello J.M. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N. DNA Res. 2:37-43(1995) [PubMed: 7788527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph, Ovary and Placenta.
[6]	"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex." Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L. Biochemistry 46:3553-3565(2007) [PubMed: 17323924] [Abstract] Cited for: CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

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Cross-references

Sequence databases
	AF215935 mRNA. Translation: AAF65540.1. AF530062 mRNA. Translation: AAQ09946.1. AY568086 mRNA. Translation: AAS68366.1. D14663 mRNA. Translation: BAA03497.1. BC000630 mRNA. Translation: AAH00630.1. BC000904 mRNA. Translation: AAH00904.1. BC012369 mRNA. Translation: AAH12369.1.
RefSeq	NP_055629.1.
UniGene	Hs.152536
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:27590N.
IntAct	Q15008.
PTM databases
PhosphoSite	Q15008.
Genome annotation databases
Ensembl	ENSG00000163636. Homo sapiens. [Contig view]
GeneID	9861.
KEGG	hsa:9861.
Organism-specific databases
H-InvDB	HIX0003420.
HGNC	HGNC:9564. PSMD6.
PharmGKB	PA33910.
HUGE	Search...
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q15008.
Enzyme and pathway databases
Reactome	REACT_11045. Signaling by Wnt. REACT_152. Cell Cycle, Mitotic. REACT_1538. Cell Cycle Checkpoints. REACT_383. DNA Replication. REACT_6185. HIV Infection. REACT_6850. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. REACT_9035. APC/C:Cdh1-mediated degradation of Skp2.
Gene expression databases
ArrayExpress	Q15008.
CleanEx	HS_PSMD6.
GermOnline	ENSG00000163636. Homo sapiens.
Family and domain databases
InterPro	IPR000717. PCI. [Graphical view]
Pfam	PF01399. PCI. 1 hit. [Graphical view]
SMART	SM00088. PINT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	37172.

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Entry information

Entry name

PSMD6_HUMAN

Accession

Primary (citable) accession number: Q15008

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents