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Protein
Submitted name:

Protocadherin 10

Gene

PCDH10

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesionSAAS annotation

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin 10Imported
Gene namesi
Name:PCDH10Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei714 – 73825HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 10401022Sequence analysisPRO_5004183005Add
BLAST

Proteomic databases

PaxDbiQ14DV7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000264360.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 12260CadherinInterPro annotationAdd
BLAST
Domaini123 – 250128CadherinInterPro annotationAdd
BLAST
Domaini251 – 358108CadherinInterPro annotationAdd
BLAST
Domaini359 – 463105CadherinInterPro annotationAdd
BLAST
Domaini464 – 574111CadherinInterPro annotationAdd
BLAST
Domaini590 – 68091CadherinInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains cadherin domains.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOVERGENiHBG054878.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030712. Protocadherin-10.
[Graphical view]
PANTHERiPTHR24028:SF0. PTHR24028:SF0. 2 hits.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14DV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVLLLFALL WMVEGVFSQL HYTVQEEQEH GTFVGNIAED LGLDITKLSA
60 70 80 90 100
RGFQTVPNSR TPYLDLNLET GVLYVNEKID REQICKQSPS CVLHLEVFLE
110 120 130 140 150
NPLELFQVEI EVLDINDNPP SFPEPDLTVE ISESATPGTR FPLESAFDPD
160 170 180 190 200
VGTNSLRDYE ITPNSYFSLD VQTQGDGNRF AELVLEKPLD REQQAVHRYV
210 220 230 240 250
LTAVDGGGGG GVGEGGGGGG GAGLPPQQQR TGTALLTIRV LDSNDNVPAF
260 270 280 290 300
DQPVYTVSLP ENSPPGTLVI QLNATDPDEG QNGEVVYSFS SHISPRAREL
310 320 330 340 350
FGLSPRTGRL EVSGELDYEE SPVYQVYVQA KDLGPNAVPA HCKVLVRVLD
360 370 380 390 400
ANDNAPEISF STVKEAVSEG AAPGTVVALF SVTDRDSEEN GQVQCELLGD
410 420 430 440 450
VPFRPKSSFK NYYTIVTEAP LDREAGDSYT LTVVARDRGE PALSTSKSIQ
460 470 480 490 500
VQVSDVNDNA PRFSQPVYDV YVTENNVPGA YIYAVSATDR DEGANAQLAY
510 520 530 540 550
SILECQIQGM SVFTYVSINS ENGYLYALRS FDYEQLKDFS FQVEARDAGS
560 570 580 590 600
PQALAGNATV NILIVDQNDN APAIVAPLPG RNGTPAREVL PRSAEPGYLL
610 620 630 640 650
TRVAAVDADD GENARLTYSI VRGNEMNLFR MDWRTGELRT ARRVPAKRDP
660 670 680 690 700
QRPYELVIEV RDHGQPPLSS TATLVVQLVD GAVEPQGGGG SGGGGSGEHQ
710 720 730 740 750
RPSRSGGGET SLDLTLILII ALGSVSFIFL LAMIVLAVRC QKEKKLNIYT
760 770 780 790 800
CLASDCCLCC CCCGGGGSTC CGRQARARKK KLSKSDIMLV QSSNVPSNPA
810 820 830 840 850
QVPIEESGGF GSHHHNQNYC YQVCLTPESA KTDLMFLKPC SPSRSTDTEH
860 870 880 890 900
NPCGAIVTGY TDQQPDIISN GSILSNETKH QRAELSYLVD RPRRVNSSAF
910 920 930 940 950
QEADIVSSKD SGHGDSEQGD SDHDATNRAQ SAGMDLFSNC TEECKALGHS
960 970 980 990 1000
DRCWMPSFVP SDGRQAADYR SNLHVPGMDS VPDTEVFETP EAQPGAERSF
1010 1020 1030 1040
STFGKEKALH STLERKELDG LLTNTRAPYK PPYLTRKRIC
Length:1,040
Mass (Da):112,920
Last modified:August 22, 2006 - v1
Checksum:iDE54507BCF484F19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111560 mRNA. Translation: AAI11561.1.
UniGeneiHs.192859.
Hs.654741.
Hs.669234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111560 mRNA. Translation: AAI11561.1.
UniGeneiHs.192859.
Hs.654741.
Hs.669234.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000264360.

Proteomic databases

PaxDbiQ14DV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOVERGENiHBG054878.

Miscellaneous databases

ChiTaRSiPCDH10. human.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030712. Protocadherin-10.
[Graphical view]
PANTHERiPTHR24028:SF0. PTHR24028:SF0. 2 hits.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ14DV7_HUMAN
AccessioniPrimary (citable) accession number: Q14DV7
Entry historyi
Integrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: May 11, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.