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Protein

UDP-3-O-acylglucosamine N-acyltransferase 1

Gene

lpxD1

Organism
Francisella tularensis subsp. tularensis (strain FSC 198)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotation

Pathwayi: LPS lipid A biosynthesis

This protein is involved in the pathway LPS lipid A biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway LPS lipid A biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei246Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00973.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase 1UniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Name:lpxD1UniRule annotation
Synonyms:lpxD2
Ordered Locus Names:FTF0286c
OrganismiFrancisella tularensis subsp. tularensis (strain FSC 198)
Taxonomic identifieri393115 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002643741 – 347UDP-3-O-acylglucosamine N-acyltransferase 1Add BLAST347

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ14JF8.
SMRiQ14JF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000294340.
KOiK02536.
OMAiAHSVKLG.

Family and domain databases

CDDicd03352. LbH_LpxD. 1 hit.
HAMAPiMF_00523. LpxD. 1 hit.
InterProiView protein in InterPro
IPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR007691. LpxD.
IPR011004. Trimer_LpxA-like_sf.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
PANTHERiPTHR43378. PTHR43378. 1 hit.
PfamiView protein in Pfam
PF00132. Hexapep. 3 hits.
PF04613. LpxD. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.
PROSITEiView protein in PROSITE
PS00101. HEXAPEP_TRANSFERASES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14JF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQYTLKQISE HLNAKVINEP SGEVIITGLT YAEQAKENDL TLIDKQEHIK
60 70 80 90 100
LWQNSKATAA IVSKKISKEL AQVNDKPLIV VNNADLAMAK ILELFSVPYP
110 120 130 140 150
EQNGIHEKAI IDPTAKIGKN VSIGPSAYIG KNVEIGDNTI IYANVCIYND
160 170 180 190 200
AKVGTNCIIW PSVIIRDRTI IGHFCRLCSN CSIGSDGFGY RPSEDGRTIV
210 220 230 240 250
RIPHIGNVVI GSFVDIGSNT CINNAKYGST IIGDYTKIDN LVQIGHNVII
260 270 280 290 300
GKGCMICGQA GISGSVTIGD GVIIAGNAGI KDHTNIGSDA RIGGKAGVMW
310 320 330 340
DVPAGESHMG YPAYKDSELA KQWIAIRKLP ETMKKLKAIA KSLNIDL
Length:347
Mass (Da):37,384
Last modified:August 22, 2006 - v1
Checksum:i968EE375BCEE5C25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286280 Genomic DNA. Translation: CAL08302.1.
RefSeqiWP_003021676.1. NC_008245.1.

Genome annotation databases

EnsemblBacteriaiCAL08302; CAL08302; FTF0286c.
KEGGiftf:FTF0286c.

Similar proteinsi

Entry informationi

Entry nameiLPXD1_FRAT1
AccessioniPrimary (citable) accession number: Q14JF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 22, 2006
Last modified: November 22, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families