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Protein

N-alpha-acetyltransferase 25, NatB auxiliary subunit

Gene

NAA25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 25, NatB auxiliary subunit
Alternative name(s):
Mitochondrial distribution and morphology protein 20
N-terminal acetyltransferase B complex subunit MDM20
Short name:
NatB complex subunit MDM20
N-terminal acetyltransferase B complex subunit NAA25
p120
Gene namesi
Name:NAA25
Synonyms:C12orf30, MDM20, NAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25783. NAA25.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi80018.
OpenTargetsiENSG00000111300.
PharmGKBiPA165513030.

Polymorphism and mutation databases

BioMutaiNAA25.
DMDMi121948761.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943371 – 972N-alpha-acetyltransferase 25, NatB auxiliary subunitAdd BLAST972

Proteomic databases

EPDiQ14CX7.
MaxQBiQ14CX7.
PaxDbiQ14CX7.
PeptideAtlasiQ14CX7.
PRIDEiQ14CX7.

PTM databases

iPTMnetiQ14CX7.
PhosphoSitePlusiQ14CX7.

Expressioni

Gene expression databases

BgeeiENSG00000111300.
CleanExiHS_C12orf30.
ExpressionAtlasiQ14CX7. baseline and differential.
GenevisibleiQ14CX7. HS.

Organism-specific databases

HPAiHPA039322.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.

Protein-protein interaction databases

BioGridi123072. 13 interactors.
DIPiDIP-50826N.
IntActiQ14CX7. 2 interactors.
STRINGi9606.ENSP00000261745.

Structurei

3D structure databases

ProteinModelPortaliQ14CX7.
SMRiQ14CX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 44TPR 1Add BLAST34
Repeati45 – 78TPR 2Add BLAST34
Repeati79 – 112TPR 3Add BLAST34
Repeati114 – 146TPR 4Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi871 – 877Poly-Lys7

Sequence similaritiesi

Belongs to the MDM20/NAA25 family.Curated
Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG2053. Eukaryota.
ENOG410XRXD. LUCA.
GeneTreeiENSGT00390000003496.
HOGENOMiHOG000060132.
InParanoidiQ14CX7.
KOiK17973.
OMAiEKDIQYP.
OrthoDBiEOG091G029K.
PhylomeDBiQ14CX7.
TreeFamiTF315103.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR019183. N-acetylTrfase_B_cplx_non-cat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF09797. NatB_MDM20. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14CX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRGHVQDP NDRRLRPIYD YLDNGNNKMA IQQADKLLKK HKDLHCAKVL
60 70 80 90 100
KAIGLQRTGK QEEAFTLAQE VAALEPTDDN SLQALTILYR EMHRPELVTK
110 120 130 140 150
LYEAAVKKVP NSEEYHSHLF MAYARVGEYK KMQQAGMALY KIVPKNPYYF
160 170 180 190 200
WSVMSLIMQS ISAQDENLSK TMFLPLAERM VEKMVKEDKI EAEAEVELYY
210 220 230 240 250
MILERLGKYQ EALDVIRGKL GEKLTSEIQS RENKCMAMYK KLSRWPECNA
260 270 280 290 300
LSRRLLLKNS DDWQFYLTYF DSVFRLIEEA WSPPAEGEHS LEGEVHYSAE
310 320 330 340 350
KAVKFIEDRI TEESKSSRHL RGPHLAKLEL IRRLRSQGCN DEYKLGDPEE
360 370 380 390 400
LMFQYFKKFG DKPCCFTDLK VFVDLLPATQ CTKFINQLLG VVPLSTPTED
410 420 430 440 450
KLALPADIRA LQQHLCVVQL TRLLGLYHTM DKNQKLSVVR ELMLRYQHGL
460 470 480 490 500
EFGKTCLKTE LQFSDYYCLL AVHALIDVWR ETGDETTVWQ ALTLLEEGLT
510 520 530 540 550
HSPSNAQFKL LLVRIYCMLG AFEPVVDLYS SLDAKHIQHD TIGYLLTRYA
560 570 580 590 600
ESLGQYAAAS QSCNFALRFF HSNQKDTSEY IIQAYKYGAF EKIPEFIAFR
610 620 630 640 650
NRLNNSLHFA QVRTERMLLD LLLEANISTS LAESIKSMNL RPEEDDIPWE
660 670 680 690 700
DLRDNRDLNV FFSWDPKDRD VSEEHKKLSL EEETLWLRIR SLTLRLISGL
710 720 730 740 750
PSLNHPVEPK NSEKTAENGV SSRIDILRLL LQQLEATLET GKRFIEKDIQ
760 770 780 790 800
YPFLGPVPTR MGGFFNSGCS QCQISSFYLV NDIYELDTSG LEDTMEIQER
810 820 830 840 850
IENSFKSLLD QLKDVFSKCK GDLLEVKDGN LKTHPTLLEN LVFFVETISV
860 870 880 890 900
ILWVSSYCES VLRPYKLNLQ KKKKKKKETS IIMPPVFTSF QDYVTGLQTL
910 920 930 940 950
ISNVVDHIKG LETHLIALKL EELILEDTSL SPEERKFSKT VQGKVQSSYL
960 970
HSLLEMGELL KKRLETTKKL KI
Length:972
Mass (Da):112,292
Last modified:August 22, 2006 - v1
Checksum:i232B8FD14447DDD6
GO
Isoform 2 (identifier: Q14CX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     847-859: TISVILWVSSYCE → VSFCSLPKRHCCS
     860-972: Missing.

