Q14K61 (Q14K61_FRAT1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA HAMAP MF_00377

Gene names

Name:	dnaA HAMAP MF_00377 EMBL CAL08017.1
Ordered Locus Names:	FTF0001

Organism

Francisella tularensis subsp. tularensis (strain FSC 198) [Complete proteome] [HAMAP]

Taxonomic identifier

393115 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377 RuleBase RU000577
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family. HAMAP MF_00377 RuleBase RU004227

Ontologies

Keywords
Biological process	DNA replication HAMAP MF_00377 RuleBase RU000577
Cellular component	Cytoplasm HAMAP MF_00377
Ligand	ATP-binding HAMAP MF_00377 RuleBase RU000577 DNA-binding HAMAP MF_00377 RuleBase RU000577 Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: HAMAP regulation of DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA replication origin binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	211 – 218	8	ATP By similarity HAMAP MF_00377

Sequences

	Sequence		Length	Mass (Da)
	Q14K61 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: D4CFD7DC5C4B61D1	FASTA	506	57,677
	10 20 30 40 50 60 MAILYILRVI RIFFIMTTWD KCLKKIKKNL STFEYKTWIK PIHVEQNSNL FTVYCNNEYF 70 80 90 100 110 120 KKHIKSKYGN LILSTIQECH GNDLIIEYSN KKFSGEKITE VITAGPQANF FSTTSVEIKD 130 140 150 160 170 180 ESEDTKVVQE PKISKKSNSK DFSSSQELFG FDEAMLITAK EDEEYSFGLP LKEKYVFDSF 190 200 210 220 230 240 VVGDANKIAR AAAMQVSINP GKLHNPLFIY GGSGLGKTHL MQAIGNHARE VNPNAKIIYT 250 260 270 280 290 300 NSEQFIKDYV NSIRLQDQDE FQRVYRSADI LLIDDIQFIA GKEGTAQEFF HTFNALYENG 310 320 330 340 350 360 KQIILTSDKY PNEIEGLEER LVSRFGYGLT VSVDMPDLET RIAILLKKAH DLGQKLPNET 370 380 390 400 410 420 AAFIAENVRT NVRELEGALN RVLTTSKFNH KDPTIEVAQA CLRDVIKIQE KKVKIDNIQK 430 440 450 460 470 480 VVADFYRIRV KDLTSNQRSR NIARPRQIAM SLARELTSHS LPEIGNAFGG RDHTTVMHAV 490 500 KAITKLRQSN TSISDDYELL LDKISR

References

[1]

"Genome sequencing shows that European isolates of Francisella tularensis subspecies tularensis are almost identical to US laboratory strain Schu S4." Chaudhuri R.R., Ren C.-P., Desmond L., Vincent G.A., Silman N.J., Brehm J.K., Elmore M.J., Hudson M.J., Forsman M., Isherwood K.E., Gurycova D., Minton N.P., Titball R.W., Pallen M.J., Vipond R. PLoS ONE 2:E352-E352(2007) [PubMed: 17406676] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM286280 Genomic DNA. Translation: CAL08017.1.
RefSeq	YP_666215.1. NC_008245.1.
3D structure databases
ProteinModelPortal	Q14K61.
SMR	Q14K61. Positions 413-505.
ModBase	Search...
Protein-protein interaction databases
STRING	Q14K61.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4199350.
GenomeReviews	Gene locus FTF0001 in contig AM286280_GR.
KEGG	ftf:FTF0001.
PATRIC	17958611. VBIFraTul133500_0001.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0593.
HOGENOM	HBG695666.
OMA	DEVAFLI.
PhylomeDB	Q14K61.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q14K61_FRAT1

Accession

Primary (citable) accession number: Q14K61

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)