Q14D04 (MELT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ventricular zone-expressed PH domain-containing protein homolog 1

Alternative name(s):
Protein melted

Gene names

Name:	VEPH1
Synonyms:	KIAA1692, VEPH

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	833 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Domain	The PH domain is required for membrane targeting By similarity.
Sequence similarities	Belongs to the MELT/VEPH family. Contains 1 PH domain.
Sequence caution	The sequence BAB14165.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB21783.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14D04-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14D04-2)

The sequence of this isoform differs from the canonical sequence as follows:
     626-670: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q14D04-3)

The sequence of this isoform differs from the canonical sequence as follows:
     178-213: NTMLLRVLPAVYEKQPQPINRHLTELLALMSQLEQP → MVRKLSLGTCFGRYLKVFSSSIYGLWEARPRVLEAN
     214-833: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 833	833	Ventricular zone-expressed PH domain-containing protein homolog 1		PRO_0000297955
Regions
	Domain	716 – 819	104	PH
Amino acid modifications
	Modified residue	783	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	178 – 213	36	NTMLL…QLEQP → MVRKLSLGTCFGRYLKVFSS SIYGLWEARPRVLEAN in isoform 3.		VSP_027431
	Alternative sequence	214 – 833	620	Missing in isoform 3.		VSP_027432
	Alternative sequence	626 – 670	45	Missing in isoform 2.		VSP_027433
	Natural variant	208	1	S → C. Corresponds to variant rs34559487 [ dbSNP | Ensembl ].		VAR_034692
	Natural variant	263	1	V → G. Ref.3 Corresponds to variant rs1378796 [ dbSNP | Ensembl ].		VAR_034693
	Natural variant	271	1	S → C. Corresponds to variant rs1378795 [ dbSNP | Ensembl ].		VAR_034694
	Natural variant	319	1	M → V. Corresponds to variant rs11923380 [ dbSNP | Ensembl ].		VAR_034695
	Natural variant	329	1	L → V. Corresponds to variant rs34823544 [ dbSNP | Ensembl ].		VAR_034696
	Natural variant	365	1	R → Q. Corresponds to variant rs16827563 [ dbSNP | Ensembl ].		VAR_034697
	Natural variant	501	1	S → L. Corresponds to variant rs59504298 [ dbSNP | Ensembl ].		VAR_061683
	Natural variant	522	1	S → P. Ref.5 Corresponds to variant rs11918974 [ dbSNP | Ensembl ].		VAR_034698
Experimental info
	Sequence conflict	259	1	I → M in BAB55243. Ref.2
	Sequence conflict	808	1	E → A in BAB55243. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 34995B4AB43474A4	FASTA	833	94,745
