Reviewed,
UniProtKB/Swiss-Prot Q15008 (PSMD6_HUMAN)
Last modified
January 19, 2010.
Version 90.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 26S proteasome non-ATPase regulatory subunit 6 Alternative name(s): 26S proteasome regulatory subunit S10 p42A Proteasome regulatory particle subunit p44S10 Phosphonoformate immuno-associated protein 4 Breast cancer-associated protein SGA-113M | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 389 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. |
| Subunit structure | Component of the PA700 complex. |
| Sequence similarities | Belongs to the proteasome subunit S10 family. Contains 1 PCI domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Proteasome |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Inferred from Experiment. Source: Reactome negative regulation of ubiquitin-protein ligase activity during mitotic cell cycleInferred from Experiment. Source: Reactome positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleInferred from Experiment. Source: Reactome |
| Cellular component | proteasome complex Ref.1 Non-traceable author statement. Source: UniProtKB |
| Molecular function | ATPase activity Ref.1 Non-traceable author statement. Source: UniProtKB protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| PAAF1 | Q9BRP4 | 1 | EBI-359701,EBI-1056358 | |
| PSMA2 | P25787 | 1 | EBI-359701,EBI-603262 | |
| PSMB5 | P28074 | 1 | EBI-359701,EBI-357828 | |
| PSMC1 | P62191 | 1 | EBI-359701,EBI-357598 | |
| PSMC2 | P35998 | 1 | EBI-359701,EBI-359710 | |
| PSMC3 | P17980 | 1 | EBI-359701,EBI-359720 | |
| PSMC4 | P43686 | 1 | EBI-359701,EBI-743997 | |
| PSMC5 | P62195 | 1 | EBI-359701,EBI-357745 | |
| PSMC6 | P62333 | 1 | EBI-359701,EBI-357669 | |
| PSMD1 | Q99460 | 1 | EBI-359701,EBI-357874 | |
| PSMD10 | O75832 | 1 | EBI-359701,EBI-752185 | |
| PSMD11 | O00231 | 1 | EBI-359701,EBI-357816 | |
| PSMD12 | O00232 | 1 | EBI-359701,EBI-359733 | |
| PSMD13 | Q9UNM6 | 1 | EBI-359701,EBI-356070 | |
| PSMD14 | O00487 | 1 | EBI-359701,EBI-722193 | |
| PSMD2 | Q13200 | 1 | EBI-359701,EBI-357648 | |
| PSMD3 | O43242 | 1 | EBI-359701,EBI-357622 | |
| PSMD4 | P55036 | 1 | EBI-359701,EBI-359318 | |
| PSMD7 | P51665 | 1 | EBI-359701,EBI-357659 | |
| PSMD8 | P48556 | 1 | EBI-359701,EBI-359304 | |
| TELO2 | Q9Y4R8 | 1 | EBI-359701,EBI-1043674 |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma." Ren S., Smith M.J., Louro I.D., McKie-Bell P., Bani M.R., Wagner M., Zochodne B., Redden D.T., Grizzle W.E., Wang N.D., Smith D.I., Herbst R.A., Bardenheuer W., Opalka B., Schutte J., Trent J.M., Ben-David Y., Ruppert J.M. Oncogene 19:1419-1427(2000) [PubMed: 10723133] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary cancer. |
| [2] | "Screening and cloning of a new immuno-associated gene regulated by phosphonoformate." Liu Y., Cheng J., Lu Y. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Breast cancer associated protein." Petroziello J.M. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N. DNA Res. 2:37-43(1995) [PubMed: 7788527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow. |
| [5] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus. |
| [6] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph, Ovary and Placenta. |
| [8] | "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex." Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L. Biochemistry 46:3553-3565(2007) [PubMed: 17323924] [Abstract] Cited for: CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [9] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF215935 mRNA. Translation: AAF65540.1. AF530062 mRNA. Translation: AAQ09946.1. AY568086 mRNA. Translation: AAS68366.1. D14663 mRNA. Translation: BAA03497.1. AK290205 mRNA. Translation: BAF82894.1. CH471055 Genomic DNA. Translation: EAW65424.1. BC000630 mRNA. Translation: AAH00630.1. BC000904 mRNA. Translation: AAH00904.1. BC012369 mRNA. Translation: AAH12369.1. |
| IPI | IPI00014151. |
| RefSeq | NP_055629.1. |
| UniGene | Hs.152536 |
3D structure databases | |
| SMR | Q15008. Positions 296-361. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-27590N. |
| IntAct | Q15008. 53 interactions. |
| STRING | Q15008. |
Proteomic databases | |
| PRIDE | Q15008. |
Genome annotation databases | |
| Ensembl | ENST00000295901; ENSP00000295901; ENSG00000163636; Homo sapiens. [Genome view] |
| GeneID | 9861. |
| KEGG | hsa:9861. |
| UCSC | uc003dma.1. human. |
Organism-specific databases | |
| CTD | 9861. |
| GeneCards | GC03M063973. |
| H-InvDB | HIX0003420. |
| HGNC | HGNC:9564. PSMD6. |
| PharmGKB | PA33910. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG08877. |
| HOGENOM | HBG318581. |
| HOVERGEN | Q15008. |
| InParanoid | Q15008. |
| OMA | ITRNIDK. |
| PhylomeDB | Q15008. |
Enzyme and pathway databases | |
| Reactome | REACT_11045. Signaling by Wnt. REACT_13. Metabolism of amino acids. REACT_13635. Regulation of activated PAK-2p34 by proteasome mediated degradation. REACT_152. Cell Cycle, Mitotic. REACT_1538. Cell Cycle Checkpoints. REACT_383. DNA Replication. REACT_578. Apoptosis. REACT_6185. HIV Infection. REACT_6850. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. REACT_9035. APC/C:Cdh1-mediated degradation of Skp2. |
Gene expression databases | |
| ArrayExpress | Q15008. |
| Bgee | Q15008. |
| CleanEx | HS_PSMD6. |
| Genevestigator | Q15008. |
| GermOnline | ENSG00000163636. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR019585. 26S_proteasome_reg_su-Rpn7. IPR000717. PCI_dom. [Graphical view] |
| Pfam | PF01399. PCI. 1 hit. PF10602. RPN7. 1 hit. [Graphical view] |
| SMART | SM00088. PINT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 37172. |
Entry information
| Entry name | PSMD6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q15008 Secondary accession number(s): A8K2E0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with


