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Q14CX7

- NAA25_HUMAN

UniProt

Q14CX7 - NAA25_HUMAN

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Protein

N-alpha-acetyltransferase 25, NatB auxiliary subunit

Gene

NAA25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 25, NatB auxiliary subunit
Alternative name(s):
Mitochondrial distribution and morphology protein 20
N-terminal acetyltransferase B complex subunit MDM20
Short name:
NatB complex subunit MDM20
N-terminal acetyltransferase B complex subunit NAA25
p120
Gene namesi
Name:NAA25
Synonyms:C12orf30, MDM20, NAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:25783. NAA25.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165513030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 972972N-alpha-acetyltransferase 25, NatB auxiliary subunitPRO_0000294337Add
BLAST

Proteomic databases

MaxQBiQ14CX7.
PaxDbiQ14CX7.
PRIDEiQ14CX7.

PTM databases

PhosphoSiteiQ14CX7.

Expressioni

Gene expression databases

BgeeiQ14CX7.
CleanExiHS_C12orf30.
ExpressionAtlasiQ14CX7. baseline and differential.
GenevestigatoriQ14CX7.

Organism-specific databases

HPAiHPA039322.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK2P249411EBI-1048503,EBI-375096

Protein-protein interaction databases

BioGridi123072. 9 interactions.
IntActiQ14CX7. 2 interactions.
STRINGi9606.ENSP00000261745.

Structurei

3D structure databases

ProteinModelPortaliQ14CX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 4434TPR 1Add
BLAST
Repeati45 – 7834TPR 2Add
BLAST
Repeati79 – 11234TPR 3Add
BLAST
Repeati114 – 14633TPR 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi871 – 8777Poly-Lys

Sequence similaritiesi

Belongs to the MDM20/NAA25 family.Curated
Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG259643.
GeneTreeiENSGT00390000003496.
HOGENOMiHOG000060132.
InParanoidiQ14CX7.
KOiK17973.
OMAiQCTKFIN.
OrthoDBiEOG75F4CR.
PhylomeDBiQ14CX7.
TreeFamiTF315103.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR019183. N-acetylTrfase_B_cplx_non-cat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF09797. NatB_MDM20. 1 hit.
[Graphical view]
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14CX7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRGHVQDP NDRRLRPIYD YLDNGNNKMA IQQADKLLKK HKDLHCAKVL
60 70 80 90 100
KAIGLQRTGK QEEAFTLAQE VAALEPTDDN SLQALTILYR EMHRPELVTK
110 120 130 140 150
LYEAAVKKVP NSEEYHSHLF MAYARVGEYK KMQQAGMALY KIVPKNPYYF
160 170 180 190 200
WSVMSLIMQS ISAQDENLSK TMFLPLAERM VEKMVKEDKI EAEAEVELYY
210 220 230 240 250
MILERLGKYQ EALDVIRGKL GEKLTSEIQS RENKCMAMYK KLSRWPECNA
260 270 280 290 300
LSRRLLLKNS DDWQFYLTYF DSVFRLIEEA WSPPAEGEHS LEGEVHYSAE
310 320 330 340 350
KAVKFIEDRI TEESKSSRHL RGPHLAKLEL IRRLRSQGCN DEYKLGDPEE
360 370 380 390 400
LMFQYFKKFG DKPCCFTDLK VFVDLLPATQ CTKFINQLLG VVPLSTPTED
410 420 430 440 450
KLALPADIRA LQQHLCVVQL TRLLGLYHTM DKNQKLSVVR ELMLRYQHGL
460 470 480 490 500
EFGKTCLKTE LQFSDYYCLL AVHALIDVWR ETGDETTVWQ ALTLLEEGLT
510 520 530 540 550
HSPSNAQFKL LLVRIYCMLG AFEPVVDLYS SLDAKHIQHD TIGYLLTRYA
560 570 580 590 600
ESLGQYAAAS QSCNFALRFF HSNQKDTSEY IIQAYKYGAF EKIPEFIAFR
610 620 630 640 650
NRLNNSLHFA QVRTERMLLD LLLEANISTS LAESIKSMNL RPEEDDIPWE
660 670 680 690 700
DLRDNRDLNV FFSWDPKDRD VSEEHKKLSL EEETLWLRIR SLTLRLISGL
710 720 730 740 750
PSLNHPVEPK NSEKTAENGV SSRIDILRLL LQQLEATLET GKRFIEKDIQ
760 770 780 790 800
YPFLGPVPTR MGGFFNSGCS QCQISSFYLV NDIYELDTSG LEDTMEIQER
810 820 830 840 850
IENSFKSLLD QLKDVFSKCK GDLLEVKDGN LKTHPTLLEN LVFFVETISV
860 870 880 890 900
ILWVSSYCES VLRPYKLNLQ KKKKKKKETS IIMPPVFTSF QDYVTGLQTL
910 920 930 940 950
ISNVVDHIKG LETHLIALKL EELILEDTSL SPEERKFSKT VQGKVQSSYL
960 970
HSLLEMGELL KKRLETTKKL KI
Length:972
Mass (Da):112,292
Last modified:August 22, 2006 - v1
Checksum:i232B8FD14447DDD6
GO
Isoform 2 (identifier: Q14CX7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     847-859: TISVILWVSSYCE → VSFCSLPKRHCCS
     860-972: Missing.

