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Protein
Submitted name:

Axin-1

Gene

Axin1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathwayPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-195253 Degradation of beta-catenin by the destruction complex
R-MMU-196299 Beta-catenin phosphorylation cascade
R-MMU-201681 TCF dependent signaling in response to WNT
R-MMU-4641257 Degradation of AXIN
R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-MMU-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Submitted name:
Axin-1Imported
Submitted name:
Axin1 proteinImported
Gene namesi
Name:Axin1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1096327 Axin1

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSMUSG00000024182

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 216RGSInterPro annotationAdd BLAST124
Domaini750 – 832DIXInterPro annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili394 – 424Sequence analysisAdd BLAST31
Coiled coili710 – 733Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00390000010011
HOGENOMiHOG000231228
HOVERGENiHBG004324

Family and domain databases

CDDicd11582 Axin_TNKS_binding, 1 hit
Gene3Di1.10.196.10, 2 hits
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR029797 AXIN1
IPR014936 Axin_b-cat-bd
IPR032101 Axin_TNKS-bd
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10845:SF11 PTHR10845:SF11, 1 hit
PfamiView protein in Pfam
PF16646 AXIN1_TNKS_BD, 1 hit
PF08833 Axin_b-cat_bind, 1 hit
PF00778 DIX, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50841 DIX, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q14DJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSPKMNVQE QGFPLDLGAS FTEDAPRPPV PGEEGELVST DSRPVNHSFC
60 70 80 90 100
SGKGTSIKSE TSTATPRRSD LDLGYEPEGS ASPTPPYLRW AESLHSLLDD
110 120 130 140 150
QDGISLFRTF LKQEGCADLL DFWFACSGFR KLEPCDSNEE KRLKLARAIY
160 170 180 190 200
RKYILDSNGI VSRQTKPATK SFIKDCVMKQ QIDPAMFDQA QTEIQSTMEE
210 220 230 240 250
NTYPSFLKSD IYLEYTRTGS ESPKVCSDQS SGSGTGKGMS GYLPTLNEDE
260 270 280 290 300
EWKCDQDADE DDGRDPLPPS RLTQKLLLET AAPRAPSSRR YNEGRELRYG
310 320 330 340 350
SWREPVNPYY VNSGYALAPA TSANDSEQQS LSSDADTLSL TDSSVDGIPP
360 370 380 390 400
YRIRKQHRRE MQESIQVNGR VPLPHIPRTY RMPKEIRVEP QKFAEELIHR
410 420 430 440 450
LEAVQRTREA EEKLEERLKR VRMEEEGEDG EMPSGPMASH KLPSVPAWHH
460 470 480 490 500
FPPRYVDMGC SGLRDAHEEN PESILDEHVQ RVMRTPGCQS PGPGHRSPDS
510 520 530 540 550
GHVAKTAVLG GTASGHGKHV PKLGLKLDTA GLHHHRHVHH HVHHNSARPK
560 570 580 590 600
EQMEAEVARR VQSSFSWGPE THGHAKPRSY SENAGTTLSA GDLAFGGKTS
610 620 630 640 650
APSKRNTKKA ESGKNANAEV PSTTEDAEKN QKIMQWIIEG EKEISRHRKA
660 670 680 690 700
GHGSSGLRKQ QAHESSRPLS IERPGAVHPW VSAQLRNSVQ PSHLFIQDPT
710 720 730 740 750
MPPNPAPNPL TQLEEARRRL EEEEKRANKL PSKQRTKSQR KAGGGSAPPC
760 770 780 790 800
DSIVVAYYFC GEPIPYRTLV RGRAVTLGQF KELLTKKGSY RYYFKKVSDE
810 820 830
FDCGVVFEEV REDEAVLPVF EEKIIGKVEK VD
Length:832
Mass (Da):92,990
Last modified:August 22, 2006 - v1
Checksum:i020E1BB57C73CEBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126438 Genomic DNA No translation available.
AC140047 Genomic DNA No translation available.
BC113171 mRNA Translation: AAI13172.1
RefSeqiNP_001153070.1, NM_001159598.1
UniGeneiMm.23684

Genome annotation databases

EnsembliENSMUST00000118904; ENSMUSP00000113756; ENSMUSG00000024182
ENSMUST00000163421; ENSMUSP00000132000; ENSMUSG00000024182
GeneIDi12005
UCSCiuc008bdn.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ14DJ8_MOUSE
AccessioniPrimary (citable) accession number: Q14DJ8
Entry historyiIntegrated into UniProtKB/TrEMBL: August 22, 2006
Last sequence update: August 22, 2006
Last modified: June 20, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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