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Protein

Receptor-transporting protein 5

Gene

RTP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-transporting protein 5
Alternative name(s):
3CxxC-type zinc finger protein 5
CXXC-type zinc finger protein 11
Gene namesi
Name:RTP5
Synonyms:C2orf85, CXXC11, Z3CXXC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26585. RTP5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei544 – 56017HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717177.

Polymorphism and mutation databases

BioMutaiCXXC11.
DMDMi281371551.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Receptor-transporting protein 5PRO_0000348428Add
BLAST

Proteomic databases

PaxDbiQ14D33.
PRIDEiQ14D33.

PTM databases

PhosphoSiteiQ14D33.

Expressioni

Gene expression databases

BgeeiQ14D33.
ExpressionAtlasiQ14D33. baseline and differential.
GenevisibleiQ14D33. HS.

Organism-specific databases

HPAiHPA050902.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN2P356093EBI-10217913,EBI-77797
BEND5Q7L4P63EBI-10217913,EBI-724373
CALCOCO2Q131373EBI-10217913,EBI-739580
CARD9Q9H2573EBI-10217913,EBI-751319
DOCK8Q8NF50-23EBI-10217913,EBI-10174653
GOLGA2Q083793EBI-10217913,EBI-618309
HNRPKQ6IBN13EBI-10217913,EBI-3440248
KRT40Q6A1623EBI-10217913,EBI-10171697
LZTS2Q9BRK43EBI-10217913,EBI-741037
MDFIQ997503EBI-10217913,EBI-724076
MIPOL1Q8TD103EBI-10217913,EBI-2548751
MTUS2Q5JR593EBI-10217913,EBI-742948
PDE4DIPQ5VU433EBI-10217913,EBI-1105124
PNMA1Q8ND903EBI-10217913,EBI-302345
PNMA2Q9UL423EBI-10217913,EBI-302355
PSMA3P257883EBI-10217913,EBI-348380
PSMA6P609003EBI-10217913,EBI-357793
PSTPIP1O435863EBI-10217913,EBI-1050964
RBPMSQ930623EBI-10217913,EBI-740322
RINT1Q6NUQ13EBI-10217913,EBI-726876
ROPN1Q9HAT03EBI-10217913,EBI-1378139
SP100P234973EBI-10217913,EBI-751145
SPDL1Q96EA43EBI-10217913,EBI-715381
SPERTQ8NA613EBI-10217913,EBI-741724
TRAF1Q130773EBI-10217913,EBI-359224
TRIM23P364063EBI-10217913,EBI-740098
TSGA10Q9BZW73EBI-10217913,EBI-744794

GO - Molecular functioni

Protein-protein interaction databases

BioGridi130013. 27 interactions.
IntActiQ14D33. 27 interactions.
STRINGi9606.ENSP00000345374.

Structurei

3D structure databases

ProteinModelPortaliQ14D33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8R5. Eukaryota.
ENOG41114I2. LUCA.
GeneTreeiENSGT00530000063222.
HOGENOMiHOG000168479.
InParanoidiQ14D33.
OMAiFWLMCMC.
OrthoDBiEOG70S769.
PhylomeDBiQ14D33.
TreeFamiTF333246.

