Q14TF0 (Q14TF0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glutamate-cysteine ligase EMBL BAE97618.1

Submitted name:
Glutamate-cysteine ligase, catalytic subunit, isoform CRA_a EMBL EAX04425.1
Submitted name:
cDNA, FLJ94028, Homo sapiens glutamate-cysteine ligase, catalytic subunit (GCLC),mRNA EMBL BAG36264.1

Gene names

Name:	GCLC EMBL BAE97618.1
ORF Names:	hCG_21942 EMBL EAX04425.1

Organism

Homo sapiens (Human) EMBL BAE97618.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	637 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Ligase EMBL BAE97618.1
Gene Ontology (GO)
Biological_process	L-ascorbic acid metabolic process Inferred from electronic annotation. Source: Compara glutathione biosynthetic process Inferred from electronic annotation. Source: InterPro negative regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of protein ubiquitination Inferred from electronic annotation. Source: Compara positive regulation of proteasomal ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: Compara regulation of mitochondrial depolarization Inferred from electronic annotation. Source: Compara response to arsenic-containing substance Inferred from electronic annotation. Source: Compara response to nitrosative stress Inferred from electronic annotation. Source: Compara response to xenobiotic stimulus Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara glutamate-cysteine ligase complex Inferred from electronic annotation. Source: Compara
Molecular_function	glutamate-cysteine ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q14TF0 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 511F33F106A15504	FASTA	637	72,766
	10 20 30 40 50 60 MGLLSQGSPL SWEETKRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE VEYMLVSFDH 70 80 90 100 110 120 ENKKVRLVLS GEKVLETLQE KGERTNPNHP TLWRPEYGSY MIEGTPGQPY GGTMSEFNTV 130 140 150 160 170 180 EANMRKRRKE ATSILEENQA LCTITSFPRL GCPGFTLPEV KPNPVEGGAS KSLFFPDEAI 190 200 210 220 230 240 NKHPRFSTLT RNIRHRRGEK VVINVPIFKD KNTPSPFIET FTEDDEASRA SKPDHIYMDA 250 260 270 280 290 300 MGFGMGNCCL QVTFQACSIS EARYLYDQLA TICPIVMALS AASPFYRGYV SDIDCRWGVI 310 320 330 340 350 360 SASVDDRTRE ERGLEPLKNN NYRISKSRYD SIDSYLSKCG EKYNDIDLTI DKEIYEQLLQ 370 380 390 400 410 420 EGIDHLLAQH VAHLFIRDPL TLFEEKIHLD DANESDHFEN IQSTNWQTMR FKPPPPNSDI 430 440 450 460 470 480 GWRVEFRPME VQLTDFENSA YVVFVVLLTR VILSYKLDFL IPLSKVDENM KVAQKRDAVL 490 500 510 520 530 540 QGMFYFRKDI CKGGNAVVDG CGKAQNSTEL AAEEYTLMSI DTIINGKEGV FPGLIPILNS 550 560 570 580 590 600 YLENMEVDVD TRCSILNYLK LIKKRASGEL MTVARWMREF IANHPDYKQD SVITDEMNYS 610 620 630 LILKCNQIAN ELCECPELLG SAFRKVKYSG SKTDSSN

References

[1]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Homo sapiens glutamate-cysteine ligase." Gupta S.K., Tripathi U., Rathore R., Singh A.K. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Thalamus EMBL BAG36264.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB262176 mRNA. Translation: BAE97618.1. AK313480 mRNA. Translation: BAG36264.1. CH471081 Genomic DNA. Translation: EAX04425.1.
IPI	IPI00215768.
RefSeq	NP_001184044.1. NM_001197115.1. NP_001489.1. NM_001498.3.
UniGene	Hs.654465.
3D structure databases
ProteinModelPortal	Q14TF0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q14TF0.
Proteomic databases
PRIDE	Q14TF0.
Protocols and materials databases
DNASU	2729.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2729.
KEGG	hsa:2729.
Organism-specific databases
CTD	2729.
PharmGKB	PA28612.
Phylogenomic databases
HOVERGEN	HBG005924.
KO	K11204.
OMA	GILQFLH.
PhylomeDB	Q14TF0.
Gene expression databases
ArrayExpress	Q14TF0.
Bgee	Q14TF0.
Family and domain databases
InterPro	IPR004308. GCS. [Graphical view]
PANTHER	PTHR11164. PTHR11164. 1 hit.
Pfam	PF03074. GCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q14TF0.
ChiTaRS	GCLC. human.
GenomeRNAi	2729.
NextBio	10756.

Entry information

Entry name

Q14TF0_HUMAN

Accession

Primary (citable) accession number: Q14TF0

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.