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Protein

Transmembrane protein 132B

Gene

TMEM132B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 132B
Gene namesi
Name:TMEM132B
Synonyms:KIAA1786, KIAA1906
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29397. TMEM132B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 903ExtracellularSequence analysisAdd BLAST903
Transmembranei904 – 924HelicalSequence analysisAdd BLAST21
Topological domaini925 – 1078CytoplasmicSequence analysisAdd BLAST154

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114795.
OpenTargetsiENSG00000139364.
PharmGKBiPA143485652.

Polymorphism and mutation databases

BioMutaiTMEM132B.
DMDMi145566963.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002846201 – 1078Transmembrane protein 132BAdd BLAST1078

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi343N-linked (GlcNAc...)Sequence analysis1
Glycosylationi366N-linked (GlcNAc...)Sequence analysis1
Glycosylationi381N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ14DG7.
PeptideAtlasiQ14DG7.
PRIDEiQ14DG7.

PTM databases

iPTMnetiQ14DG7.
PhosphoSitePlusiQ14DG7.

Expressioni

Gene expression databases

BgeeiENSG00000139364.
CleanExiHS_TMEM132B.
GenevisibleiQ14DG7. HS.

Organism-specific databases

HPAiHPA035661.
HPA035662.

Structurei

3D structure databases

ProteinModelPortaliQ14DG7.
SMRiQ14DG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM132 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4789. Eukaryota.
ENOG410XQCD. LUCA.
GeneTreeiENSGT00550000074550.
HOGENOMiHOG000154481.
HOVERGENiHBG108534.
InParanoidiQ14DG7.
KOiK17599.
OMAiGASVGHE.
OrthoDBiEOG091G013Z.
PhylomeDBiQ14DG7.
TreeFamiTF314981.

Family and domain databases

InterProiIPR026307. TMEM132.
IPR031436. TMEM132_C.
IPR031437. TMEM132_M.
IPR031435. TMEM132_N.
[Graphical view]
PANTHERiPTHR13388. PTHR13388. 1 hit.
PfamiPF16070. TMEM132. 1 hit.
PF15706. TMEM132D_C. 1 hit.
PF15705. TMEM132D_N. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14DG7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGAASRMDT TAVCTGGVTE SRGIVDSLQK FSSLPAYLPT NLHISNAEES
60 70 80 90 100
FFLKEANQDL TRNSSLQARV EPFFIYRART PPIINASYGP FSVEKIIPQE
110 120 130 140 150
LLLTSTAFGN MDKFPFNWKL KSHILDSSIY SNRPKVQTLF YVTGMGWDDS
160 170 180 190 200
DLTEDLPCVK MFAFPEAREV AASCRLQGAP GLCVAELELL PEWFSSGLDL
210 220 230 240 250
EPEEEIPALL GGTTMELFFT LYPADKAGQC PLEEEGKWEN NIHSGLESPQ
260 270 280 290 300
QAFPARERIG SVVVYPTQDD LKWSLVSLDE NVVISVPLNL VREGDTATFL
310 320 330 340 350
VSLTSSSVAD QFTLRIKAAA GVKITAVRVS SEDQWAVQEE IDNGSTQTSA
360 370 380 390 400
TLTCMGHRPD TQSRVNGSFY EILQVDFGID NSSDLAGAQQ ITWQVEYPIE
410 420 430 440 450
DSMSELVVSE IFVSQTTFVG IVPLAMDTEV LNTAILTGKP VSVPVKVVGV
460 470 480 490 500
QEDGSVVDVS ESVECKSADE DVIKVSNNCD SIFVNGKEMK SKVDTIVNFT
510 520 530 540 550
HQHFTSQFEV TVWAPRLPLQ IEISDTELSQ IKGWRIPVAA NRRPTRESDD
560 570 580 590 600
EDDEEKKGRG CSLQYQHATV RVLTQFVAES PDLGQLTYML GPDWQFDITD
610 620 630 640 650
LVTEFMKVEE PKIAQLQDGR TLAGREPGIT TVQVLSPLSD SILAEKTVIV
660 670 680 690 700
LDDRVTIAEL GVQLVAGMSL SLQPHRADKR AIVSTAAALD VLQSPQQEAI
710 720 730 740 750
VSSWILFSDG SVTPLDIYDP KDYSVTVSSL DEMVVSVQAN LESKWPIVVA
760 770 780 790 800
EGEGQGPLIK LEMMISEPCQ KTKRKSVLAV GKGNVKVKFE PSSDEHQGGS
810 820 830 840 850
NDIEGINREY KDHLSNSIER EGNQERAVQE WFHRGTPVGQ EESTNKSTTP
860 870 880 890 900
QSPMEGKNKL LKSGGPDAFT SFPTQGKSPD PNNPSDLTVT SRGLTDLEIG
910 920 930 940 950
MYALLCVFCL AILVFLINCV AFAWKYRHKR FAVSEQGNIP HSHDWVWLGN
960 970 980 990 1000
EVELLENPVD ITLPSEECTT MIDRGLQFEE RNFLLNGSSQ KTFHSQLLRP
1010 1020 1030 1040 1050
SDYVYEKEIK NEPMNSSGPK RKRVKFTSYT TILPEDGGPY TNSILFDSDD
1060 1070
NIKWVCQDMG LGDSQDFRDY MESLQDQM
Length:1,078
Mass (Da):119,477
Last modified:April 17, 2007 - v2
Checksum:i05119ADDA42AF379
GO
Isoform 2 (identifier: Q14DG7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     476-502: SNNCDSIFVNGKEMKSKVDTIVNFTHQ → RGDLSTAVLSAQSFLSFLLLSPRSCSH
     503-1078: Missing.

