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Protein

Signal peptidase complex subunit 2

Gene

SPCS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118363-MONOMER.
BRENDAi3.4.21.89. 2681.
ReactomeiR-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-HSA-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
R-HSA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex subunit 2 (EC:3.4.-.-)
Alternative name(s):
Microsomal signal peptidase 25 kDa subunit
Short name:
SPase 25 kDa subunit
Gene namesi
Name:SPCS2
Synonyms:KIAA0102, SPC25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28962. SPCS2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 86CytoplasmicSequence analysisAdd BLAST85
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 111LumenalSequence analysis4
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 226CytoplasmicSequence analysisAdd BLAST94

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000118363.
PharmGKBiPA128394559.

Polymorphism and mutation databases

BioMutaiSPCS2.
DMDMi6648110.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002211582 – 226Signal peptidase complex subunit 2Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei169N6-acetyllysineCombined sources1
Modified residuei191N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15005.
MaxQBiQ15005.
PaxDbiQ15005.
PeptideAtlasiQ15005.
PRIDEiQ15005.
TopDownProteomicsiQ15005.

PTM databases

iPTMnetiQ15005.
PhosphoSitePlusiQ15005.
SwissPalmiQ15005.

Expressioni

Gene expression databases

BgeeiENSG00000118363.
CleanExiHS_SPC25.
HS_SPCS2.
ExpressionAtlasiQ15005. baseline and differential.
GenevisibleiQ15005. HS.

Organism-specific databases

HPAiHPA013386.

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

Protein-protein interaction databases

BioGridi115133. 39 interactors.
DIPiDIP-47276N.
IntActiQ15005. 13 interactors.
MINTiMINT-1382200.
STRINGi9606.ENSP00000263672.

Structurei

3D structure databases

ProteinModelPortaliQ15005.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPCS2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4072. Eukaryota.
ENOG4111HIK. LUCA.
GeneTreeiENSGT00440000038181.
HOVERGENiHBG093979.
InParanoidiQ15005.
KOiK12947.
PhylomeDBiQ15005.
TreeFamiTF314545.

Family and domain databases

InterProiIPR009582. SigPept_cplx_su2.
[Graphical view]
PfamiPF06703. SPC25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAVQGGR SGGSGGCSGA GGASNCGTGS GRSGLLDKWK IDDKPVKIDK
60 70 80 90 100
WDGSAVKNSL DDSAKKVLLE KYKYVENFGL IDGRLTICTI SCFFAIVALI
110 120 130 140 150
WDYMHPFPES KPVLALCVIS YFVMMGILTI YTSYKEKSIF LVAHRKDPTG
160 170 180 190 200
MDPDDIWQLS SSLKRFDDKY TLKLTFISGR TKQQREAEFT KSIAKFFDHS
210 220
GTLVMDAYEP EISRLHDSLA IERKIK
Length:226
Mass (Da):25,003
Last modified:May 30, 2000 - v3
Checksum:iC1EDF687E9F7A57A
GO

Sequence cautioni

The sequence AAH08063 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH70276 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH82231 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA03492 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64A → V in AAH64957 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008063 mRNA. Translation: AAH08063.3. Different initiation.
BC064957 mRNA. Translation: AAH64957.1.
BC070276 mRNA. Translation: AAH70276.2. Different initiation.
BC082231 mRNA. Translation: AAH82231.2. Different initiation.
BC106066 mRNA. Translation: AAI06067.1.
L38950 mRNA. Translation: AAA60992.1.
D14658 mRNA. Translation: BAA03492.1. Different initiation.
CR542233 mRNA. Translation: CAG47029.1.
CR542243 mRNA. Translation: CAG47039.1.
CCDSiCCDS44681.1.
RefSeqiNP_055567.2. NM_014752.2.
UniGeneiHs.282700.
Hs.719927.

Genome annotation databases

EnsembliENST00000263672; ENSP00000263672; ENSG00000118363.
GeneIDi9789.
KEGGihsa:9789.
UCSCiuc001ovu.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008063 mRNA. Translation: AAH08063.3. Different initiation.
BC064957 mRNA. Translation: AAH64957.1.
BC070276 mRNA. Translation: AAH70276.2. Different initiation.
BC082231 mRNA. Translation: AAH82231.2. Different initiation.
BC106066 mRNA. Translation: AAI06067.1.
L38950 mRNA. Translation: AAA60992.1.
D14658 mRNA. Translation: BAA03492.1. Different initiation.
CR542233 mRNA. Translation: CAG47029.1.
CR542243 mRNA. Translation: CAG47039.1.
CCDSiCCDS44681.1.
RefSeqiNP_055567.2. NM_014752.2.
UniGeneiHs.282700.
Hs.719927.

3D structure databases

ProteinModelPortaliQ15005.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115133. 39 interactors.
DIPiDIP-47276N.
IntActiQ15005. 13 interactors.
MINTiMINT-1382200.
STRINGi9606.ENSP00000263672.

PTM databases

iPTMnetiQ15005.
PhosphoSitePlusiQ15005.
SwissPalmiQ15005.

Polymorphism and mutation databases

BioMutaiSPCS2.
DMDMi6648110.

Proteomic databases

EPDiQ15005.
MaxQBiQ15005.
PaxDbiQ15005.
PeptideAtlasiQ15005.
PRIDEiQ15005.
TopDownProteomicsiQ15005.

Protocols and materials databases

DNASUi9789.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263672; ENSP00000263672; ENSG00000118363.
GeneIDi9789.
KEGGihsa:9789.
UCSCiuc001ovu.2. human.

Organism-specific databases

CTDi9789.
GeneCardsiSPCS2.
H-InvDBHIX0028705.
HGNCiHGNC:28962. SPCS2.
HPAiHPA013386.
neXtProtiNX_Q15005.
OpenTargetsiENSG00000118363.
PharmGKBiPA128394559.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4072. Eukaryota.
ENOG4111HIK. LUCA.
GeneTreeiENSGT00440000038181.
HOVERGENiHBG093979.
InParanoidiQ15005.
KOiK12947.
PhylomeDBiQ15005.
TreeFamiTF314545.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118363-MONOMER.
BRENDAi3.4.21.89. 2681.
ReactomeiR-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-HSA-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
R-HSA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Miscellaneous databases

ChiTaRSiSPCS2. human.
GenomeRNAii9789.
PROiQ15005.

Gene expression databases

BgeeiENSG00000118363.
CleanExiHS_SPC25.
HS_SPCS2.
ExpressionAtlasiQ15005. baseline and differential.
GenevisibleiQ15005. HS.

Family and domain databases

InterProiIPR009582. SigPept_cplx_su2.
[Graphical view]
PfamiPF06703. SPC25. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPCS2_HUMAN
AccessioniPrimary (citable) accession number: Q15005
Secondary accession number(s): Q15507
, Q3KQT0, Q641R4, Q6FG65, Q6IRX0, Q6P1P4, Q96HU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.