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Protein

Condensin complex subunit 2

Gene

NCAPH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.1 Publication

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic chromosome condensation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121152-MONOMER.
ReactomeiR-HSA-2514853. Condensation of Prometaphase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin complex subunit 2
Alternative name(s):
Barren homolog protein 1
Chromosome-associated protein H
Short name:
hCAP-H
Non-SMC condensin I complex subunit H
XCAP-H homolog
Gene namesi
Name:NCAPH
Synonyms:BRRN, BRRN1, CAPH, KIAA0074
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:1112. NCAPH.

Subcellular locationi

GO - Cellular componenti

  • condensin complex Source: UniProtKB
  • cytosol Source: Reactome
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121152.
PharmGKBiPA162397273.

Polymorphism and mutation databases

DMDMi116241306.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000950381 – 741Condensin complex subunit 2Add BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei28PhosphoserineBy similarity1
Modified residuei49PhosphothreonineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei598PhosphothreonineCombined sources1
Modified residuei605PhosphothreonineCombined sources1
Modified residuei637N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ15003.
MaxQBiQ15003.
PaxDbiQ15003.
PeptideAtlasiQ15003.
PRIDEiQ15003.

PTM databases

iPTMnetiQ15003.
PhosphoSitePlusiQ15003.

Miscellaneous databases

PMAP-CutDBQ15003.

Expressioni

Tissue specificityi

Widely expressed at low level. Expressed in proliferating cells.1 Publication

Gene expression databases

BgeeiENSG00000121152.
CleanExiHS_NCAPH.
ExpressionAtlasiQ15003. baseline and differential.
GenevisibleiQ15003. HS.

Organism-specific databases

HPAiHPA002647.
HPA003008.

Interactioni

Subunit structurei

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DDX3XO005712EBI-1046410,EBI-353779
NCAPD2Q150215EBI-1046410,EBI-1044041
NCAPGQ9BPX33EBI-1046410,EBI-970214
SMC2O953473EBI-1046410,EBI-355822
SMC4Q9NTJ32EBI-1046410,EBI-356173

Protein-protein interaction databases

BioGridi116970. 48 interactors.
DIPiDIP-43899N.
IntActiQ15003. 24 interactors.
MINTiMINT-5004625.
STRINGi9606.ENSP00000240423.

Structurei

3D structure databases

ProteinModelPortaliQ15003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CND2 (condensin subunit 2) family.Curated

Phylogenomic databases

eggNOGiKOG2328. Eukaryota.
COG5229. LUCA.
GeneTreeiENSGT00390000004149.
HOGENOMiHOG000231887.
HOVERGENiHBG036823.
InParanoidiQ15003.
KOiK06676.
OMAiDAEPTNF.
OrthoDBiEOG091G01HE.
PhylomeDBiQ15003.
TreeFamiTF105678.

Family and domain databases

InterProiIPR022816. Condensin_barren_su2.
[Graphical view]
PfamiPF05786. Cnd2. 1 hit.
[Graphical view]
PIRSFiPIRSF017126. Condensin_H. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15003-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPPGPALPA TMNNSSSETR GHPHSASSPS ERVFPMPLPR KAPLNIPGTP
60 70 80 90 100
VLEDFPQNDD EKERLQRRRS RVFDLQFSTD SPRLLASPSS RSIDISATIP
110 120 130 140 150
KFTNTQITEH YSTCIKLSTE NKITTKNAFG LHLIDFMSEI LKQKDTEPTN
160 170 180 190 200
FKVAAGTLDA STKIYAVRVD AVHADVYRVL GGLGKDAPSL EEVEGHVADG
210 220 230 240 250
SATEMGTTKK AVKPKKKHLH RTIEQNINNL NVSEADRKCE IDPMFQKTAA
260 270 280 290 300
SFDECSTAGV FLSTLHCQDY RSELLFPSDV QTLSTGEPLE LPELGCVEMT
310 320 330 340 350
DLKAPLQQCA EDRQICPSLA GFQFTQWDSE THNESVSALV DKFKKNDQVF
360 370 380 390 400
DINAEVDESD CGDFPDGSLG DDFDANDEPD HTAVGDHEEF RSWKEPCQVQ
410 420 430 440 450
SCQEEMISLG DGDIRTMCPL LSMKPGEYSY FSPRTMSMWA GPDHWRFRPR
460 470 480 490 500
RKQDAPSQSE NKKKSTKKDF EIDFEDDIDF DVYFRKTKAA TILTKSTLEN
510 520 530 540 550
QNWRATTLPT DFNYNVDTLV QLHLKPGTRL LKMAQGHRVE TEHYEEIEDY
560 570 580 590 600
DYNNPNDTSN FCPGLQAADS DDEDLDDLFV GPVGNSDLSP YPCHPPKTAQ
610 620 630 640 650
QNGDTPEAQG LDITTYGESN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS
660 670 680 690 700
MWSLLTALSG KEADAEANHR EAGKEAALAE VADEKMLSGL TKDLQRSLPP
710 720 730 740
VMAQNLSIPL AFACLLHLAN EKNLKLEGTE DLSDVLVRQG D
Length:741
Mass (Da):82,563
Last modified:October 17, 2006 - v3
Checksum:iB5B34A36CAE0C28E
GO
Isoform 2 (identifier: Q15003-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Note: No experimental confirmation available.
Show »
Length:605
Mass (Da):67,495
Checksum:i4ABE503B4CB20935
GO

