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Protein

Peptidyl-tRNA hydrolase

Gene

pth

Organism
Francisella tularensis subsp. tularensis (strain FSC 198)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.UniRule annotation

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolaseUniRule annotation (EC:3.1.1.29UniRule annotation)
Short name:
PTHUniRule annotation
Gene namesi
Name:pthUniRule annotation
Ordered Locus Names:FTF0680c
OrganismiFrancisella tularensis subsp. tularensis (strain FSC 198)
Taxonomic identifieri393115 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002640401 – 191Peptidyl-tRNA hydrolaseAdd BLAST191

Proteomic databases

PRIDEiQ14IE8

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ14IE8
SMRiQ14IE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004796
KOiK01056
OMAiRYAHTRH

Family and domain databases

CDDicd00462 PTH, 1 hit
Gene3Di3.40.50.1470, 1 hit
HAMAPiMF_00083 Pept_tRNA_hydro_bact, 1 hit
InterProiView protein in InterPro
IPR001328 Pept_tRNA_hydro
IPR018171 Pept_tRNA_hydro_CS
IPR036416 Pept_tRNA_hydro_sf
PANTHERiPTHR17224 PTHR17224, 1 hit
PfamiView protein in Pfam
PF01195 Pept_tRNA_hydro, 1 hit
SUPFAMiSSF53178 SSF53178, 1 hit
TIGRFAMsiTIGR00447 pth, 1 hit
PROSITEiView protein in PROSITE
PS01196 PEPT_TRNA_HYDROL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q14IE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKIKMIIGL GNIGKEYQDT RHNVGEWFIA KIAQDNNQSF SSNPKLNCNL
60 70 80 90 100
AKVSIDYNNV VLVFPTTYMN NSGLAVSKVA NFYKIAPAEI LVVHDELDID
110 120 130 140 150
SGEIRLKKGG GHGGHNGLRS INQHLGTNDY LRLRIGIGHP GHKSKVANYV
160 170 180 190
LSNPSIAQKK DIDSAIDNGI CFLDDIINYK LEPVMQKLHT K
Length:191
Mass (Da):21,137
Last modified:August 22, 2006 - v1
Checksum:i983F0CCC7718660A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286280 Genomic DNA Translation: CAL08696.1
RefSeqiWP_003020470.1, NC_008245.1

Genome annotation databases

EnsemblBacteriaiCAL08696; CAL08696; FTF0680c
KEGGiftf:FTF0680c

Similar proteinsi

Entry informationi

Entry nameiPTH_FRAT1
AccessioniPrimary (citable) accession number: Q14IE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 22, 2006
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health