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Q14FS1

- Q14FS1_FRAT1

UniProt

Q14FS1 - Q14FS1_FRAT1

Protein

Glutamate decarboxylase

Gene

gad

Organism
Francisella tularensis subsp. tularensis (strain FSC 198)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciFTUL393115:GJUT-1768-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    Name:gadImported
    Ordered Locus Names:FTF1722cImported
    OrganismiFrancisella tularensis subsp. tularensis (strain FSC 198)Imported
    Taxonomic identifieri393115 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000001821: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi393115.FTF1722c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14FS1.
    SMRiQ14FS1. Positions 13-435.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000070228.
    KOiK01580.
    OMAiERQTGID.
    OrthoDBiEOG6TFCPW.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q14FS1-1 [UniParc]FASTAAdd to Basket

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    MALHGKKDTI DNLDFFEQSL PKFKLPLNSQ DPLEVYQEIK DELMLDGNSK    50
    QNLATFCQTE VDDFIHKLMD DCIDKNMIDK DEYPQTAEIE SRCVNILANL 100
    WNSSAENAIG CSTTGSSEAA MLGGMAMKWR WRDKMKAQGK DYTKPNLVTG 150
    PVQVCWHKFA RYWDIELREI PMSNESLIMT PEAVLERCDE NTIGVVPTLG 200
    VTFTGQYEPV EQVCKALDDF ERQTGVDIPV HVDAASGGFL APFVEPELKW 250
    DFRLPRVKSI NSSGHKFGLS PLGVGWVIWA DKKYLPDDLI FNVNYLGGNM 300
    PAFALNFSRL GGQIVAQYYN FVRLGFEGYK KVHQLCYDVA EYIAKELRKM 350
    EIFEIIHAGE GGIPAVSWSL KATKEYSLFD ISEKVRAKGW QIAAYTMPNN 400
    REDLVVMRVL VRRGFSYDLA QLMIRDLVAV IDSLEGKLKI LKRSSFAH 448
    Length:448
    Mass (Da):50,815
    Last modified:August 22, 2006 - v1
    Checksum:i2A48F8FD23CA64D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM286280 Genomic DNA. Translation: CAL09738.1.
    RefSeqiYP_667757.1. NC_008245.1.

    Genome annotation databases

    EnsemblBacteriaiCAL09738; CAL09738; FTF1722c.
    GeneIDi4199207.
    KEGGiftf:FTF1722c.
    PATRICi17962740. VBIFraTul133500_2000.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM286280 Genomic DNA. Translation: CAL09738.1 .
    RefSeqi YP_667757.1. NC_008245.1.

    3D structure databases

    ProteinModelPortali Q14FS1.
    SMRi Q14FS1. Positions 13-435.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 393115.FTF1722c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL09738 ; CAL09738 ; FTF1722c .
    GeneIDi 4199207.
    KEGGi ftf:FTF1722c.
    PATRICi 17962740. VBIFraTul133500_2000.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000070228.
    KOi K01580.
    OMAi ERQTGID.
    OrthoDBi EOG6TFCPW.

    Enzyme and pathway databases

    BioCyci FTUL393115:GJUT-1768-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing shows that European isolates of Francisella tularensis subspecies tularensis are almost identical to US laboratory strain Schu S4."
      Chaudhuri R.R., Ren C.-P., Desmond L., Vincent G.A., Silman N.J., Brehm J.K., Elmore M.J., Hudson M.J., Forsman M., Isherwood K.E., Gurycova D., Minton N.P., Titball R.W., Pallen M.J., Vipond R.
      PLoS ONE 2:E352-E352(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FSC 198Imported.

    Entry informationi

    Entry nameiQ14FS1_FRAT1
    AccessioniPrimary (citable) accession number: Q14FS1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 22, 2006
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3