Q14J39 (Q14J39_FRAT1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glycine cleavage system P protein, subunit 2 EMBL CAL08426.1
EC=1.4.4.2 EMBL CAL08426.1

Gene names

Name:	gcvP2 EMBL CAL08426.1
Ordered Locus Names:	FTF0410

Organism

Francisella tularensis subsp. tularensis (strain FSC 198) [Complete proteome] [HAMAP] EMBL CAL08426.1

Taxonomic identifier

393115 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella › Francisella tularensis › Francisella tularensis subsp. tularensis

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. SAAS SAAS020580
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. SAAS SAAS020580
Cofactor	Pyridoxal phosphate By similarity. SAAS SAAS020580
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity. SAAS SAAS020580

Ontologies

Keywords
Ligand	Pyridoxal phosphate SAAS SAAS020580
Molecular function	Oxidoreductase SAAS SAAS020580 EMBL CAL08426.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q14J39 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 3A277BFAE851FBED	FASTA	481	52,739
	10 20 30 40 50 60 MVIFEKTRGK NSPSVMPSKK GDVSNIPTDM LRTKKPILPE QAELDVVRHY TQLSRKNFCI 70 80 90 100 110 120 DTNFYPLGSC TMKYNPRAAH KYASLAGFLE RHPYASAQSV QGTLECLYDL QNLIKELTGM 130 140 150 160 170 180 TGVSLAPMAG AQGEFAGVAM IKAYHHKRSD FERDEIIVPD AAHGTNPATA KVCGLKVIEI 190 200 210 220 230 240 PTKKDGDIDI EALDKVLGPK TAGIMLTNPS TVGVFERNIA VIAKKVHEAG GLLYYDGANL 250 260 270 280 290 300 NAIMGKACPG DMGFDVLHMN LHKTFATPHG GGGPGAGPVA VNDKLKEFLP VPMVGKKDDK 310 320 330 340 350 360 FVWLEEKDVS NTIGRLSAFN GNIGVLIRAY IYGAMLGGNG LTEASEIATL NANYMMARLK 370 380 390 400 410 420 EEGFTIAYPD RRASHEFIVT LKPEFLNYGV TATDFAKCLI DKGVHAPTMY FPLLVPECLL 430 440 450 460 470 480 IEPTETENVD SMEKFIQAMV EIRDIAKKDP QYLKGAPYNL PARRLDDVKA TKELDIVWQP K

References

[1]

"Genome sequencing shows that European isolates of Francisella tularensis subspecies tularensis are almost identical to US laboratory strain Schu S4." Chaudhuri R.R., Ren C.-P., Desmond L., Vincent G.A., Silman N.J., Brehm J.K., Elmore M.J., Hudson M.J., Forsman M., Isherwood K.E., Gurycova D., Minton N.P., Titball R.W., Pallen M.J., Vipond R. PLoS ONE 2:E352-E352(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FSC 198.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM286280 Genomic DNA. Translation: CAL08426.1.
RefSeq	YP_666587.1. NC_008245.1.
3D structure databases
ProteinModelPortal	Q14J39.
ModBase	Search...
Protein-protein interaction databases
STRING	393115.FTF0410.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAL08426; CAL08426; FTF0410.
GeneID	4199280.
KEGG	ftf:FTF0410.
PATRIC	17959548. VBIFraTul133500_0455.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1003.
HOGENOM	HOG000239368.
KO	K00283.
OMA	RHYTRLS.
ProtClustDB	PRK04366.
Enzyme and pathway databases
BioCyc	FTUL393115:GJUT-419-MONOMER.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11773. PTHR11773. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q14J39_FRAT1

Accession

Primary (citable) accession number: Q14J39

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)