Note: No experimental confirmation available.

Show »
Length:859
Mass (Da):99,269
Checksum:i5918C0A1EB63A438
GO

Sequence cautioni

The sequence BAB14432.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAE46062.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021I → T in BAB14432. (PubMed:14702039)Curated
Sequence conflicti466 – 4661Y → S in BAB14432. (PubMed:14702039)Curated
Sequence conflicti672 – 6721S → T in BAB14432. (PubMed:14702039)Curated
Sequence conflicti817 – 8171S → G in CAE46062. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti426 – 4261L → F.
Corresponds to variant rs16941860 [ dbSNP | Ensembl ].
VAR_054099
Natural varianti789 – 7891S → R in a breast cancer sample; somatic mutation. 1 Publication
VAR_035872
Natural varianti876 – 8761K → R.
Corresponds to variant rs12231744 [ dbSNP | Ensembl ].
VAR_033156
Natural varianti915 – 9151L → I.
Corresponds to variant rs12298022 [ dbSNP | Ensembl ].
VAR_054100

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei847 – 85913TISVI…SSYCE → VSFCSLPKRHCCS in isoform 2. 1 PublicationVSP_026629Add
BLAST
Alternative sequencei860 – 972113Missing in isoform 2. 1 PublicationVSP_026630Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB054990 mRNA. Translation: BAC80174.1.
BX641140 mRNA. Translation: CAE46062.1. Different initiation.
BC034357 mRNA. Translation: AAH34357.1.
BC113585 mRNA. Translation: AAI13586.1.
BC113587 mRNA. Translation: AAI13588.1.
AK023151 mRNA. Translation: BAB14432.1. Different initiation.
CCDSiCCDS9159.1. [Q14CX7-1]
RefSeqiNP_079229.2. NM_024953.3. [Q14CX7-1]
UniGeneiHs.530941.

Genome annotation databases

EnsembliENST00000261745; ENSP00000261745; ENSG00000111300. [Q14CX7-1]
GeneIDi80018.
KEGGihsa:80018.
UCSCiuc001ttm.3. human. [Q14CX7-1]

Polymorphism databases

DMDMi121948761.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB054990 mRNA. Translation: BAC80174.1 .
BX641140 mRNA. Translation: CAE46062.1 . Different initiation.
BC034357 mRNA. Translation: AAH34357.1 .
BC113585 mRNA. Translation: AAI13586.1 .
BC113587 mRNA. Translation: AAI13588.1 .
AK023151 mRNA. Translation: BAB14432.1 . Different initiation.
CCDSi CCDS9159.1. [Q14CX7-1 ]
RefSeqi NP_079229.2. NM_024953.3. [Q14CX7-1 ]
UniGenei Hs.530941.

3D structure databases

ProteinModelPortali Q14CX7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123072. 9 interactions.
IntActi Q14CX7. 2 interactions.
STRINGi 9606.ENSP00000261745.

PTM databases

PhosphoSitei Q14CX7.

Polymorphism databases

DMDMi 121948761.

Proteomic databases

MaxQBi Q14CX7.
PaxDbi Q14CX7.
PRIDEi Q14CX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261745 ; ENSP00000261745 ; ENSG00000111300 . [Q14CX7-1 ]
GeneIDi 80018.
KEGGi hsa:80018.
UCSCi uc001ttm.3. human. [Q14CX7-1 ]

Organism-specific databases

CTDi 80018.
GeneCardsi GC12M112464.
H-InvDB HIX0011004.
HGNCi HGNC:25783. NAA25.
HPAi HPA039322.
MIMi 612755. gene.
neXtProti NX_Q14CX7.
PharmGKBi PA165513030.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259643.
GeneTreei ENSGT00390000003496.
HOGENOMi HOG000060132.
InParanoidi Q14CX7.
KOi K17973.
OMAi QCTKFIN.
OrthoDBi EOG75F4CR.
PhylomeDBi Q14CX7.
TreeFami TF315103.

Miscellaneous databases

ChiTaRSi NAA25. human.
GenomeRNAii 80018.
NextBioi 70134.
PROi Q14CX7.
SOURCEi Search...

Gene expression databases

Bgeei Q14CX7.
CleanExi HS_C12orf30.
ExpressionAtlasi Q14CX7. baseline and differential.
Genevestigatori Q14CX7.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR019183. N-acetylTrfase_B_cplx_non-cat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
Pfami PF09797. NatB_MDM20. 1 hit.
[Graphical view ]
PROSITEi PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "P120 which associates with nascent polypeptide chain."
    Hotokezaka H., Wiedmann M.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterine endothelium.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 100-972.
  5. "Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression."
    Starheim K.K., Arnesen T., Gromyko D., Ryningen A., Varhaug J.E., Lillehaug J.R.
    Biochem. J. 415:325-331(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NAT5, SUBCELLULAR LOCATION.
  6. "A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates."
    Polevoda B., Arnesen T., Sherman F.
    BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-789.

Entry informationi

Entry nameiNAA25_HUMAN
AccessioniPrimary (citable) accession number: Q14CX7
Secondary accession number(s): A0JLU7
, Q6MZH1, Q7Z4N6, Q9H911
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: August 22, 2006
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3