	10 20 30 40 50 60 MHQLFRLVLG QKDLSRAGDL FSLDDSEIED SLTEALEQIK IISSSSDYQT NNNDQAVVEI 70 80 90 100 110 120 CITRITTAIR ETESIEKHAK ALVGLWDSCL EHNLRPFGKD EDTPHAKIAS DIMSCILQNY 130 140 150 160 170 180 NRPPVMALAI PIAVKFLHRG NKELCRNMSN YLSLAAITKA DLLADHTEVI VKSILQGNTM 190 200 210 220 230 240 LLRVLPAVYE KQPQPINRHL TELLALMSQL EQPEQYHLLR LLHVAAKKKQ LEVVQKCIPF 250 260 270 280 290 300 LIGHLKDSTH NDIILNILIE IAVYEPVALN SFLPMLKEIG ERFPYLTGQM ARIYGAVGHV 310 320 330 340 350 360 DEERARSCLT YLVSQLANME HSFHHILLLE IKSITDTFSS ILGPQSRDIF RMSNSFTAIA 370 380 390 400 410 420 KLLTRQLENT KAGSGRRKIS TEIEFPEKLE ETKLIVTENE DHEKLQVKIQ AFEDKINAGS 430 440 450 460 470 480 NTPGSIRRYS LGQVSKEERK NIRFNRSKSL AFHTMLTKGV GSDDGEDENR GDIPASISLS 490 500 510 520 530 540 EIDPLGQGND KLPFKTDTER SQLGESSVSY PNIIHIDSEN LSETVKENSQ EETPETTASP 550 560 570 580 590 600 IEYQDKLYLH LKKNLSKVKA YAMEIGKKIP VPDQCTIEDT VRSCVAKLFF TCSLKGHYCL 610 620 630 640 650 660 YSKSSFILIS QEPQPWIQIM FLFQQSLFPE PLSIQSHSVQ FLRALWEKTQ AGGAHSFETA 670 680 690 700 710 720 MMESTFPQQK DLDQVQLHLE EVRFFDVFGF SETAGAWQCF MCNNPEKATV VNQDGQPLIE 730 740 750 760 770 780 GKLKEKQVRW KFIKRWKTRY FTLAGNQLLF QKGKSKDDPD DCPIELSKVQ SVKAVAKKRR 790 800 810 820 830 DRSLPRAFEI FTDNKTYVFK AKDEKNAEEW LQCINVAVAQ AKERESREVT TYL
	Isoform 2 [UniParc]. Checksum: 4D65E7A98FFF7854	FASTA	788	89,684
	10 20 30 40 50 60 MHQLFRLVLG QKDLSRAGDL FSLDDSEIED SLTEALEQIK IISSSSDYQT NNNDQAVVEI 70 80 90 100 110 120 CITRITTAIR ETESIEKHAK ALVGLWDSCL EHNLRPFGKD EDTPHAKIAS DIMSCILQNY 130 140 150 160 170 180 NRPPVMALAI PIAVKFLHRG NKELCRNMSN YLSLAAITKA DLLADHTEVI VKSILQGNTM 190 200 210 220 230 240 LLRVLPAVYE KQPQPINRHL TELLALMSQL EQPEQYHLLR LLHVAAKKKQ LEVVQKCIPF 250 260 270 280 290 300 LIGHLKDSTH NDIILNILIE IAVYEPVALN SFLPMLKEIG ERFPYLTGQM ARIYGAVGHV 310 320 330 340 350 360 DEERARSCLT YLVSQLANME HSFHHILLLE IKSITDTFSS ILGPQSRDIF RMSNSFTAIA 370 380 390 400 410 420 KLLTRQLENT KAGSGRRKIS TEIEFPEKLE ETKLIVTENE DHEKLQVKIQ AFEDKINAGS 430 440 450 460 470 480 NTPGSIRRYS LGQVSKEERK NIRFNRSKSL AFHTMLTKGV GSDDGEDENR GDIPASISLS 490 500 510 520 530 540 EIDPLGQGND KLPFKTDTER SQLGESSVSY PNIIHIDSEN LSETVKENSQ EETPETTASP 550 560 570 580 590 600 IEYQDKLYLH LKKNLSKVKA YAMEIGKKIP VPDQCTIEDT VRSCVAKLFF TCSLKGHYCL 610 620 630 640 650 660 YSKSSFILIS QEPQPWIQIM FLFQQDLDQV QLHLEEVRFF DVFGFSETAG AWQCFMCNNP 670 680 690 700 710 720 EKATVVNQDG QPLIEGKLKE KQVRWKFIKR WKTRYFTLAG NQLLFQKGKS KDDPDDCPIE 730 740 750 760 770 780 LSKVQSVKAV AKKRRDRSLP RAFEIFTDNK TYVFKAKDEK NAEEWLQCIN VAVAQAKERE SREVTTYL
	Isoform 3 [UniParc]. Checksum: 16757EB780A31BF8	FASTA	213	23,877
	10 20 30 40 50 60 MHQLFRLVLG QKDLSRAGDL FSLDDSEIED SLTEALEQIK IISSSSDYQT NNNDQAVVEI 70 80 90 100 110 120 CITRITTAIR ETESIEKHAK ALVGLWDSCL EHNLRPFGKD EDTPHAKIAS DIMSCILQNY 130 140 150 160 170 180 NRPPVMALAI PIAVKFLHRG NKELCRNMSN YLSLAAITKA DLLADHTEVI VKSILQGMVR 190 200 210 KLSLGTCFGR YLKVFSSSIY GLWEARPRVL EAN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed: 11214970] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-263. Tissue: Brain.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT PRO-522. Tissue: Brain, Kidney and Skin.
