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Protein
Submitted name:

Glutamate-cysteine ligase

Gene

GCLC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate-cysteine ligaseImported
Submitted name:
Glutamate-cysteine ligase, catalytic subunit, isoform CRA_aImported
Submitted name:
cDNA, FLJ94028, Homo sapiens glutamate-cysteine ligase, catalytic subunit (GCLC),mRNAImported
Gene namesi
Name:GCLCImported
ORF Names:hCG_21942Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000001084.10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28612.

Expressioni

Gene expression databases

BgeeiENSG00000001084.

Interactioni

GO - Molecular functioni

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3754. Eukaryota.
ENOG410XQIG. LUCA.
HOVERGENiHBG005924.
KOiK11204.
OMAiWRIPKSR.
OrthoDBiEOG091G03DC.

Family and domain databases

InterProiView protein in InterPro
IPR004308. GCS.
PANTHERiPTHR11164. PTHR11164. 1 hit.
PfamiView protein in Pfam
PF03074. GCS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14TF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLSQGSPL SWEETKRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE
60 70 80 90 100
VEYMLVSFDH ENKKVRLVLS GEKVLETLQE KGERTNPNHP TLWRPEYGSY
110 120 130 140 150
MIEGTPGQPY GGTMSEFNTV EANMRKRRKE ATSILEENQA LCTITSFPRL
160 170 180 190 200
GCPGFTLPEV KPNPVEGGAS KSLFFPDEAI NKHPRFSTLT RNIRHRRGEK
210 220 230 240 250
VVINVPIFKD KNTPSPFIET FTEDDEASRA SKPDHIYMDA MGFGMGNCCL
260 270 280 290 300
QVTFQACSIS EARYLYDQLA TICPIVMALS AASPFYRGYV SDIDCRWGVI
310 320 330 340 350
SASVDDRTRE ERGLEPLKNN NYRISKSRYD SIDSYLSKCG EKYNDIDLTI
360 370 380 390 400
DKEIYEQLLQ EGIDHLLAQH VAHLFIRDPL TLFEEKIHLD DANESDHFEN
410 420 430 440 450
IQSTNWQTMR FKPPPPNSDI GWRVEFRPME VQLTDFENSA YVVFVVLLTR
460 470 480 490 500
VILSYKLDFL IPLSKVDENM KVAQKRDAVL QGMFYFRKDI CKGGNAVVDG
510 520 530 540 550
CGKAQNSTEL AAEEYTLMSI DTIINGKEGV FPGLIPILNS YLENMEVDVD
560 570 580 590 600
TRCSILNYLK LIKKRASGEL MTVARWMREF IANHPDYKQD SVITDEMNYS
610 620 630
LILKCNQIAN ELCECPELLG SAFRKVKYSG SKTDSSN
Length:637
Mass (Da):72,766
Last modified:August 22, 2006 - v1
Checksum:i511F33F106A15504
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB262176 mRNA. Translation: BAE97618.1.
AK313480 mRNA. Translation: BAG36264.1.
CH471081 Genomic DNA. Translation: EAX04425.1.
CH471081 Genomic DNA. Translation: EAX04426.1.
RefSeqiNP_001184044.1. NM_001197115.1.
NP_001489.1. NM_001498.3.
UniGeneiHs.654465.

Genome annotation databases

GeneIDi2729.
KEGGihsa:2729.
UCSCiuc003pbw.3. human.

Similar proteinsi

Entry informationi

Entry nameiQ14TF0_HUMAN
AccessioniPrimary (citable) accession number: Q14TF0
Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: September 27, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.