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Protein

ER membrane protein complex subunit 2

Gene

EMC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 2
Alternative name(s):
Tetratricopeptide repeat protein 35
Short name:
TPR repeat protein 35
Gene namesi
Name:EMC2
Synonyms:KIAA0103, TTC35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104412.7.
HGNCiHGNC:28963. EMC2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104412.
PharmGKBiPA162407224.

Polymorphism and mutation databases

BioMutaiEMC2.
DMDMi3183217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001063532 – 297ER membrane protein complex subunit 2Add BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei255N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15006.
MaxQBiQ15006.
PaxDbiQ15006.
PeptideAtlasiQ15006.
PRIDEiQ15006.

PTM databases

iPTMnetiQ15006.
PhosphoSitePlusiQ15006.
SwissPalmiQ15006.

Expressioni

Gene expression databases

BgeeiENSG00000104412.
CleanExiHS_TTC35.
ExpressionAtlasiQ15006. baseline and differential.
GenevisibleiQ15006. HS.

Organism-specific databases

HPAiHPA022838.

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115046. 107 interactors.
IntActiQ15006. 101 interactors.
MINTiMINT-1136081.
STRINGi9606.ENSP00000220853.

Structurei

3D structure databases

ProteinModelPortaliQ15006.
SMRiQ15006.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati87 – 120TPR 1Add BLAST34
Repeati155 – 188TPR 2Add BLAST34
Repeati192 – 225TPR 3Add BLAST34

Sequence similaritiesi

Belongs to the EMC2 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG3060. Eukaryota.
ENOG410YT6B. LUCA.
GeneTreeiENSGT00390000011922.
HOGENOMiHOG000007547.
HOVERGENiHBG055231.
InParanoidiQ15006.
OMAiHLYCEQY.
OrthoDBiEOG091G0EOK.
PhylomeDBiQ15006.
TreeFamiTF312997.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiView protein in InterPro
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom_sf.
IPR019734. TPR_repeat.
SMARTiView protein in SMART
SM00028. TPR. 3 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVSELYDV TWEEMRDKMR KWREENSRNS EQIVEVGEEL INEYASKLGD
60 70 80 90 100
DIWIIYEQVM IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM
110 120 130 140 150
ERYDDAIQLY DRILQEDPTN TAARKRKIAI RKAQGKNVEA IRELNEYLEQ
160 170 180 190 200
FVGDQEAWHE LAELYINEHD YAKAAFCLEE LMMTNPHNHL YCQQYAEVKY
210 220 230 240 250
TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA SNPKASAKTK
260 270 280 290
KDNMKYASWA ASQINRAYQF AGRSKKETKY SLKAVEDMLE TLQITQS
Length:297
Mass (Da):34,834
Last modified:November 1, 1996 - v1
Checksum:iCA5903AEC3B3E36A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145N → S in AAH20753 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14659 mRNA. Translation: BAA03493.1.
CR457402 mRNA. Translation: CAG33683.1.
BC020753 mRNA. Translation: AAH20753.1.
BC021667 mRNA. Translation: AAH21667.1.
CCDSiCCDS6309.1.
RefSeqiNP_055488.1. NM_014673.4.
UniGeneiHs.654351.

Genome annotation databases

EnsembliENST00000220853; ENSP00000220853; ENSG00000104412.
GeneIDi9694.
KEGGihsa:9694.
UCSCiuc003ymw.2. human.

Similar proteinsi

Entry informationi

Entry nameiEMC2_HUMAN
AccessioniPrimary (citable) accession number: Q15006
Secondary accession number(s): Q8WUE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families