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Q14TF0

- Q14TF0_HUMAN

UniProt

Q14TF0 - Q14TF0_HUMAN

Protein
Submitted name:

Glutamate-cysteine ligase

Gene

GCLC

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. glutamate-cysteine ligase activity Source: InterPro

    GO - Biological processi

    1. apoptotic mitochondrial changes Source: Ensembl
    2. glutathione biosynthetic process Source: InterPro
    3. L-ascorbic acid metabolic process Source: Ensembl
    4. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    5. negative regulation of neuron apoptotic process Source: Ensembl
    6. negative regulation of protein ubiquitination Source: Ensembl
    7. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
    8. regulation of mitochondrial depolarization Source: Ensembl
    9. response to arsenic-containing substance Source: Ensembl
    10. response to nitrosative stress Source: Ensembl
    11. response to xenobiotic stimulus Source: Ensembl

    Keywords - Molecular functioni

    LigaseImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glutamate-cysteine ligaseImported
    Submitted name:
    Glutamate-cysteine ligase, catalytic subunit, isoform CRA_aImported
    Submitted name:
    cDNA, FLJ94028, Homo sapiens glutamate-cysteine ligase, catalytic subunit (GCLC),mRNAImported
    Gene namesi
    Name:GCLCImported
    ORF Names:hCG_21942Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. glutamate-cysteine ligase complex Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28612.

    Structurei

    3D structure databases

    SMRiQ14TF0. Positions 2-610.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG005924.
    KOiK11204.
    OMAiRWMREFI.
    PhylomeDBiQ14TF0.

    Family and domain databases

    InterProiIPR004308. GCS.
    [Graphical view]
    PANTHERiPTHR11164. PTHR11164. 1 hit.
    PfamiPF03074. GCS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14TF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLLSQGSPL SWEETKRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE    50
    VEYMLVSFDH ENKKVRLVLS GEKVLETLQE KGERTNPNHP TLWRPEYGSY 100
    MIEGTPGQPY GGTMSEFNTV EANMRKRRKE ATSILEENQA LCTITSFPRL 150
    GCPGFTLPEV KPNPVEGGAS KSLFFPDEAI NKHPRFSTLT RNIRHRRGEK 200
    VVINVPIFKD KNTPSPFIET FTEDDEASRA SKPDHIYMDA MGFGMGNCCL 250
    QVTFQACSIS EARYLYDQLA TICPIVMALS AASPFYRGYV SDIDCRWGVI 300
    SASVDDRTRE ERGLEPLKNN NYRISKSRYD SIDSYLSKCG EKYNDIDLTI 350
    DKEIYEQLLQ EGIDHLLAQH VAHLFIRDPL TLFEEKIHLD DANESDHFEN 400
    IQSTNWQTMR FKPPPPNSDI GWRVEFRPME VQLTDFENSA YVVFVVLLTR 450
    VILSYKLDFL IPLSKVDENM KVAQKRDAVL QGMFYFRKDI CKGGNAVVDG 500
    CGKAQNSTEL AAEEYTLMSI DTIINGKEGV FPGLIPILNS YLENMEVDVD 550
    TRCSILNYLK LIKKRASGEL MTVARWMREF IANHPDYKQD SVITDEMNYS 600
    LILKCNQIAN ELCECPELLG SAFRKVKYSG SKTDSSN 637
    Length:637
    Mass (Da):72,766
    Last modified:August 22, 2006 - v1
    Checksum:i511F33F106A15504
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB262176 mRNA. Translation: BAE97618.1.
    AK313480 mRNA. Translation: BAG36264.1.
    CH471081 Genomic DNA. Translation: EAX04425.1.
    CH471081 Genomic DNA. Translation: EAX04426.1.
    RefSeqiNP_001184044.1. NM_001197115.1.
    NP_001489.1. NM_001498.3.
    UniGeneiHs.654465.

    Genome annotation databases

    GeneIDi2729.
    KEGGihsa:2729.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB262176 mRNA. Translation: BAE97618.1 .
    AK313480 mRNA. Translation: BAG36264.1 .
    CH471081 Genomic DNA. Translation: EAX04425.1 .
    CH471081 Genomic DNA. Translation: EAX04426.1 .
    RefSeqi NP_001184044.1. NM_001197115.1.
    NP_001489.1. NM_001498.3.
    UniGenei Hs.654465.

    3D structure databases

    SMRi Q14TF0. Positions 2-610.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 2729.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2729.
    KEGGi hsa:2729.

    Organism-specific databases

    CTDi 2729.
    PharmGKBi PA28612.

    Phylogenomic databases

    HOVERGENi HBG005924.
    KOi K11204.
    OMAi RWMREFI.
    PhylomeDBi Q14TF0.

    Miscellaneous databases

    ChiTaRSi GCLC. human.
    GenomeRNAii 2729.
    NextBioi 10756.

    Family and domain databases

    InterProi IPR004308. GCS.
    [Graphical view ]
    PANTHERi PTHR11164. PTHR11164. 1 hit.
    Pfami PF03074. GCS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Cited for: NUCLEOTIDE SEQUENCE.
    3. "Homo sapiens glutamate-cysteine ligase."
      Gupta S.K., Tripathi U., Rathore R., Singh A.K.
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "NEDO functional analysis of protein and research application project."
      Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: ThalamusImported.

    Entry informationi

    Entry nameiQ14TF0_HUMAN
    AccessioniPrimary (citable) accession number: Q14TF0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 22, 2006
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.