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Protein

ER membrane protein complex subunit 2

Gene

EMC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 2
Alternative name(s):
Tetratricopeptide repeat protein 35
Short name:
TPR repeat protein 35
Gene namesi
Name:EMC2
Synonyms:KIAA0103, TTC35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:28963. EMC2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • ER membrane protein complex Source: UniProtKB
  • mitochondrion Source: Ensembl
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407224.

Polymorphism and mutation databases

BioMutaiEMC2.
DMDMi3183217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 297296ER membrane protein complex subunit 2PRO_0000106353Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei255 – 2551N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15006.
MaxQBiQ15006.
PaxDbiQ15006.
PeptideAtlasiQ15006.
PRIDEiQ15006.

PTM databases

iPTMnetiQ15006.
PhosphoSiteiQ15006.
SwissPalmiQ15006.

Expressioni

Gene expression databases

BgeeiQ15006.
CleanExiHS_TTC35.
ExpressionAtlasiQ15006. baseline and differential.
GenevisibleiQ15006. HS.

Organism-specific databases

HPAiHPA022838.
HPA053030.

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
COX4NBQ53Y033EBI-359031,EBI-10235116
EMC9Q9Y3B64EBI-359031,EBI-748366
IKZF3Q9UKT93EBI-359031,EBI-747204

Protein-protein interaction databases

BioGridi115046. 105 interactions.
IntActiQ15006. 97 interactions.
MINTiMINT-1136081.
STRINGi9606.ENSP00000220853.

Structurei

3D structure databases

ProteinModelPortaliQ15006.
SMRiQ15006. Positions 59-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati87 – 12034TPR 1Add
BLAST
Repeati155 – 18834TPR 2Add
BLAST
Repeati192 – 22534TPR 3Add
BLAST

Sequence similaritiesi

Belongs to the EMC2 family.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG3060. Eukaryota.
ENOG410YT6B. LUCA.
GeneTreeiENSGT00390000011922.
HOGENOMiHOG000007547.
HOVERGENiHBG055231.
InParanoidiQ15006.
OMAiGGVWEYL.
PhylomeDBiQ15006.
TreeFamiTF312997.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVSELYDV TWEEMRDKMR KWREENSRNS EQIVEVGEEL INEYASKLGD
60 70 80 90 100
DIWIIYEQVM IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM
110 120 130 140 150
ERYDDAIQLY DRILQEDPTN TAARKRKIAI RKAQGKNVEA IRELNEYLEQ
160 170 180 190 200
FVGDQEAWHE LAELYINEHD YAKAAFCLEE LMMTNPHNHL YCQQYAEVKY
210 220 230 240 250
TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA SNPKASAKTK
260 270 280 290
KDNMKYASWA ASQINRAYQF AGRSKKETKY SLKAVEDMLE TLQITQS
Length:297
Mass (Da):34,834
Last modified:November 1, 1996 - v1
Checksum:iCA5903AEC3B3E36A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451N → S in AAH20753 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14659 mRNA. Translation: BAA03493.1.
CR457402 mRNA. Translation: CAG33683.1.
BC020753 mRNA. Translation: AAH20753.1.
BC021667 mRNA. Translation: AAH21667.1.
CCDSiCCDS6309.1.
RefSeqiNP_055488.1. NM_014673.3.
UniGeneiHs.654351.

Genome annotation databases

EnsembliENST00000220853; ENSP00000220853; ENSG00000104412.
GeneIDi9694.
KEGGihsa:9694.
UCSCiuc003ymw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14659 mRNA. Translation: BAA03493.1.
CR457402 mRNA. Translation: CAG33683.1.
BC020753 mRNA. Translation: AAH20753.1.
BC021667 mRNA. Translation: AAH21667.1.
CCDSiCCDS6309.1.
RefSeqiNP_055488.1. NM_014673.3.
UniGeneiHs.654351.

3D structure databases

ProteinModelPortaliQ15006.
SMRiQ15006. Positions 59-251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115046. 105 interactions.
IntActiQ15006. 97 interactions.
MINTiMINT-1136081.
STRINGi9606.ENSP00000220853.

PTM databases

iPTMnetiQ15006.
PhosphoSiteiQ15006.
SwissPalmiQ15006.

Polymorphism and mutation databases

BioMutaiEMC2.
DMDMi3183217.

Proteomic databases

EPDiQ15006.
MaxQBiQ15006.
PaxDbiQ15006.
PeptideAtlasiQ15006.
PRIDEiQ15006.

Protocols and materials databases

DNASUi9694.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220853; ENSP00000220853; ENSG00000104412.
GeneIDi9694.
KEGGihsa:9694.
UCSCiuc003ymw.2. human.

Organism-specific databases

CTDi9694.
GeneCardsiEMC2.
HGNCiHGNC:28963. EMC2.
HPAiHPA022838.
HPA053030.
MIMi607722. gene.
neXtProtiNX_Q15006.
PharmGKBiPA162407224.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3060. Eukaryota.
ENOG410YT6B. LUCA.
GeneTreeiENSGT00390000011922.
HOGENOMiHOG000007547.
HOVERGENiHBG055231.
InParanoidiQ15006.
OMAiGGVWEYL.
PhylomeDBiQ15006.
TreeFamiTF312997.

Miscellaneous databases

GeneWikiiTTC35.
GenomeRNAii9694.
NextBioi36423.
PROiQ15006.
SOURCEiSearch...

Gene expression databases

BgeeiQ15006.
CleanExiHS_TTC35.
ExpressionAtlasiQ15006. baseline and differential.
GenevisibleiQ15006. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
    DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Urinary bladder.
  4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-255, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION IN THE EMC COMPLEX, SUBCELLULAR LOCATION.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEMC2_HUMAN
AccessioniPrimary (citable) accession number: Q15006
Secondary accession number(s): Q8WUE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.