[6]	"Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates." Muto E., Tabata Y., Taneda T., Aoki Y., Muto A., Arai K., Watanabe S. Biochimie 86:523-531(2004) [PubMed: 15388229] [Abstract] Cited for: IDENTIFICATION.
[7]	"Drosophila Melted modulates FOXO and TOR activity." Teleman A.A., Chen Y.-W., Cohen S.M. Dev. Cell 9:271-281(2005) [PubMed: 16054033] [Abstract] Cited for: IDENTIFICATION.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-783, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB051479 mRNA. Translation: BAB21783.1. Different initiation. AK022666 mRNA. Translation: BAB14165.1. Different initiation. AK027625 mRNA. Translation: BAB55243.1. AL713656 mRNA. Translation: CAD28465.2. CH471052 Genomic DNA. Translation: EAW78705.1. CH471052 Genomic DNA. Translation: EAW78706.1. CH471052 Genomic DNA. Translation: EAW78707.1. BC042159 mRNA. Translation: AAH42159.1. BC057999 mRNA. Translation: AAH57999.1. BC101660 mRNA. Translation: AAI01661.1. BC111017 mRNA. Translation: AAI11018.1. BC113555 mRNA. Translation: AAI13556.1.
IPI	IPI00447507. IPI00478192. IPI00855826.
RefSeq	NP_001161383.1. NM_001167911.1. NP_001161384.1. NM_001167912.1. NP_001161387.1. NM_001167915.1. NP_001161388.1. NM_001167916.1. NP_078897.2. NM_024621.2.
UniGene	Hs.658046.
3D structure databases
ProteinModelPortal	Q14D04.
SMR	Q14D04. Positions 713-822.
ModBase	Search...
Protein-protein interaction databases
STRING	Q14D04.
PTM databases
PhosphoSite	Q14D04.
Polymorphism databases
DMDM	121946695.
Proteomic databases
PRIDE	Q14D04.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000362010; ENSP00000354919; ENSG00000197415. ENST00000392832; ENSP00000376577; ENSG00000197415.
GeneID	79674.
KEGG	hsa:79674.
UCSC	uc003fbj.1. human. uc003fbm.2. human. uc010hvu.1. human.
Organism-specific databases
CTD	79674.
GeneCards	GC03M156977.
H-InvDB	HIX0003801.
HGNC	HGNC:25735. VEPH1.
HPA	HPA026645.
MIM	609594. gene.
neXtProt	NX_Q14D04.
PharmGKB	PA134952229.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06055.
GeneTree	ENSGT00390000018660.
HOVERGEN	HBG097059.
InParanoid	Q14D04.
OMA	IPFLIGH.
OrthoDB	EOG40K7Z5.
PhylomeDB	Q14D04.
Gene expression databases
ArrayExpress	Q14D04.
Bgee	Q14D04.
Genevestigator	Q14D04.
Family and domain databases
InterPro	IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
Pfam	PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	68910.
SOURCE	Search...

Entry information

Entry name

MELT_HUMAN

Accession

Primary (citable) accession number: Q14D04
Secondary accession number(s): D3DNL0 , Q2TAA9, Q3MIX2, Q6PEL3, Q86TL5, Q8TCR3, Q96SP7, Q9C0H1, Q9H9Q7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	August 22, 2006
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.