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Q14CX7

- NAA25_HUMAN

UniProt

Q14CX7 - NAA25_HUMAN

Protein

N-alpha-acetyltransferase 25, NatB auxiliary subunit

Gene

NAA25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-alpha-acetyltransferase 25, NatB auxiliary subunit
    Alternative name(s):
    Mitochondrial distribution and morphology protein 20
    N-terminal acetyltransferase B complex subunit MDM20
    Short name:
    NatB complex subunit MDM20
    N-terminal acetyltransferase B complex subunit NAA25
    p120
    Gene namesi
    Name:NAA25
    Synonyms:C12orf30, MDM20, NAP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:25783. NAA25.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165513030.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 972972N-alpha-acetyltransferase 25, NatB auxiliary subunitPRO_0000294337Add
    BLAST

    Proteomic databases

    MaxQBiQ14CX7.
    PaxDbiQ14CX7.
    PRIDEiQ14CX7.

    PTM databases

    PhosphoSiteiQ14CX7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14CX7.
    BgeeiQ14CX7.
    CleanExiHS_C12orf30.
    GenevestigatoriQ14CX7.

    Organism-specific databases

    HPAiHPA039322.

    Interactioni

    Subunit structurei

    Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK2P249411EBI-1048503,EBI-375096

    Protein-protein interaction databases

    BioGridi123072. 7 interactions.
    IntActiQ14CX7. 2 interactions.
    STRINGi9606.ENSP00000261745.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14CX7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 4434TPR 1Add
    BLAST
    Repeati45 – 7834TPR 2Add
    BLAST
    Repeati79 – 11234TPR 3Add
    BLAST
    Repeati114 – 14633TPR 4Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi871 – 8777Poly-Lys

    Sequence similaritiesi

    Belongs to the MDM20/NAA25 family.Curated
    Contains 4 TPR repeats.Curated

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiNOG259643.
    HOGENOMiHOG000060132.
    InParanoidiQ14CX7.
    KOiK17973.
    OMAiQCTKFIN.
    OrthoDBiEOG75F4CR.
    PhylomeDBiQ14CX7.
    TreeFamiTF315103.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR019183. N-acetylTrfase_B_cplx_non-cat.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PfamiPF09797. NatB_MDM20. 1 hit.
    [Graphical view]
    PROSITEiPS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14CX7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATRGHVQDP NDRRLRPIYD YLDNGNNKMA IQQADKLLKK HKDLHCAKVL    50
    KAIGLQRTGK QEEAFTLAQE VAALEPTDDN SLQALTILYR EMHRPELVTK 100
    LYEAAVKKVP NSEEYHSHLF MAYARVGEYK KMQQAGMALY KIVPKNPYYF 150
    WSVMSLIMQS ISAQDENLSK TMFLPLAERM VEKMVKEDKI EAEAEVELYY 200
    MILERLGKYQ EALDVIRGKL GEKLTSEIQS RENKCMAMYK KLSRWPECNA 250
    LSRRLLLKNS DDWQFYLTYF DSVFRLIEEA WSPPAEGEHS LEGEVHYSAE 300
    KAVKFIEDRI TEESKSSRHL RGPHLAKLEL IRRLRSQGCN DEYKLGDPEE 350
    LMFQYFKKFG DKPCCFTDLK VFVDLLPATQ CTKFINQLLG VVPLSTPTED 400
    KLALPADIRA LQQHLCVVQL TRLLGLYHTM DKNQKLSVVR ELMLRYQHGL 450
    EFGKTCLKTE LQFSDYYCLL AVHALIDVWR ETGDETTVWQ ALTLLEEGLT 500
    HSPSNAQFKL LLVRIYCMLG AFEPVVDLYS SLDAKHIQHD TIGYLLTRYA 550
    ESLGQYAAAS QSCNFALRFF HSNQKDTSEY IIQAYKYGAF EKIPEFIAFR 600
    NRLNNSLHFA QVRTERMLLD LLLEANISTS LAESIKSMNL RPEEDDIPWE 650
    DLRDNRDLNV FFSWDPKDRD VSEEHKKLSL EEETLWLRIR SLTLRLISGL 700
    PSLNHPVEPK NSEKTAENGV SSRIDILRLL LQQLEATLET GKRFIEKDIQ 750
    YPFLGPVPTR MGGFFNSGCS QCQISSFYLV NDIYELDTSG LEDTMEIQER 800
    IENSFKSLLD QLKDVFSKCK GDLLEVKDGN LKTHPTLLEN LVFFVETISV 850
    ILWVSSYCES VLRPYKLNLQ KKKKKKKETS IIMPPVFTSF QDYVTGLQTL 900
    ISNVVDHIKG LETHLIALKL EELILEDTSL SPEERKFSKT VQGKVQSSYL 950
    HSLLEMGELL KKRLETTKKL KI 972
    Length:972
    Mass (Da):112,292
    Last modified:August 22, 2006 - v1
    Checksum:i232B8FD14447DDD6
    GO
    Isoform 2 (identifier: Q14CX7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         847-859: TISVILWVSSYCE → VSFCSLPKRHCCS
         860-972: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:859
    Mass (Da):99,269
    Checksum:i5918C0A1EB63A438
    GO