Family and domain databases

InterProiIPR026689. CXXC11.
IPR026096. R-trans_p.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERiPTHR14402. PTHR14402. 1 hit.
PTHR14402:SF2. PTHR14402:SF2. 1 hit.
PfamiPF13695. zf-3CxxC. 1 hit.
[Graphical view]
SMARTiSM01328. zf-3CxxC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14D33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRAGADMWA STFTLAMAER KPQDVWVLLP EHSLVPGCLD GGGVQYLLVG
60 70 80 90 100
LSRLQCGHCP GTWDSAHVHV LFHLWWDRAS HRGLVKMRIW GQRCRLCPAP
110 120 130 140 150
GDCQVRPPGE QPFLSRLVLH ILQDCYGDGP GPARHPREAY EGCCEACELG
160 170 180 190 200
VCFLQKAPDP AWSANATKGN FPATAWGGTG TVSRGKPLST PGDDLGKGGV
210 220 230 240 250
VIAIPFSLVG TSNDQVPIAE GPAPPAGASL PVTGSCEALV IGQGSIFLSG
260 270 280 290 300
DSVAMPGGKG FPVAIGDPLF HGPGLLGSSI QTFELKGFLF KGRGSLCSPV
310 320 330 340 350
GVAQGWGPIS LNNGLVPVGK HTPTVFYCVG LSASGEGSLT FPSSLTSIFT
360 370 380 390 400
NTLSEPTDGP VATKEASITF PFIFTDVKDA VAEVAEGNGK EGGGQGLVPV
410 420 430 440 450
GHDALPETNA GGLPSQVKGS LALPFPADVQ GKDAFTDITE GKEKEGGLVT
460 470 480 490 500
AGHDAPLEAN AEGPITVSEG CITIPFAVFD VIKRKGGGHV AYGPQGNGCF
510 520 530 540 550
SQGYYQKRQL RSRFHKARCG CRREEDERPG RACRRPHAEP YEDFWIWVSM
560 570
TVCVFWLMCM CRLNPGIYPQ QV
Length:572
Mass (Da):60,488
Last modified:December 15, 2009 - v2
Checksum:i00A839AA4AEC48BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti241 – 2411I → T in BAC03544 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti101 – 1011G → E.3 Publications
Corresponds to variant rs7420371 [ dbSNP | Ensembl ].
VAR_060791
Natural varianti412 – 4121G → D.1 Publication
VAR_069402

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090909 mRNA. Translation: BAC03544.1.
AC131097 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW71299.1.
BC113517 mRNA. Translation: AAI13518.1.
BC113519 mRNA. Translation: AAI13520.1.
CCDSiCCDS42843.1.
RefSeqiNP_776182.2. NM_173821.2.
UniGeneiHs.376307.

Genome annotation databases

EnsembliENST00000343216; ENSP00000345374; ENSG00000188011.
ENST00000617264; ENSP00000482049; ENSG00000277949.
GeneIDi285093.
KEGGihsa:285093.
UCSCiuc010fzu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090909 mRNA. Translation: BAC03544.1.
AC131097 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW71299.1.
BC113517 mRNA. Translation: AAI13518.1.
BC113519 mRNA. Translation: AAI13520.1.
CCDSiCCDS42843.1.
RefSeqiNP_776182.2. NM_173821.2.
UniGeneiHs.376307.

3D structure databases

ProteinModelPortaliQ14D33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130013. 27 interactions.
IntActiQ14D33. 27 interactions.
STRINGi9606.ENSP00000345374.

PTM databases

PhosphoSiteiQ14D33.

Polymorphism and mutation databases

BioMutaiCXXC11.
DMDMi281371551.

Proteomic databases

PaxDbiQ14D33.
PRIDEiQ14D33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343216; ENSP00000345374; ENSG00000188011.
ENST00000617264; ENSP00000482049; ENSG00000277949.
GeneIDi285093.
KEGGihsa:285093.
UCSCiuc010fzu.2. human.

Organism-specific databases

CTDi285093.
GeneCardsiRTP5.
HGNCiHGNC:26585. RTP5.
HPAiHPA050902.
neXtProtiNX_Q14D33.
PharmGKBiPA164717177.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8R5. Eukaryota.
ENOG41114I2. LUCA.
GeneTreeiENSGT00530000063222.
HOGENOMiHOG000168479.
InParanoidiQ14D33.
OMAiFWLMCMC.
OrthoDBiEOG70S769.
PhylomeDBiQ14D33.
TreeFamiTF333246.

Miscellaneous databases

GenomeRNAii285093.
NextBioi95267.
PROiQ14D33.

Gene expression databases

BgeeiQ14D33.
ExpressionAtlasiQ14D33. baseline and differential.
GenevisibleiQ14D33. HS.

Family and domain databases

InterProiIPR026689. CXXC11.
IPR026096. R-trans_p.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERiPTHR14402. PTHR14402. 1 hit.
PTHR14402:SF2. PTHR14402:SF2. 1 hit.
PfamiPF13695. zf-3CxxC. 1 hit.
[Graphical view]
SMARTiSM01328. zf-3CxxC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-101.
    Tissue: Amygdala.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-101.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-101.
    Tissue: Brain.
  5. Cited for: VARIANT ASP-412.

Entry informationi

Entry nameiRTP5_HUMAN
AccessioniPrimary (citable) accession number: Q14D33
Secondary accession number(s): Q8N2A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 15, 2009
Last modified: May 11, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.