Note: No experimental confirmation available.
Show »
Length:859
Mass (Da):99,269
Checksum:i5918C0A1EB63A438
GO

Sequence cautioni

The sequence BAB14432 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAE46062 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202I → T in BAB14432 (PubMed:14702039).Curated1
Sequence conflicti466Y → S in BAB14432 (PubMed:14702039).Curated1
Sequence conflicti672S → T in BAB14432 (PubMed:14702039).Curated1
Sequence conflicti817S → G in CAE46062 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054099426L → F.Corresponds to variant rs16941860dbSNPEnsembl.1
Natural variantiVAR_035872789S → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_033156876K → R.Corresponds to variant rs12231744dbSNPEnsembl.1
Natural variantiVAR_054100915L → I.Corresponds to variant rs12298022dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026629847 – 859TISVI…SSYCE → VSFCSLPKRHCCS in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_026630860 – 972Missing in isoform 2. 1 PublicationAdd BLAST113

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054990 mRNA. Translation: BAC80174.1.
BX641140 mRNA. Translation: CAE46062.1. Different initiation.
BC034357 mRNA. Translation: AAH34357.1.
BC113585 mRNA. Translation: AAI13586.1.
BC113587 mRNA. Translation: AAI13588.1.
AK023151 mRNA. Translation: BAB14432.1. Different initiation.
CCDSiCCDS9159.1. [Q14CX7-1]
RefSeqiNP_079229.2. NM_024953.3. [Q14CX7-1]
UniGeneiHs.530941.

Genome annotation databases

EnsembliENST00000261745; ENSP00000261745; ENSG00000111300. [Q14CX7-1]
GeneIDi80018.
KEGGihsa:80018.
UCSCiuc001ttm.4. human. [Q14CX7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054990 mRNA. Translation: BAC80174.1.
BX641140 mRNA. Translation: CAE46062.1. Different initiation.
BC034357 mRNA. Translation: AAH34357.1.
BC113585 mRNA. Translation: AAI13586.1.
BC113587 mRNA. Translation: AAI13588.1.
AK023151 mRNA. Translation: BAB14432.1. Different initiation.
CCDSiCCDS9159.1. [Q14CX7-1]
RefSeqiNP_079229.2. NM_024953.3. [Q14CX7-1]
UniGeneiHs.530941.

3D structure databases

ProteinModelPortaliQ14CX7.
SMRiQ14CX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123072. 13 interactors.
DIPiDIP-50826N.
IntActiQ14CX7. 2 interactors.
STRINGi9606.ENSP00000261745.

PTM databases

iPTMnetiQ14CX7.
PhosphoSitePlusiQ14CX7.

Polymorphism and mutation databases

BioMutaiNAA25.
DMDMi121948761.

Proteomic databases

EPDiQ14CX7.
MaxQBiQ14CX7.
PaxDbiQ14CX7.
PeptideAtlasiQ14CX7.
PRIDEiQ14CX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261745; ENSP00000261745; ENSG00000111300. [Q14CX7-1]
GeneIDi80018.
KEGGihsa:80018.
UCSCiuc001ttm.4. human. [Q14CX7-1]

Organism-specific databases

CTDi80018.
DisGeNETi80018.
GeneCardsiNAA25.
H-InvDBHIX0011004.
HGNCiHGNC:25783. NAA25.
HPAiHPA039322.
MIMi612755. gene.
neXtProtiNX_Q14CX7.
OpenTargetsiENSG00000111300.
PharmGKBiPA165513030.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2053. Eukaryota.
ENOG410XRXD. LUCA.
GeneTreeiENSGT00390000003496.
HOGENOMiHOG000060132.
InParanoidiQ14CX7.
KOiK17973.
OMAiEKDIQYP.
OrthoDBiEOG091G029K.
PhylomeDBiQ14CX7.
TreeFamiTF315103.

Miscellaneous databases

ChiTaRSiNAA25. human.
GenomeRNAii80018.
PROiQ14CX7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111300.
CleanExiHS_C12orf30.
ExpressionAtlasiQ14CX7. baseline and differential.
GenevisibleiQ14CX7. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR019183. N-acetylTrfase_B_cplx_non-cat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF09797. NatB_MDM20. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAA25_HUMAN
AccessioniPrimary (citable) accession number: Q14CX7
Secondary accession number(s): A0JLU7
, Q6MZH1, Q7Z4N6, Q9H911
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: August 22, 2006
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.