    Sequence cautioni

    The sequence BAB14432.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAE46062.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti202 – 2021I → T in BAB14432. (PubMed:14702039)Curated
    Sequence conflicti466 – 4661Y → S in BAB14432. (PubMed:14702039)Curated
    Sequence conflicti672 – 6721S → T in BAB14432. (PubMed:14702039)Curated
    Sequence conflicti817 – 8171S → G in CAE46062. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti426 – 4261L → F.
    Corresponds to variant rs16941860 [ dbSNP | Ensembl ].
    VAR_054099
    Natural varianti789 – 7891S → R in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035872
    Natural varianti876 – 8761K → R.
    Corresponds to variant rs12231744 [ dbSNP | Ensembl ].
    VAR_033156
    Natural varianti915 – 9151L → I.
    Corresponds to variant rs12298022 [ dbSNP | Ensembl ].
    VAR_054100

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei847 – 85913TISVI…SSYCE → VSFCSLPKRHCCS in isoform 2. 1 PublicationVSP_026629Add
    BLAST
    Alternative sequencei860 – 972113Missing in isoform 2. 1 PublicationVSP_026630Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB054990 mRNA. Translation: BAC80174.1.
    BX641140 mRNA. Translation: CAE46062.1. Different initiation.
    BC034357 mRNA. Translation: AAH34357.1.
    BC113585 mRNA. Translation: AAI13586.1.
    BC113587 mRNA. Translation: AAI13588.1.
    AK023151 mRNA. Translation: BAB14432.1. Different initiation.
    CCDSiCCDS9159.1. [Q14CX7-1]
    RefSeqiNP_079229.2. NM_024953.3. [Q14CX7-1]
    UniGeneiHs.530941.

    Genome annotation databases

    EnsembliENST00000261745; ENSP00000261745; ENSG00000111300. [Q14CX7-1]
    GeneIDi80018.
    KEGGihsa:80018.
    UCSCiuc001ttm.3. human. [Q14CX7-1]

    Polymorphism databases

    DMDMi121948761.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB054990 mRNA. Translation: BAC80174.1 .
    BX641140 mRNA. Translation: CAE46062.1 . Different initiation.
    BC034357 mRNA. Translation: AAH34357.1 .
    BC113585 mRNA. Translation: AAI13586.1 .
    BC113587 mRNA. Translation: AAI13588.1 .
    AK023151 mRNA. Translation: BAB14432.1 . Different initiation.
    CCDSi CCDS9159.1. [Q14CX7-1 ]
    RefSeqi NP_079229.2. NM_024953.3. [Q14CX7-1 ]
    UniGenei Hs.530941.

    3D structure databases

    ProteinModelPortali Q14CX7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123072. 7 interactions.
    IntActi Q14CX7. 2 interactions.
    STRINGi 9606.ENSP00000261745.

    PTM databases

    PhosphoSitei Q14CX7.

    Polymorphism databases

    DMDMi 121948761.

    Proteomic databases

    MaxQBi Q14CX7.
    PaxDbi Q14CX7.
    PRIDEi Q14CX7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261745 ; ENSP00000261745 ; ENSG00000111300 . [Q14CX7-1 ]
    GeneIDi 80018.
    KEGGi hsa:80018.
    UCSCi uc001ttm.3. human. [Q14CX7-1 ]

    Organism-specific databases

    CTDi 80018.
    GeneCardsi GC12M112464.
    H-InvDB HIX0011004.
    HGNCi HGNC:25783. NAA25.
    HPAi HPA039322.
    MIMi 612755. gene.
    neXtProti NX_Q14CX7.
    PharmGKBi PA165513030.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259643.
    HOGENOMi HOG000060132.
    InParanoidi Q14CX7.
    KOi K17973.
    OMAi QCTKFIN.
    OrthoDBi EOG75F4CR.
    PhylomeDBi Q14CX7.
    TreeFami TF315103.

    Miscellaneous databases

    ChiTaRSi NAA25. human.
    GenomeRNAii 80018.
    NextBioi 70134.
    PROi Q14CX7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14CX7.
    Bgeei Q14CX7.
    CleanExi HS_C12orf30.
    Genevestigatori Q14CX7.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR019183. N-acetylTrfase_B_cplx_non-cat.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    Pfami PF09797. NatB_MDM20. 1 hit.
    [Graphical view ]
    PROSITEi PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "P120 which associates with nascent polypeptide chain."
      Hotokezaka H., Wiedmann M.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Uterine endothelium.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 100-972.
    5. "Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression."
      Starheim K.K., Arnesen T., Gromyko D., Ryningen A., Varhaug J.E., Lillehaug J.R.
      Biochem. J. 415:325-331(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NAT5, SUBCELLULAR LOCATION.
    6. "A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates."
      Polevoda B., Arnesen T., Sherman F.
      BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-789.

    Entry informationi

    Entry nameiNAA25_HUMAN
    AccessioniPrimary (citable) accession number: Q14CX7
    Secondary accession number(s): A0JLU7
    , Q6MZH1, Q7Z4N6, Q9H911
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3