Note: No experimental confirmation available.
Show »
Length:502
Mass (Da):54,864
Checksum:i4F0BB45B9DB02306
GO
Isoform 3 (identifier: Q14DG7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-488: Missing.

Show »
Length:590
Mass (Da):66,097
Checksum:i1E16CF04D33A4F28
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti735V → G in BAC04053 (PubMed:14702039).Curated1
Sequence conflicti957N → D in BAC04053 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031786658A → V.1 PublicationCorresponds to variant rs16919359dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0245761 – 488Missing in isoform 3. 2 PublicationsAdd BLAST488
Alternative sequenceiVSP_024577476 – 502SNNCD…NFTHQ → RGDLSTAVLSAQSFLSFLLL SPRSCSH in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_024578503 – 1078Missing in isoform 2. 1 PublicationAdd BLAST576

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093028 Genomic DNA. No translation available.
AC026370 Genomic DNA. No translation available.
AC073618 Genomic DNA. No translation available.
AC004806 Genomic DNA. No translation available.
AC005146 Genomic DNA. No translation available.
AK093097 mRNA. Translation: BAC04053.1.
BC113366 mRNA. Translation: AAI13367.1.
BC113368 mRNA. Translation: AAI13369.1.
BC131621 mRNA. Translation: AAI31622.1.
AB058689 mRNA. Translation: BAB47415.1.
AB067493 mRNA. Translation: BAB67799.1.
CCDSiCCDS41859.1. [Q14DG7-1]
CCDS66501.1. [Q14DG7-3]
RefSeqiNP_001273148.1. NM_001286219.1. [Q14DG7-3]
NP_443139.2. NM_052907.3. [Q14DG7-1]
XP_011536156.1. XM_011537854.2. [Q14DG7-3]
UniGeneiHs.524838.
Hs.616436.

Genome annotation databases

EnsembliENST00000299308; ENSP00000299308; ENSG00000139364. [Q14DG7-1]
ENST00000613307; ENSP00000482788; ENSG00000139364. [Q14DG7-3]
GeneIDi114795.
KEGGihsa:114795.
UCSCiuc001uhe.3. human. [Q14DG7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093028 Genomic DNA. No translation available.
AC026370 Genomic DNA. No translation available.
AC073618 Genomic DNA. No translation available.
AC004806 Genomic DNA. No translation available.
AC005146 Genomic DNA. No translation available.
AK093097 mRNA. Translation: BAC04053.1.
BC113366 mRNA. Translation: AAI13367.1.
BC113368 mRNA. Translation: AAI13369.1.
BC131621 mRNA. Translation: AAI31622.1.
AB058689 mRNA. Translation: BAB47415.1.
AB067493 mRNA. Translation: BAB67799.1.
CCDSiCCDS41859.1. [Q14DG7-1]
CCDS66501.1. [Q14DG7-3]
RefSeqiNP_001273148.1. NM_001286219.1. [Q14DG7-3]
NP_443139.2. NM_052907.3. [Q14DG7-1]
XP_011536156.1. XM_011537854.2. [Q14DG7-3]
UniGeneiHs.524838.
Hs.616436.

3D structure databases

ProteinModelPortaliQ14DG7.
SMRiQ14DG7.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ14DG7.
PhosphoSitePlusiQ14DG7.

Polymorphism and mutation databases

BioMutaiTMEM132B.
DMDMi145566963.

Proteomic databases

PaxDbiQ14DG7.
PeptideAtlasiQ14DG7.
PRIDEiQ14DG7.

Protocols and materials databases

DNASUi114795.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299308; ENSP00000299308; ENSG00000139364. [Q14DG7-1]
ENST00000613307; ENSP00000482788; ENSG00000139364. [Q14DG7-3]
GeneIDi114795.
KEGGihsa:114795.
UCSCiuc001uhe.3. human. [Q14DG7-1]

Organism-specific databases

CTDi114795.
DisGeNETi114795.
GeneCardsiTMEM132B.
H-InvDBHIX0011124.
HGNCiHGNC:29397. TMEM132B.
HPAiHPA035661.
HPA035662.
neXtProtiNX_Q14DG7.
OpenTargetsiENSG00000139364.
PharmGKBiPA143485652.
HUGEiSearch...
Search...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4789. Eukaryota.
ENOG410XQCD. LUCA.
GeneTreeiENSGT00550000074550.
HOGENOMiHOG000154481.
HOVERGENiHBG108534.
InParanoidiQ14DG7.
KOiK17599.
OMAiGASVGHE.
OrthoDBiEOG091G013Z.
PhylomeDBiQ14DG7.
TreeFamiTF314981.

Miscellaneous databases

ChiTaRSiTMEM132B. human.
GenomeRNAii114795.
PROiQ14DG7.

Gene expression databases

BgeeiENSG00000139364.
CleanExiHS_TMEM132B.
GenevisibleiQ14DG7. HS.

Family and domain databases

InterProiIPR026307. TMEM132.
IPR031436. TMEM132_C.
IPR031437. TMEM132_M.
IPR031435. TMEM132_N.
[Graphical view]
PANTHERiPTHR13388. PTHR13388. 1 hit.
PfamiPF16070. TMEM132. 1 hit.
PF15706. TMEM132D_C. 1 hit.
PF15705. TMEM132D_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT132B_HUMAN
AccessioniPrimary (citable) accession number: Q14DG7
Secondary accession number(s): A2RRG8
, Q8NA73, Q96JN9, Q96PY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.