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Protein

Ankyrin repeat and death domain-containing protein 1B

Gene

Ankdd1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and death domain-containing protein 1B
Gene namesi
Name:Ankdd1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2444730. Ankdd1b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003321611 – 521Ankyrin repeat and death domain-containing protein 1BAdd BLAST521

Proteomic databases

PRIDEiQ14DN9.

PTM databases

PhosphoSitePlusiQ14DN9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047117.
ExpressionAtlasiQ14DN9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ14DN9.
SMRiQ14DN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati60 – 89ANK 1Add BLAST30
Repeati93 – 122ANK 2Add BLAST30
Repeati126 – 155ANK 3Add BLAST30
Repeati159 – 190ANK 4Add BLAST32
Repeati194 – 223ANK 5Add BLAST30
Repeati227 – 256ANK 6Add BLAST30
Repeati260 – 289ANK 7Add BLAST30
Repeati293 – 322ANK 8Add BLAST30
Repeati326 – 355ANK 9Add BLAST30
Repeati359 – 388ANK 10Add BLAST30
Domaini420 – 508DeathPROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Contains 10 ANK repeats.PROSITE-ProRule annotation
Contains 1 death domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

GeneTreeiENSGT00790000122981.
HOGENOMiHOG000273862.
HOVERGENiHBG100885.
InParanoidiQ14DN9.
OMAiGADQKAK.
OrthoDBiEOG091G0IU8.
TreeFamiTF333615.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
[Graphical view]
SMARTiSM00248. ANK. 10 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 8 hits.
PS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14DN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPESAQGHG ARAPMLQAAR GLKANLRDVA TRPWRSLARM PKPEVQDPET
60 70 80 90 100
AAAGHEGLLA IERSFQNAAK SSNLDLMEKL FEKKVNINAV NNMNRTALHF
110 120 130 140 150
AVGRNSLSAV DFLLSHKARV DVADKHGLTV IHLAAWSGSF EIMLMLVKAG
160 170 180 190 200
ADQRAKNQEG MNALHLAAQN NNLHIVDYLI HDLHLHDLNQ PNERGRKPFH
210 220 230 240 250
LAAERGHVEM IEKLIFLNLH TSEKDKDGNT ALHLAAMHGH SPAVQVLLTQ
260 270 280 290 300
WSEVNESNEL NVSALQTATR NGHTALVNFL LGENADLQQQ KESKEPPLHL
310 320 330 340 350
AVINNRPAVV NSLLSARHDV DVLDQRRQTP LHVAADLGNV ELVETLLKAG
360 370 380 390 400
CNLKITDKQG KTALAVAARS QHSLVVDMLI KAERYYAWRE EHRESIQDSA
410 420 430 440 450
VSSTLTFKQD HSLETRQIRT LLWNLAYRQL KKKDWQRLAR LWSFTEDQIR
460 470 480 490 500
AIEEQWSGND SFHEHGYRAL LIWLHGALLT QLDPAKQLYE ELLCAGFPEL
510 520
AEKIRQFKSK TDSSSKKCAV S
Length:521
Mass (Da):58,456
Last modified:April 3, 2013 - v3
Checksum:i72AE37B9DB204DE6
GO
Isoform 2 (identifier: Q14DN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: MNPESAQGHG...KKVNINAVNN → MRA
     259-259: E → ENGETPFLLAVVGGHEECSRVLLAGGSDVNIPNK

Show »
Length:465
Mass (Da):52,161
Checksum:i3436ED9E5E23AF0F
GO

Sequence cautioni

The sequence BAC28528 differs from that shown. Fragment of a putative isoform.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti313Missing in AAI12418 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0462621 – 92MNPES…NAVNN → MRA in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_046263259E → ENGETPFLLAVVGGHEECSR VLLAGGSDVNIPNK in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112417 mRNA. Translation: AAI12418.1.
GL456167 Genomic DNA. No translation available.
AK033960 mRNA. Translation: BAC28528.1. Sequence problems.
CCDSiCCDS49334.1. [Q14DN9-2]
RefSeqiNP_001036179.1. NM_001042714.1. [Q14DN9-2]
UniGeneiMm.470057.

Genome annotation databases

EnsembliENSMUST00000055607; ENSMUSP00000061643; ENSMUSG00000047117. [Q14DN9-2]
GeneIDi271144.
KEGGimmu:271144.
UCSCiuc007rmy.1. mouse. [Q14DN9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112417 mRNA. Translation: AAI12418.1.
GL456167 Genomic DNA. No translation available.
AK033960 mRNA. Translation: BAC28528.1. Sequence problems.
CCDSiCCDS49334.1. [Q14DN9-2]
RefSeqiNP_001036179.1. NM_001042714.1. [Q14DN9-2]
UniGeneiMm.470057.

3D structure databases

ProteinModelPortaliQ14DN9.
SMRiQ14DN9.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ14DN9.

Proteomic databases

PRIDEiQ14DN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055607; ENSMUSP00000061643; ENSMUSG00000047117. [Q14DN9-2]
GeneIDi271144.
KEGGimmu:271144.
UCSCiuc007rmy.1. mouse. [Q14DN9-2]

Organism-specific databases

CTDi728780.
MGIiMGI:2444730. Ankdd1b.

Phylogenomic databases

GeneTreeiENSGT00790000122981.
HOGENOMiHOG000273862.
HOVERGENiHBG100885.
InParanoidiQ14DN9.
OMAiGADQKAK.
OrthoDBiEOG091G0IU8.
TreeFamiTF333615.

Miscellaneous databases

PROiQ14DN9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047117.
ExpressionAtlasiQ14DN9. baseline and differential.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
[Graphical view]
SMARTiSM00248. ANK. 10 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 8 hits.
PS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAKD1B_MOUSE
AccessioniPrimary (citable) accession number: Q14DN9
Secondary accession number(s): Q8BZP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 3, 2013
Last modified: November 2, 2016
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.