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Protein

N-alpha-acetyltransferase 25, NatB auxiliary subunit

Gene

NAA25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.1 Publication

GO - Biological processi

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000111300-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 25, NatB auxiliary subunit
Alternative name(s):
Mitochondrial distribution and morphology protein 20
N-terminal acetyltransferase B complex subunit MDM20
Short name:
NatB complex subunit MDM20
N-terminal acetyltransferase B complex subunit NAA25
p120
Gene namesi
Name:NAA25
Synonyms:C12orf30, MDM20, NAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111300.9
HGNCiHGNC:25783 NAA25
MIMi612755 gene
neXtProtiNX_Q14CX7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi80018
OpenTargetsiENSG00000111300
PharmGKBiPA165513030

Polymorphism and mutation databases

BioMutaiNAA25
DMDMi121948761

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943371 – 972N-alpha-acetyltransferase 25, NatB auxiliary subunitAdd BLAST972

Proteomic databases

EPDiQ14CX7
MaxQBiQ14CX7
PaxDbiQ14CX7
PeptideAtlasiQ14CX7
PRIDEiQ14CX7

PTM databases

iPTMnetiQ14CX7
PhosphoSitePlusiQ14CX7

Expressioni

Gene expression databases

BgeeiENSG00000111300
CleanExiHS_C12orf30
ExpressionAtlasiQ14CX7 baseline and differential
GenevisibleiQ14CX7 HS

Organism-specific databases

HPAiHPA039322

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.

Protein-protein interaction databases

BioGridi123072, 15 interactors
DIPiDIP-50826N
IntActiQ14CX7, 3 interactors
STRINGi9606.ENSP00000261745

Structurei

3D structure databases

ProteinModelPortaliQ14CX7
SMRiQ14CX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 44TPR 1Add BLAST34
Repeati45 – 78TPR 2Add BLAST34
Repeati79 – 112TPR 3Add BLAST34
Repeati114 – 146TPR 4Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi871 – 877Poly-Lys7

Sequence similaritiesi

Belongs to the MDM20/NAA25 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG2053 Eukaryota
ENOG410XRXD LUCA
GeneTreeiENSGT00390000003496
HOGENOMiHOG000060132
InParanoidiQ14CX7
KOiK17973
OMAiHTMDKNQ
OrthoDBiEOG091G029K
PhylomeDBiQ14CX7
TreeFamiTF315103

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR019183 N-acetylTrfase_B_cplx_non-cat
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR22767:SF3 PTHR22767:SF3, 1 hit
PfamiView protein in Pfam
PF09797 NatB_MDM20, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14CX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRGHVQDP NDRRLRPIYD YLDNGNNKMA IQQADKLLKK HKDLHCAKVL
60 70 80 90 100
KAIGLQRTGK QEEAFTLAQE VAALEPTDDN SLQALTILYR EMHRPELVTK
110 120 130 140 150
LYEAAVKKVP NSEEYHSHLF MAYARVGEYK KMQQAGMALY KIVPKNPYYF
160 170 180 190 200
WSVMSLIMQS ISAQDENLSK TMFLPLAERM VEKMVKEDKI EAEAEVELYY
210 220 230 240 250
MILERLGKYQ EALDVIRGKL GEKLTSEIQS RENKCMAMYK KLSRWPECNA
260 270 280 290 300
LSRRLLLKNS DDWQFYLTYF DSVFRLIEEA WSPPAEGEHS LEGEVHYSAE
310 320 330 340 350
KAVKFIEDRI TEESKSSRHL RGPHLAKLEL IRRLRSQGCN DEYKLGDPEE
360 370 380 390 400
LMFQYFKKFG DKPCCFTDLK VFVDLLPATQ CTKFINQLLG VVPLSTPTED
410 420 430 440 450
KLALPADIRA LQQHLCVVQL TRLLGLYHTM DKNQKLSVVR ELMLRYQHGL
460 470 480 490 500
EFGKTCLKTE LQFSDYYCLL AVHALIDVWR ETGDETTVWQ ALTLLEEGLT
510 520 530 540 550
HSPSNAQFKL LLVRIYCMLG AFEPVVDLYS SLDAKHIQHD TIGYLLTRYA
560 570 580 590 600
ESLGQYAAAS QSCNFALRFF HSNQKDTSEY IIQAYKYGAF EKIPEFIAFR
610 620 630 640 650
NRLNNSLHFA QVRTERMLLD LLLEANISTS LAESIKSMNL RPEEDDIPWE
660 670 680 690 700
DLRDNRDLNV FFSWDPKDRD VSEEHKKLSL EEETLWLRIR SLTLRLISGL
710 720 730 740 750
PSLNHPVEPK NSEKTAENGV SSRIDILRLL LQQLEATLET GKRFIEKDIQ
760 770 780 790 800
YPFLGPVPTR MGGFFNSGCS QCQISSFYLV NDIYELDTSG LEDTMEIQER
810 820 830 840 850
IENSFKSLLD QLKDVFSKCK GDLLEVKDGN LKTHPTLLEN LVFFVETISV
860 870 880 890 900
ILWVSSYCES VLRPYKLNLQ KKKKKKKETS IIMPPVFTSF QDYVTGLQTL
910 920 930 940 950
ISNVVDHIKG LETHLIALKL EELILEDTSL SPEERKFSKT VQGKVQSSYL
960 970
HSLLEMGELL KKRLETTKKL KI
Length:972
Mass (Da):112,292
Last modified:August 22, 2006 - v1
Checksum:i232B8FD14447DDD6
GO
Isoform 2 (identifier: Q14CX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     847-859: TISVILWVSSYCE → VSFCSLPKRHCCS
     860-972: Missing.

Note: No experimental confirmation available.
Show »
Length:859
Mass (Da):99,269
Checksum:i5918C0A1EB63A438
GO

Sequence cautioni

The sequence BAB14432 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAE46062 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202I → T in BAB14432 (PubMed:14702039).Curated1
Sequence conflicti466Y → S in BAB14432 (PubMed:14702039).Curated1
Sequence conflicti672S → T in BAB14432 (PubMed:14702039).Curated1
Sequence conflicti817S → G in CAE46062 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054099426L → F. Corresponds to variant dbSNP:rs16941860Ensembl.1
Natural variantiVAR_035872789S → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_033156876K → R. Corresponds to variant dbSNP:rs12231744Ensembl.1
Natural variantiVAR_054100915L → I. Corresponds to variant dbSNP:rs12298022Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026629847 – 859TISVI…SSYCE → VSFCSLPKRHCCS in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_026630860 – 972Missing in isoform 2. 1 PublicationAdd BLAST113

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054990 mRNA Translation: BAC80174.1
BX641140 mRNA Translation: CAE46062.1 Different initiation.
BC034357 mRNA Translation: AAH34357.1
BC113585 mRNA Translation: AAI13586.1
BC113587 mRNA Translation: AAI13588.1
AK023151 mRNA Translation: BAB14432.1 Different initiation.
CCDSiCCDS9159.1 [Q14CX7-1]
RefSeqiNP_079229.2, NM_024953.3 [Q14CX7-1]
UniGeneiHs.530941

Genome annotation databases

EnsembliENST00000261745; ENSP00000261745; ENSG00000111300 [Q14CX7-1]
GeneIDi80018
KEGGihsa:80018
UCSCiuc001ttm.4 human [Q14CX7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNAA25_HUMAN
AccessioniPrimary (citable) accession number: Q14CX7
Secondary accession number(s): A0JLU7
, Q6MZH1, Q7Z4N6, Q9H911
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: August 22, 2006
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health