Sequence cautioni

The sequence BAA07556 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027882539V → A.1 PublicationCorresponds to variant rs2305935dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0551791 – 136Missing in isoform 2. 1 PublicationAdd BLAST136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38553 mRNA. Translation: BAA07556.1. Different initiation.
AK303725 mRNA. Translation: BAG64701.1.
AC021188 Genomic DNA. No translation available.
BC024211 mRNA. Translation: AAH24211.1.
CCDSiCCDS2021.1. [Q15003-1]
CCDS62960.1. [Q15003-2]
RefSeqiNP_001268639.1. NM_001281710.1.
NP_001268640.1. NM_001281711.1.
NP_001268641.1. NM_001281712.1. [Q15003-2]
NP_056156.2. NM_015341.4. [Q15003-1]
UniGeneiHs.308045.

Genome annotation databases

EnsembliENST00000240423; ENSP00000240423; ENSG00000121152. [Q15003-1]
ENST00000427946; ENSP00000400774; ENSG00000121152. [Q15003-2]
GeneIDi23397.
KEGGihsa:23397.
UCSCiuc002svz.3. human. [Q15003-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38553 mRNA. Translation: BAA07556.1. Different initiation.
AK303725 mRNA. Translation: BAG64701.1.
AC021188 Genomic DNA. No translation available.
BC024211 mRNA. Translation: AAH24211.1.
CCDSiCCDS2021.1. [Q15003-1]
CCDS62960.1. [Q15003-2]
RefSeqiNP_001268639.1. NM_001281710.1.
NP_001268640.1. NM_001281711.1.
NP_001268641.1. NM_001281712.1. [Q15003-2]
NP_056156.2. NM_015341.4. [Q15003-1]
UniGeneiHs.308045.

3D structure databases

ProteinModelPortaliQ15003.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116970. 48 interactors.
DIPiDIP-43899N.
IntActiQ15003. 24 interactors.
MINTiMINT-5004625.
STRINGi9606.ENSP00000240423.

PTM databases

iPTMnetiQ15003.
PhosphoSitePlusiQ15003.

Polymorphism and mutation databases

DMDMi116241306.

Proteomic databases

EPDiQ15003.
MaxQBiQ15003.
PaxDbiQ15003.
PeptideAtlasiQ15003.
PRIDEiQ15003.

Protocols and materials databases

DNASUi23397.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240423; ENSP00000240423; ENSG00000121152. [Q15003-1]
ENST00000427946; ENSP00000400774; ENSG00000121152. [Q15003-2]
GeneIDi23397.
KEGGihsa:23397.
UCSCiuc002svz.3. human. [Q15003-1]

Organism-specific databases

CTDi23397.
GeneCardsiNCAPH.
HGNCiHGNC:1112. NCAPH.
HPAiHPA002647.
HPA003008.
MIMi602332. gene.
neXtProtiNX_Q15003.
OpenTargetsiENSG00000121152.
PharmGKBiPA162397273.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2328. Eukaryota.
COG5229. LUCA.
GeneTreeiENSGT00390000004149.
HOGENOMiHOG000231887.
HOVERGENiHBG036823.
InParanoidiQ15003.
KOiK06676.
OMAiDAEPTNF.
OrthoDBiEOG091G01HE.
PhylomeDBiQ15003.
TreeFamiTF105678.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121152-MONOMER.
ReactomeiR-HSA-2514853. Condensation of Prometaphase Chromosomes.

Miscellaneous databases

ChiTaRSiNCAPH. human.
GeneWikiiNCAPH.
GenomeRNAii23397.
PMAP-CutDBQ15003.
PROiQ15003.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121152.
CleanExiHS_NCAPH.
ExpressionAtlasiQ15003. baseline and differential.
GenevisibleiQ15003. HS.

Family and domain databases

InterProiIPR022816. Condensin_barren_su2.
[Graphical view]
PfamiPF05786. Cnd2. 1 hit.
[Graphical view]
PIRSFiPIRSF017126. Condensin_H. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCND2_HUMAN
AccessioniPrimary (citable) accession number: Q15003
Secondary accession number(s): B4E189, Q8TB87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.